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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 1-179368829-A-T (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=1&pos=179368829&ref=A&alt=T&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "1",
"pos": 179368829,
"ref": "A",
"alt": "T",
"effect": "missense_variant",
"transcript": "ENST00000367618.8",
"consequences": [
{
"aa_ref": "M",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 26,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "AXDND1",
"gene_hgnc_id": 26564,
"hgvs_c": "c.127A>T",
"hgvs_p": "p.Met43Leu",
"transcript": "NM_144696.6",
"protein_id": "NP_653297.3",
"transcript_support_level": null,
"aa_start": 43,
"aa_end": null,
"aa_length": 1012,
"cds_start": 127,
"cds_end": null,
"cds_length": 3039,
"cdna_start": 263,
"cdna_end": null,
"cdna_length": 3391,
"mane_select": "ENST00000367618.8",
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "M",
"aa_alt": "L",
"canonical": true,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 26,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "AXDND1",
"gene_hgnc_id": 26564,
"hgvs_c": "c.127A>T",
"hgvs_p": "p.Met43Leu",
"transcript": "ENST00000367618.8",
"protein_id": "ENSP00000356590.3",
"transcript_support_level": 1,
"aa_start": 43,
"aa_end": null,
"aa_length": 1012,
"cds_start": 127,
"cds_end": null,
"cds_length": 3039,
"cdna_start": 263,
"cdna_end": null,
"cdna_length": 3391,
"mane_select": "NM_144696.6",
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": false,
"strand": true,
"consequences": [
"non_coding_transcript_exon_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 26,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "AXDND1",
"gene_hgnc_id": 26564,
"hgvs_c": "n.127A>T",
"hgvs_p": null,
"transcript": "ENST00000511157.5",
"protein_id": "ENSP00000424373.1",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": null,
"cds_start": -4,
"cds_end": null,
"cds_length": null,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 3375,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "M",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 25,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "AXDND1",
"gene_hgnc_id": 26564,
"hgvs_c": "c.127A>T",
"hgvs_p": "p.Met43Leu",
"transcript": "ENST00000617277.4",
"protein_id": "ENSP00000482167.1",
"transcript_support_level": 5,
"aa_start": 43,
"aa_end": null,
"aa_length": 529,
"cds_start": 127,
"cds_end": null,
"cds_length": 1590,
"cdna_start": 514,
"cdna_end": null,
"cdna_length": 3405,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "M",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 3,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "AXDND1",
"gene_hgnc_id": 26564,
"hgvs_c": "c.127A>T",
"hgvs_p": "p.Met43Leu",
"transcript": "ENST00000508229.5",
"protein_id": "ENSP00000422992.1",
"transcript_support_level": 4,
"aa_start": 43,
"aa_end": null,
"aa_length": 77,
"cds_start": 127,
"cds_end": null,
"cds_length": 236,
"cdna_start": 477,
"cdna_end": null,
"cdna_length": 586,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "M",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 27,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "AXDND1",
"gene_hgnc_id": 26564,
"hgvs_c": "c.127A>T",
"hgvs_p": "p.Met43Leu",
"transcript": "XM_011509165.2",
"protein_id": "XP_011507467.1",
"transcript_support_level": null,
"aa_start": 43,
"aa_end": null,
"aa_length": 1014,
"cds_start": 127,
"cds_end": null,
"cds_length": 3045,
"cdna_start": 263,
"cdna_end": null,
"cdna_length": 3397,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "M",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 27,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "AXDND1",
"gene_hgnc_id": 26564,
"hgvs_c": "c.127A>T",
"hgvs_p": "p.Met43Leu",
"transcript": "XM_011509166.4",
"protein_id": "XP_011507468.1",
"transcript_support_level": null,
"aa_start": 43,
"aa_end": null,
"aa_length": 1014,
"cds_start": 127,
"cds_end": null,
"cds_length": 3045,
"cdna_start": 274,
"cdna_end": null,
"cdna_length": 3408,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "M",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 27,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "AXDND1",
"gene_hgnc_id": 26564,
"hgvs_c": "c.127A>T",
"hgvs_p": "p.Met43Leu",
"transcript": "XM_011509167.4",
"protein_id": "XP_011507469.1",
"transcript_support_level": null,
"aa_start": 43,
"aa_end": null,
"aa_length": 1014,
"cds_start": 127,
"cds_end": null,
"cds_length": 3045,
"cdna_start": 389,
"cdna_end": null,
"cdna_length": 3523,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "M",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 27,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "AXDND1",
"gene_hgnc_id": 26564,
"hgvs_c": "c.127A>T",
"hgvs_p": "p.Met43Leu",
"transcript": "XM_011509168.2",
"protein_id": "XP_011507470.1",
"transcript_support_level": null,
"aa_start": 43,
"aa_end": null,
"aa_length": 1014,
"cds_start": 127,
"cds_end": null,
"cds_length": 3045,
"cdna_start": 510,
"cdna_end": null,
"cdna_length": 3644,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "M",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 2,
"exon_rank_end": null,
"exon_count": 26,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "AXDND1",
"gene_hgnc_id": 26564,
"hgvs_c": "c.64A>T",
"hgvs_p": "p.Met22Leu",
"transcript": "XM_011509169.2",
"protein_id": "XP_011507471.1",
"transcript_support_level": null,
"aa_start": 22,
"aa_end": null,
"aa_length": 993,
"cds_start": 64,
"cds_end": null,
"cds_length": 2982,
"cdna_start": 307,
"cdna_end": null,
"cdna_length": 3441,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "M",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 26,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "AXDND1",
"gene_hgnc_id": 26564,
"hgvs_c": "c.127A>T",
"hgvs_p": "p.Met43Leu",
"transcript": "XM_011509170.2",
"protein_id": "XP_011507472.1",
"transcript_support_level": null,
"aa_start": 43,
"aa_end": null,
"aa_length": 978,
"cds_start": 127,
"cds_end": null,
"cds_length": 2937,
"cdna_start": 263,
"cdna_end": null,
"cdna_length": 3289,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "M",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 25,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "AXDND1",
"gene_hgnc_id": 26564,
"hgvs_c": "c.127A>T",
"hgvs_p": "p.Met43Leu",
"transcript": "XM_011509174.2",
"protein_id": "XP_011507476.1",
"transcript_support_level": null,
"aa_start": 43,
"aa_end": null,
"aa_length": 940,
"cds_start": 127,
"cds_end": null,
"cds_length": 2823,
"cdna_start": 263,
"cdna_end": null,
"cdna_length": 3175,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "M",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 24,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "AXDND1",
"gene_hgnc_id": 26564,
"hgvs_c": "c.127A>T",
"hgvs_p": "p.Met43Leu",
"transcript": "XM_011509175.2",
"protein_id": "XP_011507477.1",
"transcript_support_level": null,
"aa_start": 43,
"aa_end": null,
"aa_length": 938,
"cds_start": 127,
"cds_end": null,
"cds_length": 2817,
"cdna_start": 263,
"cdna_end": null,
"cdna_length": 3169,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "M",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 25,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "AXDND1",
"gene_hgnc_id": 26564,
"hgvs_c": "c.127A>T",
"hgvs_p": "p.Met43Leu",
"transcript": "XM_011509176.2",
"protein_id": "XP_011507478.1",
"transcript_support_level": null,
"aa_start": 43,
"aa_end": null,
"aa_length": 915,
"cds_start": 127,
"cds_end": null,
"cds_length": 2748,
"cdna_start": 263,
"cdna_end": null,
"cdna_length": 3100,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "M",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 21,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "AXDND1",
"gene_hgnc_id": 26564,
"hgvs_c": "c.127A>T",
"hgvs_p": "p.Met43Leu",
"transcript": "XM_011509178.3",
"protein_id": "XP_011507480.1",
"transcript_support_level": null,
"aa_start": 43,
"aa_end": null,
"aa_length": 815,
"cds_start": 127,
"cds_end": null,
"cds_length": 2448,
"cdna_start": 263,
"cdna_end": null,
"cdna_length": 2679,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "M",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 21,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "AXDND1",
"gene_hgnc_id": 26564,
"hgvs_c": "c.127A>T",
"hgvs_p": "p.Met43Leu",
"transcript": "XM_011509180.2",
"protein_id": "XP_011507482.1",
"transcript_support_level": null,
"aa_start": 43,
"aa_end": null,
"aa_length": 797,
"cds_start": 127,
"cds_end": null,
"cds_length": 2394,
"cdna_start": 263,
"cdna_end": null,
"cdna_length": 2618,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "M",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 18,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "AXDND1",
"gene_hgnc_id": 26564,
"hgvs_c": "c.127A>T",
"hgvs_p": "p.Met43Leu",
"transcript": "XM_047444817.1",
"protein_id": "XP_047300773.1",
"transcript_support_level": null,
"aa_start": 43,
"aa_end": null,
"aa_length": 655,
"cds_start": 127,
"cds_end": null,
"cds_length": 1968,
"cdna_start": 263,
"cdna_end": null,
"cdna_length": 2276,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "M",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"initiator_codon_variant"
],
"exon_rank": 2,
"exon_rank_end": null,
"exon_count": 5,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "AXDND1",
"gene_hgnc_id": 26564,
"hgvs_c": "c.1A>T",
"hgvs_p": "p.Met1?",
"transcript": "ENST00000509175.5",
"protein_id": "ENSP00000425019.1",
"transcript_support_level": 4,
"aa_start": 1,
"aa_end": null,
"aa_length": 150,
"cds_start": 1,
"cds_end": null,
"cds_length": 455,
"cdna_start": 311,
"cdna_end": null,
"cdna_length": 765,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "M",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"initiator_codon_variant"
],
"exon_rank": 2,
"exon_rank_end": null,
"exon_count": 4,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "AXDND1",
"gene_hgnc_id": 26564,
"hgvs_c": "c.1A>T",
"hgvs_p": "p.Met1?",
"transcript": "ENST00000511889.5",
"protein_id": "ENSP00000425198.1",
"transcript_support_level": 4,
"aa_start": 1,
"aa_end": null,
"aa_length": 122,
"cds_start": 1,
"cds_end": null,
"cds_length": 369,
"cdna_start": 185,
"cdna_end": null,
"cdna_length": 553,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "M",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"initiator_codon_variant"
],
"exon_rank": 2,
"exon_rank_end": null,
"exon_count": 26,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "AXDND1",
"gene_hgnc_id": 26564,
"hgvs_c": "c.1A>T",
"hgvs_p": "p.Met1?",
"transcript": "XM_011509171.2",
"protein_id": "XP_011507473.1",
"transcript_support_level": null,
"aa_start": 1,
"aa_end": null,
"aa_length": 972,
"cds_start": 1,
"cds_end": null,
"cds_length": 2919,
"cdna_start": 60,
"cdna_end": null,
"cdna_length": 3194,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "M",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"initiator_codon_variant"
],
"exon_rank": 2,
"exon_rank_end": null,
"exon_count": 26,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "AXDND1",
"gene_hgnc_id": 26564,
"hgvs_c": "c.1A>T",
"hgvs_p": "p.Met1?",
"transcript": "XM_024453104.2",
"protein_id": "XP_024308872.1",
"transcript_support_level": null,
"aa_start": 1,
"aa_end": null,
"aa_length": 972,
"cds_start": 1,
"cds_end": null,
"cds_length": 2919,
"cdna_start": 71,
"cdna_end": null,
"cdna_length": 3205,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "M",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"initiator_codon_variant"
],
"exon_rank": 2,
"exon_rank_end": null,
"exon_count": 26,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "AXDND1",
"gene_hgnc_id": 26564,
"hgvs_c": "c.1A>T",
"hgvs_p": "p.Met1?",
"transcript": "XM_024453107.2",
"protein_id": "XP_024308875.1",
"transcript_support_level": null,
"aa_start": 1,
"aa_end": null,
"aa_length": 972,
"cds_start": 1,
"cds_end": null,
"cds_length": 2919,
"cdna_start": 332,
"cdna_end": null,
"cdna_length": 3466,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": false,
"strand": true,
"consequences": [
"non_coding_transcript_exon_variant"
],
"exon_rank": 2,
"exon_rank_end": null,
"exon_count": 3,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "AXDND1",
"gene_hgnc_id": 26564,
"hgvs_c": "n.286A>T",
"hgvs_p": null,
"transcript": "ENST00000507383.5",
"protein_id": null,
"transcript_support_level": 4,
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}
],
"message": null
}