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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 1-24535214-G-A (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=1&pos=24535214&ref=G&alt=A&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "1",
"pos": 24535214,
"ref": "G",
"alt": "A",
"effect": "synonymous_variant",
"transcript": "ENST00000374395.9",
"consequences": [
{
"aa_ref": "R",
"aa_alt": "Q",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 3,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "RCAN3",
"gene_hgnc_id": 3042,
"hgvs_c": "c.491G>A",
"hgvs_p": "p.Arg164Gln",
"transcript": "ENST00000412742.5",
"protein_id": "ENSP00000391912.2",
"transcript_support_level": 1,
"aa_start": 164,
"aa_end": null,
"aa_length": 173,
"cds_start": 491,
"cds_end": null,
"cds_length": 522,
"cdna_start": 544,
"cdna_end": null,
"cdna_length": 667,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "R",
"aa_alt": "Q",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 2,
"exon_rank_end": null,
"exon_count": 2,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "RCAN3",
"gene_hgnc_id": 3042,
"hgvs_c": "c.317G>A",
"hgvs_p": "p.Arg106Gln",
"transcript": "ENST00000374393.4",
"protein_id": "ENSP00000363514.2",
"transcript_support_level": 1,
"aa_start": 106,
"aa_end": null,
"aa_length": 115,
"cds_start": 317,
"cds_end": null,
"cds_length": 348,
"cdna_start": 317,
"cdna_end": null,
"cdna_length": 382,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "T",
"aa_alt": "T",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 5,
"exon_rank_end": null,
"exon_count": 5,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "RCAN3",
"gene_hgnc_id": 3042,
"hgvs_c": "c.663G>A",
"hgvs_p": "p.Thr221Thr",
"transcript": "NM_013441.4",
"protein_id": "NP_038469.1",
"transcript_support_level": null,
"aa_start": 221,
"aa_end": null,
"aa_length": 241,
"cds_start": 663,
"cds_end": null,
"cds_length": 726,
"cdna_start": 1037,
"cdna_end": null,
"cdna_length": 6863,
"mane_select": "ENST00000374395.9",
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "T",
"aa_alt": "T",
"canonical": true,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 5,
"exon_rank_end": null,
"exon_count": 5,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "RCAN3",
"gene_hgnc_id": 3042,
"hgvs_c": "c.663G>A",
"hgvs_p": "p.Thr221Thr",
"transcript": "ENST00000374395.9",
"protein_id": "ENSP00000363516.3",
"transcript_support_level": 1,
"aa_start": 221,
"aa_end": null,
"aa_length": 241,
"cds_start": 663,
"cds_end": null,
"cds_length": 726,
"cdna_start": 1037,
"cdna_end": null,
"cdna_length": 6863,
"mane_select": "NM_013441.4",
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "T",
"aa_alt": "T",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 5,
"exon_rank_end": null,
"exon_count": 5,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "RCAN3",
"gene_hgnc_id": 3042,
"hgvs_c": "c.663G>A",
"hgvs_p": "p.Thr221Thr",
"transcript": "ENST00000538532.6",
"protein_id": "ENSP00000445401.2",
"transcript_support_level": 1,
"aa_start": 221,
"aa_end": null,
"aa_length": 241,
"cds_start": 663,
"cds_end": null,
"cds_length": 726,
"cdna_start": 835,
"cdna_end": null,
"cdna_length": 2421,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "T",
"aa_alt": "T",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 3,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "RCAN3",
"gene_hgnc_id": 3042,
"hgvs_c": "c.489G>A",
"hgvs_p": "p.Thr163Thr",
"transcript": "ENST00000630217.1",
"protein_id": "ENSP00000486836.1",
"transcript_support_level": 1,
"aa_start": 163,
"aa_end": null,
"aa_length": 183,
"cds_start": 489,
"cds_end": null,
"cds_length": 552,
"cdna_start": 515,
"cdna_end": null,
"cdna_length": 658,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "T",
"aa_alt": "T",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 4,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "RCAN3",
"gene_hgnc_id": 3042,
"hgvs_c": "c.288G>A",
"hgvs_p": "p.Thr96Thr",
"transcript": "ENST00000616511.4",
"protein_id": "ENSP00000478174.1",
"transcript_support_level": 1,
"aa_start": 96,
"aa_end": null,
"aa_length": 116,
"cds_start": 288,
"cds_end": null,
"cds_length": 351,
"cdna_start": 722,
"cdna_end": null,
"cdna_length": 2527,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "T",
"aa_alt": "T",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 4,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "RCAN3",
"gene_hgnc_id": 3042,
"hgvs_c": "c.288G>A",
"hgvs_p": "p.Thr96Thr",
"transcript": "ENST00000618490.4",
"protein_id": "ENSP00000484519.1",
"transcript_support_level": 1,
"aa_start": 96,
"aa_end": null,
"aa_length": 116,
"cds_start": 288,
"cds_end": null,
"cds_length": 351,
"cdna_start": 581,
"cdna_end": null,
"cdna_length": 2386,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "R",
"aa_alt": "Q",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 3,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "RCAN3",
"gene_hgnc_id": 3042,
"hgvs_c": "c.491G>A",
"hgvs_p": "p.Arg164Gln",
"transcript": "NM_001251982.1",
"protein_id": "NP_001238911.1",
"transcript_support_level": null,
"aa_start": 164,
"aa_end": null,
"aa_length": 173,
"cds_start": 491,
"cds_end": null,
"cds_length": 522,
"cdna_start": 550,
"cdna_end": null,
"cdna_length": 2356,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "R",
"aa_alt": "Q",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 2,
"exon_rank_end": null,
"exon_count": 2,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "RCAN3",
"gene_hgnc_id": 3042,
"hgvs_c": "c.317G>A",
"hgvs_p": "p.Arg106Gln",
"transcript": "NM_001251985.1",
"protein_id": "NP_001238914.1",
"transcript_support_level": null,
"aa_start": 106,
"aa_end": null,
"aa_length": 115,
"cds_start": 317,
"cds_end": null,
"cds_length": 348,
"cdna_start": 376,
"cdna_end": null,
"cdna_length": 2182,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "T",
"aa_alt": "T",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 5,
"exon_rank_end": null,
"exon_count": 5,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "RCAN3",
"gene_hgnc_id": 3042,
"hgvs_c": "c.663G>A",
"hgvs_p": "p.Thr221Thr",
"transcript": "NM_001251977.2",
"protein_id": "NP_001238906.1",
"transcript_support_level": null,
"aa_start": 221,
"aa_end": null,
"aa_length": 241,
"cds_start": 663,
"cds_end": null,
"cds_length": 726,
"cdna_start": 1004,
"cdna_end": null,
"cdna_length": 6830,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "T",
"aa_alt": "T",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 5,
"exon_rank_end": null,
"exon_count": 5,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "RCAN3",
"gene_hgnc_id": 3042,
"hgvs_c": "c.663G>A",
"hgvs_p": "p.Thr221Thr",
"transcript": "NM_001251978.1",
"protein_id": "NP_001238907.1",
"transcript_support_level": null,
"aa_start": 221,
"aa_end": null,
"aa_length": 241,
"cds_start": 663,
"cds_end": null,
"cds_length": 726,
"cdna_start": 857,
"cdna_end": null,
"cdna_length": 2663,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "T",
"aa_alt": "T",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 5,
"exon_rank_end": null,
"exon_count": 5,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "RCAN3",
"gene_hgnc_id": 3042,
"hgvs_c": "c.663G>A",
"hgvs_p": "p.Thr221Thr",
"transcript": "NM_001251979.2",
"protein_id": "NP_001238908.1",
"transcript_support_level": null,
"aa_start": 221,
"aa_end": null,
"aa_length": 241,
"cds_start": 663,
"cds_end": null,
"cds_length": 726,
"cdna_start": 842,
"cdna_end": null,
"cdna_length": 6668,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "T",
"aa_alt": "T",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 4,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "RCAN3",
"gene_hgnc_id": 3042,
"hgvs_c": "c.633G>A",
"hgvs_p": "p.Thr211Thr",
"transcript": "NM_001251980.1",
"protein_id": "NP_001238909.1",
"transcript_support_level": null,
"aa_start": 211,
"aa_end": null,
"aa_length": 231,
"cds_start": 633,
"cds_end": null,
"cds_length": 696,
"cdna_start": 692,
"cdna_end": null,
"cdna_length": 2498,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "T",
"aa_alt": "T",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 5,
"exon_rank_end": null,
"exon_count": 5,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "RCAN3",
"gene_hgnc_id": 3042,
"hgvs_c": "c.633G>A",
"hgvs_p": "p.Thr211Thr",
"transcript": "ENST00000425530.3",
"protein_id": "ENSP00000409540.2",
"transcript_support_level": 5,
"aa_start": 211,
"aa_end": null,
"aa_length": 231,
"cds_start": 633,
"cds_end": null,
"cds_length": 696,
"cdna_start": 854,
"cdna_end": null,
"cdna_length": 997,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "T",
"aa_alt": "T",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 4,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "RCAN3",
"gene_hgnc_id": 3042,
"hgvs_c": "c.489G>A",
"hgvs_p": "p.Thr163Thr",
"transcript": "NM_001251981.2",
"protein_id": "NP_001238910.1",
"transcript_support_level": null,
"aa_start": 163,
"aa_end": null,
"aa_length": 183,
"cds_start": 489,
"cds_end": null,
"cds_length": 552,
"cdna_start": 830,
"cdna_end": null,
"cdna_length": 6656,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "T",
"aa_alt": "T",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 4,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "RCAN3",
"gene_hgnc_id": 3042,
"hgvs_c": "c.489G>A",
"hgvs_p": "p.Thr163Thr",
"transcript": "ENST00000436717.6",
"protein_id": "ENSP00000414447.3",
"transcript_support_level": 3,
"aa_start": 163,
"aa_end": null,
"aa_length": 183,
"cds_start": 489,
"cds_end": null,
"cds_length": 552,
"cdna_start": 769,
"cdna_end": null,
"cdna_length": 2574,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "T",
"aa_alt": "T",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 4,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "RCAN3",
"gene_hgnc_id": 3042,
"hgvs_c": "c.288G>A",
"hgvs_p": "p.Thr96Thr",
"transcript": "NM_001251983.2",
"protein_id": "NP_001238912.1",
"transcript_support_level": null,
"aa_start": 96,
"aa_end": null,
"aa_length": 116,
"cds_start": 288,
"cds_end": null,
"cds_length": 351,
"cdna_start": 783,
"cdna_end": null,
"cdna_length": 6609,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "T",
"aa_alt": "T",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 4,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "RCAN3",
"gene_hgnc_id": 3042,
"hgvs_c": "c.288G>A",
"hgvs_p": "p.Thr96Thr",
"transcript": "NM_001251984.2",
"protein_id": "NP_001238913.1",
"transcript_support_level": null,
"aa_start": 96,
"aa_end": null,
"aa_length": 116,
"cds_start": 288,
"cds_end": null,
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"cdna_start": 588,
"cdna_end": null,
"cdna_length": 6414,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": false,
"strand": true,
"consequences": [
"non_coding_transcript_exon_variant"
],
"exon_rank": 2,
"exon_rank_end": null,
"exon_count": 3,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "RCAN3",
"gene_hgnc_id": 3042,
"hgvs_c": "n.261G>A",
"hgvs_p": null,
"transcript": "ENST00000482807.1",
"protein_id": "ENSP00000437338.1",
"transcript_support_level": 3,
"aa_start": null,
"aa_end": null,
"aa_length": null,
"cds_start": -4,
"cds_end": null,
"cds_length": null,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 497,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": false,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 3,
"intron_rank": 1,
"intron_rank_end": null,
"gene_symbol": "NCMAP-DT",
"gene_hgnc_id": 39009,
"hgvs_c": "n.142+45C>T",
"hgvs_p": null,
"transcript": "ENST00000651630.1",
"protein_id": null,
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": null,
"cds_start": -4,
"cds_end": null,
"cds_length": null,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 559,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": false,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 5,
"intron_rank": 3,
"intron_rank_end": null,
"gene_symbol": "NCMAP-DT",
"gene_hgnc_id": 39009,
"hgvs_c": "n.454-1754C>T",
"hgvs_p": null,
"transcript": "ENST00000715598.1",
"protein_id": null,
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": null,
"cds_start": -4,
"cds_end": null,
"cds_length": null,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 867,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": false,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 7,
"intron_rank": 5,
"intron_rank_end": null,
"gene_symbol": "NCMAP-DT",
"gene_hgnc_id": 39009,
"hgvs_c": "n.770+45C>T",
"hgvs_p": null,
"transcript": "ENST00000715599.1",
"protein_id": null,
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": null,
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}