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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 1-234466956-T-A (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=1&pos=234466956&ref=T&alt=A&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "1",
"pos": 234466956,
"ref": "T",
"alt": "A",
"effect": "intron_variant",
"transcript": "NM_005646.4",
"consequences": [
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 30,
"intron_rank": 4,
"intron_rank_end": null,
"gene_symbol": "TARBP1",
"gene_hgnc_id": 11568,
"hgvs_c": "c.1248+546A>T",
"hgvs_p": null,
"transcript": "NM_005646.4",
"protein_id": "NP_005637.3",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 1621,
"cds_start": null,
"cds_end": null,
"cds_length": 4866,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": "ENST00000040877.2",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_005646.4"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": true,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 30,
"intron_rank": 4,
"intron_rank_end": null,
"gene_symbol": "TARBP1",
"gene_hgnc_id": 11568,
"hgvs_c": "c.1248+546A>T",
"hgvs_p": null,
"transcript": "ENST00000040877.2",
"protein_id": "ENSP00000040877.1",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": 1621,
"cds_start": null,
"cds_end": null,
"cds_length": 4866,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": "NM_005646.4",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000040877.2"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 30,
"intron_rank": 4,
"intron_rank_end": null,
"gene_symbol": "TARBP1",
"gene_hgnc_id": 11568,
"hgvs_c": "c.1248+546A>T",
"hgvs_p": null,
"transcript": "ENST00000870826.1",
"protein_id": "ENSP00000540885.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 1620,
"cds_start": null,
"cds_end": null,
"cds_length": 4863,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000870826.1"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 29,
"intron_rank": 4,
"intron_rank_end": null,
"gene_symbol": "TARBP1",
"gene_hgnc_id": 11568,
"hgvs_c": "c.1248+546A>T",
"hgvs_p": null,
"transcript": "ENST00000943775.1",
"protein_id": "ENSP00000613834.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 1597,
"cds_start": null,
"cds_end": null,
"cds_length": 4794,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000943775.1"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 29,
"intron_rank": 4,
"intron_rank_end": null,
"gene_symbol": "TARBP1",
"gene_hgnc_id": 11568,
"hgvs_c": "c.1248+546A>T",
"hgvs_p": null,
"transcript": "ENST00000943778.1",
"protein_id": "ENSP00000613837.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 1596,
"cds_start": null,
"cds_end": null,
"cds_length": 4791,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000943778.1"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 29,
"intron_rank": 4,
"intron_rank_end": null,
"gene_symbol": "TARBP1",
"gene_hgnc_id": 11568,
"hgvs_c": "c.1248+546A>T",
"hgvs_p": null,
"transcript": "ENST00000919734.1",
"protein_id": "ENSP00000589793.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 1590,
"cds_start": null,
"cds_end": null,
"cds_length": 4773,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000919734.1"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 29,
"intron_rank": 4,
"intron_rank_end": null,
"gene_symbol": "TARBP1",
"gene_hgnc_id": 11568,
"hgvs_c": "c.1248+546A>T",
"hgvs_p": null,
"transcript": "ENST00000919735.1",
"protein_id": "ENSP00000589794.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 1587,
"cds_start": null,
"cds_end": null,
"cds_length": 4764,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000919735.1"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 29,
"intron_rank": 4,
"intron_rank_end": null,
"gene_symbol": "TARBP1",
"gene_hgnc_id": 11568,
"hgvs_c": "c.1248+546A>T",
"hgvs_p": null,
"transcript": "ENST00000943776.1",
"protein_id": "ENSP00000613835.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 1586,
"cds_start": null,
"cds_end": null,
"cds_length": 4761,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000943776.1"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 29,
"intron_rank": 4,
"intron_rank_end": null,
"gene_symbol": "TARBP1",
"gene_hgnc_id": 11568,
"hgvs_c": "c.1248+546A>T",
"hgvs_p": null,
"transcript": "ENST00000943777.1",
"protein_id": "ENSP00000613836.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 1585,
"cds_start": null,
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"cdna_start": null,
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"mane_select": null,
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"biotype": "protein_coding",
"feature": "ENST00000943777.1"
},
{
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"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
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"exon_count": 29,
"intron_rank": 4,
"intron_rank_end": null,
"gene_symbol": "TARBP1",
"gene_hgnc_id": 11568,
"hgvs_c": "c.1248+546A>T",
"hgvs_p": null,
"transcript": "ENST00000919732.1",
"protein_id": "ENSP00000589791.1",
"transcript_support_level": null,
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"cds_start": null,
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"cdna_start": null,
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"biotype": "protein_coding",
"feature": "ENST00000919732.1"
},
{
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"canonical": false,
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"strand": false,
"consequences": [
"intron_variant"
],
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"gene_symbol": "TARBP1",
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"hgvs_c": "c.1248+546A>T",
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"transcript": "ENST00000919733.1",
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},
{
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],
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"gene_symbol": "TARBP1",
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},
{
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"strand": false,
"consequences": [
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],
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"intron_rank": 4,
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"gene_symbol": "TARBP1",
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},
{
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],
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},
{
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],
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"gene_symbol": "TARBP1",
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"hgvs_c": "c.1248+546A>T",
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},
{
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],
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},
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],
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"gene_symbol": "TARBP1",
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},
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],
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"intron_rank": 4,
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"gene_symbol": "TARBP1",
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"hgvs_c": "c.1248+546A>T",
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"transcript": "XM_047429067.1",
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},
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},
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},
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],
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"gene_symbol": "TARBP1",
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"transcript": "XM_047429073.1",
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"feature": "XM_047429073.1"
},
{
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"strand": false,
"consequences": [
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],
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"exon_count": 23,
"intron_rank": 4,
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"gene_symbol": "TARBP1",
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"hgvs_c": "c.1248+546A>T",
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"transcript": "XM_017002194.3",
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},
{
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"consequences": [
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{
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"clinvar_disease": "",
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"clinvar_review_status": "",
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"custom_annotations": null
}
],
"message": null
}