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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 1-20941500-G-C (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=1&pos=20941500&ref=G&alt=C&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "1",
"pos": 20941500,
"ref": "G",
"alt": "C",
"effect": "missense_variant",
"transcript": "ENST00000602326.6",
"consequences": [
{
"aa_ref": "P",
"aa_alt": "A",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 14,
"exon_rank_end": null,
"exon_count": 37,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "EIF4G3",
"gene_hgnc_id": 3298,
"hgvs_c": "c.1654C>G",
"hgvs_p": "p.Pro552Ala",
"transcript": "NM_001391906.1",
"protein_id": "NP_001378835.1",
"transcript_support_level": null,
"aa_start": 552,
"aa_end": null,
"aa_length": 1641,
"cds_start": 1654,
"cds_end": null,
"cds_length": 4926,
"cdna_start": 2285,
"cdna_end": null,
"cdna_length": 6397,
"mane_select": "ENST00000602326.6",
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "P",
"aa_alt": "A",
"canonical": true,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 14,
"exon_rank_end": null,
"exon_count": 37,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "EIF4G3",
"gene_hgnc_id": 3298,
"hgvs_c": "c.1654C>G",
"hgvs_p": "p.Pro552Ala",
"transcript": "ENST00000602326.6",
"protein_id": "ENSP00000473510.2",
"transcript_support_level": 1,
"aa_start": 552,
"aa_end": null,
"aa_length": 1641,
"cds_start": 1654,
"cds_end": null,
"cds_length": 4926,
"cdna_start": 2285,
"cdna_end": null,
"cdna_length": 6397,
"mane_select": "NM_001391906.1",
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "P",
"aa_alt": "A",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 11,
"exon_rank_end": null,
"exon_count": 35,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "EIF4G3",
"gene_hgnc_id": 3298,
"hgvs_c": "c.1483C>G",
"hgvs_p": "p.Pro495Ala",
"transcript": "ENST00000400422.6",
"protein_id": "ENSP00000383274.2",
"transcript_support_level": 1,
"aa_start": 495,
"aa_end": null,
"aa_length": 1621,
"cds_start": 1483,
"cds_end": null,
"cds_length": 4866,
"cdna_start": 2064,
"cdna_end": null,
"cdna_length": 5762,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "P",
"aa_alt": "A",
"canonical": true,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 14,
"exon_rank_end": null,
"exon_count": 15,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "EIF4G3",
"gene_hgnc_id": 3298,
"hgvs_c": "c.1519C>G",
"hgvs_p": "p.Pro507Ala",
"transcript": "ENST00000356916.7",
"protein_id": "ENSP00000349386.3",
"transcript_support_level": 1,
"aa_start": 507,
"aa_end": null,
"aa_length": 515,
"cds_start": 1519,
"cds_end": null,
"cds_length": 1548,
"cdna_start": 2016,
"cdna_end": null,
"cdna_length": 2179,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "P",
"aa_alt": "A",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 10,
"exon_rank_end": null,
"exon_count": 33,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "EIF4G3",
"gene_hgnc_id": 3298,
"hgvs_c": "c.2416C>G",
"hgvs_p": "p.Pro806Ala",
"transcript": "ENST00000693470.1",
"protein_id": "ENSP00000509295.1",
"transcript_support_level": null,
"aa_start": 806,
"aa_end": null,
"aa_length": 1895,
"cds_start": 2416,
"cds_end": null,
"cds_length": 5688,
"cdna_start": 2416,
"cdna_end": null,
"cdna_length": 5688,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "P",
"aa_alt": "A",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 11,
"exon_rank_end": null,
"exon_count": 34,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "EIF4G3",
"gene_hgnc_id": 3298,
"hgvs_c": "c.2053C>G",
"hgvs_p": "p.Pro685Ala",
"transcript": "ENST00000634879.2",
"protein_id": "ENSP00000489051.2",
"transcript_support_level": 5,
"aa_start": 685,
"aa_end": null,
"aa_length": 1774,
"cds_start": 2053,
"cds_end": null,
"cds_length": 5325,
"cdna_start": 2053,
"cdna_end": null,
"cdna_length": 5325,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "P",
"aa_alt": "A",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 10,
"exon_rank_end": null,
"exon_count": 33,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "EIF4G3",
"gene_hgnc_id": 3298,
"hgvs_c": "c.1972C>G",
"hgvs_p": "p.Pro658Ala",
"transcript": "ENST00000685872.1",
"protein_id": "ENSP00000509442.1",
"transcript_support_level": null,
"aa_start": 658,
"aa_end": null,
"aa_length": 1747,
"cds_start": 1972,
"cds_end": null,
"cds_length": 5244,
"cdna_start": 2416,
"cdna_end": null,
"cdna_length": 6528,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "P",
"aa_alt": "A",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 13,
"exon_rank_end": null,
"exon_count": 37,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "EIF4G3",
"gene_hgnc_id": 3298,
"hgvs_c": "c.1633C>G",
"hgvs_p": "p.Pro545Ala",
"transcript": "NM_001391907.1",
"protein_id": "NP_001378836.1",
"transcript_support_level": null,
"aa_start": 545,
"aa_end": null,
"aa_length": 1671,
"cds_start": 1633,
"cds_end": null,
"cds_length": 5016,
"cdna_start": 2264,
"cdna_end": null,
"cdna_length": 6487,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "P",
"aa_alt": "A",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 12,
"exon_rank_end": null,
"exon_count": 36,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "EIF4G3",
"gene_hgnc_id": 3298,
"hgvs_c": "c.1540C>G",
"hgvs_p": "p.Pro514Ala",
"transcript": "ENST00000684485.1",
"protein_id": "ENSP00000507662.1",
"transcript_support_level": null,
"aa_start": 514,
"aa_end": null,
"aa_length": 1640,
"cds_start": 1540,
"cds_end": null,
"cds_length": 4923,
"cdna_start": 3618,
"cdna_end": null,
"cdna_length": 7832,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "P",
"aa_alt": "A",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 13,
"exon_rank_end": null,
"exon_count": 36,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "EIF4G3",
"gene_hgnc_id": 3298,
"hgvs_c": "c.1633C>G",
"hgvs_p": "p.Pro545Ala",
"transcript": "NM_001438678.1",
"protein_id": "NP_001425607.1",
"transcript_support_level": null,
"aa_start": 545,
"aa_end": null,
"aa_length": 1634,
"cds_start": 1633,
"cds_end": null,
"cds_length": 4905,
"cdna_start": 2141,
"cdna_end": null,
"cdna_length": 6253,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "P",
"aa_alt": "A",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 12,
"exon_rank_end": null,
"exon_count": 35,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "EIF4G3",
"gene_hgnc_id": 3298,
"hgvs_c": "c.1633C>G",
"hgvs_p": "p.Pro545Ala",
"transcript": "NM_001438679.1",
"protein_id": "NP_001425608.1",
"transcript_support_level": null,
"aa_start": 545,
"aa_end": null,
"aa_length": 1634,
"cds_start": 1633,
"cds_end": null,
"cds_length": 4905,
"cdna_start": 1958,
"cdna_end": null,
"cdna_length": 6070,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "P",
"aa_alt": "A",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 13,
"exon_rank_end": null,
"exon_count": 36,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "EIF4G3",
"gene_hgnc_id": 3298,
"hgvs_c": "c.1630C>G",
"hgvs_p": "p.Pro544Ala",
"transcript": "NM_001391905.1",
"protein_id": "NP_001378834.1",
"transcript_support_level": null,
"aa_start": 544,
"aa_end": null,
"aa_length": 1633,
"cds_start": 1630,
"cds_end": null,
"cds_length": 4902,
"cdna_start": 2138,
"cdna_end": null,
"cdna_length": 6250,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "P",
"aa_alt": "A",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 12,
"exon_rank_end": null,
"exon_count": 35,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "EIF4G3",
"gene_hgnc_id": 3298,
"hgvs_c": "c.1630C>G",
"hgvs_p": "p.Pro544Ala",
"transcript": "ENST00000688741.1",
"protein_id": "ENSP00000509547.1",
"transcript_support_level": null,
"aa_start": 544,
"aa_end": null,
"aa_length": 1633,
"cds_start": 1630,
"cds_end": null,
"cds_length": 4902,
"cdna_start": 1961,
"cdna_end": null,
"cdna_length": 6064,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "P",
"aa_alt": "A",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 12,
"exon_rank_end": null,
"exon_count": 35,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "EIF4G3",
"gene_hgnc_id": 3298,
"hgvs_c": "c.1597C>G",
"hgvs_p": "p.Pro533Ala",
"transcript": "NM_001391902.1",
"protein_id": "NP_001378831.1",
"transcript_support_level": null,
"aa_start": 533,
"aa_end": null,
"aa_length": 1622,
"cds_start": 1597,
"cds_end": null,
"cds_length": 4869,
"cdna_start": 2228,
"cdna_end": null,
"cdna_length": 6340,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "P",
"aa_alt": "A",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 11,
"exon_rank_end": null,
"exon_count": 34,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "EIF4G3",
"gene_hgnc_id": 3298,
"hgvs_c": "c.1597C>G",
"hgvs_p": "p.Pro533Ala",
"transcript": "NM_001391903.1",
"protein_id": "NP_001378832.1",
"transcript_support_level": null,
"aa_start": 533,
"aa_end": null,
"aa_length": 1622,
"cds_start": 1597,
"cds_end": null,
"cds_length": 4869,
"cdna_start": 2044,
"cdna_end": null,
"cdna_length": 6156,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "P",
"aa_alt": "A",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 11,
"exon_rank_end": null,
"exon_count": 35,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "EIF4G3",
"gene_hgnc_id": 3298,
"hgvs_c": "c.1486C>G",
"hgvs_p": "p.Pro496Ala",
"transcript": "NM_001391904.1",
"protein_id": "NP_001378833.1",
"transcript_support_level": null,
"aa_start": 496,
"aa_end": null,
"aa_length": 1622,
"cds_start": 1486,
"cds_end": null,
"cds_length": 4869,
"cdna_start": 2117,
"cdna_end": null,
"cdna_length": 6340,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "P",
"aa_alt": "A",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 11,
"exon_rank_end": null,
"exon_count": 35,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "EIF4G3",
"gene_hgnc_id": 3298,
"hgvs_c": "c.1483C>G",
"hgvs_p": "p.Pro495Ala",
"transcript": "NM_001198801.3",
"protein_id": "NP_001185730.1",
"transcript_support_level": null,
"aa_start": 495,
"aa_end": null,
"aa_length": 1621,
"cds_start": 1483,
"cds_end": null,
"cds_length": 4866,
"cdna_start": 2114,
"cdna_end": null,
"cdna_length": 6337,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "P",
"aa_alt": "A",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 12,
"exon_rank_end": null,
"exon_count": 35,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "EIF4G3",
"gene_hgnc_id": 3298,
"hgvs_c": "c.1507C>G",
"hgvs_p": "p.Pro503Ala",
"transcript": "NM_001391901.1",
"protein_id": "NP_001378830.1",
"transcript_support_level": null,
"aa_start": 503,
"aa_end": null,
"aa_length": 1592,
"cds_start": 1507,
"cds_end": null,
"cds_length": 4779,
"cdna_start": 2138,
"cdna_end": null,
"cdna_length": 6250,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "P",
"aa_alt": "A",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 12,
"exon_rank_end": null,
"exon_count": 35,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "EIF4G3",
"gene_hgnc_id": 3298,
"hgvs_c": "c.1504C>G",
"hgvs_p": "p.Pro502Ala",
"transcript": "NM_001198802.3",
"protein_id": "NP_001185731.1",
"transcript_support_level": null,
"aa_start": 502,
"aa_end": null,
"aa_length": 1591,
"cds_start": 1504,
"cds_end": null,
"cds_length": 4776,
"cdna_start": 2135,
"cdna_end": null,
"cdna_length": 6247,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "P",
"aa_alt": "A",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 12,
"exon_rank_end": null,
"exon_count": 35,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "EIF4G3",
"gene_hgnc_id": 3298,
"hgvs_c": "c.1504C>G",
"hgvs_p": "p.Pro502Ala",
"transcript": "ENST00000686579.1",
"protein_id": "ENSP00000509941.1",
"transcript_support_level": null,
"aa_start": 502,
"aa_end": null,
"aa_length": 1591,
"cds_start": 1504,
"cds_end": null,
"cds_length": 4776,
"cdna_start": 2523,
"cdna_end": null,
"cdna_length": 6631,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "P",
"aa_alt": "A",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 11,
"exon_rank_end": null,
"exon_count": 34,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "EIF4G3",
"gene_hgnc_id": 3298,
"hgvs_c": "c.1486C>G",
"hgvs_p": "p.Pro496Ala",
"transcript": "NM_001391892.1",
"protein_id": "NP_001378821.1",
"transcript_support_level": null,
"aa_start": 496,
"aa_end": null,
"aa_length": 1585,
"cds_start": 1486,
"cds_end": null,
"cds_length": 4758,
"cdna_start": 2117,
"cdna_end": null,
"cdna_length": 6229,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "P",
"aa_alt": "A",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 9,
"exon_rank_end": null,
"exon_count": 32,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "EIF4G3",
"gene_hgnc_id": 3298,
"hgvs_c": "c.1486C>G",
"hgvs_p": "p.Pro496Ala",
"transcript": "NM_001391893.1",
"protein_id": "NP_001378822.1",
"transcript_support_level": null,
"aa_start": 496,
"aa_end": null,
"aa_length": 1585,
"cds_start": 1486,
"cds_end": null,
"cds_length": 4758,
"cdna_start": 1857,
"cdna_end": null,
"cdna_length": 5969,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "P",
"aa_alt": "A",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 11,
"exon_rank_end": null,
"exon_count": 34,
"intron_rank": null,
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}
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}