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GeneBe API Showcase

This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.

API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.

Documentation & Advanced Usage

Complete API documentation:docs.genebe.net/docs/api/overview/

Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/

Python client for pandas:pypi.org/project/genebe/

Java CLI for VCF files:github.com/pstawinski/genebe-cli

All tools documented at:docs.genebe.net

API Request Examples for Variant: 1-248850445-G-A (hg38)

Bash / cURL Example

bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=1&pos=248850445&ref=G&alt=A&genome=hg38&allGenes=true"

API Response

json
{
  "message": null,
  "variants": [
    {
      "acmg_by_gene": [
        {
          "benign_score": 2,
          "criteria": [
            "BP4_Moderate"
          ],
          "effects": [
            "missense_variant"
          ],
          "gene_symbol": "ZNF692",
          "hgnc_id": 26049,
          "hgvs_c": "c.1340C>T",
          "hgvs_p": "p.Thr447Met",
          "inheritance_mode": "AR",
          "pathogenic_score": 0,
          "score": -2,
          "transcript": "NM_001136036.3",
          "verdict": "Likely_benign"
        }
      ],
      "acmg_classification": "Likely_benign",
      "acmg_criteria": "BP4_Moderate",
      "acmg_score": -2,
      "allele_count_reference_population": 150,
      "alphamissense_prediction": null,
      "alphamissense_score": 0.2065,
      "alt": "A",
      "apogee2_prediction": null,
      "apogee2_score": null,
      "bayesdelnoaf_prediction": "Benign",
      "bayesdelnoaf_score": -0.46,
      "chr": "1",
      "clinvar_classification": "Uncertain significance",
      "clinvar_disease": "not specified",
      "clinvar_review_status": "criteria provided, single submitter",
      "clinvar_submissions_summary": "US:1",
      "computational_prediction_selected": "Benign",
      "computational_score_selected": 0.0774717926979065,
      "computational_source_selected": "MetaRNN",
      "consequences": [
        {
          "aa_alt": "M",
          "aa_end": null,
          "aa_length": 519,
          "aa_ref": "T",
          "aa_start": 442,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 1942,
          "cdna_start": 1505,
          "cds_end": null,
          "cds_length": 1560,
          "cds_start": 1325,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 12,
          "exon_rank": 12,
          "exon_rank_end": null,
          "feature": "NM_017865.4",
          "gene_hgnc_id": 26049,
          "gene_symbol": "ZNF692",
          "hgvs_c": "c.1325C>T",
          "hgvs_p": "p.Thr442Met",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": "ENST00000306601.9",
          "protein_coding": true,
          "protein_id": "NP_060335.2",
          "strand": false,
          "transcript": "NM_017865.4",
          "transcript_support_level": null
        },
        {
          "aa_alt": "M",
          "aa_end": null,
          "aa_length": 519,
          "aa_ref": "T",
          "aa_start": 442,
          "biotype": "protein_coding",
          "canonical": true,
          "cdna_end": null,
          "cdna_length": 1942,
          "cdna_start": 1505,
          "cds_end": null,
          "cds_length": 1560,
          "cds_start": 1325,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 12,
          "exon_rank": 12,
          "exon_rank_end": null,
          "feature": "ENST00000306601.9",
          "gene_hgnc_id": 26049,
          "gene_symbol": "ZNF692",
          "hgvs_c": "c.1325C>T",
          "hgvs_p": "p.Thr442Met",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": "NM_017865.4",
          "protein_coding": true,
          "protein_id": "ENSP00000305483.5",
          "strand": false,
          "transcript": "ENST00000306601.9",
          "transcript_support_level": 1
        },
        {
          "aa_alt": "M",
          "aa_end": null,
          "aa_length": 474,
          "aa_ref": "T",
          "aa_start": 397,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 1710,
          "cdna_start": 1273,
          "cds_end": null,
          "cds_length": 1425,
          "cds_start": 1190,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 11,
          "exon_rank": 11,
          "exon_rank_end": null,
          "feature": "ENST00000366471.7",
          "gene_hgnc_id": 26049,
          "gene_symbol": "ZNF692",
          "hgvs_c": "c.1190C>T",
          "hgvs_p": "p.Thr397Met",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000355427.3",
          "strand": false,
          "transcript": "ENST00000366471.7",
          "transcript_support_level": 1
        },
        {
          "aa_alt": null,
          "aa_end": null,
          "aa_length": null,
          "aa_ref": null,
          "aa_start": null,
          "biotype": "nonsense_mediated_decay",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 2704,
          "cdna_start": null,
          "cds_end": null,
          "cds_length": null,
          "cds_start": null,
          "consequences": [
            "non_coding_transcript_exon_variant"
          ],
          "exon_count": 10,
          "exon_rank": 10,
          "exon_rank_end": null,
          "feature": "ENST00000463519.5",
          "gene_hgnc_id": 26049,
          "gene_symbol": "ZNF692",
          "hgvs_c": "n.*1570C>T",
          "hgvs_p": null,
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": false,
          "protein_id": "ENSP00000436308.1",
          "strand": false,
          "transcript": "ENST00000463519.5",
          "transcript_support_level": 1
        },
        {
          "aa_alt": null,
          "aa_end": null,
          "aa_length": null,
          "aa_ref": null,
          "aa_start": null,
          "biotype": "retained_intron",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 2026,
          "cdna_start": null,
          "cds_end": null,
          "cds_length": null,
          "cds_start": null,
          "consequences": [
            "non_coding_transcript_exon_variant"
          ],
          "exon_count": 8,
          "exon_rank": 8,
          "exon_rank_end": null,
          "feature": "ENST00000533927.5",
          "gene_hgnc_id": 26049,
          "gene_symbol": "ZNF692",
          "hgvs_c": "n.1590C>T",
          "hgvs_p": null,
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": false,
          "protein_id": null,
          "strand": false,
          "transcript": "ENST00000533927.5",
          "transcript_support_level": 1
        },
        {
          "aa_alt": null,
          "aa_end": null,
          "aa_length": null,
          "aa_ref": null,
          "aa_start": null,
          "biotype": "nonsense_mediated_decay",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 2704,
          "cdna_start": null,
          "cds_end": null,
          "cds_length": null,
          "cds_start": null,
          "consequences": [
            "3_prime_UTR_variant"
          ],
          "exon_count": 10,
          "exon_rank": 10,
          "exon_rank_end": null,
          "feature": "ENST00000463519.5",
          "gene_hgnc_id": 26049,
          "gene_symbol": "ZNF692",
          "hgvs_c": "n.*1570C>T",
          "hgvs_p": null,
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": false,
          "protein_id": "ENSP00000436308.1",
          "strand": false,
          "transcript": "ENST00000463519.5",
          "transcript_support_level": 1
        },
        {
          "aa_alt": "M",
          "aa_end": null,
          "aa_length": 524,
          "aa_ref": "T",
          "aa_start": 447,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 2348,
          "cdna_start": 1911,
          "cds_end": null,
          "cds_length": 1575,
          "cds_start": 1340,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 12,
          "exon_rank": 12,
          "exon_rank_end": null,
          "feature": "NM_001136036.3",
          "gene_hgnc_id": 26049,
          "gene_symbol": "ZNF692",
          "hgvs_c": "c.1340C>T",
          "hgvs_p": "p.Thr447Met",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "NP_001129508.1",
          "strand": false,
          "transcript": "NM_001136036.3",
          "transcript_support_level": null
        },
        {
          "aa_alt": "M",
          "aa_end": null,
          "aa_length": 524,
          "aa_ref": "T",
          "aa_start": 447,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 2065,
          "cdna_start": 1686,
          "cds_end": null,
          "cds_length": 1575,
          "cds_start": 1340,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 12,
          "exon_rank": 12,
          "exon_rank_end": null,
          "feature": "ENST00000451251.5",
          "gene_hgnc_id": 26049,
          "gene_symbol": "ZNF692",
          "hgvs_c": "c.1340C>T",
          "hgvs_p": "p.Thr447Met",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000391200.1",
          "strand": false,
          "transcript": "ENST00000451251.5",
          "transcript_support_level": 2
        },
        {
          "aa_alt": "M",
          "aa_end": null,
          "aa_length": 519,
          "aa_ref": "T",
          "aa_start": 442,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 1876,
          "cdna_start": 1439,
          "cds_end": null,
          "cds_length": 1560,
          "cds_start": 1325,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 12,
          "exon_rank": 12,
          "exon_rank_end": null,
          "feature": "ENST00000869877.1",
          "gene_hgnc_id": 26049,
          "gene_symbol": "ZNF692",
          "hgvs_c": "c.1325C>T",
          "hgvs_p": "p.Thr442Met",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000539936.1",
          "strand": false,
          "transcript": "ENST00000869877.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "M",
          "aa_end": null,
          "aa_length": 519,
          "aa_ref": "T",
          "aa_start": 442,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 2374,
          "cdna_start": 1937,
          "cds_end": null,
          "cds_length": 1560,
          "cds_start": 1325,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 11,
          "exon_rank": 11,
          "exon_rank_end": null,
          "feature": "ENST00000869881.1",
          "gene_hgnc_id": 26049,
          "gene_symbol": "ZNF692",
          "hgvs_c": "c.1325C>T",
          "hgvs_p": "p.Thr442Met",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000539940.1",
          "strand": false,
          "transcript": "ENST00000869881.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "M",
          "aa_end": null,
          "aa_length": 519,
          "aa_ref": "T",
          "aa_start": 442,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 1976,
          "cdna_start": 1535,
          "cds_end": null,
          "cds_length": 1560,
          "cds_start": 1325,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 13,
          "exon_rank": 13,
          "exon_rank_end": null,
          "feature": "ENST00000914628.1",
          "gene_hgnc_id": 26049,
          "gene_symbol": "ZNF692",
          "hgvs_c": "c.1325C>T",
          "hgvs_p": "p.Thr442Met",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000584687.1",
          "strand": false,
          "transcript": "ENST00000914628.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "M",
          "aa_end": null,
          "aa_length": 519,
          "aa_ref": "T",
          "aa_start": 442,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 1934,
          "cdna_start": 1494,
          "cds_end": null,
          "cds_length": 1560,
          "cds_start": 1325,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 12,
          "exon_rank": 12,
          "exon_rank_end": null,
          "feature": "ENST00000964809.1",
          "gene_hgnc_id": 26049,
          "gene_symbol": "ZNF692",
          "hgvs_c": "c.1325C>T",
          "hgvs_p": "p.Thr442Met",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000634868.1",
          "strand": false,
          "transcript": "ENST00000964809.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "M",
          "aa_end": null,
          "aa_length": 518,
          "aa_ref": "T",
          "aa_start": 441,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 1939,
          "cdna_start": 1502,
          "cds_end": null,
          "cds_length": 1557,
          "cds_start": 1322,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 12,
          "exon_rank": 12,
          "exon_rank_end": null,
          "feature": "NM_001350072.2",
          "gene_hgnc_id": 26049,
          "gene_symbol": "ZNF692",
          "hgvs_c": "c.1322C>T",
          "hgvs_p": "p.Thr441Met",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "NP_001337001.1",
          "strand": false,
          "transcript": "NM_001350072.2",
          "transcript_support_level": null
        },
        {
          "aa_alt": "M",
          "aa_end": null,
          "aa_length": 518,
          "aa_ref": "T",
          "aa_start": 441,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 1967,
          "cdna_start": 1526,
          "cds_end": null,
          "cds_length": 1557,
          "cds_start": 1322,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 12,
          "exon_rank": 12,
          "exon_rank_end": null,
          "feature": "ENST00000869878.1",
          "gene_hgnc_id": 26049,
          "gene_symbol": "ZNF692",
          "hgvs_c": "c.1322C>T",
          "hgvs_p": "p.Thr441Met",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000539937.1",
          "strand": false,
          "transcript": "ENST00000869878.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "M",
          "aa_end": null,
          "aa_length": 518,
          "aa_ref": "T",
          "aa_start": 441,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 2037,
          "cdna_start": 1597,
          "cds_end": null,
          "cds_length": 1557,
          "cds_start": 1322,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 12,
          "exon_rank": 12,
          "exon_rank_end": null,
          "feature": "ENST00000964808.1",
          "gene_hgnc_id": 26049,
          "gene_symbol": "ZNF692",
          "hgvs_c": "c.1322C>T",
          "hgvs_p": "p.Thr441Met",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000634867.1",
          "strand": false,
          "transcript": "ENST00000964808.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "M",
          "aa_end": null,
          "aa_length": 507,
          "aa_ref": "T",
          "aa_start": 430,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 1870,
          "cdna_start": 1429,
          "cds_end": null,
          "cds_length": 1524,
          "cds_start": 1289,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 12,
          "exon_rank": 12,
          "exon_rank_end": null,
          "feature": "ENST00000964812.1",
          "gene_hgnc_id": 26049,
          "gene_symbol": "ZNF692",
          "hgvs_c": "c.1289C>T",
          "hgvs_p": "p.Thr430Met",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000634871.1",
          "strand": false,
          "transcript": "ENST00000964812.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "M",
          "aa_end": null,
          "aa_length": 506,
          "aa_ref": "T",
          "aa_start": 429,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 1775,
          "cdna_start": 1335,
          "cds_end": null,
          "cds_length": 1521,
          "cds_start": 1286,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 12,
          "exon_rank": 12,
          "exon_rank_end": null,
          "feature": "ENST00000869880.1",
          "gene_hgnc_id": 26049,
          "gene_symbol": "ZNF692",
          "hgvs_c": "c.1286C>T",
          "hgvs_p": "p.Thr429Met",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000539939.1",
          "strand": false,
          "transcript": "ENST00000869880.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "M",
          "aa_end": null,
          "aa_length": 488,
          "aa_ref": "T",
          "aa_start": 411,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 1857,
          "cdna_start": 1421,
          "cds_end": null,
          "cds_length": 1467,
          "cds_start": 1232,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 11,
          "exon_rank": 11,
          "exon_rank_end": null,
          "feature": "ENST00000964810.1",
          "gene_hgnc_id": 26049,
          "gene_symbol": "ZNF692",
          "hgvs_c": "c.1232C>T",
          "hgvs_p": "p.Thr411Met",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000634869.1",
          "strand": false,
          "transcript": "ENST00000964810.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "M",
          "aa_end": null,
          "aa_length": 487,
          "aa_ref": "T",
          "aa_start": 410,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 1845,
          "cdna_start": 1409,
          "cds_end": null,
          "cds_length": 1464,
          "cds_start": 1229,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 11,
          "exon_rank": 11,
          "exon_rank_end": null,
          "feature": "ENST00000964811.1",
          "gene_hgnc_id": 26049,
          "gene_symbol": "ZNF692",
          "hgvs_c": "c.1229C>T",
          "hgvs_p": "p.Thr410Met",
          "intron_rank": null,
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}
For research and educational, non-commercial use only. Not for clinical or diagnostic use. GeneBe does not provide medical advice. Data use for AI modeling is prohibited: if used, the cost is $0.001 per byte of downloaded uncompressed data.