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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 1-236537507-T-A (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=1&pos=236537507&ref=T&alt=A&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "1",
"pos": 236537507,
"ref": "T",
"alt": "A",
"effect": "missense_variant",
"transcript": "ENST00000366584.9",
"consequences": [
{
"aa_ref": "F",
"aa_alt": "Y",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "LGALS8",
"gene_hgnc_id": 6569,
"hgvs_c": "c.56T>A",
"hgvs_p": "p.Phe19Tyr",
"transcript": "NM_201544.4",
"protein_id": "NP_963838.1",
"transcript_support_level": null,
"aa_start": 19,
"aa_end": null,
"aa_length": 317,
"cds_start": 56,
"cds_end": null,
"cds_length": 954,
"cdna_start": 239,
"cdna_end": null,
"cdna_length": 5957,
"mane_select": "ENST00000366584.9",
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "F",
"aa_alt": "Y",
"canonical": true,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "LGALS8",
"gene_hgnc_id": 6569,
"hgvs_c": "c.56T>A",
"hgvs_p": "p.Phe19Tyr",
"transcript": "ENST00000366584.9",
"protein_id": "ENSP00000355543.4",
"transcript_support_level": 1,
"aa_start": 19,
"aa_end": null,
"aa_length": 317,
"cds_start": 56,
"cds_end": null,
"cds_length": 954,
"cdna_start": 239,
"cdna_end": null,
"cdna_length": 5957,
"mane_select": "NM_201544.4",
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "F",
"aa_alt": "Y",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 12,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "LGALS8",
"gene_hgnc_id": 6569,
"hgvs_c": "c.56T>A",
"hgvs_p": "p.Phe19Tyr",
"transcript": "ENST00000450372.6",
"protein_id": "ENSP00000408657.2",
"transcript_support_level": 1,
"aa_start": 19,
"aa_end": null,
"aa_length": 359,
"cds_start": 56,
"cds_end": null,
"cds_length": 1080,
"cdna_start": 437,
"cdna_end": null,
"cdna_length": 6281,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "F",
"aa_alt": "Y",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "LGALS8",
"gene_hgnc_id": 6569,
"hgvs_c": "c.56T>A",
"hgvs_p": "p.Phe19Tyr",
"transcript": "ENST00000341872.10",
"protein_id": "ENSP00000342139.6",
"transcript_support_level": 1,
"aa_start": 19,
"aa_end": null,
"aa_length": 317,
"cds_start": 56,
"cds_end": null,
"cds_length": 954,
"cdna_start": 437,
"cdna_end": null,
"cdna_length": 2437,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "F",
"aa_alt": "Y",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 2,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "LGALS8",
"gene_hgnc_id": 6569,
"hgvs_c": "c.56T>A",
"hgvs_p": "p.Phe19Tyr",
"transcript": "ENST00000525042.1",
"protein_id": "ENSP00000431884.1",
"transcript_support_level": 1,
"aa_start": 19,
"aa_end": null,
"aa_length": 300,
"cds_start": 56,
"cds_end": null,
"cds_length": 903,
"cdna_start": 56,
"cdna_end": null,
"cdna_length": 903,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "F",
"aa_alt": "Y",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 12,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "LGALS8",
"gene_hgnc_id": 6569,
"hgvs_c": "c.56T>A",
"hgvs_p": "p.Phe19Tyr",
"transcript": "NM_006499.5",
"protein_id": "NP_006490.3",
"transcript_support_level": null,
"aa_start": 19,
"aa_end": null,
"aa_length": 359,
"cds_start": 56,
"cds_end": null,
"cds_length": 1080,
"cdna_start": 278,
"cdna_end": null,
"cdna_length": 6122,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "F",
"aa_alt": "Y",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 12,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "LGALS8",
"gene_hgnc_id": 6569,
"hgvs_c": "c.56T>A",
"hgvs_p": "p.Phe19Tyr",
"transcript": "NM_201545.2",
"protein_id": "NP_963839.1",
"transcript_support_level": null,
"aa_start": 19,
"aa_end": null,
"aa_length": 359,
"cds_start": 56,
"cds_end": null,
"cds_length": 1080,
"cdna_start": 307,
"cdna_end": null,
"cdna_length": 6151,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "F",
"aa_alt": "Y",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 12,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "LGALS8",
"gene_hgnc_id": 6569,
"hgvs_c": "c.56T>A",
"hgvs_p": "p.Phe19Tyr",
"transcript": "ENST00000352231.6",
"protein_id": "ENSP00000309576.2",
"transcript_support_level": 2,
"aa_start": 19,
"aa_end": null,
"aa_length": 359,
"cds_start": 56,
"cds_end": null,
"cds_length": 1080,
"cdna_start": 256,
"cdna_end": null,
"cdna_length": 1402,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "F",
"aa_alt": "Y",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 14,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "LGALS8",
"gene_hgnc_id": 6569,
"hgvs_c": "c.56T>A",
"hgvs_p": "p.Phe19Tyr",
"transcript": "ENST00000526589.5",
"protein_id": "ENSP00000435460.1",
"transcript_support_level": 5,
"aa_start": 19,
"aa_end": null,
"aa_length": 359,
"cds_start": 56,
"cds_end": null,
"cds_length": 1080,
"cdna_start": 576,
"cdna_end": null,
"cdna_length": 6420,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "F",
"aa_alt": "Y",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "LGALS8",
"gene_hgnc_id": 6569,
"hgvs_c": "c.56T>A",
"hgvs_p": "p.Phe19Tyr",
"transcript": "ENST00000527974.5",
"protein_id": "ENSP00000431398.1",
"transcript_support_level": 5,
"aa_start": 19,
"aa_end": null,
"aa_length": 359,
"cds_start": 56,
"cds_end": null,
"cds_length": 1080,
"cdna_start": 205,
"cdna_end": null,
"cdna_length": 1349,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "F",
"aa_alt": "Y",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "LGALS8",
"gene_hgnc_id": 6569,
"hgvs_c": "c.56T>A",
"hgvs_p": "p.Phe19Tyr",
"transcript": "NM_201543.4",
"protein_id": "NP_963837.1",
"transcript_support_level": null,
"aa_start": 19,
"aa_end": null,
"aa_length": 317,
"cds_start": 56,
"cds_end": null,
"cds_length": 954,
"cdna_start": 278,
"cdna_end": null,
"cdna_length": 5996,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "F",
"aa_alt": "Y",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "LGALS8",
"gene_hgnc_id": 6569,
"hgvs_c": "c.56T>A",
"hgvs_p": "p.Phe19Tyr",
"transcript": "ENST00000526634.5",
"protein_id": "ENSP00000437040.1",
"transcript_support_level": 5,
"aa_start": 19,
"aa_end": null,
"aa_length": 317,
"cds_start": 56,
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"cdna_start": 319,
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"mane_select": null,
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"biotype": null,
"feature": null
},
{
"aa_ref": "F",
"aa_alt": "Y",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "LGALS8",
"gene_hgnc_id": 6569,
"hgvs_c": "c.56T>A",
"hgvs_p": "p.Phe19Tyr",
"transcript": "ENST00000416919.6",
"protein_id": "ENSP00000410843.2",
"transcript_support_level": 5,
"aa_start": 19,
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"aa_length": 300,
"cds_start": 56,
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"cdna_start": 437,
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"mane_select": null,
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"biotype": null,
"feature": null
},
{
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"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
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],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": null,
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"gene_symbol": "LGALS8",
"gene_hgnc_id": 6569,
"hgvs_c": "c.56T>A",
"hgvs_p": "p.Phe19Tyr",
"transcript": "ENST00000323938.10",
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},
{
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"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 6,
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"exon_count": 11,
"intron_rank": null,
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"gene_symbol": "LGALS8",
"gene_hgnc_id": 6569,
"hgvs_c": "c.56T>A",
"hgvs_p": "p.Phe19Tyr",
"transcript": "ENST00000406509.7",
"protein_id": "ENSP00000385999.3",
"transcript_support_level": 5,
"aa_start": 19,
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"cds_start": 56,
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"cdna_start": 466,
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"mane_select": null,
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"biotype": null,
"feature": null
},
{
"aa_ref": "F",
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"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 7,
"intron_rank": null,
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"gene_symbol": "LGALS8",
"gene_hgnc_id": 6569,
"hgvs_c": "c.56T>A",
"hgvs_p": "p.Phe19Tyr",
"transcript": "ENST00000238181.11",
"protein_id": "ENSP00000238181.7",
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},
{
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"protein_coding": true,
"strand": true,
"consequences": [
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],
"exon_rank": 5,
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"exon_count": 8,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "LGALS8",
"gene_hgnc_id": 6569,
"hgvs_c": "c.56T>A",
"hgvs_p": "p.Phe19Tyr",
"transcript": "ENST00000454943.6",
"protein_id": "ENSP00000405504.2",
"transcript_support_level": 5,
"aa_start": 19,
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"cdna_start": 399,
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"mane_select": null,
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"biotype": null,
"feature": null
},
{
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"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 6,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "LGALS8",
"gene_hgnc_id": 6569,
"hgvs_c": "c.56T>A",
"hgvs_p": "p.Phe19Tyr",
"transcript": "ENST00000430527.6",
"protein_id": "ENSP00000398630.2",
"transcript_support_level": 5,
"aa_start": 19,
"aa_end": null,
"aa_length": 120,
"cds_start": 56,
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"cdna_start": 261,
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"mane_select": null,
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"feature": null
},
{
"aa_ref": "F",
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"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 5,
"intron_rank": null,
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"gene_symbol": "LGALS8",
"gene_hgnc_id": 6569,
"hgvs_c": "c.56T>A",
"hgvs_p": "p.Phe19Tyr",
"transcript": "ENST00000481485.5",
"protein_id": "ENSP00000435632.1",
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},
{
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"strand": true,
"consequences": [
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],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 4,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "LGALS8",
"gene_hgnc_id": 6569,
"hgvs_c": "c.56T>A",
"hgvs_p": "p.Phe19Tyr",
"transcript": "ENST00000529489.5",
"protein_id": "ENSP00000437007.1",
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"feature": null
},
{
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"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 12,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "LGALS8",
"gene_hgnc_id": 6569,
"hgvs_c": "c.56T>A",
"hgvs_p": "p.Phe19Tyr",
"transcript": "XM_047420409.1",
"protein_id": "XP_047276365.1",
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"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "F",
"aa_alt": "Y",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 5,
"exon_rank_end": null,
"exon_count": 13,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "LGALS8",
"gene_hgnc_id": 6569,
"hgvs_c": "c.56T>A",
"hgvs_p": "p.Phe19Tyr",
"transcript": "XM_047420410.1",
"protein_id": "XP_047276366.1",
"transcript_support_level": null,
"aa_start": 19,
"aa_end": null,
"aa_length": 359,
"cds_start": 56,
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"cds_length": 1080,
"cdna_start": 399,
"cdna_end": null,
"cdna_length": 6243,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "F",
"aa_alt": "Y",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 5,
"exon_rank_end": null,
"exon_count": 13,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "LGALS8",
"gene_hgnc_id": 6569,
"hgvs_c": "c.56T>A",
"hgvs_p": "p.Phe19Tyr",
"transcript": "XM_047420411.1",
"protein_id": "XP_047276367.1",
"transcript_support_level": null,
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}