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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 1-23073389-A-G (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=1&pos=23073389&ref=A&alt=G&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "1",
"pos": 23073389,
"ref": "A",
"alt": "G",
"effect": "missense_variant",
"transcript": "ENST00000400181.9",
"consequences": [
{
"aa_ref": "K",
"aa_alt": "E",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 15,
"exon_rank_end": null,
"exon_count": 21,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "KDM1A",
"gene_hgnc_id": 29079,
"hgvs_c": "c.1720A>G",
"hgvs_p": "p.Lys574Glu",
"transcript": "NM_001009999.3",
"protein_id": "NP_001009999.1",
"transcript_support_level": null,
"aa_start": 574,
"aa_end": null,
"aa_length": 876,
"cds_start": 1720,
"cds_end": null,
"cds_length": 2631,
"cdna_start": 1849,
"cdna_end": null,
"cdna_length": 3085,
"mane_select": "ENST00000400181.9",
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "K",
"aa_alt": "E",
"canonical": true,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 15,
"exon_rank_end": null,
"exon_count": 21,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "KDM1A",
"gene_hgnc_id": 29079,
"hgvs_c": "c.1720A>G",
"hgvs_p": "p.Lys574Glu",
"transcript": "ENST00000400181.9",
"protein_id": "ENSP00000383042.5",
"transcript_support_level": 1,
"aa_start": 574,
"aa_end": null,
"aa_length": 876,
"cds_start": 1720,
"cds_end": null,
"cds_length": 2631,
"cdna_start": 1849,
"cdna_end": null,
"cdna_length": 3085,
"mane_select": "NM_001009999.3",
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "K",
"aa_alt": "E",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 13,
"exon_rank_end": null,
"exon_count": 19,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "KDM1A",
"gene_hgnc_id": 29079,
"hgvs_c": "c.1648A>G",
"hgvs_p": "p.Lys550Glu",
"transcript": "ENST00000356634.7",
"protein_id": "ENSP00000349049.3",
"transcript_support_level": 1,
"aa_start": 550,
"aa_end": null,
"aa_length": 852,
"cds_start": 1648,
"cds_end": null,
"cds_length": 2559,
"cdna_start": 1797,
"cdna_end": null,
"cdna_length": 3033,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "K",
"aa_alt": "E",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 14,
"exon_rank_end": null,
"exon_count": 20,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "KDM1A",
"gene_hgnc_id": 29079,
"hgvs_c": "c.1726A>G",
"hgvs_p": "p.Lys576Glu",
"transcript": "NM_001410762.1",
"protein_id": "NP_001397691.1",
"transcript_support_level": null,
"aa_start": 576,
"aa_end": null,
"aa_length": 878,
"cds_start": 1726,
"cds_end": null,
"cds_length": 2637,
"cdna_start": 1855,
"cdna_end": null,
"cdna_length": 3091,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "K",
"aa_alt": "E",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 14,
"exon_rank_end": null,
"exon_count": 20,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "KDM1A",
"gene_hgnc_id": 29079,
"hgvs_c": "c.1726A>G",
"hgvs_p": "p.Lys576Glu",
"transcript": "ENST00000685102.1",
"protein_id": "ENSP00000509257.1",
"transcript_support_level": null,
"aa_start": 576,
"aa_end": null,
"aa_length": 878,
"cds_start": 1726,
"cds_end": null,
"cds_length": 2637,
"cdna_start": 1880,
"cdna_end": null,
"cdna_length": 3099,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "K",
"aa_alt": "E",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 13,
"exon_rank_end": null,
"exon_count": 19,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "KDM1A",
"gene_hgnc_id": 29079,
"hgvs_c": "c.1666A>G",
"hgvs_p": "p.Lys556Glu",
"transcript": "NM_001363654.2",
"protein_id": "NP_001350583.1",
"transcript_support_level": null,
"aa_start": 556,
"aa_end": null,
"aa_length": 858,
"cds_start": 1666,
"cds_end": null,
"cds_length": 2577,
"cdna_start": 1795,
"cdna_end": null,
"cdna_length": 3031,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "K",
"aa_alt": "E",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 13,
"exon_rank_end": null,
"exon_count": 19,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "KDM1A",
"gene_hgnc_id": 29079,
"hgvs_c": "c.1666A>G",
"hgvs_p": "p.Lys556Glu",
"transcript": "ENST00000465864.2",
"protein_id": "ENSP00000473297.2",
"transcript_support_level": 5,
"aa_start": 556,
"aa_end": null,
"aa_length": 858,
"cds_start": 1666,
"cds_end": null,
"cds_length": 2577,
"cdna_start": 1820,
"cdna_end": null,
"cdna_length": 3039,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "K",
"aa_alt": "E",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 13,
"exon_rank_end": null,
"exon_count": 19,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "KDM1A",
"gene_hgnc_id": 29079,
"hgvs_c": "c.1648A>G",
"hgvs_p": "p.Lys550Glu",
"transcript": "NM_015013.4",
"protein_id": "NP_055828.2",
"transcript_support_level": null,
"aa_start": 550,
"aa_end": null,
"aa_length": 852,
"cds_start": 1648,
"cds_end": null,
"cds_length": 2559,
"cdna_start": 1777,
"cdna_end": null,
"cdna_length": 3013,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "K",
"aa_alt": "E",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 14,
"exon_rank_end": null,
"exon_count": 19,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "KDM1A",
"gene_hgnc_id": 29079,
"hgvs_c": "c.1708A>G",
"hgvs_p": "p.Lys570Glu",
"transcript": "ENST00000691404.1",
"protein_id": "ENSP00000509252.1",
"transcript_support_level": null,
"aa_start": 570,
"aa_end": null,
"aa_length": 840,
"cds_start": 1708,
"cds_end": null,
"cds_length": 2523,
"cdna_start": 1862,
"cdna_end": null,
"cdna_length": 3853,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "K",
"aa_alt": "E",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 13,
"exon_rank_end": null,
"exon_count": 18,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "KDM1A",
"gene_hgnc_id": 29079,
"hgvs_c": "c.1648A>G",
"hgvs_p": "p.Lys550Glu",
"transcript": "ENST00000692975.1",
"protein_id": "ENSP00000509892.1",
"transcript_support_level": null,
"aa_start": 550,
"aa_end": null,
"aa_length": 820,
"cds_start": 1648,
"cds_end": null,
"cds_length": 2463,
"cdna_start": 1802,
"cdna_end": null,
"cdna_length": 3793,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "K",
"aa_alt": "E",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 13,
"exon_rank_end": null,
"exon_count": 19,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "KDM1A",
"gene_hgnc_id": 29079,
"hgvs_c": "c.1648A>G",
"hgvs_p": "p.Lys550Glu",
"transcript": "NM_001410763.1",
"protein_id": "NP_001397692.1",
"transcript_support_level": null,
"aa_start": 550,
"aa_end": null,
"aa_length": 802,
"cds_start": 1648,
"cds_end": null,
"cds_length": 2409,
"cdna_start": 1777,
"cdna_end": null,
"cdna_length": 3742,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "K",
"aa_alt": "E",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 13,
"exon_rank_end": null,
"exon_count": 19,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "KDM1A",
"gene_hgnc_id": 29079,
"hgvs_c": "c.1648A>G",
"hgvs_p": "p.Lys550Glu",
"transcript": "ENST00000691682.1",
"protein_id": "ENSP00000509679.1",
"transcript_support_level": null,
"aa_start": 550,
"aa_end": null,
"aa_length": 802,
"cds_start": 1648,
"cds_end": null,
"cds_length": 2409,
"cdna_start": 1802,
"cdna_end": null,
"cdna_length": 3710,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "K",
"aa_alt": "E",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 12,
"exon_rank_end": null,
"exon_count": 18,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "KDM1A",
"gene_hgnc_id": 29079,
"hgvs_c": "c.1474A>G",
"hgvs_p": "p.Lys492Glu",
"transcript": "ENST00000690627.1",
"protein_id": "ENSP00000508820.1",
"transcript_support_level": null,
"aa_start": 492,
"aa_end": null,
"aa_length": 794,
"cds_start": 1474,
"cds_end": null,
"cds_length": 2385,
"cdna_start": 1628,
"cdna_end": null,
"cdna_length": 2847,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "K",
"aa_alt": "E",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 11,
"exon_rank_end": null,
"exon_count": 17,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "KDM1A",
"gene_hgnc_id": 29079,
"hgvs_c": "c.1414A>G",
"hgvs_p": "p.Lys472Glu",
"transcript": "ENST00000686771.1",
"protein_id": "ENSP00000510484.1",
"transcript_support_level": null,
"aa_start": 472,
"aa_end": null,
"aa_length": 774,
"cds_start": 1414,
"cds_end": null,
"cds_length": 2325,
"cdna_start": 1568,
"cdna_end": null,
"cdna_length": 2787,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "K",
"aa_alt": "E",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 14,
"exon_rank_end": null,
"exon_count": 18,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "KDM1A",
"gene_hgnc_id": 29079,
"hgvs_c": "c.1708A>G",
"hgvs_p": "p.Lys570Glu",
"transcript": "ENST00000686270.1",
"protein_id": "ENSP00000509279.1",
"transcript_support_level": null,
"aa_start": 570,
"aa_end": null,
"aa_length": 771,
"cds_start": 1708,
"cds_end": null,
"cds_length": 2316,
"cdna_start": 1862,
"cdna_end": null,
"cdna_length": 2778,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "K",
"aa_alt": "E",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 13,
"exon_rank_end": null,
"exon_count": 17,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "KDM1A",
"gene_hgnc_id": 29079,
"hgvs_c": "c.1666A>G",
"hgvs_p": "p.Lys556Glu",
"transcript": "ENST00000692056.1",
"protein_id": "ENSP00000509505.1",
"transcript_support_level": null,
"aa_start": 556,
"aa_end": null,
"aa_length": 757,
"cds_start": 1666,
"cds_end": null,
"cds_length": 2274,
"cdna_start": 1820,
"cdna_end": null,
"cdna_length": 2736,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "K",
"aa_alt": "E",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 10,
"exon_rank_end": null,
"exon_count": 16,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "KDM1A",
"gene_hgnc_id": 29079,
"hgvs_c": "c.1279A>G",
"hgvs_p": "p.Lys427Glu",
"transcript": "ENST00000692209.1",
"protein_id": "ENSP00000510201.1",
"transcript_support_level": null,
"aa_start": 427,
"aa_end": null,
"aa_length": 729,
"cds_start": 1279,
"cds_end": null,
"cds_length": 2190,
"cdna_start": 1433,
"cdna_end": null,
"cdna_length": 2652,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "K",
"aa_alt": "E",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 13,
"exon_rank_end": null,
"exon_count": 17,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "KDM1A",
"gene_hgnc_id": 29079,
"hgvs_c": "c.1648A>G",
"hgvs_p": "p.Lys550Glu",
"transcript": "ENST00000693156.1",
"protein_id": "ENSP00000510144.1",
"transcript_support_level": null,
"aa_start": 550,
"aa_end": null,
"aa_length": 700,
"cds_start": 1648,
"cds_end": null,
"cds_length": 2103,
"cdna_start": 1802,
"cdna_end": null,
"cdna_length": 2673,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "K",
"aa_alt": "E",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 13,
"exon_rank_end": null,
"exon_count": 16,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "KDM1A",
"gene_hgnc_id": 29079,
"hgvs_c": "c.1648A>G",
"hgvs_p": "p.Lys550Glu",
"transcript": "ENST00000686339.1",
"protein_id": "ENSP00000510111.1",
"transcript_support_level": null,
"aa_start": 550,
"aa_end": null,
"aa_length": 684,
"cds_start": 1648,
"cds_end": null,
"cds_length": 2055,
"cdna_start": 1802,
"cdna_end": null,
"cdna_length": 2483,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "K",
"aa_alt": "E",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 14,
"exon_rank_end": null,
"exon_count": 15,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "KDM1A",
"gene_hgnc_id": 29079,
"hgvs_c": "c.1708A>G",
"hgvs_p": "p.Lys570Glu",
"transcript": "ENST00000688680.1",
"protein_id": "ENSP00000509483.1",
"transcript_support_level": null,
"aa_start": 570,
"aa_end": null,
"aa_length": 586,
"cds_start": 1708,
"cds_end": null,
"cds_length": 1761,
"cdna_start": 1862,
"cdna_end": null,
"cdna_length": 3984,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "K",
"aa_alt": "E",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 14,
"exon_rank_end": null,
"exon_count": 15,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "KDM1A",
"gene_hgnc_id": 29079,
"hgvs_c": "c.1708A>G",
"hgvs_p": "p.Lys570Glu",
"transcript": "ENST00000691694.1",
"protein_id": "ENSP00000509771.1",
"transcript_support_level": null,
"aa_start": 570,
"aa_end": null,
"aa_length": 582,
"cds_start": 1708,
"cds_end": null,
"cds_length": 1749,
"cdna_start": 1862,
"cdna_end": null,
"cdna_length": 2797,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "K",
"aa_alt": "E",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 14,
"exon_rank_end": null,
"exon_count": 20,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "KDM1A",
"gene_hgnc_id": 29079,
"hgvs_c": "c.1708A>G",
"hgvs_p": "p.Lys570Glu",
"transcript": "XM_005245786.3",
"protein_id": "XP_005245843.1",
"transcript_support_level": null,
"aa_start": 570,
"aa_end": null,
"aa_length": 872,
"cds_start": 1708,
"cds_end": null,
"cds_length": 2619,
"cdna_start": 1837,
"cdna_end": null,
"cdna_length": 3073,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "K",
"aa_alt": "E",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 14,
"exon_rank_end": null,
"exon_count": 20,
"intron_rank": null,
"intron_rank_end": null,
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}
],
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}