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GeneBe API Showcase

This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.

API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.

Documentation & Advanced Usage

Complete API documentation:docs.genebe.net/docs/api/overview/

Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/

Python client for pandas:pypi.org/project/genebe/

Java CLI for VCF files:github.com/pstawinski/genebe-cli

All tools documented at:docs.genebe.net

API Request Examples for Variant: 1-226064454-G-T (hg38)

Bash / cURL Example

bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=1&pos=226064454&ref=G&alt=T&genome=hg38&allGenes=true"

API Response

json
{
  "message": null,
  "variants": [
    {
      "acmg_by_gene": [
        {
          "benign_score": 0,
          "criteria": [
            "PM1",
            "PM2",
            "PP2",
            "PP3"
          ],
          "effects": [
            "missense_variant"
          ],
          "gene_symbol": "H3-3A",
          "hgnc_id": 4764,
          "hgvs_c": "c.103G>T",
          "hgvs_p": "p.Gly35Trp",
          "inheritance_mode": "AD",
          "pathogenic_score": 6,
          "score": 6,
          "transcript": "NM_002107.7",
          "verdict": "Likely_pathogenic"
        },
        {
          "benign_score": 0,
          "criteria": [
            "PM2",
            "PP3"
          ],
          "effects": [
            "upstream_gene_variant"
          ],
          "gene_symbol": "ENSG00000299101",
          "hgnc_id": null,
          "hgvs_c": "n.-37C>A",
          "hgvs_p": null,
          "inheritance_mode": "",
          "pathogenic_score": 3,
          "score": 3,
          "transcript": "ENST00000760479.1",
          "verdict": "Uncertain_significance"
        }
      ],
      "acmg_classification": "Likely_pathogenic",
      "acmg_criteria": "PM1,PM2,PP2,PP3",
      "acmg_score": 6,
      "allele_count_reference_population": 0,
      "alphamissense_prediction": null,
      "alphamissense_score": 0.9752,
      "alt": "T",
      "apogee2_prediction": null,
      "apogee2_score": null,
      "bayesdelnoaf_prediction": "Uncertain_significance",
      "bayesdelnoaf_score": -0.06,
      "chr": "1",
      "clinvar_classification": "",
      "clinvar_disease": "",
      "clinvar_review_status": "",
      "clinvar_submissions_summary": "",
      "computational_prediction_selected": "Pathogenic",
      "computational_score_selected": 0.7652701139450073,
      "computational_source_selected": "MetaRNN",
      "consequences": [
        {
          "aa_alt": "W",
          "aa_end": null,
          "aa_length": 136,
          "aa_ref": "G",
          "aa_start": 35,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 1070,
          "cdna_start": 222,
          "cds_end": null,
          "cds_length": 411,
          "cds_start": 103,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 4,
          "exon_rank": 2,
          "exon_rank_end": null,
          "feature": "NM_002107.7",
          "gene_hgnc_id": 4764,
          "gene_symbol": "H3-3A",
          "hgvs_c": "c.103G>T",
          "hgvs_p": "p.Gly35Trp",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": "ENST00000366815.10",
          "protein_coding": true,
          "protein_id": "NP_002098.1",
          "strand": true,
          "transcript": "NM_002107.7",
          "transcript_support_level": null
        },
        {
          "aa_alt": "W",
          "aa_end": null,
          "aa_length": 136,
          "aa_ref": "G",
          "aa_start": 35,
          "biotype": "protein_coding",
          "canonical": true,
          "cdna_end": null,
          "cdna_length": 1070,
          "cdna_start": 222,
          "cds_end": null,
          "cds_length": 411,
          "cds_start": 103,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 4,
          "exon_rank": 2,
          "exon_rank_end": null,
          "feature": "ENST00000366815.10",
          "gene_hgnc_id": 4764,
          "gene_symbol": "H3-3A",
          "hgvs_c": "c.103G>T",
          "hgvs_p": "p.Gly35Trp",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": "NM_002107.7",
          "protein_coding": true,
          "protein_id": "ENSP00000355780.3",
          "strand": true,
          "transcript": "ENST00000366815.10",
          "transcript_support_level": 1
        },
        {
          "aa_alt": "W",
          "aa_end": null,
          "aa_length": 136,
          "aa_ref": "G",
          "aa_start": 35,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 1308,
          "cdna_start": 478,
          "cds_end": null,
          "cds_length": 411,
          "cds_start": 103,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 3,
          "exon_rank": 1,
          "exon_rank_end": null,
          "feature": "ENST00000366813.1",
          "gene_hgnc_id": 4764,
          "gene_symbol": "H3-3A",
          "hgvs_c": "c.103G>T",
          "hgvs_p": "p.Gly35Trp",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000355778.1",
          "strand": true,
          "transcript": "ENST00000366813.1",
          "transcript_support_level": 1
        },
        {
          "aa_alt": "W",
          "aa_end": null,
          "aa_length": 140,
          "aa_ref": "G",
          "aa_start": 35,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 1091,
          "cdna_start": 231,
          "cds_end": null,
          "cds_length": 423,
          "cds_start": 103,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 4,
          "exon_rank": 2,
          "exon_rank_end": null,
          "feature": "ENST00000921925.1",
          "gene_hgnc_id": 4764,
          "gene_symbol": "H3-3A",
          "hgvs_c": "c.103G>T",
          "hgvs_p": "p.Gly35Trp",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000591984.1",
          "strand": true,
          "transcript": "ENST00000921925.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "W",
          "aa_end": null,
          "aa_length": 136,
          "aa_ref": "G",
          "aa_start": 35,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 1310,
          "cdna_start": 462,
          "cds_end": null,
          "cds_length": 411,
          "cds_start": 103,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 5,
          "exon_rank": 3,
          "exon_rank_end": null,
          "feature": "NM_001379043.1",
          "gene_hgnc_id": 4764,
          "gene_symbol": "H3-3A",
          "hgvs_c": "c.103G>T",
          "hgvs_p": "p.Gly35Trp",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "NP_001365972.1",
          "strand": true,
          "transcript": "NM_001379043.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "W",
          "aa_end": null,
          "aa_length": 136,
          "aa_ref": "G",
          "aa_start": 35,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 1161,
          "cdna_start": 313,
          "cds_end": null,
          "cds_length": 411,
          "cds_start": 103,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 5,
          "exon_rank": 3,
          "exon_rank_end": null,
          "feature": "NM_001379045.1",
          "gene_hgnc_id": 4764,
          "gene_symbol": "H3-3A",
          "hgvs_c": "c.103G>T",
          "hgvs_p": "p.Gly35Trp",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "NP_001365974.1",
          "strand": true,
          "transcript": "NM_001379045.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "W",
          "aa_end": null,
          "aa_length": 136,
          "aa_ref": "G",
          "aa_start": 35,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 1166,
          "cdna_start": 318,
          "cds_end": null,
          "cds_length": 411,
          "cds_start": 103,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 5,
          "exon_rank": 3,
          "exon_rank_end": null,
          "feature": "NM_001379046.1",
          "gene_hgnc_id": 4764,
          "gene_symbol": "H3-3A",
          "hgvs_c": "c.103G>T",
          "hgvs_p": "p.Gly35Trp",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "NP_001365975.1",
          "strand": true,
          "transcript": "NM_001379046.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "W",
          "aa_end": null,
          "aa_length": 136,
          "aa_ref": "G",
          "aa_start": 35,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 1094,
          "cdna_start": 246,
          "cds_end": null,
          "cds_length": 411,
          "cds_start": 103,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 5,
          "exon_rank": 3,
          "exon_rank_end": null,
          "feature": "NM_001379047.1",
          "gene_hgnc_id": 4764,
          "gene_symbol": "H3-3A",
          "hgvs_c": "c.103G>T",
          "hgvs_p": "p.Gly35Trp",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "NP_001365976.1",
          "strand": true,
          "transcript": "NM_001379047.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "W",
          "aa_end": null,
          "aa_length": 136,
          "aa_ref": "G",
          "aa_start": 35,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 799,
          "cdna_start": 447,
          "cds_end": null,
          "cds_length": 411,
          "cds_start": 103,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 5,
          "exon_rank": 3,
          "exon_rank_end": null,
          "feature": "ENST00000366816.5",
          "gene_hgnc_id": 4764,
          "gene_symbol": "H3-3A",
          "hgvs_c": "c.103G>T",
          "hgvs_p": "p.Gly35Trp",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000355781.1",
          "strand": true,
          "transcript": "ENST00000366816.5",
          "transcript_support_level": 3
        },
        {
          "aa_alt": "W",
          "aa_end": null,
          "aa_length": 136,
          "aa_ref": "G",
          "aa_start": 35,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 1151,
          "cdna_start": 325,
          "cds_end": null,
          "cds_length": 411,
          "cds_start": 103,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 4,
          "exon_rank": 2,
          "exon_rank_end": null,
          "feature": "ENST00000655399.1",
          "gene_hgnc_id": 4764,
          "gene_symbol": "H3-3A",
          "hgvs_c": "c.103G>T",
          "hgvs_p": "p.Gly35Trp",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000499800.1",
          "strand": true,
          "transcript": "ENST00000655399.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "W",
          "aa_end": null,
          "aa_length": 136,
          "aa_ref": "G",
          "aa_start": 35,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 895,
          "cdna_start": 314,
          "cds_end": null,
          "cds_length": 411,
          "cds_start": 103,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 4,
          "exon_rank": 2,
          "exon_rank_end": null,
          "feature": "ENST00000661429.1",
          "gene_hgnc_id": 4764,
          "gene_symbol": "H3-3A",
          "hgvs_c": "c.103G>T",
          "hgvs_p": "p.Gly35Trp",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000499385.1",
          "strand": true,
          "transcript": "ENST00000661429.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "W",
          "aa_end": null,
          "aa_length": 136,
          "aa_ref": "G",
          "aa_start": 35,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 607,
          "cdna_start": 257,
          "cds_end": null,
          "cds_length": 411,
          "cds_start": 103,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 4,
          "exon_rank": 2,
          "exon_rank_end": null,
          "feature": "ENST00000666609.1",
          "gene_hgnc_id": 4764,
          "gene_symbol": "H3-3A",
          "hgvs_c": "c.103G>T",
          "hgvs_p": "p.Gly35Trp",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000499275.1",
          "strand": true,
          "transcript": "ENST00000666609.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "W",
          "aa_end": null,
          "aa_length": 136,
          "aa_ref": "G",
          "aa_start": 35,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 998,
          "cdna_start": 322,
          "cds_end": null,
          "cds_length": 411,
          "cds_start": 103,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 5,
          "exon_rank": 3,
          "exon_rank_end": null,
          "feature": "ENST00000904835.1",
          "gene_hgnc_id": 4764,
          "gene_symbol": "H3-3A",
          "hgvs_c": "c.103G>T",
          "hgvs_p": "p.Gly35Trp",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000574894.1",
          "strand": true,
          "transcript": "ENST00000904835.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "W",
          "aa_end": null,
          "aa_length": 136,
          "aa_ref": "G",
          "aa_start": 35,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 1046,
          "cdna_start": 215,
          "cds_end": null,
          "cds_length": 411,
          "cds_start": 103,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 4,
          "exon_rank": 2,
          "exon_rank_end": null,
          "feature": "ENST00000904836.1",
          "gene_hgnc_id": 4764,
          "gene_symbol": "H3-3A",
          "hgvs_c": "c.103G>T",
          "hgvs_p": "p.Gly35Trp",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000574895.1",
          "strand": true,
          "transcript": "ENST00000904836.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "W",
          "aa_end": null,
          "aa_length": 136,
          "aa_ref": "G",
          "aa_start": 35,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 1019,
          "cdna_start": 198,
          "cds_end": null,
          "cds_length": 411,
          "cds_start": 103,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 4,
          "exon_rank": 2,
          "exon_rank_end": null,
          "feature": "ENST00000904838.1",
          "gene_hgnc_id": 4764,
          "gene_symbol": "H3-3A",
          "hgvs_c": "c.103G>T",
          "hgvs_p": "p.Gly35Trp",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000574897.1",
          "strand": true,
          "transcript": "ENST00000904838.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "W",
          "aa_end": null,
          "aa_length": 136,
          "aa_ref": "G",
          "aa_start": 35,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 763,
          "cdna_start": 423,
          "cds_end": null,
          "cds_length": 411,
          "cds_start": 103,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 5,
          "exon_rank": 3,
          "exon_rank_end": null,
          "feature": "ENST00000904839.1",
          "gene_hgnc_id": 4764,
          "gene_symbol": "H3-3A",
          "hgvs_c": "c.103G>T",
          "hgvs_p": "p.Gly35Trp",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000574898.1",
          "strand": true,
          "transcript": "ENST00000904839.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "W",
          "aa_end": null,
          "aa_length": 136,
          "aa_ref": "G",
          "aa_start": 35,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 1110,
          "cdna_start": 280,
          "cds_end": null,
          "cds_length": 411,
          "cds_start": 103,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 4,
          "exon_rank": 2,
          "exon_rank_end": null,
          "feature": "ENST00000904840.1",
          "gene_hgnc_id": 4764,
          "gene_symbol": "H3-3A",
          "hgvs_c": "c.103G>T",
          "hgvs_p": "p.Gly35Trp",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000574899.1",
          "strand": true,
          "transcript": "ENST00000904840.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "W",
          "aa_end": null,
          "aa_length": 136,
          "aa_ref": "G",
          "aa_start": 35,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 1202,
          "cdna_start": 372,
          "cds_end": null,
          "cds_length": 411,
          "cds_start": 103,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 4,
          "exon_rank": 2,
          "exon_rank_end": null,
          "feature": "ENST00000904841.1",
          "gene_hgnc_id": 4764,
          "gene_symbol": "H3-3A",
          "hgvs_c": "c.103G>T",
          "hgvs_p": "p.Gly35Trp",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000574900.1",
          "strand": true,
          "transcript": "ENST00000904841.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "W",
          "aa_end": null,
          "aa_length": 136,
          "aa_ref": "G",
          "aa_start": 35,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 855,
          "cdna_start": 515,
          "cds_end": null,
          "cds_length": 411,
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For research and educational, non-commercial use only. Not for clinical or diagnostic use. GeneBe does not provide medical advice. Data use for AI modeling is prohibited: if used, the cost is $0.001 per byte of downloaded uncompressed data.