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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 1-225422182-A-T (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=1&pos=225422182&ref=A&alt=T&genome=hg38&allGenes=true"API Response
json
{
"message": null,
"variants": [
{
"acmg_by_gene": [
{
"benign_score": 5,
"criteria": [
"PM2",
"BP4_Strong",
"BP7"
],
"effects": [
"synonymous_variant"
],
"gene_symbol": "LBR",
"hgnc_id": 6518,
"hgvs_c": "c.261T>A",
"hgvs_p": "p.Pro87Pro",
"inheritance_mode": "AD,AR",
"pathogenic_score": 2,
"score": -3,
"transcript": "NM_002296.4",
"verdict": "Likely_benign"
}
],
"acmg_classification": "Likely_benign",
"acmg_criteria": "PM2,BP4_Strong,BP7",
"acmg_score": -3,
"allele_count_reference_population": 0,
"alphamissense_prediction": null,
"alphamissense_score": null,
"alt": "T",
"apogee2_prediction": null,
"apogee2_score": null,
"bayesdelnoaf_prediction": "Benign",
"bayesdelnoaf_score": -0.55,
"chr": "1",
"clinvar_classification": "",
"clinvar_disease": "",
"clinvar_review_status": "",
"clinvar_submissions_summary": "",
"computational_prediction_selected": "Benign",
"computational_score_selected": -0.550000011920929,
"computational_source_selected": "BayesDel_noAF",
"consequences": [
{
"aa_alt": "P",
"aa_end": null,
"aa_length": 615,
"aa_ref": "P",
"aa_start": 87,
"biotype": "protein_coding",
"canonical": false,
"cdna_end": null,
"cdna_length": 3748,
"cdna_start": 360,
"cds_end": null,
"cds_length": 1848,
"cds_start": 261,
"consequences": [
"synonymous_variant"
],
"exon_count": 14,
"exon_rank": 3,
"exon_rank_end": null,
"feature": "NM_002296.4",
"gene_hgnc_id": 6518,
"gene_symbol": "LBR",
"hgvs_c": "c.261T>A",
"hgvs_p": "p.Pro87Pro",
"intron_rank": null,
"intron_rank_end": null,
"mane_plus": null,
"mane_select": "ENST00000272163.9",
"protein_coding": true,
"protein_id": "NP_002287.2",
"strand": false,
"transcript": "NM_002296.4",
"transcript_support_level": null
},
{
"aa_alt": "P",
"aa_end": null,
"aa_length": 615,
"aa_ref": "P",
"aa_start": 87,
"biotype": "protein_coding",
"canonical": true,
"cdna_end": null,
"cdna_length": 3748,
"cdna_start": 360,
"cds_end": null,
"cds_length": 1848,
"cds_start": 261,
"consequences": [
"synonymous_variant"
],
"exon_count": 14,
"exon_rank": 3,
"exon_rank_end": null,
"feature": "ENST00000272163.9",
"gene_hgnc_id": 6518,
"gene_symbol": "LBR",
"hgvs_c": "c.261T>A",
"hgvs_p": "p.Pro87Pro",
"intron_rank": null,
"intron_rank_end": null,
"mane_plus": null,
"mane_select": "NM_002296.4",
"protein_coding": true,
"protein_id": "ENSP00000272163.4",
"strand": false,
"transcript": "ENST00000272163.9",
"transcript_support_level": 1
},
{
"aa_alt": "P",
"aa_end": null,
"aa_length": 615,
"aa_ref": "P",
"aa_start": 87,
"biotype": "protein_coding",
"canonical": false,
"cdna_end": null,
"cdna_length": 3779,
"cdna_start": 391,
"cds_end": null,
"cds_length": 1848,
"cds_start": 261,
"consequences": [
"synonymous_variant"
],
"exon_count": 14,
"exon_rank": 3,
"exon_rank_end": null,
"feature": "NM_194442.3",
"gene_hgnc_id": 6518,
"gene_symbol": "LBR",
"hgvs_c": "c.261T>A",
"hgvs_p": "p.Pro87Pro",
"intron_rank": null,
"intron_rank_end": null,
"mane_plus": null,
"mane_select": null,
"protein_coding": true,
"protein_id": "NP_919424.1",
"strand": false,
"transcript": "NM_194442.3",
"transcript_support_level": null
},
{
"aa_alt": "P",
"aa_end": null,
"aa_length": 615,
"aa_ref": "P",
"aa_start": 87,
"biotype": "protein_coding",
"canonical": false,
"cdna_end": null,
"cdna_length": 3812,
"cdna_start": 425,
"cds_end": null,
"cds_length": 1848,
"cds_start": 261,
"consequences": [
"synonymous_variant"
],
"exon_count": 14,
"exon_rank": 3,
"exon_rank_end": null,
"feature": "ENST00000338179.6",
"gene_hgnc_id": 6518,
"gene_symbol": "LBR",
"hgvs_c": "c.261T>A",
"hgvs_p": "p.Pro87Pro",
"intron_rank": null,
"intron_rank_end": null,
"mane_plus": null,
"mane_select": null,
"protein_coding": true,
"protein_id": "ENSP00000339883.2",
"strand": false,
"transcript": "ENST00000338179.6",
"transcript_support_level": 5
},
{
"aa_alt": "P",
"aa_end": null,
"aa_length": 615,
"aa_ref": "P",
"aa_start": 87,
"biotype": "protein_coding",
"canonical": false,
"cdna_end": null,
"cdna_length": 4412,
"cdna_start": 422,
"cds_end": null,
"cds_length": 1848,
"cds_start": 261,
"consequences": [
"synonymous_variant"
],
"exon_count": 14,
"exon_rank": 3,
"exon_rank_end": null,
"feature": "ENST00000885795.1",
"gene_hgnc_id": 6518,
"gene_symbol": "LBR",
"hgvs_c": "c.261T>A",
"hgvs_p": "p.Pro87Pro",
"intron_rank": null,
"intron_rank_end": null,
"mane_plus": null,
"mane_select": null,
"protein_coding": true,
"protein_id": "ENSP00000555854.1",
"strand": false,
"transcript": "ENST00000885795.1",
"transcript_support_level": null
},
{
"aa_alt": "P",
"aa_end": null,
"aa_length": 615,
"aa_ref": "P",
"aa_start": 87,
"biotype": "protein_coding",
"canonical": false,
"cdna_end": null,
"cdna_length": 4269,
"cdna_start": 883,
"cds_end": null,
"cds_length": 1848,
"cds_start": 261,
"consequences": [
"synonymous_variant"
],
"exon_count": 14,
"exon_rank": 3,
"exon_rank_end": null,
"feature": "ENST00000885800.1",
"gene_hgnc_id": 6518,
"gene_symbol": "LBR",
"hgvs_c": "c.261T>A",
"hgvs_p": "p.Pro87Pro",
"intron_rank": null,
"intron_rank_end": null,
"mane_plus": null,
"mane_select": null,
"protein_coding": true,
"protein_id": "ENSP00000555859.1",
"strand": false,
"transcript": "ENST00000885800.1",
"transcript_support_level": null
},
{
"aa_alt": "P",
"aa_end": null,
"aa_length": 615,
"aa_ref": "P",
"aa_start": 87,
"biotype": "protein_coding",
"canonical": false,
"cdna_end": null,
"cdna_length": 3978,
"cdna_start": 589,
"cds_end": null,
"cds_length": 1848,
"cds_start": 261,
"consequences": [
"synonymous_variant"
],
"exon_count": 14,
"exon_rank": 3,
"exon_rank_end": null,
"feature": "ENST00000885801.1",
"gene_hgnc_id": 6518,
"gene_symbol": "LBR",
"hgvs_c": "c.261T>A",
"hgvs_p": "p.Pro87Pro",
"intron_rank": null,
"intron_rank_end": null,
"mane_plus": null,
"mane_select": null,
"protein_coding": true,
"protein_id": "ENSP00000555860.1",
"strand": false,
"transcript": "ENST00000885801.1",
"transcript_support_level": null
},
{
"aa_alt": "P",
"aa_end": null,
"aa_length": 615,
"aa_ref": "P",
"aa_start": 87,
"biotype": "protein_coding",
"canonical": false,
"cdna_end": null,
"cdna_length": 6013,
"cdna_start": 2625,
"cds_end": null,
"cds_length": 1848,
"cds_start": 261,
"consequences": [
"synonymous_variant"
],
"exon_count": 13,
"exon_rank": 2,
"exon_rank_end": null,
"feature": "ENST00000885803.1",
"gene_hgnc_id": 6518,
"gene_symbol": "LBR",
"hgvs_c": "c.261T>A",
"hgvs_p": "p.Pro87Pro",
"intron_rank": null,
"intron_rank_end": null,
"mane_plus": null,
"mane_select": null,
"protein_coding": true,
"protein_id": "ENSP00000555862.1",
"strand": false,
"transcript": "ENST00000885803.1",
"transcript_support_level": null
},
{
"aa_alt": "P",
"aa_end": null,
"aa_length": 615,
"aa_ref": "P",
"aa_start": 87,
"biotype": "protein_coding",
"canonical": false,
"cdna_end": null,
"cdna_length": 2858,
"cdna_start": 370,
"cds_end": null,
"cds_length": 1848,
"cds_start": 261,
"consequences": [
"synonymous_variant"
],
"exon_count": 14,
"exon_rank": 3,
"exon_rank_end": null,
"feature": "ENST00000945207.1",
"gene_hgnc_id": 6518,
"gene_symbol": "LBR",
"hgvs_c": "c.261T>A",
"hgvs_p": "p.Pro87Pro",
"intron_rank": null,
"intron_rank_end": null,
"mane_plus": null,
"mane_select": null,
"protein_coding": true,
"protein_id": "ENSP00000615266.1",
"strand": false,
"transcript": "ENST00000945207.1",
"transcript_support_level": null
},
{
"aa_alt": "P",
"aa_end": null,
"aa_length": 615,
"aa_ref": "P",
"aa_start": 87,
"biotype": "protein_coding",
"canonical": false,
"cdna_end": null,
"cdna_length": 4380,
"cdna_start": 993,
"cds_end": null,
"cds_length": 1848,
"cds_start": 261,
"consequences": [
"synonymous_variant"
],
"exon_count": 14,
"exon_rank": 3,
"exon_rank_end": null,
"feature": "ENST00000945208.1",
"gene_hgnc_id": 6518,
"gene_symbol": "LBR",
"hgvs_c": "c.261T>A",
"hgvs_p": "p.Pro87Pro",
"intron_rank": null,
"intron_rank_end": null,
"mane_plus": null,
"mane_select": null,
"protein_coding": true,
"protein_id": "ENSP00000615267.1",
"strand": false,
"transcript": "ENST00000945208.1",
"transcript_support_level": null
},
{
"aa_alt": "P",
"aa_end": null,
"aa_length": 615,
"aa_ref": "P",
"aa_start": 87,
"biotype": "protein_coding",
"canonical": false,
"cdna_end": null,
"cdna_length": 2787,
"cdna_start": 293,
"cds_end": null,
"cds_length": 1848,
"cds_start": 261,
"consequences": [
"synonymous_variant"
],
"exon_count": 14,
"exon_rank": 3,
"exon_rank_end": null,
"feature": "ENST00000945209.1",
"gene_hgnc_id": 6518,
"gene_symbol": "LBR",
"hgvs_c": "c.261T>A",
"hgvs_p": "p.Pro87Pro",
"intron_rank": null,
"intron_rank_end": null,
"mane_plus": null,
"mane_select": null,
"protein_coding": true,
"protein_id": "ENSP00000615268.1",
"strand": false,
"transcript": "ENST00000945209.1",
"transcript_support_level": null
},
{
"aa_alt": "P",
"aa_end": null,
"aa_length": 614,
"aa_ref": "P",
"aa_start": 87,
"biotype": "protein_coding",
"canonical": false,
"cdna_end": null,
"cdna_length": 3776,
"cdna_start": 391,
"cds_end": null,
"cds_length": 1845,
"cds_start": 261,
"consequences": [
"synonymous_variant"
],
"exon_count": 14,
"exon_rank": 3,
"exon_rank_end": null,
"feature": "ENST00000885794.1",
"gene_hgnc_id": 6518,
"gene_symbol": "LBR",
"hgvs_c": "c.261T>A",
"hgvs_p": "p.Pro87Pro",
"intron_rank": null,
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"mane_plus": null,
"mane_select": null,
"protein_coding": true,
"protein_id": "ENSP00000555853.1",
"strand": false,
"transcript": "ENST00000885794.1",
"transcript_support_level": null
},
{
"aa_alt": "P",
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"aa_length": 614,
"aa_ref": "P",
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"biotype": "protein_coding",
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"cdna_start": 440,
"cds_end": null,
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"consequences": [
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],
"exon_count": 14,
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"feature": "ENST00000885797.1",
"gene_hgnc_id": 6518,
"gene_symbol": "LBR",
"hgvs_c": "c.261T>A",
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"mane_plus": null,
"mane_select": null,
"protein_coding": true,
"protein_id": "ENSP00000555856.1",
"strand": false,
"transcript": "ENST00000885797.1",
"transcript_support_level": null
},
{
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"aa_ref": "P",
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"biotype": "protein_coding",
"canonical": false,
"cdna_end": null,
"cdna_length": 3927,
"cdna_start": 542,
"cds_end": null,
"cds_length": 1845,
"cds_start": 261,
"consequences": [
"synonymous_variant"
],
"exon_count": 14,
"exon_rank": 3,
"exon_rank_end": null,
"feature": "ENST00000885802.1",
"gene_hgnc_id": 6518,
"gene_symbol": "LBR",
"hgvs_c": "c.261T>A",
"hgvs_p": "p.Pro87Pro",
"intron_rank": null,
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"mane_plus": null,
"mane_select": null,
"protein_coding": true,
"protein_id": "ENSP00000555861.1",
"strand": false,
"transcript": "ENST00000885802.1",
"transcript_support_level": null
},
{
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"aa_ref": "P",
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"biotype": "protein_coding",
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"cdna_end": null,
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"consequences": [
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],
"exon_count": 14,
"exon_rank": 3,
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"feature": "ENST00000933594.1",
"gene_hgnc_id": 6518,
"gene_symbol": "LBR",
"hgvs_c": "c.261T>A",
"hgvs_p": "p.Pro87Pro",
"intron_rank": null,
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"mane_plus": null,
"mane_select": null,
"protein_coding": true,
"protein_id": "ENSP00000603653.1",
"strand": false,
"transcript": "ENST00000933594.1",
"transcript_support_level": null
},
{
"aa_alt": "P",
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"aa_ref": "P",
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"biotype": "protein_coding",
"canonical": false,
"cdna_end": null,
"cdna_length": 3729,
"cdna_start": 366,
"cds_end": null,
"cds_length": 1824,
"cds_start": 261,
"consequences": [
"synonymous_variant"
],
"exon_count": 14,
"exon_rank": 3,
"exon_rank_end": null,
"feature": "ENST00000945206.1",
"gene_hgnc_id": 6518,
"gene_symbol": "LBR",
"hgvs_c": "c.261T>A",
"hgvs_p": "p.Pro87Pro",
"intron_rank": null,
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"mane_plus": null,
"mane_select": null,
"protein_coding": true,
"protein_id": "ENSP00000615265.1",
"strand": false,
"transcript": "ENST00000945206.1",
"transcript_support_level": null
},
{
"aa_alt": "P",
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"aa_length": 605,
"aa_ref": "P",
"aa_start": 87,
"biotype": "protein_coding",
"canonical": false,
"cdna_end": null,
"cdna_length": 3745,
"cdna_start": 390,
"cds_end": null,
"cds_length": 1818,
"cds_start": 261,
"consequences": [
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],
"exon_count": 14,
"exon_rank": 3,
"exon_rank_end": null,
"feature": "ENST00000945205.1",
"gene_hgnc_id": 6518,
"gene_symbol": "LBR",
"hgvs_c": "c.261T>A",
"hgvs_p": "p.Pro87Pro",
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"protein_coding": true,
"protein_id": "ENSP00000615264.1",
"strand": false,
"transcript": "ENST00000945205.1",
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},
{
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"biotype": "protein_coding",
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"consequences": [
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],
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"feature": "ENST00000933595.1",
"gene_hgnc_id": 6518,
"gene_symbol": "LBR",
"hgvs_c": "c.261T>A",
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"mane_plus": null,
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"protein_coding": true,
"protein_id": "ENSP00000603654.1",
"strand": false,
"transcript": "ENST00000933595.1",
"transcript_support_level": null
},
{
"aa_alt": "P",
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"aa_ref": "P",
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"biotype": "protein_coding",
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"cds_end": null,
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"consequences": [
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],
"exon_count": 13,
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"feature": "ENST00000945203.1",
"gene_hgnc_id": 6518,
"gene_symbol": "LBR",
"hgvs_c": "c.261T>A",
"hgvs_p": "p.Pro87Pro",
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"protein_coding": true,
"protein_id": "ENSP00000615262.1",
"strand": false,
"transcript": "ENST00000945203.1",
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},
{
"aa_alt": "P",
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"aa_ref": "P",
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"biotype": "protein_coding",
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"cdna_end": null,
"cdna_length": 3665,
"cdna_start": 388,
"cds_end": null,
"cds_length": 1743,
"cds_start": 261,
"consequences": [
"synonymous_variant"
],
"exon_count": 14,
"exon_rank": 3,
"exon_rank_end": null,
"feature": "ENST00000933596.1",
"gene_hgnc_id": 6518,
"gene_symbol": "LBR",
"hgvs_c": "c.261T>A",
"hgvs_p": "p.Pro87Pro",
"intron_rank": null,
"intron_rank_end": null,
"mane_plus": null,
"mane_select": null,
"protein_coding": true,
"protein_id": "ENSP00000603655.1",
"strand": false,
"transcript": "ENST00000933596.1",
"transcript_support_level": null
},
{
"aa_alt": "P",
"aa_end": null,
"aa_length": 573,
"aa_ref": "P",
"aa_start": 87,
"biotype": "protein_coding",
"canonical": false,
"cdna_end": null,
"cdna_length": 3709,
"cdna_start": 440,
"cds_end": null,
"cds_length": 1722,
"cds_start": 261,
"consequences": [
"synonymous_variant"
],
"exon_count": 13,
"exon_rank": 3,
"exon_rank_end": null,
"feature": "ENST00000885796.1",
"gene_hgnc_id": 6518,
"gene_symbol": "LBR",
"hgvs_c": "c.261T>A",
"hgvs_p": "p.Pro87Pro",
"intron_rank": null,
"intron_rank_end": null,
"mane_plus": null,
"mane_select": null,
"protein_coding": true,
"protein_id": "ENSP00000555855.1",
"strand": false,
"transcript": "ENST00000885796.1",
"transcript_support_level": null
},
{
"aa_alt": "P",
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