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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 1-230979107-T-G (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=1&pos=230979107&ref=T&alt=G&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "1",
"pos": 230979107,
"ref": "T",
"alt": "G",
"effect": "start_lost",
"transcript": "NM_001346992.2",
"consequences": [
{
"aa_ref": "M",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"start_lost"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 6,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ARV1",
"gene_hgnc_id": 29561,
"hgvs_c": "c.2T>G",
"hgvs_p": "p.Met1?",
"transcript": "NM_022786.3",
"protein_id": "NP_073623.1",
"transcript_support_level": null,
"aa_start": 1,
"aa_end": null,
"aa_length": 271,
"cds_start": 2,
"cds_end": null,
"cds_length": 816,
"cdna_start": 14,
"cdna_end": null,
"cdna_length": 1428,
"mane_select": "ENST00000310256.7",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_022786.3"
},
{
"aa_ref": "M",
"aa_alt": "R",
"canonical": true,
"protein_coding": true,
"strand": true,
"consequences": [
"start_lost"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 6,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ARV1",
"gene_hgnc_id": 29561,
"hgvs_c": "c.2T>G",
"hgvs_p": "p.Met1?",
"transcript": "ENST00000310256.7",
"protein_id": "ENSP00000312458.2",
"transcript_support_level": 1,
"aa_start": 1,
"aa_end": null,
"aa_length": 271,
"cds_start": 2,
"cds_end": null,
"cds_length": 816,
"cdna_start": 14,
"cdna_end": null,
"cdna_length": 1428,
"mane_select": "NM_022786.3",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000310256.7"
},
{
"aa_ref": "M",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"start_lost"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 7,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ARV1",
"gene_hgnc_id": 29561,
"hgvs_c": "c.2T>G",
"hgvs_p": "p.Met1?",
"transcript": "ENST00000893839.1",
"protein_id": "ENSP00000563898.1",
"transcript_support_level": null,
"aa_start": 1,
"aa_end": null,
"aa_length": 312,
"cds_start": 2,
"cds_end": null,
"cds_length": 939,
"cdna_start": 36,
"cdna_end": null,
"cdna_length": 1434,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000893839.1"
},
{
"aa_ref": "M",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"start_lost"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 6,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ARV1",
"gene_hgnc_id": 29561,
"hgvs_c": "c.2T>G",
"hgvs_p": "p.Met1?",
"transcript": "ENST00000893842.1",
"protein_id": "ENSP00000563901.1",
"transcript_support_level": null,
"aa_start": 1,
"aa_end": null,
"aa_length": 312,
"cds_start": 2,
"cds_end": null,
"cds_length": 939,
"cdna_start": 38,
"cdna_end": null,
"cdna_length": 2471,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000893842.1"
},
{
"aa_ref": "M",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"start_lost"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 7,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ARV1",
"gene_hgnc_id": 29561,
"hgvs_c": "c.2T>G",
"hgvs_p": "p.Met1?",
"transcript": "ENST00000960456.1",
"protein_id": "ENSP00000630515.1",
"transcript_support_level": null,
"aa_start": 1,
"aa_end": null,
"aa_length": 308,
"cds_start": 2,
"cds_end": null,
"cds_length": 927,
"cdna_start": 9,
"cdna_end": null,
"cdna_length": 1386,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000960456.1"
},
{
"aa_ref": "M",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"start_lost"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 7,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ARV1",
"gene_hgnc_id": 29561,
"hgvs_c": "c.2T>G",
"hgvs_p": "p.Met1?",
"transcript": "NM_001346992.2",
"protein_id": "NP_001333921.1",
"transcript_support_level": null,
"aa_start": 1,
"aa_end": null,
"aa_length": 304,
"cds_start": 2,
"cds_end": null,
"cds_length": 915,
"cdna_start": 14,
"cdna_end": null,
"cdna_length": 1527,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001346992.2"
},
{
"aa_ref": "M",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"start_lost"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 6,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ARV1",
"gene_hgnc_id": 29561,
"hgvs_c": "c.2T>G",
"hgvs_p": "p.Met1?",
"transcript": "ENST00000893841.1",
"protein_id": "ENSP00000563900.1",
"transcript_support_level": null,
"aa_start": 1,
"aa_end": null,
"aa_length": 275,
"cds_start": 2,
"cds_end": null,
"cds_length": 828,
"cdna_start": 20,
"cdna_end": null,
"cdna_length": 1306,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000893841.1"
},
{
"aa_ref": "M",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"start_lost"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 5,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ARV1",
"gene_hgnc_id": 29561,
"hgvs_c": "c.2T>G",
"hgvs_p": "p.Met1?",
"transcript": "ENST00000893843.1",
"protein_id": "ENSP00000563902.1",
"transcript_support_level": null,
"aa_start": 1,
"aa_end": null,
"aa_length": 271,
"cds_start": 2,
"cds_end": null,
"cds_length": 816,
"cdna_start": 36,
"cdna_end": null,
"cdna_length": 2346,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000893843.1"
},
{
"aa_ref": "M",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"start_lost"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 6,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ARV1",
"gene_hgnc_id": 29561,
"hgvs_c": "c.2T>G",
"hgvs_p": "p.Met1?",
"transcript": "ENST00000936179.1",
"protein_id": "ENSP00000606238.1",
"transcript_support_level": null,
"aa_start": 1,
"aa_end": null,
"aa_length": 264,
"cds_start": 2,
"cds_end": null,
"cds_length": 795,
"cdna_start": 39,
"cdna_end": null,
"cdna_length": 1294,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000936179.1"
},
{
"aa_ref": "M",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"start_lost"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 5,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ARV1",
"gene_hgnc_id": 29561,
"hgvs_c": "c.2T>G",
"hgvs_p": "p.Met1?",
"transcript": "ENST00000366658.6",
"protein_id": "ENSP00000355618.2",
"transcript_support_level": 5,
"aa_start": 1,
"aa_end": null,
"aa_length": 231,
"cds_start": 2,
"cds_end": null,
"cds_length": 696,
"cdna_start": 14,
"cdna_end": null,
"cdna_length": 1170,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000366658.6"
},
{
"aa_ref": "M",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"start_lost"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 4,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ARV1",
"gene_hgnc_id": 29561,
"hgvs_c": "c.2T>G",
"hgvs_p": "p.Met1?",
"transcript": "ENST00000936180.1",
"protein_id": "ENSP00000606239.1",
"transcript_support_level": null,
"aa_start": 1,
"aa_end": null,
"aa_length": 231,
"cds_start": 2,
"cds_end": null,
"cds_length": 696,
"cdna_start": 6,
"cdna_end": null,
"cdna_length": 4027,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000936180.1"
},
{
"aa_ref": "M",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"start_lost"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 5,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ARV1",
"gene_hgnc_id": 29561,
"hgvs_c": "c.2T>G",
"hgvs_p": "p.Met1?",
"transcript": "ENST00000893838.1",
"protein_id": "ENSP00000563897.1",
"transcript_support_level": null,
"aa_start": 1,
"aa_end": null,
"aa_length": 196,
"cds_start": 2,
"cds_end": null,
"cds_length": 591,
"cdna_start": 10,
"cdna_end": null,
"cdna_length": 1714,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000893838.1"
},
{
"aa_ref": "M",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"start_lost"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 5,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ARV1",
"gene_hgnc_id": 29561,
"hgvs_c": "c.2T>G",
"hgvs_p": "p.Met1?",
"transcript": "ENST00000893840.1",
"protein_id": "ENSP00000563899.1",
"transcript_support_level": null,
"aa_start": 1,
"aa_end": null,
"aa_length": 196,
"cds_start": 2,
"cds_end": null,
"cds_length": 591,
"cdna_start": 38,
"cdna_end": null,
"cdna_length": 1079,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000893840.1"
},
{
"aa_ref": "M",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"start_lost"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 7,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ARV1",
"gene_hgnc_id": 29561,
"hgvs_c": "c.2T>G",
"hgvs_p": "p.Met1?",
"transcript": "XM_024449202.2",
"protein_id": "XP_024304970.1",
"transcript_support_level": null,
"aa_start": 1,
"aa_end": null,
"aa_length": 312,
"cds_start": 2,
"cds_end": null,
"cds_length": 939,
"cdna_start": 14,
"cdna_end": null,
"cdna_length": 1551,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "XM_024449202.2"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": false,
"strand": true,
"consequences": [
"non_coding_transcript_exon_variant"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 5,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ARV1",
"gene_hgnc_id": 29561,
"hgvs_c": "n.127T>G",
"hgvs_p": null,
"transcript": "ENST00000497753.1",
"protein_id": null,
"transcript_support_level": 5,
"aa_start": null,
"aa_end": null,
"aa_length": null,
"cds_start": null,
"cds_end": null,
"cds_length": null,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 1072,
"mane_select": null,
"mane_plus": null,
"biotype": "pseudogene",
"feature": "ENST00000497753.1"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": false,
"strand": true,
"consequences": [
"non_coding_transcript_exon_variant"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 7,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ARV1",
"gene_hgnc_id": 29561,
"hgvs_c": "n.14T>G",
"hgvs_p": null,
"transcript": "NR_144538.2",
"protein_id": null,
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": null,
"cds_start": null,
"cds_end": null,
"cds_length": null,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 1607,
"mane_select": null,
"mane_plus": null,
"biotype": "pseudogene",
"feature": "NR_144538.2"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": false,
"strand": true,
"consequences": [
"non_coding_transcript_exon_variant"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ARV1",
"gene_hgnc_id": 29561,
"hgvs_c": "n.14T>G",
"hgvs_p": null,
"transcript": "XR_002957381.2",
"protein_id": null,
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": null,
"cds_start": null,
"cds_end": null,
"cds_length": null,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 1730,
"mane_select": null,
"mane_plus": null,
"biotype": "pseudogene",
"feature": "XR_002957381.2"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": false,
"strand": true,
"consequences": [
"non_coding_transcript_exon_variant"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ARV1",
"gene_hgnc_id": 29561,
"hgvs_c": "n.14T>G",
"hgvs_p": null,
"transcript": "XR_007063028.1",
"protein_id": null,
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": null,
"cds_start": null,
"cds_end": null,
"cds_length": null,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 1706,
"mane_select": null,
"mane_plus": null,
"biotype": "pseudogene",
"feature": "XR_007063028.1"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"upstream_gene_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 23,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TTC13",
"gene_hgnc_id": 26204,
"hgvs_c": "c.-277A>C",
"hgvs_p": null,
"transcript": "NM_024525.5",
"protein_id": "NP_078801.3",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 860,
"cds_start": null,
"cds_end": null,
"cds_length": 2583,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 3276,
"mane_select": "ENST00000366661.9",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_024525.5"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": true,
"protein_coding": true,
"strand": true,
"consequences": [
"upstream_gene_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 23,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TTC13",
"gene_hgnc_id": 26204,
"hgvs_c": "c.-277A>C",
"hgvs_p": null,
"transcript": "ENST00000366661.9",
"protein_id": "ENSP00000355621.4",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": 860,
"cds_start": null,
"cds_end": null,
"cds_length": 2583,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 3276,
"mane_select": "NM_024525.5",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000366661.9"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"upstream_gene_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 21,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TTC13",
"gene_hgnc_id": 26204,
"hgvs_c": "c.-277A>C",
"hgvs_p": null,
"transcript": "ENST00000366662.8",
"protein_id": "ENSP00000355622.4",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": 806,
"cds_start": null,
"cds_end": null,
"cds_length": 2421,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 3112,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000366662.8"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"upstream_gene_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 23,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TTC13",
"gene_hgnc_id": 26204,
"hgvs_c": "c.-277A>C",
"hgvs_p": null,
"transcript": "NM_001376510.1",
"protein_id": "NP_001363439.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 859,
"cds_start": null,
"cds_end": null,
"cds_length": 2580,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 3273,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001376510.1"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"upstream_gene_variant"
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