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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 1-20893882-T-G (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=1&pos=20893882&ref=T&alt=G&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "1",
"pos": 20893882,
"ref": "T",
"alt": "G",
"effect": "intron_variant",
"transcript": "ENST00000602326.6",
"consequences": [
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 37,
"intron_rank": 17,
"intron_rank_end": null,
"gene_symbol": "EIF4G3",
"gene_hgnc_id": 3298,
"hgvs_c": "c.2134-246A>C",
"hgvs_p": null,
"transcript": "NM_001391906.1",
"protein_id": "NP_001378835.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 1641,
"cds_start": -4,
"cds_end": null,
"cds_length": 4926,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 6397,
"mane_select": "ENST00000602326.6",
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": true,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 37,
"intron_rank": 17,
"intron_rank_end": null,
"gene_symbol": "EIF4G3",
"gene_hgnc_id": 3298,
"hgvs_c": "c.2134-246A>C",
"hgvs_p": null,
"transcript": "ENST00000602326.6",
"protein_id": "ENSP00000473510.2",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": 1641,
"cds_start": -4,
"cds_end": null,
"cds_length": 4926,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 6397,
"mane_select": "NM_001391906.1",
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 35,
"intron_rank": 14,
"intron_rank_end": null,
"gene_symbol": "EIF4G3",
"gene_hgnc_id": 3298,
"hgvs_c": "c.1963-246A>C",
"hgvs_p": null,
"transcript": "ENST00000400422.6",
"protein_id": "ENSP00000383274.2",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": 1621,
"cds_start": -4,
"cds_end": null,
"cds_length": 4866,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 5762,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 33,
"intron_rank": 13,
"intron_rank_end": null,
"gene_symbol": "EIF4G3",
"gene_hgnc_id": 3298,
"hgvs_c": "c.2896-246A>C",
"hgvs_p": null,
"transcript": "ENST00000693470.1",
"protein_id": "ENSP00000509295.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 1895,
"cds_start": -4,
"cds_end": null,
"cds_length": 5688,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 5688,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 34,
"intron_rank": 14,
"intron_rank_end": null,
"gene_symbol": "EIF4G3",
"gene_hgnc_id": 3298,
"hgvs_c": "c.2533-246A>C",
"hgvs_p": null,
"transcript": "ENST00000634879.2",
"protein_id": "ENSP00000489051.2",
"transcript_support_level": 5,
"aa_start": null,
"aa_end": null,
"aa_length": 1774,
"cds_start": -4,
"cds_end": null,
"cds_length": 5325,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 5325,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 33,
"intron_rank": 13,
"intron_rank_end": null,
"gene_symbol": "EIF4G3",
"gene_hgnc_id": 3298,
"hgvs_c": "c.2452-246A>C",
"hgvs_p": null,
"transcript": "ENST00000685872.1",
"protein_id": "ENSP00000509442.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 1747,
"cds_start": -4,
"cds_end": null,
"cds_length": 5244,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 6528,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 37,
"intron_rank": 16,
"intron_rank_end": null,
"gene_symbol": "EIF4G3",
"gene_hgnc_id": 3298,
"hgvs_c": "c.2113-246A>C",
"hgvs_p": null,
"transcript": "NM_001391907.1",
"protein_id": "NP_001378836.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 1671,
"cds_start": -4,
"cds_end": null,
"cds_length": 5016,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 6487,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 36,
"intron_rank": 15,
"intron_rank_end": null,
"gene_symbol": "EIF4G3",
"gene_hgnc_id": 3298,
"hgvs_c": "c.2020-246A>C",
"hgvs_p": null,
"transcript": "ENST00000684485.1",
"protein_id": "ENSP00000507662.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 1640,
"cds_start": -4,
"cds_end": null,
"cds_length": 4923,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 7832,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 36,
"intron_rank": 16,
"intron_rank_end": null,
"gene_symbol": "EIF4G3",
"gene_hgnc_id": 3298,
"hgvs_c": "c.2113-246A>C",
"hgvs_p": null,
"transcript": "NM_001438678.1",
"protein_id": "NP_001425607.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 1634,
"cds_start": -4,
"cds_end": null,
"cds_length": 4905,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 6253,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
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"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 35,
"intron_rank": 15,
"intron_rank_end": null,
"gene_symbol": "EIF4G3",
"gene_hgnc_id": 3298,
"hgvs_c": "c.2113-246A>C",
"hgvs_p": null,
"transcript": "NM_001438679.1",
"protein_id": "NP_001425608.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 1634,
"cds_start": -4,
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"cdna_start": null,
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"cdna_length": 6070,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
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"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 36,
"intron_rank": 16,
"intron_rank_end": null,
"gene_symbol": "EIF4G3",
"gene_hgnc_id": 3298,
"hgvs_c": "c.2110-246A>C",
"hgvs_p": null,
"transcript": "NM_001391905.1",
"protein_id": "NP_001378834.1",
"transcript_support_level": null,
"aa_start": null,
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},
{
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"protein_coding": true,
"strand": false,
"consequences": [
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],
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"exon_count": 35,
"intron_rank": 15,
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"gene_symbol": "EIF4G3",
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"hgvs_c": "c.2110-246A>C",
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"transcript": "ENST00000688741.1",
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},
{
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"strand": false,
"consequences": [
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],
"exon_rank": null,
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"exon_count": 35,
"intron_rank": 15,
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"gene_symbol": "EIF4G3",
"gene_hgnc_id": 3298,
"hgvs_c": "c.2077-246A>C",
"hgvs_p": null,
"transcript": "NM_001391902.1",
"protein_id": "NP_001378831.1",
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},
{
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"strand": false,
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],
"exon_rank": null,
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"gene_symbol": "EIF4G3",
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"hgvs_c": "c.2077-246A>C",
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"transcript": "NM_001391903.1",
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},
{
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],
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"gene_symbol": "EIF4G3",
"gene_hgnc_id": 3298,
"hgvs_c": "c.1966-246A>C",
"hgvs_p": null,
"transcript": "NM_001391904.1",
"protein_id": "NP_001378833.1",
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},
{
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"strand": false,
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],
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"intron_rank": 14,
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"gene_symbol": "EIF4G3",
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"hgvs_c": "c.1963-246A>C",
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"transcript": "NM_001198801.3",
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},
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],
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"gene_symbol": "EIF4G3",
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"hgvs_c": "c.1987-246A>C",
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"transcript": "NM_001391901.1",
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},
{
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],
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"intron_rank": 15,
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"gene_symbol": "EIF4G3",
"gene_hgnc_id": 3298,
"hgvs_c": "c.1984-246A>C",
"hgvs_p": null,
"transcript": "NM_001198802.3",
"protein_id": "NP_001185731.1",
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},
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],
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"gene_symbol": "EIF4G3",
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},
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],
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"gene_symbol": "EIF4G3",
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},
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"strand": false,
"consequences": [
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],
"exon_rank": null,
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"intron_rank": 14,
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"gene_symbol": "EIF4G3",
"gene_hgnc_id": 3298,
"hgvs_c": "c.1966-246A>C",
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"transcript": "NM_001391894.1",
"protein_id": "NP_001378823.1",
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},
{
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"protein_coding": true,
"strand": false,
"consequences": [
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],
"exon_rank": null,
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"exon_count": 32,
"intron_rank": 12,
"intron_rank_end": null,
"gene_symbol": "EIF4G3",
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"hgvs_c": "c.1966-246A>C",
"hgvs_p": null,
"transcript": "NM_003760.4",
"protein_id": "NP_003751.2",
"transcript_support_level": null,
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}
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}