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GeneBe API Showcase

This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.

API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.

Documentation & Advanced Usage

Complete API documentation:docs.genebe.net/docs/api/overview/

Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/

Python client for pandas:pypi.org/project/genebe/

Java CLI for VCF files:github.com/pstawinski/genebe-cli

All tools documented at:docs.genebe.net

API Request Examples for Variant: 1-244855577-C-T (hg38)

Bash / cURL Example

bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=1&pos=244855577&ref=C&alt=T&genome=hg38&allGenes=true"

API Response

json
{
  "variants": [
    {
      "chr": "1",
      "pos": 244855577,
      "ref": "C",
      "alt": "T",
      "effect": "synonymous_variant",
      "transcript": "ENST00000640218.2",
      "consequences": [
        {
          "aa_ref": "R",
          "aa_alt": "R",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "synonymous_variant"
          ],
          "exon_rank": 12,
          "exon_rank_end": null,
          "exon_count": 14,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "HNRNPU",
          "gene_hgnc_id": 5048,
          "hgvs_c": "c.2199G>A",
          "hgvs_p": "p.Arg733Arg",
          "transcript": "NM_031844.3",
          "protein_id": "NP_114032.2",
          "transcript_support_level": null,
          "aa_start": 733,
          "aa_end": null,
          "aa_length": 825,
          "cds_start": 2199,
          "cds_end": null,
          "cds_length": 2478,
          "cdna_start": 2435,
          "cdna_end": null,
          "cdna_length": 6867,
          "mane_select": "ENST00000640218.2",
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": "R",
          "aa_alt": "R",
          "canonical": true,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "synonymous_variant"
          ],
          "exon_rank": 12,
          "exon_rank_end": null,
          "exon_count": 14,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "HNRNPU",
          "gene_hgnc_id": 5048,
          "hgvs_c": "c.2199G>A",
          "hgvs_p": "p.Arg733Arg",
          "transcript": "ENST00000640218.2",
          "protein_id": "ENSP00000491215.1",
          "transcript_support_level": 1,
          "aa_start": 733,
          "aa_end": null,
          "aa_length": 825,
          "cds_start": 2199,
          "cds_end": null,
          "cds_length": 2478,
          "cdna_start": 2435,
          "cdna_end": null,
          "cdna_length": 6867,
          "mane_select": "NM_031844.3",
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": "R",
          "aa_alt": "R",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "synonymous_variant"
          ],
          "exon_rank": 12,
          "exon_rank_end": null,
          "exon_count": 14,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "HNRNPU",
          "gene_hgnc_id": 5048,
          "hgvs_c": "c.2142G>A",
          "hgvs_p": "p.Arg714Arg",
          "transcript": "ENST00000444376.7",
          "protein_id": "ENSP00000393151.2",
          "transcript_support_level": 1,
          "aa_start": 714,
          "aa_end": null,
          "aa_length": 806,
          "cds_start": 2142,
          "cds_end": null,
          "cds_length": 2421,
          "cdna_start": 2395,
          "cdna_end": null,
          "cdna_length": 6827,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": "R",
          "aa_alt": "R",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "synonymous_variant"
          ],
          "exon_rank": 9,
          "exon_rank_end": null,
          "exon_count": 11,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "HNRNPU",
          "gene_hgnc_id": 5048,
          "hgvs_c": "c.1371G>A",
          "hgvs_p": "p.Arg457Arg",
          "transcript": "ENST00000639628.2",
          "protein_id": "ENSP00000491340.1",
          "transcript_support_level": 1,
          "aa_start": 457,
          "aa_end": null,
          "aa_length": 549,
          "cds_start": 1371,
          "cds_end": null,
          "cds_length": 1650,
          "cdna_start": 3242,
          "cdna_end": null,
          "cdna_length": 7674,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": "R",
          "aa_alt": "R",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "synonymous_variant"
          ],
          "exon_rank": 12,
          "exon_rank_end": null,
          "exon_count": 14,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "HNRNPU",
          "gene_hgnc_id": 5048,
          "hgvs_c": "c.2142G>A",
          "hgvs_p": "p.Arg714Arg",
          "transcript": "NM_004501.3",
          "protein_id": "NP_004492.2",
          "transcript_support_level": null,
          "aa_start": 714,
          "aa_end": null,
          "aa_length": 806,
          "cds_start": 2142,
          "cds_end": null,
          "cds_length": 2421,
          "cdna_start": 2360,
          "cdna_end": null,
          "cdna_length": 6789,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": "R",
          "aa_alt": "R",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "synonymous_variant"
          ],
          "exon_rank": 10,
          "exon_rank_end": null,
          "exon_count": 12,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "HNRNPU",
          "gene_hgnc_id": 5048,
          "hgvs_c": "c.1956G>A",
          "hgvs_p": "p.Arg652Arg",
          "transcript": "ENST00000283179.14",
          "protein_id": "ENSP00000283179.10",
          "transcript_support_level": 5,
          "aa_start": 652,
          "aa_end": null,
          "aa_length": 744,
          "cds_start": 1956,
          "cds_end": null,
          "cds_length": 2235,
          "cdna_start": 2143,
          "cdna_end": null,
          "cdna_length": 3120,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": "R",
          "aa_alt": "R",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "synonymous_variant"
          ],
          "exon_rank": 12,
          "exon_rank_end": null,
          "exon_count": 14,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "HNRNPU",
          "gene_hgnc_id": 5048,
          "hgvs_c": "c.1908G>A",
          "hgvs_p": "p.Arg636Arg",
          "transcript": "ENST00000638475.1",
          "protein_id": "ENSP00000491305.1",
          "transcript_support_level": 5,
          "aa_start": 636,
          "aa_end": null,
          "aa_length": 728,
          "cds_start": 1908,
          "cds_end": null,
          "cds_length": 2187,
          "cdna_start": 1908,
          "cdna_end": null,
          "cdna_length": 2698,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": "R",
          "aa_alt": "R",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "synonymous_variant"
          ],
          "exon_rank": 12,
          "exon_rank_end": null,
          "exon_count": 15,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "HNRNPU",
          "gene_hgnc_id": 5048,
          "hgvs_c": "c.1818G>A",
          "hgvs_p": "p.Arg606Arg",
          "transcript": "ENST00000704074.1",
          "protein_id": "ENSP00000515674.1",
          "transcript_support_level": null,
          "aa_start": 606,
          "aa_end": null,
          "aa_length": 664,
          "cds_start": 1818,
          "cds_end": null,
          "cds_length": 1995,
          "cdna_start": 1820,
          "cdna_end": null,
          "cdna_length": 3015,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": "R",
          "aa_alt": "R",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "synonymous_variant"
          ],
          "exon_rank": 11,
          "exon_rank_end": null,
          "exon_count": 13,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "HNRNPU",
          "gene_hgnc_id": 5048,
          "hgvs_c": "c.1530G>A",
          "hgvs_p": "p.Arg510Arg",
          "transcript": "ENST00000440865.2",
          "protein_id": "ENSP00000410728.2",
          "transcript_support_level": 2,
          "aa_start": 510,
          "aa_end": null,
          "aa_length": 602,
          "cds_start": 1530,
          "cds_end": null,
          "cds_length": 1809,
          "cdna_start": 1884,
          "cdna_end": null,
          "cdna_length": 3207,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": "R",
          "aa_alt": "R",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "synonymous_variant"
          ],
          "exon_rank": 9,
          "exon_rank_end": null,
          "exon_count": 11,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "HNRNPU",
          "gene_hgnc_id": 5048,
          "hgvs_c": "c.1365G>A",
          "hgvs_p": "p.Arg455Arg",
          "transcript": "ENST00000638716.1",
          "protein_id": "ENSP00000491601.1",
          "transcript_support_level": 5,
          "aa_start": 455,
          "aa_end": null,
          "aa_length": 547,
          "cds_start": 1365,
          "cds_end": null,
          "cds_length": 1644,
          "cdna_start": 1378,
          "cdna_end": null,
          "cdna_length": 2640,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": "R",
          "aa_alt": "R",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "synonymous_variant"
          ],
          "exon_rank": 9,
          "exon_rank_end": null,
          "exon_count": 10,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "HNRNPU",
          "gene_hgnc_id": 5048,
          "hgvs_c": "c.1371G>A",
          "hgvs_p": "p.Arg457Arg",
          "transcript": "ENST00000640001.1",
          "protein_id": "ENSP00000491294.1",
          "transcript_support_level": 5,
          "aa_start": 457,
          "aa_end": null,
          "aa_length": 546,
          "cds_start": 1371,
          "cds_end": null,
          "cds_length": 1641,
          "cdna_start": 3229,
          "cdna_end": null,
          "cdna_length": 4227,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": "R",
          "aa_alt": "R",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "synonymous_variant"
          ],
          "exon_rank": 6,
          "exon_rank_end": null,
          "exon_count": 7,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "HNRNPU",
          "gene_hgnc_id": 5048,
          "hgvs_c": "c.774G>A",
          "hgvs_p": "p.Arg258Arg",
          "transcript": "ENST00000639824.1",
          "protein_id": "ENSP00000491903.1",
          "transcript_support_level": 5,
          "aa_start": 258,
          "aa_end": null,
          "aa_length": 326,
          "cds_start": 774,
          "cds_end": null,
          "cds_length": 981,
          "cdna_start": 775,
          "cdna_end": null,
          "cdna_length": 1450,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": false,
          "strand": false,
          "consequences": [
            "non_coding_transcript_exon_variant"
          ],
          "exon_rank": 10,
          "exon_rank_end": null,
          "exon_count": 12,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "HNRNPU",
          "gene_hgnc_id": 5048,
          "hgvs_c": "n.1812G>A",
          "hgvs_p": null,
          "transcript": "ENST00000366525.8",
          "protein_id": null,
          "transcript_support_level": 5,
          "aa_start": null,
          "aa_end": null,
          "aa_length": null,
          "cds_start": -4,
          "cds_end": null,
          "cds_length": null,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": 2851,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": false,
          "strand": false,
          "consequences": [
            "non_coding_transcript_exon_variant"
          ],
          "exon_rank": 3,
          "exon_rank_end": null,
          "exon_count": 3,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "HNRNPU",
          "gene_hgnc_id": 5048,
          "hgvs_c": "n.3886G>A",
          "hgvs_p": null,
          "transcript": "ENST00000468690.2",
          "protein_id": null,
          "transcript_support_level": 5,
          "aa_start": null,
          "aa_end": null,
          "aa_length": null,
          "cds_start": -4,
          "cds_end": null,
          "cds_length": null,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": 5273,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": false,
          "strand": false,
          "consequences": [
            "non_coding_transcript_exon_variant"
          ],
          "exon_rank": 2,
          "exon_rank_end": null,
          "exon_count": 6,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "HNRNPU",
          "gene_hgnc_id": 5048,
          "hgvs_c": "n.186G>A",
          "hgvs_p": null,
          "transcript": "ENST00000475997.6",
          "protein_id": "ENSP00000482621.2",
          "transcript_support_level": 5,
          "aa_start": null,
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          "cds_start": -4,
          "cds_end": null,
          "cds_length": null,
          "cdna_start": null,
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          "cdna_length": 5290,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": false,
          "strand": false,
          "consequences": [
            "non_coding_transcript_exon_variant"
          ],
          "exon_rank": 11,
          "exon_rank_end": null,
          "exon_count": 13,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "HNRNPU",
          "gene_hgnc_id": 5048,
          "hgvs_c": "n.4313G>A",
          "hgvs_p": null,
          "transcript": "ENST00000476241.2",
          "protein_id": null,
          "transcript_support_level": 5,
          "aa_start": null,
          "aa_end": null,
          "aa_length": null,
          "cds_start": -4,
          "cds_end": null,
          "cds_length": null,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": 4844,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": false,
          "strand": false,
          "consequences": [
            "non_coding_transcript_exon_variant"
          ],
          "exon_rank": 9,
          "exon_rank_end": null,
          "exon_count": 15,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "HNRNPU",
          "gene_hgnc_id": 5048,
          "hgvs_c": "n.1308G>A",
          "hgvs_p": null,
          "transcript": "ENST00000638230.1",
          "protein_id": "ENSP00000492010.1",
          "transcript_support_level": 5,
          "aa_start": null,
          "aa_end": null,
          "aa_length": null,
          "cds_start": -4,
          "cds_end": null,
          "cds_length": null,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": 1922,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": false,
          "strand": false,
          "consequences": [
            "non_coding_transcript_exon_variant"
          ],
          "exon_rank": 8,
          "exon_rank_end": null,
          "exon_count": 9,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "HNRNPU",
          "gene_hgnc_id": 5048,
          "hgvs_c": "n.*485G>A",
          "hgvs_p": null,
          "transcript": "ENST00000638301.1",
          "protein_id": "ENSP00000491807.1",
          "transcript_support_level": 5,
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          "cds_start": -4,
          "cds_end": null,
          "cds_length": null,
          "cdna_start": null,
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          "cdna_length": 3650,
          "mane_select": null,
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          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": false,
          "strand": false,
          "consequences": [
            "non_coding_transcript_exon_variant"
          ],
          "exon_rank": 11,
          "exon_rank_end": null,
          "exon_count": 13,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "HNRNPU",
          "gene_hgnc_id": 5048,
          "hgvs_c": "n.4416G>A",
          "hgvs_p": null,
          "transcript": "ENST00000638952.1",
          "protein_id": null,
          "transcript_support_level": 5,
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          "aa_length": null,
          "cds_start": -4,
          "cds_end": null,
          "cds_length": null,
          "cdna_start": null,
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          "cdna_length": 5678,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": false,
          "strand": false,
          "consequences": [
            "non_coding_transcript_exon_variant"
          ],
          "exon_rank": 3,
          "exon_rank_end": null,
          "exon_count": 3,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "HNRNPU",
          "gene_hgnc_id": 5048,
          "hgvs_c": "n.1254G>A",
          "hgvs_p": null,
          "transcript": "ENST00000639064.1",
          "protein_id": null,
          "transcript_support_level": 5,
          "aa_start": null,
          "aa_end": null,
          "aa_length": null,
          "cds_start": -4,
          "cds_end": null,
          "cds_length": null,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": 2625,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": false,
          "strand": false,
          "consequences": [
            "non_coding_transcript_exon_variant"
          ],
          "exon_rank": 9,
          "exon_rank_end": null,
          "exon_count": 11,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "HNRNPU",
          "gene_hgnc_id": 5048,
          "hgvs_c": "n.*1135G>A",
          "hgvs_p": null,
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      "computational_source_selected": "BayesDel_noAF",
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      "bayesdelnoaf_score": -0.29,
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      "phylop100way_prediction": "Benign",
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      "acmg_classification": "Likely_benign",
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      "acmg_by_gene": [
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          "pathogenic_score": 2,
          "criteria": [
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          "verdict": "Likely_benign",
          "transcript": "ENST00000640218.2",
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          "hgvs_p": "p.Arg733Arg"
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      "clinvar_disease": "",
      "clinvar_classification": "",
      "clinvar_review_status": "",
      "clinvar_submissions_summary": "",
      "phenotype_combined": null,
      "pathogenicity_classification_combined": null,
      "custom_annotations": null
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  ],
  "message": null
}