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GeneBe API Showcase

This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.

API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.

Documentation & Advanced Usage

Complete API documentation:docs.genebe.net/docs/api/overview/

Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/

Python client for pandas:pypi.org/project/genebe/

Java CLI for VCF files:github.com/pstawinski/genebe-cli

All tools documented at:docs.genebe.net

API Request Examples for Variant: 1-236538910-A-C (hg38)

Bash / cURL Example

bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=1&pos=236538910&ref=A&alt=C&genome=hg38&allGenes=true"

API Response

json
{
  "message": null,
  "variants": [
    {
      "acmg_by_gene": [
        {
          "benign_score": 4,
          "criteria": [
            "PM2",
            "BP4_Strong"
          ],
          "effects": [
            "missense_variant"
          ],
          "gene_symbol": "LGALS8",
          "hgnc_id": 6569,
          "hgvs_c": "c.166A>C",
          "hgvs_p": "p.Met56Leu",
          "inheritance_mode": "AR",
          "pathogenic_score": 2,
          "score": -2,
          "transcript": "NM_006499.5",
          "verdict": "Likely_benign"
        }
      ],
      "acmg_classification": "Likely_benign",
      "acmg_criteria": "PM2,BP4_Strong",
      "acmg_score": -2,
      "allele_count_reference_population": 0,
      "alphamissense_prediction": null,
      "alphamissense_score": 0.0943,
      "alt": "C",
      "apogee2_prediction": null,
      "apogee2_score": null,
      "bayesdelnoaf_prediction": "Benign",
      "bayesdelnoaf_score": -0.66,
      "chr": "1",
      "clinvar_classification": "",
      "clinvar_disease": "",
      "clinvar_review_status": "",
      "clinvar_submissions_summary": "",
      "computational_prediction_selected": "Benign",
      "computational_score_selected": 0.022184818983078003,
      "computational_source_selected": "MetaRNN",
      "consequences": [
        {
          "aa_alt": "L",
          "aa_end": null,
          "aa_length": 317,
          "aa_ref": "M",
          "aa_start": 56,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 5957,
          "cdna_start": 349,
          "cds_end": null,
          "cds_length": 954,
          "cds_start": 166,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 10,
          "exon_rank": 4,
          "exon_rank_end": null,
          "feature": "NM_201544.4",
          "gene_hgnc_id": 6569,
          "gene_symbol": "LGALS8",
          "hgvs_c": "c.166A>C",
          "hgvs_p": "p.Met56Leu",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": "ENST00000366584.9",
          "protein_coding": true,
          "protein_id": "NP_963838.1",
          "strand": true,
          "transcript": "NM_201544.4",
          "transcript_support_level": null
        },
        {
          "aa_alt": "L",
          "aa_end": null,
          "aa_length": 317,
          "aa_ref": "M",
          "aa_start": 56,
          "biotype": "protein_coding",
          "canonical": true,
          "cdna_end": null,
          "cdna_length": 5957,
          "cdna_start": 349,
          "cds_end": null,
          "cds_length": 954,
          "cds_start": 166,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 10,
          "exon_rank": 4,
          "exon_rank_end": null,
          "feature": "ENST00000366584.9",
          "gene_hgnc_id": 6569,
          "gene_symbol": "LGALS8",
          "hgvs_c": "c.166A>C",
          "hgvs_p": "p.Met56Leu",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": "NM_201544.4",
          "protein_coding": true,
          "protein_id": "ENSP00000355543.4",
          "strand": true,
          "transcript": "ENST00000366584.9",
          "transcript_support_level": 1
        },
        {
          "aa_alt": "L",
          "aa_end": null,
          "aa_length": 359,
          "aa_ref": "M",
          "aa_start": 56,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 6281,
          "cdna_start": 547,
          "cds_end": null,
          "cds_length": 1080,
          "cds_start": 166,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 12,
          "exon_rank": 5,
          "exon_rank_end": null,
          "feature": "ENST00000450372.6",
          "gene_hgnc_id": 6569,
          "gene_symbol": "LGALS8",
          "hgvs_c": "c.166A>C",
          "hgvs_p": "p.Met56Leu",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000408657.2",
          "strand": true,
          "transcript": "ENST00000450372.6",
          "transcript_support_level": 1
        },
        {
          "aa_alt": "L",
          "aa_end": null,
          "aa_length": 317,
          "aa_ref": "M",
          "aa_start": 56,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 2437,
          "cdna_start": 547,
          "cds_end": null,
          "cds_length": 954,
          "cds_start": 166,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 11,
          "exon_rank": 5,
          "exon_rank_end": null,
          "feature": "ENST00000341872.10",
          "gene_hgnc_id": 6569,
          "gene_symbol": "LGALS8",
          "hgvs_c": "c.166A>C",
          "hgvs_p": "p.Met56Leu",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000342139.6",
          "strand": true,
          "transcript": "ENST00000341872.10",
          "transcript_support_level": 1
        },
        {
          "aa_alt": "L",
          "aa_end": null,
          "aa_length": 300,
          "aa_ref": "M",
          "aa_start": 56,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 903,
          "cdna_start": 166,
          "cds_end": null,
          "cds_length": 903,
          "cds_start": 166,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 8,
          "exon_rank": 3,
          "exon_rank_end": null,
          "feature": "ENST00000525042.1",
          "gene_hgnc_id": 6569,
          "gene_symbol": "LGALS8",
          "hgvs_c": "c.166A>C",
          "hgvs_p": "p.Met56Leu",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000431884.1",
          "strand": true,
          "transcript": "ENST00000525042.1",
          "transcript_support_level": 1
        },
        {
          "aa_alt": "L",
          "aa_end": null,
          "aa_length": 392,
          "aa_ref": "M",
          "aa_start": 89,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 4576,
          "cdna_start": 832,
          "cds_end": null,
          "cds_length": 1179,
          "cds_start": 265,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 12,
          "exon_rank": 5,
          "exon_rank_end": null,
          "feature": "ENST00000891073.1",
          "gene_hgnc_id": 6569,
          "gene_symbol": "LGALS8",
          "hgvs_c": "c.265A>C",
          "hgvs_p": "p.Met89Leu",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000561132.1",
          "strand": true,
          "transcript": "ENST00000891073.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "L",
          "aa_end": null,
          "aa_length": 359,
          "aa_ref": "M",
          "aa_start": 56,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 6122,
          "cdna_start": 388,
          "cds_end": null,
          "cds_length": 1080,
          "cds_start": 166,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 12,
          "exon_rank": 5,
          "exon_rank_end": null,
          "feature": "NM_006499.5",
          "gene_hgnc_id": 6569,
          "gene_symbol": "LGALS8",
          "hgvs_c": "c.166A>C",
          "hgvs_p": "p.Met56Leu",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "NP_006490.3",
          "strand": true,
          "transcript": "NM_006499.5",
          "transcript_support_level": null
        },
        {
          "aa_alt": "L",
          "aa_end": null,
          "aa_length": 359,
          "aa_ref": "M",
          "aa_start": 56,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 6151,
          "cdna_start": 417,
          "cds_end": null,
          "cds_length": 1080,
          "cds_start": 166,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 12,
          "exon_rank": 5,
          "exon_rank_end": null,
          "feature": "NM_201545.2",
          "gene_hgnc_id": 6569,
          "gene_symbol": "LGALS8",
          "hgvs_c": "c.166A>C",
          "hgvs_p": "p.Met56Leu",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "NP_963839.1",
          "strand": true,
          "transcript": "NM_201545.2",
          "transcript_support_level": null
        },
        {
          "aa_alt": "L",
          "aa_end": null,
          "aa_length": 359,
          "aa_ref": "M",
          "aa_start": 56,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 1402,
          "cdna_start": 366,
          "cds_end": null,
          "cds_length": 1080,
          "cds_start": 166,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 12,
          "exon_rank": 5,
          "exon_rank_end": null,
          "feature": "ENST00000352231.6",
          "gene_hgnc_id": 6569,
          "gene_symbol": "LGALS8",
          "hgvs_c": "c.166A>C",
          "hgvs_p": "p.Met56Leu",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000309576.2",
          "strand": true,
          "transcript": "ENST00000352231.6",
          "transcript_support_level": 2
        },
        {
          "aa_alt": "L",
          "aa_end": null,
          "aa_length": 359,
          "aa_ref": "M",
          "aa_start": 56,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 6420,
          "cdna_start": 686,
          "cds_end": null,
          "cds_length": 1080,
          "cds_start": 166,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 14,
          "exon_rank": 7,
          "exon_rank_end": null,
          "feature": "ENST00000526589.5",
          "gene_hgnc_id": 6569,
          "gene_symbol": "LGALS8",
          "hgvs_c": "c.166A>C",
          "hgvs_p": "p.Met56Leu",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000435460.1",
          "strand": true,
          "transcript": "ENST00000526589.5",
          "transcript_support_level": 5
        },
        {
          "aa_alt": "L",
          "aa_end": null,
          "aa_length": 359,
          "aa_ref": "M",
          "aa_start": 56,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 1349,
          "cdna_start": 315,
          "cds_end": null,
          "cds_length": 1080,
          "cds_start": 166,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 11,
          "exon_rank": 4,
          "exon_rank_end": null,
          "feature": "ENST00000527974.5",
          "gene_hgnc_id": 6569,
          "gene_symbol": "LGALS8",
          "hgvs_c": "c.166A>C",
          "hgvs_p": "p.Met56Leu",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000431398.1",
          "strand": true,
          "transcript": "ENST00000527974.5",
          "transcript_support_level": 5
        },
        {
          "aa_alt": "L",
          "aa_end": null,
          "aa_length": 359,
          "aa_ref": "M",
          "aa_start": 56,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 5800,
          "cdna_start": 629,
          "cds_end": null,
          "cds_length": 1080,
          "cds_start": 166,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 12,
          "exon_rank": 5,
          "exon_rank_end": null,
          "feature": "ENST00000891071.1",
          "gene_hgnc_id": 6569,
          "gene_symbol": "LGALS8",
          "hgvs_c": "c.166A>C",
          "hgvs_p": "p.Met56Leu",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000561130.1",
          "strand": true,
          "transcript": "ENST00000891071.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "L",
          "aa_end": null,
          "aa_length": 359,
          "aa_ref": "M",
          "aa_start": 56,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 4563,
          "cdna_start": 800,
          "cds_end": null,
          "cds_length": 1080,
          "cds_start": 166,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 11,
          "exon_rank": 4,
          "exon_rank_end": null,
          "feature": "ENST00000891072.1",
          "gene_hgnc_id": 6569,
          "gene_symbol": "LGALS8",
          "hgvs_c": "c.166A>C",
          "hgvs_p": "p.Met56Leu",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000561131.1",
          "strand": true,
          "transcript": "ENST00000891072.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "L",
          "aa_end": null,
          "aa_length": 359,
          "aa_ref": "M",
          "aa_start": 56,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 2573,
          "cdna_start": 551,
          "cds_end": null,
          "cds_length": 1080,
          "cds_start": 166,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 11,
          "exon_rank": 4,
          "exon_rank_end": null,
          "feature": "ENST00000891077.1",
          "gene_hgnc_id": 6569,
          "gene_symbol": "LGALS8",
          "hgvs_c": "c.166A>C",
          "hgvs_p": "p.Met56Leu",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000561136.1",
          "strand": true,
          "transcript": "ENST00000891077.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "L",
          "aa_end": null,
          "aa_length": 359,
          "aa_ref": "M",
          "aa_start": 56,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 2626,
          "cdna_start": 604,
          "cds_end": null,
          "cds_length": 1080,
          "cds_start": 166,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 11,
          "exon_rank": 4,
          "exon_rank_end": null,
          "feature": "ENST00000891078.1",
          "gene_hgnc_id": 6569,
          "gene_symbol": "LGALS8",
          "hgvs_c": "c.166A>C",
          "hgvs_p": "p.Met56Leu",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000561137.1",
          "strand": true,
          "transcript": "ENST00000891078.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "L",
          "aa_end": null,
          "aa_length": 359,
          "aa_ref": "M",
          "aa_start": 56,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 2472,
          "cdna_start": 456,
          "cds_end": null,
          "cds_length": 1080,
          "cds_start": 166,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 11,
          "exon_rank": 4,
          "exon_rank_end": null,
          "feature": "ENST00000891081.1",
          "gene_hgnc_id": 6569,
          "gene_symbol": "LGALS8",
          "hgvs_c": "c.166A>C",
          "hgvs_p": "p.Met56Leu",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000561140.1",
          "strand": true,
          "transcript": "ENST00000891081.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "L",
          "aa_end": null,
          "aa_length": 359,
          "aa_ref": "M",
          "aa_start": 56,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 1786,
          "cdna_start": 501,
          "cds_end": null,
          "cds_length": 1080,
          "cds_start": 166,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 12,
          "exon_rank": 5,
          "exon_rank_end": null,
          "feature": "ENST00000891082.1",
          "gene_hgnc_id": 6569,
          "gene_symbol": "LGALS8",
          "hgvs_c": "c.166A>C",
          "hgvs_p": "p.Met56Leu",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000561141.1",
          "strand": true,
          "transcript": "ENST00000891082.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "L",
          "aa_end": null,
          "aa_length": 359,
          "aa_ref": "M",
          "aa_start": 56,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 1469,
          "cdna_start": 433,
          "cds_end": null,
          "cds_length": 1080,
          "cds_start": 166,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 12,
          "exon_rank": 5,
          "exon_rank_end": null,
          "feature": "ENST00000891083.1",
          "gene_hgnc_id": 6569,
          "gene_symbol": "LGALS8",
          "hgvs_c": "c.166A>C",
          "hgvs_p": "p.Met56Leu",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000561142.1",
          "strand": true,
          "transcript": "ENST00000891083.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "L",
          "aa_end": null,
          "aa_length": 359,
          "aa_ref": "M",
          "aa_start": 56,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 1849,
          "cdna_start": 811,
          "cds_end": null,
          "cds_length": 1080,
          "cds_start": 166,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 11,
          "exon_rank": 4,
          "exon_rank_end": null,
          "feature": "ENST00000891084.1",
          "gene_hgnc_id": 6569,
          "gene_symbol": "LGALS8",
          "hgvs_c": "c.166A>C",
          "hgvs_p": "p.Met56Leu",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000561143.1",
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For research and educational, non-commercial use only. Not for clinical or diagnostic use. GeneBe does not provide medical advice. Data use for AI modeling is prohibited: if used, the cost is $0.001 per byte of downloaded uncompressed data.