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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 1-17643083-G-C (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=1&pos=17643083&ref=G&alt=C&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "1",
"pos": 17643083,
"ref": "G",
"alt": "C",
"effect": "intron_variant",
"transcript": "ENST00000361221.8",
"consequences": [
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 29,
"intron_rank": 21,
"intron_rank_end": null,
"gene_symbol": "ARHGEF10L",
"gene_hgnc_id": 25540,
"hgvs_c": "c.2272+2781G>C",
"hgvs_p": null,
"transcript": "NM_018125.4",
"protein_id": "NP_060595.3",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 1279,
"cds_start": -4,
"cds_end": null,
"cds_length": 3840,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 4625,
"mane_select": "ENST00000361221.8",
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": true,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 29,
"intron_rank": 21,
"intron_rank_end": null,
"gene_symbol": "ARHGEF10L",
"gene_hgnc_id": 25540,
"hgvs_c": "c.2272+2781G>C",
"hgvs_p": null,
"transcript": "ENST00000361221.8",
"protein_id": "ENSP00000355060.3",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": 1279,
"cds_start": -4,
"cds_end": null,
"cds_length": 3840,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 4625,
"mane_select": "NM_018125.4",
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 27,
"intron_rank": 19,
"intron_rank_end": null,
"gene_symbol": "ARHGEF10L",
"gene_hgnc_id": 25540,
"hgvs_c": "c.2155+2781G>C",
"hgvs_p": null,
"transcript": "ENST00000375415.5",
"protein_id": "ENSP00000364564.1",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": 1240,
"cds_start": -4,
"cds_end": null,
"cds_length": 3723,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 4035,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 27,
"intron_rank": 19,
"intron_rank_end": null,
"gene_symbol": "ARHGEF10L",
"gene_hgnc_id": 25540,
"hgvs_c": "c.2155+2781G>C",
"hgvs_p": null,
"transcript": "NM_001011722.2",
"protein_id": "NP_001011722.2",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 1240,
"cds_start": -4,
"cds_end": null,
"cds_length": 3723,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 4261,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 27,
"intron_rank": 19,
"intron_rank_end": null,
"gene_symbol": "ARHGEF10L",
"gene_hgnc_id": 25540,
"hgvs_c": "c.2143+2781G>C",
"hgvs_p": null,
"transcript": "NM_001438939.1",
"protein_id": "NP_001425868.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 1236,
"cds_start": -4,
"cds_end": null,
"cds_length": 3711,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 4496,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 27,
"intron_rank": 19,
"intron_rank_end": null,
"gene_symbol": "ARHGEF10L",
"gene_hgnc_id": 25540,
"hgvs_c": "c.2143+2781G>C",
"hgvs_p": null,
"transcript": "NM_001438940.1",
"protein_id": "NP_001425869.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 1236,
"cds_start": -4,
"cds_end": null,
"cds_length": 3711,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 4505,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 27,
"intron_rank": 19,
"intron_rank_end": null,
"gene_symbol": "ARHGEF10L",
"gene_hgnc_id": 25540,
"hgvs_c": "c.2143+2781G>C",
"hgvs_p": null,
"transcript": "NM_001438941.1",
"protein_id": "NP_001425870.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 1236,
"cds_start": -4,
"cds_end": null,
"cds_length": 3711,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 4500,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 27,
"intron_rank": 19,
"intron_rank_end": null,
"gene_symbol": "ARHGEF10L",
"gene_hgnc_id": 25540,
"hgvs_c": "c.2143+2781G>C",
"hgvs_p": null,
"transcript": "NM_001438942.1",
"protein_id": "NP_001425871.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 1236,
"cds_start": -4,
"cds_end": null,
"cds_length": 3711,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 4260,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 26,
"intron_rank": 18,
"intron_rank_end": null,
"gene_symbol": "ARHGEF10L",
"gene_hgnc_id": 25540,
"hgvs_c": "c.2140+2781G>C",
"hgvs_p": null,
"transcript": "NM_001319837.2",
"protein_id": "NP_001306766.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 1235,
"cds_start": -4,
"cds_end": null,
"cds_length": 3708,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 4339,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 27,
"intron_rank": 19,
"intron_rank_end": null,
"gene_symbol": "ARHGEF10L",
"gene_hgnc_id": 25540,
"hgvs_c": "c.2140+2781G>C",
"hgvs_p": null,
"transcript": "NM_001438943.1",
"protein_id": "NP_001425872.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 1235,
"cds_start": -4,
"cds_end": null,
"cds_length": 3708,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 4493,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 27,
"intron_rank": 19,
"intron_rank_end": null,
"gene_symbol": "ARHGEF10L",
"gene_hgnc_id": 25540,
"hgvs_c": "c.2140+2781G>C",
"hgvs_p": null,
"transcript": "NM_001438944.1",
"protein_id": "NP_001425873.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 1235,
"cds_start": -4,
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"cds_length": 3708,
"cdna_start": null,
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"mane_select": null,
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"biotype": null,
"feature": null
},
{
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"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 27,
"intron_rank": 19,
"intron_rank_end": null,
"gene_symbol": "ARHGEF10L",
"gene_hgnc_id": 25540,
"hgvs_c": "c.2140+2781G>C",
"hgvs_p": null,
"transcript": "NM_001438945.1",
"protein_id": "NP_001425874.1",
"transcript_support_level": null,
"aa_start": null,
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"aa_length": 1235,
"cds_start": -4,
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"cdna_start": null,
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"mane_select": null,
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"biotype": null,
"feature": null
},
{
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"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 21,
"intron_rank": 13,
"intron_rank_end": null,
"gene_symbol": "ARHGEF10L",
"gene_hgnc_id": 25540,
"hgvs_c": "c.1606+2781G>C",
"hgvs_p": null,
"transcript": "NM_001328124.1",
"protein_id": "NP_001315053.1",
"transcript_support_level": null,
"aa_start": null,
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"cds_start": -4,
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"cdna_start": null,
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"feature": null
},
{
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"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
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],
"exon_rank": null,
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"exon_count": 20,
"intron_rank": 12,
"intron_rank_end": null,
"gene_symbol": "ARHGEF10L",
"gene_hgnc_id": 25540,
"hgvs_c": "c.1591+2781G>C",
"hgvs_p": null,
"transcript": "NM_001438946.1",
"protein_id": "NP_001425875.1",
"transcript_support_level": null,
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},
{
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"strand": true,
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"intron_variant"
],
"exon_rank": null,
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"exon_count": 20,
"intron_rank": 12,
"intron_rank_end": null,
"gene_symbol": "ARHGEF10L",
"gene_hgnc_id": 25540,
"hgvs_c": "c.1591+2781G>C",
"hgvs_p": null,
"transcript": "ENST00000375408.7",
"protein_id": "ENSP00000364557.3",
"transcript_support_level": 5,
"aa_start": null,
"aa_end": null,
"aa_length": 1052,
"cds_start": -4,
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"mane_select": null,
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"feature": null
},
{
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"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
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"exon_count": 18,
"intron_rank": 10,
"intron_rank_end": null,
"gene_symbol": "ARHGEF10L",
"gene_hgnc_id": 25540,
"hgvs_c": "c.1381+2781G>C",
"hgvs_p": null,
"transcript": "NM_001319838.1",
"protein_id": "NP_001306767.1",
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},
{
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"protein_coding": false,
"strand": true,
"consequences": [
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],
"exon_rank": null,
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"exon_count": 16,
"intron_rank": 7,
"intron_rank_end": null,
"gene_symbol": "ARHGEF10L",
"gene_hgnc_id": 25540,
"hgvs_c": "n.889+2781G>C",
"hgvs_p": null,
"transcript": "ENST00000167825.5",
"protein_id": "ENSP00000167825.5",
"transcript_support_level": 2,
"aa_start": null,
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"mane_select": null,
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"feature": null
},
{
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"protein_coding": false,
"strand": true,
"consequences": [
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],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 4,
"intron_rank": 2,
"intron_rank_end": null,
"gene_symbol": "ARHGEF10L",
"gene_hgnc_id": 25540,
"hgvs_c": "n.330+2781G>C",
"hgvs_p": null,
"transcript": "ENST00000466782.1",
"protein_id": null,
"transcript_support_level": 3,
"aa_start": null,
"aa_end": null,
"aa_length": null,
"cds_start": -4,
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"cdna_start": null,
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"mane_select": null,
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"feature": null
},
{
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"canonical": false,
"protein_coding": false,
"strand": true,
"consequences": [
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],
"exon_rank": null,
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"exon_count": 20,
"intron_rank": 12,
"intron_rank_end": null,
"gene_symbol": "ARHGEF10L",
"gene_hgnc_id": 25540,
"hgvs_c": "n.2537+2781G>C",
"hgvs_p": null,
"transcript": "ENST00000469726.5",
"protein_id": null,
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},
{
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"strand": true,
"consequences": [
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],
"exon_rank": null,
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"intron_rank": 22,
"intron_rank_end": null,
"gene_symbol": "ARHGEF10L",
"gene_hgnc_id": 25540,
"hgvs_c": "n.3315+2781G>C",
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"transcript": "NR_137287.2",
"protein_id": null,
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},
{
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"strand": true,
"consequences": [
"intron_variant"
],
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"intron_rank": 21,
"intron_rank_end": null,
"gene_symbol": "ARHGEF10L",
"gene_hgnc_id": 25540,
"hgvs_c": "n.3195+2781G>C",
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"transcript": "NR_137288.2",
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"feature": null
},
{
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"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 28,
"intron_rank": 20,
"intron_rank_end": null,
"gene_symbol": "ARHGEF10L",
"gene_hgnc_id": 25540,
"hgvs_c": "c.2167+2781G>C",
"hgvs_p": null,
"transcript": "XM_005245923.3",
"protein_id": "XP_005245980.2",
"transcript_support_level": null,
"aa_start": null,
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"aa_length": 1244,
"cds_start": -4,
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"cdna_start": null,
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"cdna_length": 4526,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
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"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 28,
"intron_rank": 20,
"intron_rank_end": null,
"gene_symbol": "ARHGEF10L",
"gene_hgnc_id": 25540,
"hgvs_c": "c.2167+2781G>C",
"hgvs_p": null,
"transcript": "XM_006710728.1",
"protein_id": "XP_006710791.1",
"transcript_support_level": null,
"aa_start": null,
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