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GeneBe API Showcase

This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.

API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.

Documentation & Advanced Usage

Complete API documentation:docs.genebe.net/docs/api/overview/

Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/

Python client for pandas:pypi.org/project/genebe/

Java CLI for VCF files:github.com/pstawinski/genebe-cli

All tools documented at:docs.genebe.net

API Request Examples for Variant: 1-200553438-GG-CA (hg38)

Bash / cURL Example

bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=1&pos=200553438&ref=GG&alt=CA&genome=hg38&allGenes=true"

API Response

json
{
  "variants": [
    {
      "chr": "1",
      "pos": 200553438,
      "ref": "GG",
      "alt": "CA",
      "effect": "missense_variant",
      "transcript": "NM_014875.3",
      "consequences": [
        {
          "aa_ref": "SP",
          "aa_alt": "SA",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": null,
          "exon_rank_end": null,
          "exon_count": 30,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "KIF14",
          "gene_hgnc_id": 19181,
          "hgvs_c": "c.4896_4897delCCinsTG",
          "hgvs_p": "p.Pro1633Ala",
          "transcript": "NM_014875.3",
          "protein_id": "NP_055690.1",
          "transcript_support_level": null,
          "aa_start": 1632,
          "aa_end": null,
          "aa_length": 1648,
          "cds_start": 4896,
          "cds_end": null,
          "cds_length": 4947,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": "ENST00000367350.5",
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "NM_014875.3"
        },
        {
          "aa_ref": "SP",
          "aa_alt": "SA",
          "canonical": true,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": null,
          "exon_rank_end": null,
          "exon_count": 30,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "KIF14",
          "gene_hgnc_id": 19181,
          "hgvs_c": "c.4896_4897delCCinsTG",
          "hgvs_p": "p.Pro1633Ala",
          "transcript": "ENST00000367350.5",
          "protein_id": "ENSP00000356319.4",
          "transcript_support_level": 2,
          "aa_start": 1632,
          "aa_end": null,
          "aa_length": 1648,
          "cds_start": 4896,
          "cds_end": null,
          "cds_length": 4947,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": "NM_014875.3",
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000367350.5"
        },
        {
          "aa_ref": "SP",
          "aa_alt": "SA",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": null,
          "exon_rank_end": null,
          "exon_count": 29,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "KIF14",
          "gene_hgnc_id": 19181,
          "hgvs_c": "c.4896_4897delCCinsTG",
          "hgvs_p": "p.Pro1633Ala",
          "transcript": "ENST00000614960.4",
          "protein_id": "ENSP00000483069.1",
          "transcript_support_level": 1,
          "aa_start": 1632,
          "aa_end": null,
          "aa_length": 1648,
          "cds_start": 4896,
          "cds_end": null,
          "cds_length": 4947,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000614960.4"
        },
        {
          "aa_ref": "SP",
          "aa_alt": "SA",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": null,
          "exon_rank_end": null,
          "exon_count": 31,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "KIF14",
          "gene_hgnc_id": 19181,
          "hgvs_c": "c.5013_5014delCCinsTG",
          "hgvs_p": "p.Pro1672Ala",
          "transcript": "ENST00000928797.1",
          "protein_id": "ENSP00000598856.1",
          "transcript_support_level": null,
          "aa_start": 1671,
          "aa_end": null,
          "aa_length": 1687,
          "cds_start": 5013,
          "cds_end": null,
          "cds_length": 5064,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000928797.1"
        },
        {
          "aa_ref": "SP",
          "aa_alt": "SA",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": null,
          "exon_rank_end": null,
          "exon_count": 29,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "KIF14",
          "gene_hgnc_id": 19181,
          "hgvs_c": "c.4737_4738delCCinsTG",
          "hgvs_p": "p.Pro1580Ala",
          "transcript": "ENST00000928795.1",
          "protein_id": "ENSP00000598854.1",
          "transcript_support_level": null,
          "aa_start": 1579,
          "aa_end": null,
          "aa_length": 1595,
          "cds_start": 4737,
          "cds_end": null,
          "cds_length": 4788,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000928795.1"
        },
        {
          "aa_ref": "SP",
          "aa_alt": "SA",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": null,
          "exon_rank_end": null,
          "exon_count": 29,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "KIF14",
          "gene_hgnc_id": 19181,
          "hgvs_c": "c.4737_4738delCCinsTG",
          "hgvs_p": "p.Pro1580Ala",
          "transcript": "ENST00000928796.1",
          "protein_id": "ENSP00000598855.1",
          "transcript_support_level": null,
          "aa_start": 1579,
          "aa_end": null,
          "aa_length": 1595,
          "cds_start": 4737,
          "cds_end": null,
          "cds_length": 4788,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000928796.1"
        },
        {
          "aa_ref": "SP",
          "aa_alt": "SA",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": null,
          "exon_rank_end": null,
          "exon_count": 28,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "KIF14",
          "gene_hgnc_id": 19181,
          "hgvs_c": "c.3423_3424delCCinsTG",
          "hgvs_p": "p.Pro1142Ala",
          "transcript": "NM_001305792.1",
          "protein_id": "NP_001292721.1",
          "transcript_support_level": null,
          "aa_start": 1141,
          "aa_end": null,
          "aa_length": 1157,
          "cds_start": 3423,
          "cds_end": null,
          "cds_length": 3474,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "NM_001305792.1"
        },
        {
          "aa_ref": "SP",
          "aa_alt": "SA",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": null,
          "exon_rank_end": null,
          "exon_count": 31,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "KIF14",
          "gene_hgnc_id": 19181,
          "hgvs_c": "c.4896_4897delCCinsTG",
          "hgvs_p": "p.Pro1633Ala",
          "transcript": "XM_011510231.3",
          "protein_id": "XP_011508533.1",
          "transcript_support_level": null,
          "aa_start": 1632,
          "aa_end": null,
          "aa_length": 1648,
          "cds_start": 4896,
          "cds_end": null,
          "cds_length": 4947,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "XM_011510231.3"
        },
        {
          "aa_ref": "SP",
          "aa_alt": "SA",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": null,
          "exon_rank_end": null,
          "exon_count": 30,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "KIF14",
          "gene_hgnc_id": 19181,
          "hgvs_c": "c.4896_4897delCCinsTG",
          "hgvs_p": "p.Pro1633Ala",
          "transcript": "XM_011510232.3",
          "protein_id": "XP_011508534.1",
          "transcript_support_level": null,
          "aa_start": 1632,
          "aa_end": null,
          "aa_length": 1648,
          "cds_start": 4896,
          "cds_end": null,
          "cds_length": 4947,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "XM_011510232.3"
        },
        {
          "aa_ref": "SP",
          "aa_alt": "SA",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": null,
          "exon_rank_end": null,
          "exon_count": 31,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "KIF14",
          "gene_hgnc_id": 19181,
          "hgvs_c": "c.4812_4813delCCinsTG",
          "hgvs_p": "p.Pro1605Ala",
          "transcript": "XM_011510233.3",
          "protein_id": "XP_011508535.1",
          "transcript_support_level": null,
          "aa_start": 1604,
          "aa_end": null,
          "aa_length": 1620,
          "cds_start": 4812,
          "cds_end": null,
          "cds_length": 4863,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "XM_011510233.3"
        },
        {
          "aa_ref": "SP",
          "aa_alt": "SA",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": null,
          "exon_rank_end": null,
          "exon_count": 32,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "KIF14",
          "gene_hgnc_id": 19181,
          "hgvs_c": "c.4812_4813delCCinsTG",
          "hgvs_p": "p.Pro1605Ala",
          "transcript": "XM_047436181.1",
          "protein_id": "XP_047292137.1",
          "transcript_support_level": null,
          "aa_start": 1604,
          "aa_end": null,
          "aa_length": 1620,
          "cds_start": 4812,
          "cds_end": null,
          "cds_length": 4863,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "XM_047436181.1"
        },
        {
          "aa_ref": "SP",
          "aa_alt": "SA",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": null,
          "exon_rank_end": null,
          "exon_count": 30,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "KIF14",
          "gene_hgnc_id": 19181,
          "hgvs_c": "c.4812_4813delCCinsTG",
          "hgvs_p": "p.Pro1605Ala",
          "transcript": "XM_047436184.1",
          "protein_id": "XP_047292140.1",
          "transcript_support_level": null,
          "aa_start": 1604,
          "aa_end": null,
          "aa_length": 1620,
          "cds_start": 4812,
          "cds_end": null,
          "cds_length": 4863,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "XM_047436184.1"
        },
        {
          "aa_ref": "SP",
          "aa_alt": "SA",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": null,
          "exon_rank_end": null,
          "exon_count": 31,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "KIF14",
          "gene_hgnc_id": 19181,
          "hgvs_c": "c.4812_4813delCCinsTG",
          "hgvs_p": "p.Pro1605Ala",
          "transcript": "XM_047436190.1",
          "protein_id": "XP_047292146.1",
          "transcript_support_level": null,
          "aa_start": 1604,
          "aa_end": null,
          "aa_length": 1620,
          "cds_start": 4812,
          "cds_end": null,
          "cds_length": 4863,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "XM_047436190.1"
        },
        {
          "aa_ref": "SP",
          "aa_alt": "SA",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": null,
          "exon_rank_end": null,
          "exon_count": 30,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "KIF14",
          "gene_hgnc_id": 19181,
          "hgvs_c": "c.4767_4768delCCinsTG",
          "hgvs_p": "p.Pro1590Ala",
          "transcript": "XM_017003006.2",
          "protein_id": "XP_016858495.1",
          "transcript_support_level": null,
          "aa_start": 1589,
          "aa_end": null,
          "aa_length": 1605,
          "cds_start": 4767,
          "cds_end": null,
          "cds_length": 4818,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
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          "biotype": "protein_coding",
          "feature": "XM_017003006.2"
        },
        {
          "aa_ref": "SP",
          "aa_alt": "SA",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": null,
          "exon_rank_end": null,
          "exon_count": 31,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "KIF14",
          "gene_hgnc_id": 19181,
          "hgvs_c": "c.4683_4684delCCinsTG",
          "hgvs_p": "p.Pro1562Ala",
          "transcript": "XM_047436195.1",
          "protein_id": "XP_047292151.1",
          "transcript_support_level": null,
          "aa_start": 1561,
          "aa_end": null,
          "aa_length": 1577,
          "cds_start": 4683,
          "cds_end": null,
          "cds_length": 4734,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "XM_047436195.1"
        },
        {
          "aa_ref": "SP",
          "aa_alt": "SA",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": null,
          "exon_rank_end": null,
          "exon_count": 31,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "KIF14",
          "gene_hgnc_id": 19181,
          "hgvs_c": "c.4524_4525delCCinsTG",
          "hgvs_p": "p.Pro1509Ala",
          "transcript": "XM_011510235.3",
          "protein_id": "XP_011508537.1",
          "transcript_support_level": null,
          "aa_start": 1508,
          "aa_end": null,
          "aa_length": 1524,
          "cds_start": 4524,
          "cds_end": null,
          "cds_length": 4575,
          "cdna_start": null,
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          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "XM_011510235.3"
        },
        {
          "aa_ref": "SP",
          "aa_alt": "SA",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": null,
          "exon_rank_end": null,
          "exon_count": 30,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "KIF14",
          "gene_hgnc_id": 19181,
          "hgvs_c": "c.4524_4525delCCinsTG",
          "hgvs_p": "p.Pro1509Ala",
          "transcript": "XM_047436197.1",
          "protein_id": "XP_047292153.1",
          "transcript_support_level": null,
          "aa_start": 1508,
          "aa_end": null,
          "aa_length": 1524,
          "cds_start": 4524,
          "cds_end": null,
          "cds_length": 4575,
          "cdna_start": null,
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          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "XM_047436197.1"
        },
        {
          "aa_ref": "SP",
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          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": null,
          "exon_rank_end": null,
          "exon_count": 31,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "KIF14",
          "gene_hgnc_id": 19181,
          "hgvs_c": "c.4524_4525delCCinsTG",
          "hgvs_p": "p.Pro1509Ala",
          "transcript": "XM_047436198.1",
          "protein_id": "XP_047292154.1",
          "transcript_support_level": null,
          "aa_start": 1508,
          "aa_end": null,
          "aa_length": 1524,
          "cds_start": 4524,
          "cds_end": null,
          "cds_length": 4575,
          "cdna_start": null,
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          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "XM_047436198.1"
        },
        {
          "aa_ref": "SP",
          "aa_alt": "SA",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": null,
          "exon_rank_end": null,
          "exon_count": 31,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "KIF14",
          "gene_hgnc_id": 19181,
          "hgvs_c": "c.4395_4396delCCinsTG",
          "hgvs_p": "p.Pro1466Ala",
          "transcript": "XM_047436199.1",
          "protein_id": "XP_047292155.1",
          "transcript_support_level": null,
          "aa_start": 1465,
          "aa_end": null,
          "aa_length": 1481,
          "cds_start": 4395,
          "cds_end": null,
          "cds_length": 4446,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "XM_047436199.1"
        },
        {
          "aa_ref": "SP",
          "aa_alt": "SA",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": null,
          "exon_rank_end": null,
          "exon_count": 30,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "KIF14",
          "gene_hgnc_id": 19181,
          "hgvs_c": "c.4329_4330delCCinsTG",
          "hgvs_p": "p.Pro1444Ala",
          "transcript": "XM_017003007.2",
          "protein_id": "XP_016858496.1",
          "transcript_support_level": null,
          "aa_start": 1443,
          "aa_end": null,
          "aa_length": 1459,
          "cds_start": 4329,
          "cds_end": null,
          "cds_length": 4380,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "XM_017003007.2"
        }
      ],
      "gene_symbol": "KIF14",
      "gene_hgnc_id": 19181,
      "dbsnp": null,
      "frequency_reference_population": null,
      "hom_count_reference_population": 0,
      "allele_count_reference_population": 0,
      "gnomad_exomes_af": null,
      "gnomad_genomes_af": null,
      "gnomad_exomes_ac": null,
      "gnomad_genomes_ac": null,
      "gnomad_exomes_homalt": null,
      "gnomad_genomes_homalt": null,
      "gnomad_mito_homoplasmic": null,
      "gnomad_mito_heteroplasmic": null,
      "computational_score_selected": null,
      "computational_prediction_selected": null,
      "computational_source_selected": null,
      "splice_score_selected": null,
      "splice_prediction_selected": null,
      "splice_source_selected": null,
      "revel_score": null,
      "revel_prediction": null,
      "alphamissense_score": null,
      "alphamissense_prediction": null,
      "bayesdelnoaf_score": null,
      "bayesdelnoaf_prediction": null,
      "phylop100way_score": 0,
      "phylop100way_prediction": "Benign",
      "spliceai_max_score": null,
      "spliceai_max_prediction": null,
      "dbscsnv_ada_score": null,
      "dbscsnv_ada_prediction": null,
      "apogee2_score": null,
      "apogee2_prediction": null,
      "mitotip_score": null,
      "mitotip_prediction": null,
      "acmg_score": -2,
      "acmg_classification": "Likely_benign",
      "acmg_criteria": "BP6_Moderate",
      "acmg_by_gene": [
        {
          "score": -2,
          "benign_score": 2,
          "pathogenic_score": 0,
          "criteria": [
            "BP6_Moderate"
          ],
          "verdict": "Likely_benign",
          "transcript": "NM_014875.3",
          "gene_symbol": "KIF14",
          "hgnc_id": 19181,
          "effects": [
            "missense_variant"
          ],
          "inheritance_mode": "AR",
          "hgvs_c": "c.4896_4897delCCinsTG",
          "hgvs_p": "p.Pro1633Ala"
        }
      ],
      "clinvar_disease": "not provided",
      "clinvar_classification": "Likely benign",
      "clinvar_review_status": "criteria provided, single submitter",
      "clinvar_submissions_summary": "LB:1",
      "phenotype_combined": "not provided",
      "pathogenicity_classification_combined": "Likely benign",
      "custom_annotations": null
    }
  ],
  "message": null
}