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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 1-3068848-G-A (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=1&pos=3068848&ref=G&alt=A&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "1",
"pos": 3068848,
"ref": "G",
"alt": "A",
"effect": "non_coding_transcript_exon_variant",
"transcript": "ENST00000702683.2",
"consequences": [
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": false,
"strand": false,
"consequences": [
"non_coding_transcript_exon_variant"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 1,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PRDM16-DT",
"gene_hgnc_id": 48664,
"hgvs_c": "n.300C>T",
"hgvs_p": null,
"transcript": "ENST00000702683.2",
"protein_id": null,
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": null,
"cds_start": -4,
"cds_end": null,
"cds_length": null,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 676,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": false,
"strand": false,
"consequences": [
"non_coding_transcript_exon_variant"
],
"exon_rank": 2,
"exon_rank_end": null,
"exon_count": 2,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PRDM16-DT",
"gene_hgnc_id": 48664,
"hgvs_c": "n.202C>T",
"hgvs_p": null,
"transcript": "ENST00000818119.1",
"protein_id": null,
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": null,
"cds_start": -4,
"cds_end": null,
"cds_length": null,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 396,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"3_prime_UTR_variant"
],
"exon_rank": 2,
"exon_rank_end": null,
"exon_count": 7,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "LOC124903827",
"gene_hgnc_id": null,
"hgvs_c": "c.*100C>T",
"hgvs_p": null,
"transcript": "XM_047436534.1",
"protein_id": "XP_047292490.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 557,
"cds_start": -4,
"cds_end": null,
"cds_length": 1674,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 10286,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"3_prime_UTR_variant"
],
"exon_rank": 2,
"exon_rank_end": null,
"exon_count": 6,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "LOC124903827",
"gene_hgnc_id": null,
"hgvs_c": "c.*100C>T",
"hgvs_p": null,
"transcript": "XM_047436535.1",
"protein_id": "XP_047292491.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 557,
"cds_start": -4,
"cds_end": null,
"cds_length": 1674,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 10778,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"3_prime_UTR_variant"
],
"exon_rank": 2,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "LOC124903827",
"gene_hgnc_id": null,
"hgvs_c": "c.*100C>T",
"hgvs_p": null,
"transcript": "XM_047436536.1",
"protein_id": "XP_047292492.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 557,
"cds_start": -4,
"cds_end": null,
"cds_length": 1674,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 10027,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"3_prime_UTR_variant"
],
"exon_rank": 2,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "LOC124903827",
"gene_hgnc_id": null,
"hgvs_c": "c.*100C>T",
"hgvs_p": null,
"transcript": "XM_047436539.1",
"protein_id": "XP_047292495.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 557,
"cds_start": -4,
"cds_end": null,
"cds_length": 1674,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 9551,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"3_prime_UTR_variant"
],
"exon_rank": 2,
"exon_rank_end": null,
"exon_count": 7,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "LOC124903827",
"gene_hgnc_id": null,
"hgvs_c": "c.*100C>T",
"hgvs_p": null,
"transcript": "XM_047436540.1",
"protein_id": "XP_047292496.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 557,
"cds_start": -4,
"cds_end": null,
"cds_length": 1674,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 10475,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"3_prime_UTR_variant"
],
"exon_rank": 2,
"exon_rank_end": null,
"exon_count": 4,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "LOC124903827",
"gene_hgnc_id": null,
"hgvs_c": "c.*100C>T",
"hgvs_p": null,
"transcript": "XM_047436541.1",
"protein_id": "XP_047292497.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 557,
"cds_start": -4,
"cds_end": null,
"cds_length": 1674,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 11686,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"3_prime_UTR_variant"
],
"exon_rank": 2,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "LOC124903827",
"gene_hgnc_id": null,
"hgvs_c": "c.*100C>T",
"hgvs_p": null,
"transcript": "XM_047436542.1",
"protein_id": "XP_047292498.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 557,
"cds_start": -4,
"cds_end": null,
"cds_length": 1674,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 9328,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"3_prime_UTR_variant"
],
"exon_rank": 2,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "LOC124903827",
"gene_hgnc_id": null,
"hgvs_c": "c.*100C>T",
"hgvs_p": null,
"transcript": "XM_047436543.1",
"protein_id": "XP_047292499.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 557,
"cds_start": -4,
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"cdna_start": null,
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"mane_select": null,
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"biotype": null,
"feature": null
},
{
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"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"3_prime_UTR_variant"
],
"exon_rank": 2,
"exon_rank_end": null,
"exon_count": 6,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "LOC124903827",
"gene_hgnc_id": null,
"hgvs_c": "c.*100C>T",
"hgvs_p": null,
"transcript": "XM_047436544.1",
"protein_id": "XP_047292500.1",
"transcript_support_level": null,
"aa_start": null,
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"cds_start": -4,
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"cdna_start": null,
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"mane_select": null,
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"feature": null
},
{
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"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"3_prime_UTR_variant"
],
"exon_rank": 2,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": null,
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"gene_symbol": "LOC124903827",
"gene_hgnc_id": null,
"hgvs_c": "c.*100C>T",
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"transcript": "XM_047436547.1",
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},
{
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"strand": false,
"consequences": [
"3_prime_UTR_variant"
],
"exon_rank": 2,
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"exon_count": 5,
"intron_rank": null,
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"gene_symbol": "LOC124903827",
"gene_hgnc_id": null,
"hgvs_c": "c.*100C>T",
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"transcript": "XM_047436549.1",
"protein_id": "XP_047292505.1",
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},
{
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"strand": false,
"consequences": [
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],
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"intron_rank": null,
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"gene_symbol": "LOC124903827",
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"hgvs_c": "c.*100C>T",
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},
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],
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},
{
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],
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"gene_symbol": "LOC124903827",
"gene_hgnc_id": null,
"hgvs_c": "c.*100C>T",
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},
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],
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"gene_symbol": "LOC124903827",
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"hgvs_c": "c.*100C>T",
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},
{
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"strand": false,
"consequences": [
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],
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"intron_rank": null,
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"gene_symbol": "LOC124903827",
"gene_hgnc_id": null,
"hgvs_c": "c.*100C>T",
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"transcript": "XM_047436565.1",
"protein_id": "XP_047292521.1",
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},
{
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"strand": false,
"consequences": [
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],
"exon_rank": 2,
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"gene_symbol": "LOC124903827",
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"transcript": "XM_047436566.1",
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],
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},
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],
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},
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"consequences": [
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],
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"intron_rank": null,
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"gene_symbol": "LOC124903827",
"gene_hgnc_id": null,
"hgvs_c": "c.*100C>T",
"hgvs_p": null,
"transcript": "XM_047436574.1",
"protein_id": "XP_047292530.1",
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"feature": null
},
{
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"strand": false,
"consequences": [
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],
"exon_rank": 2,
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"gene_symbol": "LOC124903827",
"gene_hgnc_id": null,
"hgvs_c": "c.*100C>T",
"hgvs_p": null,
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"protein_id": "XP_047292534.1",
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"phenotype_combined": "not provided",
"pathogenicity_classification_combined": "Benign",
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}
],
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}