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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 1-222730104-C-T (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=1&pos=222730104&ref=C&alt=T&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "1",
"pos": 222730104,
"ref": "C",
"alt": "T",
"effect": "missense_variant",
"transcript": "NM_144695.4",
"consequences": [
{
"aa_ref": "H",
"aa_alt": "Y",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 11,
"exon_rank_end": null,
"exon_count": 13,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "BROX",
"gene_hgnc_id": 26512,
"hgvs_c": "c.916C>T",
"hgvs_p": "p.His306Tyr",
"transcript": "NM_144695.4",
"protein_id": "NP_653296.2",
"transcript_support_level": null,
"aa_start": 306,
"aa_end": null,
"aa_length": 411,
"cds_start": 916,
"cds_end": null,
"cds_length": 1236,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": "ENST00000340934.10",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_144695.4"
},
{
"aa_ref": "H",
"aa_alt": "Y",
"canonical": true,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 11,
"exon_rank_end": null,
"exon_count": 13,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "BROX",
"gene_hgnc_id": 26512,
"hgvs_c": "c.916C>T",
"hgvs_p": "p.His306Tyr",
"transcript": "ENST00000340934.10",
"protein_id": "ENSP00000343742.5",
"transcript_support_level": 1,
"aa_start": 306,
"aa_end": null,
"aa_length": 411,
"cds_start": 916,
"cds_end": null,
"cds_length": 1236,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": "NM_144695.4",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000340934.10"
},
{
"aa_ref": "H",
"aa_alt": "Y",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 10,
"exon_rank_end": null,
"exon_count": 12,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "BROX",
"gene_hgnc_id": 26512,
"hgvs_c": "c.820C>T",
"hgvs_p": "p.His274Tyr",
"transcript": "ENST00000612948.4",
"protein_id": "ENSP00000478496.1",
"transcript_support_level": 1,
"aa_start": 274,
"aa_end": null,
"aa_length": 379,
"cds_start": 820,
"cds_end": null,
"cds_length": 1140,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000612948.4"
},
{
"aa_ref": "H",
"aa_alt": "Y",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 11,
"exon_rank_end": null,
"exon_count": 13,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "BROX",
"gene_hgnc_id": 26512,
"hgvs_c": "c.916C>T",
"hgvs_p": "p.His306Tyr",
"transcript": "NM_001375661.1",
"protein_id": "NP_001362590.1",
"transcript_support_level": null,
"aa_start": 306,
"aa_end": null,
"aa_length": 411,
"cds_start": 916,
"cds_end": null,
"cds_length": 1236,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001375661.1"
},
{
"aa_ref": "H",
"aa_alt": "Y",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 12,
"exon_rank_end": null,
"exon_count": 14,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "BROX",
"gene_hgnc_id": 26512,
"hgvs_c": "c.916C>T",
"hgvs_p": "p.His306Tyr",
"transcript": "ENST00000888412.1",
"protein_id": "ENSP00000558471.1",
"transcript_support_level": null,
"aa_start": 306,
"aa_end": null,
"aa_length": 411,
"cds_start": 916,
"cds_end": null,
"cds_length": 1236,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000888412.1"
},
{
"aa_ref": "H",
"aa_alt": "Y",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 12,
"exon_rank_end": null,
"exon_count": 14,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "BROX",
"gene_hgnc_id": 26512,
"hgvs_c": "c.916C>T",
"hgvs_p": "p.His306Tyr",
"transcript": "ENST00000888413.1",
"protein_id": "ENSP00000558472.1",
"transcript_support_level": null,
"aa_start": 306,
"aa_end": null,
"aa_length": 411,
"cds_start": 916,
"cds_end": null,
"cds_length": 1236,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000888413.1"
},
{
"aa_ref": "H",
"aa_alt": "Y",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 12,
"exon_rank_end": null,
"exon_count": 14,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "BROX",
"gene_hgnc_id": 26512,
"hgvs_c": "c.916C>T",
"hgvs_p": "p.His306Tyr",
"transcript": "ENST00000916810.1",
"protein_id": "ENSP00000586870.1",
"transcript_support_level": null,
"aa_start": 306,
"aa_end": null,
"aa_length": 411,
"cds_start": 916,
"cds_end": null,
"cds_length": 1236,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000916810.1"
},
{
"aa_ref": "H",
"aa_alt": "Y",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 12,
"exon_rank_end": null,
"exon_count": 14,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "BROX",
"gene_hgnc_id": 26512,
"hgvs_c": "c.916C>T",
"hgvs_p": "p.His306Tyr",
"transcript": "ENST00000916816.1",
"protein_id": "ENSP00000586875.1",
"transcript_support_level": null,
"aa_start": 306,
"aa_end": null,
"aa_length": 411,
"cds_start": 916,
"cds_end": null,
"cds_length": 1236,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000916816.1"
},
{
"aa_ref": "H",
"aa_alt": "Y",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 12,
"exon_rank_end": null,
"exon_count": 14,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "BROX",
"gene_hgnc_id": 26512,
"hgvs_c": "c.916C>T",
"hgvs_p": "p.His306Tyr",
"transcript": "ENST00000916817.1",
"protein_id": "ENSP00000586876.1",
"transcript_support_level": null,
"aa_start": 306,
"aa_end": null,
"aa_length": 411,
"cds_start": 916,
"cds_end": null,
"cds_length": 1236,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000916817.1"
},
{
"aa_ref": "H",
"aa_alt": "Y",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 12,
"exon_rank_end": null,
"exon_count": 14,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "BROX",
"gene_hgnc_id": 26512,
"hgvs_c": "c.916C>T",
"hgvs_p": "p.His306Tyr",
"transcript": "ENST00000916818.1",
"protein_id": "ENSP00000586877.1",
"transcript_support_level": null,
"aa_start": 306,
"aa_end": null,
"aa_length": 411,
"cds_start": 916,
"cds_end": null,
"cds_length": 1236,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000916818.1"
},
{
"aa_ref": "H",
"aa_alt": "Y",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 12,
"exon_rank_end": null,
"exon_count": 14,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "BROX",
"gene_hgnc_id": 26512,
"hgvs_c": "c.916C>T",
"hgvs_p": "p.His306Tyr",
"transcript": "ENST00000962607.1",
"protein_id": "ENSP00000632666.1",
"transcript_support_level": null,
"aa_start": 306,
"aa_end": null,
"aa_length": 411,
"cds_start": 916,
"cds_end": null,
"cds_length": 1236,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000962607.1"
},
{
"aa_ref": "H",
"aa_alt": "Y",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 12,
"exon_rank_end": null,
"exon_count": 14,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "BROX",
"gene_hgnc_id": 26512,
"hgvs_c": "c.916C>T",
"hgvs_p": "p.His306Tyr",
"transcript": "ENST00000962608.1",
"protein_id": "ENSP00000632667.1",
"transcript_support_level": null,
"aa_start": 306,
"aa_end": null,
"aa_length": 411,
"cds_start": 916,
"cds_end": null,
"cds_length": 1236,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000962608.1"
},
{
"aa_ref": "H",
"aa_alt": "Y",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 13,
"exon_rank_end": null,
"exon_count": 15,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "BROX",
"gene_hgnc_id": 26512,
"hgvs_c": "c.916C>T",
"hgvs_p": "p.His306Tyr",
"transcript": "ENST00000962609.1",
"protein_id": "ENSP00000632668.1",
"transcript_support_level": null,
"aa_start": 306,
"aa_end": null,
"aa_length": 411,
"cds_start": 916,
"cds_end": null,
"cds_length": 1236,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000962609.1"
},
{
"aa_ref": "H",
"aa_alt": "Y",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 13,
"exon_rank_end": null,
"exon_count": 15,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "BROX",
"gene_hgnc_id": 26512,
"hgvs_c": "c.916C>T",
"hgvs_p": "p.His306Tyr",
"transcript": "ENST00000962610.1",
"protein_id": "ENSP00000632669.1",
"transcript_support_level": null,
"aa_start": 306,
"aa_end": null,
"aa_length": 411,
"cds_start": 916,
"cds_end": null,
"cds_length": 1236,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000962610.1"
},
{
"aa_ref": "H",
"aa_alt": "Y",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 13,
"exon_rank_end": null,
"exon_count": 15,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "BROX",
"gene_hgnc_id": 26512,
"hgvs_c": "c.916C>T",
"hgvs_p": "p.His306Tyr",
"transcript": "ENST00000962611.1",
"protein_id": "ENSP00000632670.1",
"transcript_support_level": null,
"aa_start": 306,
"aa_end": null,
"aa_length": 411,
"cds_start": 916,
"cds_end": null,
"cds_length": 1236,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000962611.1"
},
{
"aa_ref": "H",
"aa_alt": "Y",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 11,
"exon_rank_end": null,
"exon_count": 13,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "BROX",
"gene_hgnc_id": 26512,
"hgvs_c": "c.916C>T",
"hgvs_p": "p.His306Tyr",
"transcript": "ENST00000962612.1",
"protein_id": "ENSP00000632671.1",
"transcript_support_level": null,
"aa_start": 306,
"aa_end": null,
"aa_length": 411,
"cds_start": 916,
"cds_end": null,
"cds_length": 1236,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000962612.1"
},
{
"aa_ref": "H",
"aa_alt": "Y",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 12,
"exon_rank_end": null,
"exon_count": 14,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "BROX",
"gene_hgnc_id": 26512,
"hgvs_c": "c.916C>T",
"hgvs_p": "p.His306Tyr",
"transcript": "ENST00000962613.1",
"protein_id": "ENSP00000632672.1",
"transcript_support_level": null,
"aa_start": 306,
"aa_end": null,
"aa_length": 411,
"cds_start": 916,
"cds_end": null,
"cds_length": 1236,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000962613.1"
},
{
"aa_ref": "H",
"aa_alt": "Y",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 12,
"exon_rank_end": null,
"exon_count": 14,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "BROX",
"gene_hgnc_id": 26512,
"hgvs_c": "c.916C>T",
"hgvs_p": "p.His306Tyr",
"transcript": "ENST00000962614.1",
"protein_id": "ENSP00000632673.1",
"transcript_support_level": null,
"aa_start": 306,
"aa_end": null,
"aa_length": 411,
"cds_start": 916,
"cds_end": null,
"cds_length": 1236,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000962614.1"
},
{
"aa_ref": "H",
"aa_alt": "Y",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 12,
"exon_rank_end": null,
"exon_count": 14,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "BROX",
"gene_hgnc_id": 26512,
"hgvs_c": "c.916C>T",
"hgvs_p": "p.His306Tyr",
"transcript": "ENST00000962615.1",
"protein_id": "ENSP00000632674.1",
"transcript_support_level": null,
"aa_start": 306,
"aa_end": null,
"aa_length": 411,
"cds_start": 916,
"cds_end": null,
"cds_length": 1236,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000962615.1"
},
{
"aa_ref": "H",
"aa_alt": "Y",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 10,
"exon_rank_end": null,
"exon_count": 12,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "BROX",
"gene_hgnc_id": 26512,
"hgvs_c": "c.820C>T",
"hgvs_p": "p.His274Tyr",
"transcript": "NM_001288579.2",
"protein_id": "NP_001275508.1",
"transcript_support_level": null,
"aa_start": 274,
"aa_end": null,
"aa_length": 379,
"cds_start": 820,
"cds_end": null,
"cds_length": 1140,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001288579.2"
},
{
"aa_ref": "H",
"aa_alt": "Y",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 10,
"exon_rank_end": null,
"exon_count": 12,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "BROX",
"gene_hgnc_id": 26512,
"hgvs_c": "c.820C>T",
"hgvs_p": "p.His274Tyr",
"transcript": "NM_001288580.2",
"protein_id": "NP_001275509.1",
"transcript_support_level": null,
"aa_start": 274,
"aa_end": null,
"aa_length": 379,
"cds_start": 820,
"cds_end": null,
"cds_length": 1140,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001288580.2"
},
{
"aa_ref": "H",
"aa_alt": "Y",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 10,
"exon_rank_end": null,
"exon_count": 12,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "BROX",
"gene_hgnc_id": 26512,
"hgvs_c": "c.820C>T",
"hgvs_p": "p.His274Tyr",
"transcript": "ENST00000539697.5",
"protein_id": "ENSP00000441080.1",
"transcript_support_level": 2,
"aa_start": 274,
"aa_end": null,
"aa_length": 379,
"cds_start": 820,
"cds_end": null,
"cds_length": 1140,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
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}