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GeneBe API Showcase

This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.

API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.

Documentation & Advanced Usage

Complete API documentation:docs.genebe.net/docs/api/overview/

Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/

Python client for pandas:pypi.org/project/genebe/

Java CLI for VCF files:github.com/pstawinski/genebe-cli

All tools documented at:docs.genebe.net

API Request Examples for Variant: 1-226064451-G-C (hg38)

Bash / cURL Example

bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=1&pos=226064451&ref=G&alt=C&genome=hg38&allGenes=true"

API Response

json
{
  "variants": [
    {
      "chr": "1",
      "pos": 226064451,
      "ref": "G",
      "alt": "C",
      "effect": "missense_variant",
      "transcript": "NM_002107.7",
      "consequences": [
        {
          "aa_ref": "G",
          "aa_alt": "R",
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 2,
          "exon_rank_end": null,
          "exon_count": 4,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "H3-3A",
          "gene_hgnc_id": 4764,
          "hgvs_c": "c.100G>C",
          "hgvs_p": "p.Gly34Arg",
          "transcript": "NM_002107.7",
          "protein_id": "NP_002098.1",
          "transcript_support_level": null,
          "aa_start": 34,
          "aa_end": null,
          "aa_length": 136,
          "cds_start": 100,
          "cds_end": null,
          "cds_length": 411,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": "ENST00000366815.10",
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "NM_002107.7"
        },
        {
          "aa_ref": "G",
          "aa_alt": "R",
          "canonical": true,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 2,
          "exon_rank_end": null,
          "exon_count": 4,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "H3-3A",
          "gene_hgnc_id": 4764,
          "hgvs_c": "c.100G>C",
          "hgvs_p": "p.Gly34Arg",
          "transcript": "ENST00000366815.10",
          "protein_id": "ENSP00000355780.3",
          "transcript_support_level": 1,
          "aa_start": 34,
          "aa_end": null,
          "aa_length": 136,
          "cds_start": 100,
          "cds_end": null,
          "cds_length": 411,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": "NM_002107.7",
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000366815.10"
        },
        {
          "aa_ref": "G",
          "aa_alt": "R",
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 1,
          "exon_rank_end": null,
          "exon_count": 3,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "H3-3A",
          "gene_hgnc_id": 4764,
          "hgvs_c": "c.100G>C",
          "hgvs_p": "p.Gly34Arg",
          "transcript": "ENST00000366813.1",
          "protein_id": "ENSP00000355778.1",
          "transcript_support_level": 1,
          "aa_start": 34,
          "aa_end": null,
          "aa_length": 136,
          "cds_start": 100,
          "cds_end": null,
          "cds_length": 411,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000366813.1"
        },
        {
          "aa_ref": "G",
          "aa_alt": "R",
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 2,
          "exon_rank_end": null,
          "exon_count": 4,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "H3-3A",
          "gene_hgnc_id": 4764,
          "hgvs_c": "c.100G>C",
          "hgvs_p": "p.Gly34Arg",
          "transcript": "ENST00000921925.1",
          "protein_id": "ENSP00000591984.1",
          "transcript_support_level": null,
          "aa_start": 34,
          "aa_end": null,
          "aa_length": 140,
          "cds_start": 100,
          "cds_end": null,
          "cds_length": 423,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000921925.1"
        },
        {
          "aa_ref": "G",
          "aa_alt": "R",
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 3,
          "exon_rank_end": null,
          "exon_count": 5,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "H3-3A",
          "gene_hgnc_id": 4764,
          "hgvs_c": "c.100G>C",
          "hgvs_p": "p.Gly34Arg",
          "transcript": "NM_001379043.1",
          "protein_id": "NP_001365972.1",
          "transcript_support_level": null,
          "aa_start": 34,
          "aa_end": null,
          "aa_length": 136,
          "cds_start": 100,
          "cds_end": null,
          "cds_length": 411,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "NM_001379043.1"
        },
        {
          "aa_ref": "G",
          "aa_alt": "R",
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 3,
          "exon_rank_end": null,
          "exon_count": 5,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "H3-3A",
          "gene_hgnc_id": 4764,
          "hgvs_c": "c.100G>C",
          "hgvs_p": "p.Gly34Arg",
          "transcript": "NM_001379045.1",
          "protein_id": "NP_001365974.1",
          "transcript_support_level": null,
          "aa_start": 34,
          "aa_end": null,
          "aa_length": 136,
          "cds_start": 100,
          "cds_end": null,
          "cds_length": 411,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "NM_001379045.1"
        },
        {
          "aa_ref": "G",
          "aa_alt": "R",
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 3,
          "exon_rank_end": null,
          "exon_count": 5,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "H3-3A",
          "gene_hgnc_id": 4764,
          "hgvs_c": "c.100G>C",
          "hgvs_p": "p.Gly34Arg",
          "transcript": "NM_001379046.1",
          "protein_id": "NP_001365975.1",
          "transcript_support_level": null,
          "aa_start": 34,
          "aa_end": null,
          "aa_length": 136,
          "cds_start": 100,
          "cds_end": null,
          "cds_length": 411,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "NM_001379046.1"
        },
        {
          "aa_ref": "G",
          "aa_alt": "R",
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 3,
          "exon_rank_end": null,
          "exon_count": 5,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "H3-3A",
          "gene_hgnc_id": 4764,
          "hgvs_c": "c.100G>C",
          "hgvs_p": "p.Gly34Arg",
          "transcript": "NM_001379047.1",
          "protein_id": "NP_001365976.1",
          "transcript_support_level": null,
          "aa_start": 34,
          "aa_end": null,
          "aa_length": 136,
          "cds_start": 100,
          "cds_end": null,
          "cds_length": 411,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "NM_001379047.1"
        },
        {
          "aa_ref": "G",
          "aa_alt": "R",
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 3,
          "exon_rank_end": null,
          "exon_count": 5,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "H3-3A",
          "gene_hgnc_id": 4764,
          "hgvs_c": "c.100G>C",
          "hgvs_p": "p.Gly34Arg",
          "transcript": "ENST00000366816.5",
          "protein_id": "ENSP00000355781.1",
          "transcript_support_level": 3,
          "aa_start": 34,
          "aa_end": null,
          "aa_length": 136,
          "cds_start": 100,
          "cds_end": null,
          "cds_length": 411,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000366816.5"
        },
        {
          "aa_ref": "G",
          "aa_alt": "R",
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 2,
          "exon_rank_end": null,
          "exon_count": 4,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "H3-3A",
          "gene_hgnc_id": 4764,
          "hgvs_c": "c.100G>C",
          "hgvs_p": "p.Gly34Arg",
          "transcript": "ENST00000655399.1",
          "protein_id": "ENSP00000499800.1",
          "transcript_support_level": null,
          "aa_start": 34,
          "aa_end": null,
          "aa_length": 136,
          "cds_start": 100,
          "cds_end": null,
          "cds_length": 411,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000655399.1"
        },
        {
          "aa_ref": "G",
          "aa_alt": "R",
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 2,
          "exon_rank_end": null,
          "exon_count": 4,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "H3-3A",
          "gene_hgnc_id": 4764,
          "hgvs_c": "c.100G>C",
          "hgvs_p": "p.Gly34Arg",
          "transcript": "ENST00000661429.1",
          "protein_id": "ENSP00000499385.1",
          "transcript_support_level": null,
          "aa_start": 34,
          "aa_end": null,
          "aa_length": 136,
          "cds_start": 100,
          "cds_end": null,
          "cds_length": 411,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000661429.1"
        },
        {
          "aa_ref": "G",
          "aa_alt": "R",
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 2,
          "exon_rank_end": null,
          "exon_count": 4,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "H3-3A",
          "gene_hgnc_id": 4764,
          "hgvs_c": "c.100G>C",
          "hgvs_p": "p.Gly34Arg",
          "transcript": "ENST00000666609.1",
          "protein_id": "ENSP00000499275.1",
          "transcript_support_level": null,
          "aa_start": 34,
          "aa_end": null,
          "aa_length": 136,
          "cds_start": 100,
          "cds_end": null,
          "cds_length": 411,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000666609.1"
        },
        {
          "aa_ref": "G",
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          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 3,
          "exon_rank_end": null,
          "exon_count": 5,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "H3-3A",
          "gene_hgnc_id": 4764,
          "hgvs_c": "c.100G>C",
          "hgvs_p": "p.Gly34Arg",
          "transcript": "ENST00000904835.1",
          "protein_id": "ENSP00000574894.1",
          "transcript_support_level": null,
          "aa_start": 34,
          "aa_end": null,
          "aa_length": 136,
          "cds_start": 100,
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          "cds_length": 411,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000904835.1"
        },
        {
          "aa_ref": "G",
          "aa_alt": "R",
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 2,
          "exon_rank_end": null,
          "exon_count": 4,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "H3-3A",
          "gene_hgnc_id": 4764,
          "hgvs_c": "c.100G>C",
          "hgvs_p": "p.Gly34Arg",
          "transcript": "ENST00000904836.1",
          "protein_id": "ENSP00000574895.1",
          "transcript_support_level": null,
          "aa_start": 34,
          "aa_end": null,
          "aa_length": 136,
          "cds_start": 100,
          "cds_end": null,
          "cds_length": 411,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
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          "biotype": "protein_coding",
          "feature": "ENST00000904836.1"
        },
        {
          "aa_ref": "G",
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          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 2,
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          "exon_count": 4,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "H3-3A",
          "gene_hgnc_id": 4764,
          "hgvs_c": "c.100G>C",
          "hgvs_p": "p.Gly34Arg",
          "transcript": "ENST00000904838.1",
          "protein_id": "ENSP00000574897.1",
          "transcript_support_level": null,
          "aa_start": 34,
          "aa_end": null,
          "aa_length": 136,
          "cds_start": 100,
          "cds_end": null,
          "cds_length": 411,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000904838.1"
        },
        {
          "aa_ref": "G",
          "aa_alt": "R",
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 3,
          "exon_rank_end": null,
          "exon_count": 5,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "H3-3A",
          "gene_hgnc_id": 4764,
          "hgvs_c": "c.100G>C",
          "hgvs_p": "p.Gly34Arg",
          "transcript": "ENST00000904839.1",
          "protein_id": "ENSP00000574898.1",
          "transcript_support_level": null,
          "aa_start": 34,
          "aa_end": null,
          "aa_length": 136,
          "cds_start": 100,
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          "cds_length": 411,
          "cdna_start": null,
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          "biotype": "protein_coding",
          "feature": "ENST00000904839.1"
        },
        {
          "aa_ref": "G",
          "aa_alt": "R",
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 2,
          "exon_rank_end": null,
          "exon_count": 4,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "H3-3A",
          "gene_hgnc_id": 4764,
          "hgvs_c": "c.100G>C",
          "hgvs_p": "p.Gly34Arg",
          "transcript": "ENST00000904840.1",
          "protein_id": "ENSP00000574899.1",
          "transcript_support_level": null,
          "aa_start": 34,
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          "aa_length": 136,
          "cds_start": 100,
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          "biotype": "protein_coding",
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        },
        {
          "aa_ref": "G",
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          "strand": true,
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          ],
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          "exon_count": 4,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "H3-3A",
          "gene_hgnc_id": 4764,
          "hgvs_c": "c.100G>C",
          "hgvs_p": "p.Gly34Arg",
          "transcript": "ENST00000904841.1",
          "protein_id": "ENSP00000574900.1",
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          "cds_start": 100,
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          "cdna_start": null,
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          "biotype": "protein_coding",
          "feature": "ENST00000904841.1"
        },
        {
          "aa_ref": "G",
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          "protein_coding": true,
          "strand": true,
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          ],
          "exon_rank": 2,
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          "intron_rank": null,
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          "gene_symbol": "H3-3A",
          "gene_hgnc_id": 4764,
          "hgvs_c": "c.100G>C",
          "hgvs_p": "p.Gly34Arg",
          "transcript": "ENST00000904842.1",
          "protein_id": "ENSP00000574901.1",
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          "aa_start": 34,
          "aa_end": null,
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          "cds_start": 100,
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          "cdna_start": null,
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          "cdna_length": null,
          "mane_select": null,
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          "biotype": "protein_coding",
          "feature": "ENST00000904842.1"
        },
        {
          "aa_ref": "G",
          "aa_alt": "R",
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 3,
          "exon_rank_end": null,
          "exon_count": 5,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "H3-3A",
          "gene_hgnc_id": 4764,
          "hgvs_c": "c.100G>C",
          "hgvs_p": "p.Gly34Arg",
          "transcript": "ENST00000921919.1",
          "protein_id": "ENSP00000591978.1",
          "transcript_support_level": null,
          "aa_start": 34,
          "aa_end": null,
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          "cds_start": 100,
          "cds_end": null,
          "cds_length": 411,
          "cdna_start": null,
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          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000921919.1"
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      "computational_source_selected": "MetaRNN",
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      "bayesdelnoaf_score": -0.06,
      "bayesdelnoaf_prediction": "Uncertain_significance",
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      "phylop100way_prediction": "Pathogenic",
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      "acmg_classification": "Uncertain_significance",
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      "acmg_by_gene": [
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            "PM2",
            "PP2"
          ],
          "verdict": "Uncertain_significance",
          "transcript": "NM_002107.7",
          "gene_symbol": "H3-3A",
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        {
          "score": 2,
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          "verdict": "Uncertain_significance",
          "transcript": "ENST00000760479.1",
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          "effects": [
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          "inheritance_mode": "",
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      ],
      "clinvar_disease": "",
      "clinvar_classification": "",
      "clinvar_review_status": "",
      "clinvar_submissions_summary": "",
      "phenotype_combined": null,
      "pathogenicity_classification_combined": null,
      "custom_annotations": null
    }
  ],
  "message": null
}