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GeneBe API Showcase

This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.

API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.

Documentation & Advanced Usage

Complete API documentation:docs.genebe.net/docs/api/overview/

Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/

Python client for pandas:pypi.org/project/genebe/

Java CLI for VCF files:github.com/pstawinski/genebe-cli

All tools documented at:docs.genebe.net

API Request Examples for Variant: 1-20817519-G-C (hg38)

Bash / cURL Example

bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=1&pos=20817519&ref=G&alt=C&genome=hg38&allGenes=true"

API Response

json
{
  "variants": [
    {
      "chr": "1",
      "pos": 20817519,
      "ref": "G",
      "alt": "C",
      "effect": "missense_variant",
      "transcript": "NM_001391907.1",
      "consequences": [
        {
          "aa_ref": "S",
          "aa_alt": "C",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 34,
          "exon_rank_end": null,
          "exon_count": 37,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "EIF4G3",
          "gene_hgnc_id": 3298,
          "hgvs_c": "c.4388C>G",
          "hgvs_p": "p.Ser1463Cys",
          "transcript": "NM_001391906.1",
          "protein_id": "NP_001378835.1",
          "transcript_support_level": null,
          "aa_start": 1463,
          "aa_end": null,
          "aa_length": 1641,
          "cds_start": 4388,
          "cds_end": null,
          "cds_length": 4926,
          "cdna_start": 5019,
          "cdna_end": null,
          "cdna_length": 6397,
          "mane_select": "ENST00000602326.6",
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "NM_001391906.1"
        },
        {
          "aa_ref": "S",
          "aa_alt": "C",
          "canonical": true,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 34,
          "exon_rank_end": null,
          "exon_count": 37,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "EIF4G3",
          "gene_hgnc_id": 3298,
          "hgvs_c": "c.4388C>G",
          "hgvs_p": "p.Ser1463Cys",
          "transcript": "ENST00000602326.6",
          "protein_id": "ENSP00000473510.2",
          "transcript_support_level": 1,
          "aa_start": 1463,
          "aa_end": null,
          "aa_length": 1641,
          "cds_start": 4388,
          "cds_end": null,
          "cds_length": 4926,
          "cdna_start": 5019,
          "cdna_end": null,
          "cdna_length": 6397,
          "mane_select": "NM_001391906.1",
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000602326.6"
        },
        {
          "aa_ref": "S",
          "aa_alt": "C",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 32,
          "exon_rank_end": null,
          "exon_count": 35,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "EIF4G3",
          "gene_hgnc_id": 3298,
          "hgvs_c": "c.4328C>G",
          "hgvs_p": "p.Ser1443Cys",
          "transcript": "ENST00000400422.6",
          "protein_id": "ENSP00000383274.2",
          "transcript_support_level": 1,
          "aa_start": 1443,
          "aa_end": null,
          "aa_length": 1621,
          "cds_start": 4328,
          "cds_end": null,
          "cds_length": 4866,
          "cdna_start": 4909,
          "cdna_end": null,
          "cdna_length": 5762,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000400422.6"
        },
        {
          "aa_ref": "S",
          "aa_alt": "C",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 30,
          "exon_rank_end": null,
          "exon_count": 33,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "EIF4G3",
          "gene_hgnc_id": 3298,
          "hgvs_c": "c.5150C>G",
          "hgvs_p": "p.Ser1717Cys",
          "transcript": "ENST00000693470.1",
          "protein_id": "ENSP00000509295.1",
          "transcript_support_level": null,
          "aa_start": 1717,
          "aa_end": null,
          "aa_length": 1895,
          "cds_start": 5150,
          "cds_end": null,
          "cds_length": 5688,
          "cdna_start": 5150,
          "cdna_end": null,
          "cdna_length": 5688,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000693470.1"
        },
        {
          "aa_ref": "S",
          "aa_alt": "C",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 31,
          "exon_rank_end": null,
          "exon_count": 34,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "EIF4G3",
          "gene_hgnc_id": 3298,
          "hgvs_c": "c.4787C>G",
          "hgvs_p": "p.Ser1596Cys",
          "transcript": "ENST00000634879.2",
          "protein_id": "ENSP00000489051.2",
          "transcript_support_level": 5,
          "aa_start": 1596,
          "aa_end": null,
          "aa_length": 1774,
          "cds_start": 4787,
          "cds_end": null,
          "cds_length": 5325,
          "cdna_start": 4787,
          "cdna_end": null,
          "cdna_length": 5325,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000634879.2"
        },
        {
          "aa_ref": "S",
          "aa_alt": "C",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 30,
          "exon_rank_end": null,
          "exon_count": 33,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "EIF4G3",
          "gene_hgnc_id": 3298,
          "hgvs_c": "c.4706C>G",
          "hgvs_p": "p.Ser1569Cys",
          "transcript": "ENST00000685872.1",
          "protein_id": "ENSP00000509442.1",
          "transcript_support_level": null,
          "aa_start": 1569,
          "aa_end": null,
          "aa_length": 1747,
          "cds_start": 4706,
          "cds_end": null,
          "cds_length": 5244,
          "cdna_start": 5150,
          "cdna_end": null,
          "cdna_length": 6528,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000685872.1"
        },
        {
          "aa_ref": "S",
          "aa_alt": "C",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 34,
          "exon_rank_end": null,
          "exon_count": 37,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "EIF4G3",
          "gene_hgnc_id": 3298,
          "hgvs_c": "c.4478C>G",
          "hgvs_p": "p.Ser1493Cys",
          "transcript": "NM_001391907.1",
          "protein_id": "NP_001378836.1",
          "transcript_support_level": null,
          "aa_start": 1493,
          "aa_end": null,
          "aa_length": 1671,
          "cds_start": 4478,
          "cds_end": null,
          "cds_length": 5016,
          "cdna_start": 5109,
          "cdna_end": null,
          "cdna_length": 6487,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "NM_001391907.1"
        },
        {
          "aa_ref": "S",
          "aa_alt": "C",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 33,
          "exon_rank_end": null,
          "exon_count": 36,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "EIF4G3",
          "gene_hgnc_id": 3298,
          "hgvs_c": "c.4385C>G",
          "hgvs_p": "p.Ser1462Cys",
          "transcript": "ENST00000684485.1",
          "protein_id": "ENSP00000507662.1",
          "transcript_support_level": null,
          "aa_start": 1462,
          "aa_end": null,
          "aa_length": 1640,
          "cds_start": 4385,
          "cds_end": null,
          "cds_length": 4923,
          "cdna_start": 6463,
          "cdna_end": null,
          "cdna_length": 7832,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000684485.1"
        },
        {
          "aa_ref": "S",
          "aa_alt": "C",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 33,
          "exon_rank_end": null,
          "exon_count": 36,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "EIF4G3",
          "gene_hgnc_id": 3298,
          "hgvs_c": "c.4367C>G",
          "hgvs_p": "p.Ser1456Cys",
          "transcript": "NM_001438678.1",
          "protein_id": "NP_001425607.1",
          "transcript_support_level": null,
          "aa_start": 1456,
          "aa_end": null,
          "aa_length": 1634,
          "cds_start": 4367,
          "cds_end": null,
          "cds_length": 4905,
          "cdna_start": 4875,
          "cdna_end": null,
          "cdna_length": 6253,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "NM_001438678.1"
        },
        {
          "aa_ref": "S",
          "aa_alt": "C",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 32,
          "exon_rank_end": null,
          "exon_count": 35,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "EIF4G3",
          "gene_hgnc_id": 3298,
          "hgvs_c": "c.4367C>G",
          "hgvs_p": "p.Ser1456Cys",
          "transcript": "NM_001438679.1",
          "protein_id": "NP_001425608.1",
          "transcript_support_level": null,
          "aa_start": 1456,
          "aa_end": null,
          "aa_length": 1634,
          "cds_start": 4367,
          "cds_end": null,
          "cds_length": 4905,
          "cdna_start": 4692,
          "cdna_end": null,
          "cdna_length": 6070,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "NM_001438679.1"
        },
        {
          "aa_ref": "S",
          "aa_alt": "C",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 33,
          "exon_rank_end": null,
          "exon_count": 36,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "EIF4G3",
          "gene_hgnc_id": 3298,
          "hgvs_c": "c.4364C>G",
          "hgvs_p": "p.Ser1455Cys",
          "transcript": "NM_001391905.1",
          "protein_id": "NP_001378834.1",
          "transcript_support_level": null,
          "aa_start": 1455,
          "aa_end": null,
          "aa_length": 1633,
          "cds_start": 4364,
          "cds_end": null,
          "cds_length": 4902,
          "cdna_start": 4872,
          "cdna_end": null,
          "cdna_length": 6250,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "NM_001391905.1"
        },
        {
          "aa_ref": "S",
          "aa_alt": "C",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 32,
          "exon_rank_end": null,
          "exon_count": 35,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "EIF4G3",
          "gene_hgnc_id": 3298,
          "hgvs_c": "c.4364C>G",
          "hgvs_p": "p.Ser1455Cys",
          "transcript": "ENST00000688741.1",
          "protein_id": "ENSP00000509547.1",
          "transcript_support_level": null,
          "aa_start": 1455,
          "aa_end": null,
          "aa_length": 1633,
          "cds_start": 4364,
          "cds_end": null,
          "cds_length": 4902,
          "cdna_start": 4695,
          "cdna_end": null,
          "cdna_length": 6064,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000688741.1"
        },
        {
          "aa_ref": "S",
          "aa_alt": "C",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 32,
          "exon_rank_end": null,
          "exon_count": 35,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "EIF4G3",
          "gene_hgnc_id": 3298,
          "hgvs_c": "c.4331C>G",
          "hgvs_p": "p.Ser1444Cys",
          "transcript": "NM_001391902.1",
          "protein_id": "NP_001378831.1",
          "transcript_support_level": null,
          "aa_start": 1444,
          "aa_end": null,
          "aa_length": 1622,
          "cds_start": 4331,
          "cds_end": null,
          "cds_length": 4869,
          "cdna_start": 4962,
          "cdna_end": null,
          "cdna_length": 6340,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "NM_001391902.1"
        },
        {
          "aa_ref": "S",
          "aa_alt": "C",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 31,
          "exon_rank_end": null,
          "exon_count": 34,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "EIF4G3",
          "gene_hgnc_id": 3298,
          "hgvs_c": "c.4331C>G",
          "hgvs_p": "p.Ser1444Cys",
          "transcript": "NM_001391903.1",
          "protein_id": "NP_001378832.1",
          "transcript_support_level": null,
          "aa_start": 1444,
          "aa_end": null,
          "aa_length": 1622,
          "cds_start": 4331,
          "cds_end": null,
          "cds_length": 4869,
          "cdna_start": 4778,
          "cdna_end": null,
          "cdna_length": 6156,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "NM_001391903.1"
        },
        {
          "aa_ref": "S",
          "aa_alt": "C",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 32,
          "exon_rank_end": null,
          "exon_count": 35,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "EIF4G3",
          "gene_hgnc_id": 3298,
          "hgvs_c": "c.4331C>G",
          "hgvs_p": "p.Ser1444Cys",
          "transcript": "NM_001391904.1",
          "protein_id": "NP_001378833.1",
          "transcript_support_level": null,
          "aa_start": 1444,
          "aa_end": null,
          "aa_length": 1622,
          "cds_start": 4331,
          "cds_end": null,
          "cds_length": 4869,
          "cdna_start": 4962,
          "cdna_end": null,
          "cdna_length": 6340,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "NM_001391904.1"
        },
        {
          "aa_ref": "S",
          "aa_alt": "C",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 32,
          "exon_rank_end": null,
          "exon_count": 35,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "EIF4G3",
          "gene_hgnc_id": 3298,
          "hgvs_c": "c.4328C>G",
          "hgvs_p": "p.Ser1443Cys",
          "transcript": "NM_001198801.3",
          "protein_id": "NP_001185730.1",
          "transcript_support_level": null,
          "aa_start": 1443,
          "aa_end": null,
          "aa_length": 1621,
          "cds_start": 4328,
          "cds_end": null,
          "cds_length": 4866,
          "cdna_start": 4959,
          "cdna_end": null,
          "cdna_length": 6337,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "NM_001198801.3"
        },
        {
          "aa_ref": "S",
          "aa_alt": "C",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 32,
          "exon_rank_end": null,
          "exon_count": 35,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "EIF4G3",
          "gene_hgnc_id": 3298,
          "hgvs_c": "c.4241C>G",
          "hgvs_p": "p.Ser1414Cys",
          "transcript": "NM_001391901.1",
          "protein_id": "NP_001378830.1",
          "transcript_support_level": null,
          "aa_start": 1414,
          "aa_end": null,
          "aa_length": 1592,
          "cds_start": 4241,
          "cds_end": null,
          "cds_length": 4779,
          "cdna_start": 4872,
          "cdna_end": null,
          "cdna_length": 6250,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "NM_001391901.1"
        },
        {
          "aa_ref": "S",
          "aa_alt": "C",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 32,
          "exon_rank_end": null,
          "exon_count": 35,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "EIF4G3",
          "gene_hgnc_id": 3298,
          "hgvs_c": "c.4238C>G",
          "hgvs_p": "p.Ser1413Cys",
          "transcript": "NM_001198802.3",
          "protein_id": "NP_001185731.1",
          "transcript_support_level": null,
          "aa_start": 1413,
          "aa_end": null,
          "aa_length": 1591,
          "cds_start": 4238,
          "cds_end": null,
          "cds_length": 4776,
          "cdna_start": 4869,
          "cdna_end": null,
          "cdna_length": 6247,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "NM_001198802.3"
        },
        {
          "aa_ref": "S",
          "aa_alt": "C",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 32,
          "exon_rank_end": null,
          "exon_count": 35,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "EIF4G3",
          "gene_hgnc_id": 3298,
          "hgvs_c": "c.4238C>G",
          "hgvs_p": "p.Ser1413Cys",
          "transcript": "ENST00000686579.1",
          "protein_id": "ENSP00000509941.1",
          "transcript_support_level": null,
          "aa_start": 1413,
          "aa_end": null,
          "aa_length": 1591,
          "cds_start": 4238,
          "cds_end": null,
          "cds_length": 4776,
          "cdna_start": 5257,
          "cdna_end": null,
          "cdna_length": 6631,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000686579.1"
        },
        {
          "aa_ref": "S",
          "aa_alt": "C",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 31,
          "exon_rank_end": null,
          "exon_count": 34,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "EIF4G3",
          "gene_hgnc_id": 3298,
          "hgvs_c": "c.4220C>G",
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      "alphamissense_prediction": null,
      "bayesdelnoaf_score": -0.37,
      "bayesdelnoaf_prediction": "Benign",
      "phylop100way_score": 4.121,
      "phylop100way_prediction": "Uncertain_significance",
      "spliceai_max_score": 0,
      "spliceai_max_prediction": "Benign",
      "dbscsnv_ada_score": null,
      "dbscsnv_ada_prediction": null,
      "apogee2_score": null,
      "apogee2_prediction": null,
      "mitotip_score": null,
      "mitotip_prediction": null,
      "acmg_score": 0,
      "acmg_classification": "Uncertain_significance",
      "acmg_criteria": "PM2,BP4_Moderate",
      "acmg_by_gene": [
        {
          "score": 0,
          "benign_score": 2,
          "pathogenic_score": 2,
          "criteria": [
            "PM2",
            "BP4_Moderate"
          ],
          "verdict": "Uncertain_significance",
          "transcript": "NM_001391907.1",
          "gene_symbol": "EIF4G3",
          "hgnc_id": 3298,
          "effects": [
            "missense_variant"
          ],
          "inheritance_mode": "",
          "hgvs_c": "c.4478C>G",
          "hgvs_p": "p.Ser1493Cys"
        }
      ],
      "clinvar_disease": "not specified",
      "clinvar_classification": "Uncertain significance",
      "clinvar_review_status": "criteria provided, single submitter",
      "clinvar_submissions_summary": "US:1",
      "phenotype_combined": "not specified",
      "pathogenicity_classification_combined": "Uncertain significance",
      "custom_annotations": null
    }
  ],
  "message": null
}
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