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GeneBe API Showcase

This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.

API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.

Documentation & Advanced Usage

Complete API documentation:docs.genebe.net/docs/api/overview/

Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/

Python client for pandas:pypi.org/project/genebe/

Java CLI for VCF files:github.com/pstawinski/genebe-cli

All tools documented at:docs.genebe.net

API Request Examples for Variant: 1-223259617-T-C (hg38)

Bash / cURL Example

bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=1&pos=223259617&ref=T&alt=C&genome=hg38&allGenes=true"

API Response

json
{
  "variants": [
    {
      "chr": "1",
      "pos": 223259617,
      "ref": "T",
      "alt": "C",
      "effect": "intron_variant",
      "transcript": "ENST00000366878.9",
      "consequences": [
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "intron_variant"
          ],
          "exon_rank": null,
          "exon_rank_end": null,
          "exon_count": 9,
          "intron_rank": 5,
          "intron_rank_end": null,
          "gene_symbol": "SUSD4",
          "gene_hgnc_id": 25470,
          "hgvs_c": "c.724+5013A>G",
          "hgvs_p": null,
          "transcript": "NM_017982.4",
          "protein_id": "NP_060452.3",
          "transcript_support_level": null,
          "aa_start": null,
          "aa_end": null,
          "aa_length": 490,
          "cds_start": -4,
          "cds_end": null,
          "cds_length": 1473,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": 2989,
          "mane_select": "ENST00000366878.9",
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": true,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "intron_variant"
          ],
          "exon_rank": null,
          "exon_rank_end": null,
          "exon_count": 9,
          "intron_rank": 5,
          "intron_rank_end": null,
          "gene_symbol": "SUSD4",
          "gene_hgnc_id": 25470,
          "hgvs_c": "c.724+5013A>G",
          "hgvs_p": null,
          "transcript": "ENST00000366878.9",
          "protein_id": "ENSP00000355843.4",
          "transcript_support_level": 1,
          "aa_start": null,
          "aa_end": null,
          "aa_length": 490,
          "cds_start": -4,
          "cds_end": null,
          "cds_length": 1473,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": 2989,
          "mane_select": "NM_017982.4",
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": true,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "intron_variant"
          ],
          "exon_rank": null,
          "exon_rank_end": null,
          "exon_count": 8,
          "intron_rank": 4,
          "intron_rank_end": null,
          "gene_symbol": "SUSD4",
          "gene_hgnc_id": 25470,
          "hgvs_c": "c.634+5013A>G",
          "hgvs_p": null,
          "transcript": "ENST00000608996.5",
          "protein_id": "ENSP00000477432.1",
          "transcript_support_level": 5,
          "aa_start": null,
          "aa_end": null,
          "aa_length": 462,
          "cds_start": -4,
          "cds_end": null,
          "cds_length": 1389,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": 2566,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": true,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "intron_variant"
          ],
          "exon_rank": null,
          "exon_rank_end": null,
          "exon_count": 8,
          "intron_rank": 4,
          "intron_rank_end": null,
          "gene_symbol": "SUSD4",
          "gene_hgnc_id": 25470,
          "hgvs_c": "c.511+5013A>G",
          "hgvs_p": null,
          "transcript": "ENST00000484758.6",
          "protein_id": "ENSP00000477374.1",
          "transcript_support_level": 2,
          "aa_start": null,
          "aa_end": null,
          "aa_length": 421,
          "cds_start": -4,
          "cds_end": null,
          "cds_length": 1266,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": 2736,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "intron_variant"
          ],
          "exon_rank": null,
          "exon_rank_end": null,
          "exon_count": 6,
          "intron_rank": 5,
          "intron_rank_end": null,
          "gene_symbol": "SUSD4",
          "gene_hgnc_id": 25470,
          "hgvs_c": "c.724+5013A>G",
          "hgvs_p": null,
          "transcript": "ENST00000344029.6",
          "protein_id": "ENSP00000339926.6",
          "transcript_support_level": 1,
          "aa_start": null,
          "aa_end": null,
          "aa_length": 290,
          "cds_start": -4,
          "cds_end": null,
          "cds_length": 873,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": 1056,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "intron_variant"
          ],
          "exon_rank": null,
          "exon_rank_end": null,
          "exon_count": 10,
          "intron_rank": 6,
          "intron_rank_end": null,
          "gene_symbol": "SUSD4",
          "gene_hgnc_id": 25470,
          "hgvs_c": "c.940+5013A>G",
          "hgvs_p": null,
          "transcript": "NM_001410929.1",
          "protein_id": "NP_001397858.1",
          "transcript_support_level": null,
          "aa_start": null,
          "aa_end": null,
          "aa_length": 562,
          "cds_start": -4,
          "cds_end": null,
          "cds_length": 1689,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": 3153,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "intron_variant"
          ],
          "exon_rank": null,
          "exon_rank_end": null,
          "exon_count": 10,
          "intron_rank": 6,
          "intron_rank_end": null,
          "gene_symbol": "SUSD4",
          "gene_hgnc_id": 25470,
          "hgvs_c": "c.940+5013A>G",
          "hgvs_p": null,
          "transcript": "ENST00000681285.1",
          "protein_id": "ENSP00000505301.1",
          "transcript_support_level": null,
          "aa_start": null,
          "aa_end": null,
          "aa_length": 562,
          "cds_start": -4,
          "cds_end": null,
          "cds_length": 1689,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": 3142,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "intron_variant"
          ],
          "exon_rank": null,
          "exon_rank_end": null,
          "exon_count": 10,
          "intron_rank": 6,
          "intron_rank_end": null,
          "gene_symbol": "SUSD4",
          "gene_hgnc_id": 25470,
          "hgvs_c": "c.841+5013A>G",
          "hgvs_p": null,
          "transcript": "ENST00000680429.1",
          "protein_id": "ENSP00000504955.1",
          "transcript_support_level": null,
          "aa_start": null,
          "aa_end": null,
          "aa_length": 529,
          "cds_start": -4,
          "cds_end": null,
          "cds_length": 1590,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": 3061,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "intron_variant"
          ],
          "exon_rank": null,
          "exon_rank_end": null,
          "exon_count": 10,
          "intron_rank": 6,
          "intron_rank_end": null,
          "gene_symbol": "SUSD4",
          "gene_hgnc_id": 25470,
          "hgvs_c": "c.724+5013A>G",
          "hgvs_p": null,
          "transcript": "NM_001437664.1",
          "protein_id": "NP_001424593.1",
          "transcript_support_level": null,
          "aa_start": null,
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          "aa_length": 490,
          "cds_start": -4,
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          "cds_length": 1473,
          "cdna_start": null,
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          "cdna_length": 3081,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": null,
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          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "intron_variant"
          ],
          "exon_rank": null,
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          "exon_count": 8,
          "intron_rank": 4,
          "intron_rank_end": null,
          "gene_symbol": "SUSD4",
          "gene_hgnc_id": 25470,
          "hgvs_c": "c.724+5013A>G",
          "hgvs_p": null,
          "transcript": "ENST00000343846.7",
          "protein_id": "ENSP00000344219.3",
          "transcript_support_level": 2,
          "aa_start": null,
          "aa_end": null,
          "aa_length": 490,
          "cds_start": -4,
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          "cdna_start": null,
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          "cdna_length": 3480,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
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        {
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          "canonical": false,
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          "strand": false,
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          "exon_count": 10,
          "intron_rank": 6,
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          "gene_symbol": "SUSD4",
          "gene_hgnc_id": 25470,
          "hgvs_c": "c.724+5013A>G",
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          "protein_id": "ENSP00000505262.1",
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          "aa_length": 490,
          "cds_start": -4,
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          "cdna_start": null,
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          "mane_select": null,
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          "biotype": null,
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        {
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          "canonical": false,
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          "consequences": [
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          "exon_count": 10,
          "intron_rank": 6,
          "intron_rank_end": null,
          "gene_symbol": "SUSD4",
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          "intron_rank": 5,
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          "hgvs_c": "c.724+5013A>G",
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          "gene_symbol": "SUSD4",
          "gene_hgnc_id": 25470,
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          "transcript": "NM_001438681.1",
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          "gene_symbol": "SUSD4",
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          "exon_count": 11,
          "intron_rank": 7,
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          "gene_symbol": "SUSD4",
          "gene_hgnc_id": 25470,
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        {
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        {
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          "intron_rank": 7,
          "intron_rank_end": null,
          "gene_symbol": "SUSD4",
          "gene_hgnc_id": 25470,
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      "gene_symbol": "SUSD4",
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      "gnomad_exomes_af": null,
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      "computational_source_selected": "BayesDel_noAF",
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      "splice_prediction_selected": "Benign",
      "splice_source_selected": "max_spliceai",
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      "phylop100way_prediction": "Benign",
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      "acmg_classification": "Benign",
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      "acmg_by_gene": [
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          "verdict": "Benign",
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      "clinvar_disease": "",
      "clinvar_classification": "",
      "clinvar_review_status": "",
      "clinvar_submissions_summary": "",
      "phenotype_combined": null,
      "pathogenicity_classification_combined": null,
      "custom_annotations": null
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  ],
  "message": null
}