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GeneBe API Showcase

This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.

API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.

Documentation & Advanced Usage

Complete API documentation:docs.genebe.net/docs/api/overview/

Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/

Python client for pandas:pypi.org/project/genebe/

Java CLI for VCF files:github.com/pstawinski/genebe-cli

All tools documented at:docs.genebe.net

API Request Examples for Variant: 1-193034733-G-A (hg38)

Bash / cURL Example

bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=1&pos=193034733&ref=G&alt=A&genome=hg38&allGenes=true"

API Response

json
{
  "message": null,
  "variants": [
    {
      "acmg_by_gene": [
        {
          "benign_score": 12,
          "criteria": [
            "BP4_Strong",
            "BA1"
          ],
          "effects": [
            "intron_variant"
          ],
          "gene_symbol": "UCHL5",
          "hgnc_id": 19678,
          "hgvs_c": "c.307-5076C>T",
          "hgvs_p": null,
          "inheritance_mode": "AD",
          "pathogenic_score": 0,
          "score": -12,
          "transcript": "NM_001350840.2",
          "verdict": "Benign"
        }
      ],
      "acmg_classification": "Benign",
      "acmg_criteria": "BP4_Strong,BA1",
      "acmg_score": -12,
      "allele_count_reference_population": 2922,
      "alphamissense_prediction": null,
      "alphamissense_score": null,
      "alt": "A",
      "apogee2_prediction": null,
      "apogee2_score": null,
      "bayesdelnoaf_prediction": "Benign",
      "bayesdelnoaf_score": -0.97,
      "chr": "1",
      "clinvar_classification": "",
      "clinvar_disease": "",
      "clinvar_review_status": "",
      "clinvar_submissions_summary": "",
      "computational_prediction_selected": "Benign",
      "computational_score_selected": -0.9700000286102295,
      "computational_source_selected": "BayesDel_noAF",
      "consequences": [
        {
          "aa_alt": null,
          "aa_end": null,
          "aa_length": 328,
          "aa_ref": null,
          "aa_start": null,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 5184,
          "cdna_start": null,
          "cds_end": null,
          "cds_length": 987,
          "cds_start": null,
          "consequences": [
            "intron_variant"
          ],
          "exon_count": 11,
          "exon_rank": null,
          "exon_rank_end": null,
          "feature": "NM_001199261.3",
          "gene_hgnc_id": 19678,
          "gene_symbol": "UCHL5",
          "hgvs_c": "c.247-5076C>T",
          "hgvs_p": null,
          "intron_rank": 3,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": "ENST00000367454.6",
          "protein_coding": true,
          "protein_id": "NP_001186190.1",
          "strand": false,
          "transcript": "NM_001199261.3",
          "transcript_support_level": null
        },
        {
          "aa_alt": null,
          "aa_end": null,
          "aa_length": 328,
          "aa_ref": null,
          "aa_start": null,
          "biotype": "protein_coding",
          "canonical": true,
          "cdna_end": null,
          "cdna_length": 5184,
          "cdna_start": null,
          "cds_end": null,
          "cds_length": 987,
          "cds_start": null,
          "consequences": [
            "intron_variant"
          ],
          "exon_count": 11,
          "exon_rank": null,
          "exon_rank_end": null,
          "feature": "ENST00000367454.6",
          "gene_hgnc_id": 19678,
          "gene_symbol": "UCHL5",
          "hgvs_c": "c.247-5076C>T",
          "hgvs_p": null,
          "intron_rank": 3,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": "NM_001199261.3",
          "protein_coding": true,
          "protein_id": "ENSP00000356424.1",
          "strand": false,
          "transcript": "ENST00000367454.6",
          "transcript_support_level": 1
        },
        {
          "aa_alt": null,
          "aa_end": null,
          "aa_length": 329,
          "aa_ref": null,
          "aa_start": null,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 5327,
          "cdna_start": null,
          "cds_end": null,
          "cds_length": 990,
          "cds_start": null,
          "consequences": [
            "intron_variant"
          ],
          "exon_count": 11,
          "exon_rank": null,
          "exon_rank_end": null,
          "feature": "ENST00000367455.8",
          "gene_hgnc_id": 19678,
          "gene_symbol": "UCHL5",
          "hgvs_c": "c.247-5076C>T",
          "hgvs_p": null,
          "intron_rank": 3,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000356425.3",
          "strand": false,
          "transcript": "ENST00000367455.8",
          "transcript_support_level": 1
        },
        {
          "aa_alt": null,
          "aa_end": null,
          "aa_length": 326,
          "aa_ref": null,
          "aa_start": null,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 1534,
          "cdna_start": null,
          "cds_end": null,
          "cds_length": 981,
          "cds_start": null,
          "consequences": [
            "intron_variant"
          ],
          "exon_count": 12,
          "exon_rank": null,
          "exon_rank_end": null,
          "feature": "ENST00000367448.5",
          "gene_hgnc_id": 19678,
          "gene_symbol": "UCHL5",
          "hgvs_c": "c.247-5076C>T",
          "hgvs_p": null,
          "intron_rank": 3,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000356418.1",
          "strand": false,
          "transcript": "ENST00000367448.5",
          "transcript_support_level": 1
        },
        {
          "aa_alt": null,
          "aa_end": null,
          "aa_length": 316,
          "aa_ref": null,
          "aa_start": null,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 1507,
          "cdna_start": null,
          "cds_end": null,
          "cds_length": 951,
          "cds_start": null,
          "consequences": [
            "intron_variant"
          ],
          "exon_count": 11,
          "exon_rank": null,
          "exon_rank_end": null,
          "feature": "ENST00000367449.5",
          "gene_hgnc_id": 19678,
          "gene_symbol": "UCHL5",
          "hgvs_c": "c.247-5076C>T",
          "hgvs_p": null,
          "intron_rank": 3,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000356419.1",
          "strand": false,
          "transcript": "ENST00000367449.5",
          "transcript_support_level": 1
        },
        {
          "aa_alt": null,
          "aa_end": null,
          "aa_length": 389,
          "aa_ref": null,
          "aa_start": null,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 3468,
          "cdna_start": null,
          "cds_end": null,
          "cds_length": 1170,
          "cds_start": null,
          "consequences": [
            "intron_variant"
          ],
          "exon_count": 12,
          "exon_rank": null,
          "exon_rank_end": null,
          "feature": "ENST00000941922.1",
          "gene_hgnc_id": 19678,
          "gene_symbol": "UCHL5",
          "hgvs_c": "c.349-5076C>T",
          "hgvs_p": null,
          "intron_rank": 3,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000611981.1",
          "strand": false,
          "transcript": "ENST00000941922.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": null,
          "aa_end": null,
          "aa_length": 375,
          "aa_ref": null,
          "aa_start": null,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 5303,
          "cdna_start": null,
          "cds_end": null,
          "cds_length": 1128,
          "cds_start": null,
          "consequences": [
            "intron_variant"
          ],
          "exon_count": 12,
          "exon_rank": null,
          "exon_rank_end": null,
          "feature": "NM_001350840.2",
          "gene_hgnc_id": 19678,
          "gene_symbol": "UCHL5",
          "hgvs_c": "c.307-5076C>T",
          "hgvs_p": null,
          "intron_rank": 3,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "NP_001337769.1",
          "strand": false,
          "transcript": "NM_001350840.2",
          "transcript_support_level": null
        },
        {
          "aa_alt": null,
          "aa_end": null,
          "aa_length": 368,
          "aa_ref": null,
          "aa_start": null,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 1355,
          "cdna_start": null,
          "cds_end": null,
          "cds_length": 1107,
          "cds_start": null,
          "consequences": [
            "intron_variant"
          ],
          "exon_count": 12,
          "exon_rank": null,
          "exon_rank_end": null,
          "feature": "ENST00000367450.7",
          "gene_hgnc_id": 19678,
          "gene_symbol": "UCHL5",
          "hgvs_c": "c.283-5076C>T",
          "hgvs_p": null,
          "intron_rank": 3,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000356420.3",
          "strand": false,
          "transcript": "ENST00000367450.7",
          "transcript_support_level": 5
        },
        {
          "aa_alt": null,
          "aa_end": null,
          "aa_length": 368,
          "aa_ref": null,
          "aa_start": null,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 5326,
          "cdna_start": null,
          "cds_end": null,
          "cds_length": 1107,
          "cds_start": null,
          "consequences": [
            "intron_variant"
          ],
          "exon_count": 13,
          "exon_rank": null,
          "exon_rank_end": null,
          "feature": "ENST00000941920.1",
          "gene_hgnc_id": 19678,
          "gene_symbol": "UCHL5",
          "hgvs_c": "c.283-5076C>T",
          "hgvs_p": null,
          "intron_rank": 4,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000611979.1",
          "strand": false,
          "transcript": "ENST00000941920.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": null,
          "aa_end": null,
          "aa_length": 367,
          "aa_ref": null,
          "aa_start": null,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 1812,
          "cdna_start": null,
          "cds_end": null,
          "cds_length": 1104,
          "cds_start": null,
          "consequences": [
            "intron_variant"
          ],
          "exon_count": 13,
          "exon_rank": null,
          "exon_rank_end": null,
          "feature": "ENST00000874434.1",
          "gene_hgnc_id": 19678,
          "gene_symbol": "UCHL5",
          "hgvs_c": "c.283-5076C>T",
          "hgvs_p": null,
          "intron_rank": 4,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000544493.1",
          "strand": false,
          "transcript": "ENST00000874434.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": null,
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          "aa_length": 363,
          "aa_ref": null,
          "aa_start": null,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 3428,
          "cdna_start": null,
          "cds_end": null,
          "cds_length": 1092,
          "cds_start": null,
          "consequences": [
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          ],
          "exon_count": 11,
          "exon_rank": null,
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          "feature": "ENST00000935571.1",
          "gene_hgnc_id": 19678,
          "gene_symbol": "UCHL5",
          "hgvs_c": "c.349-5076C>T",
          "hgvs_p": null,
          "intron_rank": 3,
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          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000605630.1",
          "strand": false,
          "transcript": "ENST00000935571.1",
          "transcript_support_level": null
        },
        {
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          "aa_length": 362,
          "aa_ref": null,
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          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 2017,
          "cdna_start": null,
          "cds_end": null,
          "cds_length": 1089,
          "cds_start": null,
          "consequences": [
            "intron_variant"
          ],
          "exon_count": 11,
          "exon_rank": null,
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          "feature": "ENST00000874432.1",
          "gene_hgnc_id": 19678,
          "gene_symbol": "UCHL5",
          "hgvs_c": "c.349-5076C>T",
          "hgvs_p": null,
          "intron_rank": 3,
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          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000544491.1",
          "strand": false,
          "transcript": "ENST00000874432.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": null,
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          "aa_ref": null,
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          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 5268,
          "cdna_start": null,
          "cds_end": null,
          "cds_length": 1071,
          "cds_start": null,
          "consequences": [
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          ],
          "exon_count": 12,
          "exon_rank": null,
          "exon_rank_end": null,
          "feature": "NM_001350841.2",
          "gene_hgnc_id": 19678,
          "gene_symbol": "UCHL5",
          "hgvs_c": "c.247-5076C>T",
          "hgvs_p": null,
          "intron_rank": 3,
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          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "NP_001337770.1",
          "strand": false,
          "transcript": "NM_001350841.2",
          "transcript_support_level": null
        },
        {
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          "cdna_start": null,
          "cds_end": null,
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          "cds_start": null,
          "consequences": [
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          ],
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          "feature": "NM_001350842.2",
          "gene_hgnc_id": 19678,
          "gene_symbol": "UCHL5",
          "hgvs_c": "c.247-5076C>T",
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          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "NP_001337771.1",
          "strand": false,
          "transcript": "NM_001350842.2",
          "transcript_support_level": null
        },
        {
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          "aa_ref": null,
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          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 1346,
          "cdna_start": null,
          "cds_end": null,
          "cds_length": 1068,
          "cds_start": null,
          "consequences": [
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          ],
          "exon_count": 12,
          "exon_rank": null,
          "exon_rank_end": null,
          "feature": "ENST00000367451.8",
          "gene_hgnc_id": 19678,
          "gene_symbol": "UCHL5",
          "hgvs_c": "c.247-5076C>T",
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          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000356421.4",
          "strand": false,
          "transcript": "ENST00000367451.8",
          "transcript_support_level": 5
        },
        {
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          "aa_ref": null,
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          "biotype": "protein_coding",
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          "cdna_end": null,
          "cdna_length": 5340,
          "cdna_start": null,
          "cds_end": null,
          "cds_length": 1062,
          "cds_start": null,
          "consequences": [
            "intron_variant"
          ],
          "exon_count": 13,
          "exon_rank": null,
          "exon_rank_end": null,
          "feature": "NM_001350843.2",
          "gene_hgnc_id": 19678,
          "gene_symbol": "UCHL5",
          "hgvs_c": "c.247-5076C>T",
          "hgvs_p": null,
          "intron_rank": 3,
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          "protein_coding": true,
          "protein_id": "NP_001337772.1",
          "strand": false,
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        },
        {
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          "biotype": "protein_coding",
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          "cdna_start": null,
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          ],
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          "exon_rank": null,
          "exon_rank_end": null,
          "feature": "NM_001350844.2",
          "gene_hgnc_id": 19678,
          "gene_symbol": "UCHL5",
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          "mane_plus": null,
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          "protein_coding": true,
          "protein_id": "NP_001337773.1",
          "strand": false,
          "transcript": "NM_001350844.2",
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        },
        {
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          "aa_ref": null,
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          "biotype": "protein_coding",
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          "cdna_length": 2223,
          "cdna_start": null,
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          "cds_start": null,
          "consequences": [
            "intron_variant"
          ],
          "exon_count": 12,
          "exon_rank": null,
          "exon_rank_end": null,
          "feature": "NM_001350845.2",
          "gene_hgnc_id": 19678,
          "gene_symbol": "UCHL5",
          "hgvs_c": "c.247-5076C>T",
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          "intron_rank": 3,
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          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "NP_001337774.1",
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          "transcript": "NM_001350845.2",
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        },
        {
          "aa_alt": null,
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          "aa_ref": null,
          "aa_start": null,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 2015,
          "cdna_start": null,
          "cds_end": null,
          "cds_length": 1026,
          "cds_start": null,
          "consequences": [
            "intron_variant"
          ],
          "exon_count": 12,
          "exon_rank": null,
          "exon_rank_end": null,
          "feature": "ENST00000941923.1",
          "gene_hgnc_id": 19678,
          "gene_symbol": "UCHL5",
          "hgvs_c": "c.283-5076C>T",
          "hgvs_p": null,
          "intron_rank": 4,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000611982.1",
          "strand": false,
          "transcript": "ENST00000941923.1",
          "transcript_support_level": null
        },
        {
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          "aa_ref": null,
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          "biotype": "protein_coding",
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}
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