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GeneBe API Showcase

This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.

API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.

Documentation & Advanced Usage

Complete API documentation:docs.genebe.net/docs/api/overview/

Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/

Python client for pandas:pypi.org/project/genebe/

Java CLI for VCF files:github.com/pstawinski/genebe-cli

All tools documented at:docs.genebe.net

API Request Examples for Variant: 1-33092104-G-A (hg38)

Bash / cURL Example

bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=1&pos=33092104&ref=G&alt=A&genome=hg38&allGenes=true"

API Response

json
{
  "message": null,
  "variants": [
    {
      "acmg_by_gene": [
        {
          "benign_score": 2,
          "criteria": [
            "PM2",
            "BP4_Moderate"
          ],
          "effects": [
            "missense_variant"
          ],
          "gene_symbol": "AZIN2",
          "hgnc_id": 29957,
          "hgvs_c": "c.334G>A",
          "hgvs_p": "p.Ala112Thr",
          "inheritance_mode": "AR",
          "pathogenic_score": 2,
          "score": 0,
          "transcript": "NM_001301825.1",
          "verdict": "Uncertain_significance"
        }
      ],
      "acmg_classification": "Uncertain_significance",
      "acmg_criteria": "PM2,BP4_Moderate",
      "acmg_score": 0,
      "allele_count_reference_population": 82,
      "alphamissense_prediction": null,
      "alphamissense_score": 0.0735,
      "alt": "A",
      "apogee2_prediction": null,
      "apogee2_score": null,
      "bayesdelnoaf_prediction": "Benign",
      "bayesdelnoaf_score": -0.5,
      "chr": "1",
      "clinvar_classification": "Uncertain significance",
      "clinvar_disease": "not specified",
      "clinvar_review_status": "criteria provided, single submitter",
      "clinvar_submissions_summary": "US:1",
      "computational_prediction_selected": "Benign",
      "computational_score_selected": 0.23043331503868103,
      "computational_source_selected": "MetaRNN",
      "consequences": [
        {
          "aa_alt": "T",
          "aa_end": null,
          "aa_length": 460,
          "aa_ref": "A",
          "aa_start": 112,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 5240,
          "cdna_start": 881,
          "cds_end": null,
          "cds_length": 1383,
          "cds_start": 334,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 12,
          "exon_rank": 6,
          "exon_rank_end": null,
          "feature": "NM_052998.4",
          "gene_hgnc_id": 29957,
          "gene_symbol": "AZIN2",
          "hgvs_c": "c.334G>A",
          "hgvs_p": "p.Ala112Thr",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": "ENST00000294517.11",
          "protein_coding": true,
          "protein_id": "NP_443724.1",
          "strand": true,
          "transcript": "NM_052998.4",
          "transcript_support_level": null
        },
        {
          "aa_alt": "T",
          "aa_end": null,
          "aa_length": 460,
          "aa_ref": "A",
          "aa_start": 112,
          "biotype": "protein_coding",
          "canonical": true,
          "cdna_end": null,
          "cdna_length": 5240,
          "cdna_start": 881,
          "cds_end": null,
          "cds_length": 1383,
          "cds_start": 334,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 12,
          "exon_rank": 6,
          "exon_rank_end": null,
          "feature": "ENST00000294517.11",
          "gene_hgnc_id": 29957,
          "gene_symbol": "AZIN2",
          "hgvs_c": "c.334G>A",
          "hgvs_p": "p.Ala112Thr",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": "NM_052998.4",
          "protein_coding": true,
          "protein_id": "ENSP00000294517.6",
          "strand": true,
          "transcript": "ENST00000294517.11",
          "transcript_support_level": 1
        },
        {
          "aa_alt": "T",
          "aa_end": null,
          "aa_length": 480,
          "aa_ref": "A",
          "aa_start": 112,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 1443,
          "cdna_start": 334,
          "cds_end": null,
          "cds_length": 1443,
          "cds_start": 334,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 9,
          "exon_rank": 3,
          "exon_rank_end": null,
          "feature": "ENST00000373441.1",
          "gene_hgnc_id": 29957,
          "gene_symbol": "AZIN2",
          "hgvs_c": "c.334G>A",
          "hgvs_p": "p.Ala112Thr",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000362540.1",
          "strand": true,
          "transcript": "ENST00000373441.1",
          "transcript_support_level": 1
        },
        {
          "aa_alt": "T",
          "aa_end": null,
          "aa_length": 460,
          "aa_ref": "A",
          "aa_start": 112,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 2048,
          "cdna_start": 652,
          "cds_end": null,
          "cds_length": 1383,
          "cds_start": 334,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 11,
          "exon_rank": 5,
          "exon_rank_end": null,
          "feature": "ENST00000373443.7",
          "gene_hgnc_id": 29957,
          "gene_symbol": "AZIN2",
          "hgvs_c": "c.334G>A",
          "hgvs_p": "p.Ala112Thr",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000362542.3",
          "strand": true,
          "transcript": "ENST00000373443.7",
          "transcript_support_level": 1
        },
        {
          "aa_alt": null,
          "aa_end": null,
          "aa_length": null,
          "aa_ref": null,
          "aa_start": null,
          "biotype": "pseudogene",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 5848,
          "cdna_start": null,
          "cds_end": null,
          "cds_length": null,
          "cds_start": null,
          "consequences": [
            "non_coding_transcript_exon_variant"
          ],
          "exon_count": 7,
          "exon_rank": 2,
          "exon_rank_end": null,
          "feature": "ENST00000484656.5",
          "gene_hgnc_id": 29957,
          "gene_symbol": "AZIN2",
          "hgvs_c": "n.2524G>A",
          "hgvs_p": null,
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": false,
          "protein_id": null,
          "strand": true,
          "transcript": "ENST00000484656.5",
          "transcript_support_level": 1
        },
        {
          "aa_alt": "T",
          "aa_end": null,
          "aa_length": 480,
          "aa_ref": "A",
          "aa_start": 112,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 1864,
          "cdna_start": 406,
          "cds_end": null,
          "cds_length": 1443,
          "cds_start": 334,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 9,
          "exon_rank": 3,
          "exon_rank_end": null,
          "feature": "NM_001301825.1",
          "gene_hgnc_id": 29957,
          "gene_symbol": "AZIN2",
          "hgvs_c": "c.334G>A",
          "hgvs_p": "p.Ala112Thr",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "NP_001288754.1",
          "strand": true,
          "transcript": "NM_001301825.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "T",
          "aa_end": null,
          "aa_length": 460,
          "aa_ref": "A",
          "aa_start": 112,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 5025,
          "cdna_start": 666,
          "cds_end": null,
          "cds_length": 1383,
          "cds_start": 334,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 11,
          "exon_rank": 5,
          "exon_rank_end": null,
          "feature": "NM_001293562.2",
          "gene_hgnc_id": 29957,
          "gene_symbol": "AZIN2",
          "hgvs_c": "c.334G>A",
          "hgvs_p": "p.Ala112Thr",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "NP_001280491.1",
          "strand": true,
          "transcript": "NM_001293562.2",
          "transcript_support_level": null
        },
        {
          "aa_alt": "T",
          "aa_end": null,
          "aa_length": 460,
          "aa_ref": "A",
          "aa_start": 112,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 5028,
          "cdna_start": 669,
          "cds_end": null,
          "cds_length": 1383,
          "cds_start": 334,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 11,
          "exon_rank": 5,
          "exon_rank_end": null,
          "feature": "NM_001376722.1",
          "gene_hgnc_id": 29957,
          "gene_symbol": "AZIN2",
          "hgvs_c": "c.334G>A",
          "hgvs_p": "p.Ala112Thr",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "NP_001363651.1",
          "strand": true,
          "transcript": "NM_001376722.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "T",
          "aa_end": null,
          "aa_length": 460,
          "aa_ref": "A",
          "aa_start": 112,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 5121,
          "cdna_start": 762,
          "cds_end": null,
          "cds_length": 1383,
          "cds_start": 334,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 10,
          "exon_rank": 4,
          "exon_rank_end": null,
          "feature": "NM_001376724.1",
          "gene_hgnc_id": 29957,
          "gene_symbol": "AZIN2",
          "hgvs_c": "c.334G>A",
          "hgvs_p": "p.Ala112Thr",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "NP_001363653.1",
          "strand": true,
          "transcript": "NM_001376724.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "T",
          "aa_end": null,
          "aa_length": 460,
          "aa_ref": "A",
          "aa_start": 112,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 5052,
          "cdna_start": 694,
          "cds_end": null,
          "cds_length": 1383,
          "cds_start": 334,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 11,
          "exon_rank": 5,
          "exon_rank_end": null,
          "feature": "ENST00000910998.1",
          "gene_hgnc_id": 29957,
          "gene_symbol": "AZIN2",
          "hgvs_c": "c.334G>A",
          "hgvs_p": "p.Ala112Thr",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000581057.1",
          "strand": true,
          "transcript": "ENST00000910998.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "T",
          "aa_end": null,
          "aa_length": 460,
          "aa_ref": "A",
          "aa_start": 112,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 2430,
          "cdna_start": 1032,
          "cds_end": null,
          "cds_length": 1383,
          "cds_start": 334,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 10,
          "exon_rank": 4,
          "exon_rank_end": null,
          "feature": "ENST00000910999.1",
          "gene_hgnc_id": 29957,
          "gene_symbol": "AZIN2",
          "hgvs_c": "c.334G>A",
          "hgvs_p": "p.Ala112Thr",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000581058.1",
          "strand": true,
          "transcript": "ENST00000910999.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "T",
          "aa_end": null,
          "aa_length": 460,
          "aa_ref": "A",
          "aa_start": 112,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 2333,
          "cdna_start": 938,
          "cds_end": null,
          "cds_length": 1383,
          "cds_start": 334,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 11,
          "exon_rank": 5,
          "exon_rank_end": null,
          "feature": "ENST00000911000.1",
          "gene_hgnc_id": 29957,
          "gene_symbol": "AZIN2",
          "hgvs_c": "c.334G>A",
          "hgvs_p": "p.Ala112Thr",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000581059.1",
          "strand": true,
          "transcript": "ENST00000911000.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "T",
          "aa_end": null,
          "aa_length": 460,
          "aa_ref": "A",
          "aa_start": 112,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 2275,
          "cdna_start": 880,
          "cds_end": null,
          "cds_length": 1383,
          "cds_start": 334,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 12,
          "exon_rank": 6,
          "exon_rank_end": null,
          "feature": "ENST00000911001.1",
          "gene_hgnc_id": 29957,
          "gene_symbol": "AZIN2",
          "hgvs_c": "c.334G>A",
          "hgvs_p": "p.Ala112Thr",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000581060.1",
          "strand": true,
          "transcript": "ENST00000911001.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "T",
          "aa_end": null,
          "aa_length": 460,
          "aa_ref": "A",
          "aa_start": 112,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 2068,
          "cdna_start": 675,
          "cds_end": null,
          "cds_length": 1383,
          "cds_start": 334,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 11,
          "exon_rank": 5,
          "exon_rank_end": null,
          "feature": "ENST00000911003.1",
          "gene_hgnc_id": 29957,
          "gene_symbol": "AZIN2",
          "hgvs_c": "c.334G>A",
          "hgvs_p": "p.Ala112Thr",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000581062.1",
          "strand": true,
          "transcript": "ENST00000911003.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "T",
          "aa_end": null,
          "aa_length": 460,
          "aa_ref": "A",
          "aa_start": 112,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 2328,
          "cdna_start": 935,
          "cds_end": null,
          "cds_length": 1383,
          "cds_start": 334,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 11,
          "exon_rank": 5,
          "exon_rank_end": null,
          "feature": "ENST00000911005.1",
          "gene_hgnc_id": 29957,
          "gene_symbol": "AZIN2",
          "hgvs_c": "c.334G>A",
          "hgvs_p": "p.Ala112Thr",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000581064.1",
          "strand": true,
          "transcript": "ENST00000911005.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "T",
          "aa_end": null,
          "aa_length": 460,
          "aa_ref": "A",
          "aa_start": 112,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 2541,
          "cdna_start": 1146,
          "cds_end": null,
          "cds_length": 1383,
          "cds_start": 334,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 12,
          "exon_rank": 6,
          "exon_rank_end": null,
          "feature": "ENST00000911006.1",
          "gene_hgnc_id": 29957,
          "gene_symbol": "AZIN2",
          "hgvs_c": "c.334G>A",
          "hgvs_p": "p.Ala112Thr",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000581065.1",
          "strand": true,
          "transcript": "ENST00000911006.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "T",
          "aa_end": null,
          "aa_length": 460,
          "aa_ref": "A",
          "aa_start": 112,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 2726,
          "cdna_start": 1338,
          "cds_end": null,
          "cds_length": 1383,
          "cds_start": 334,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 10,
          "exon_rank": 4,
          "exon_rank_end": null,
          "feature": "ENST00000951909.1",
          "gene_hgnc_id": 29957,
          "gene_symbol": "AZIN2",
          "hgvs_c": "c.334G>A",
          "hgvs_p": "p.Ala112Thr",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000621968.1",
          "strand": true,
          "transcript": "ENST00000951909.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "T",
          "aa_end": null,
          "aa_length": 455,
          "aa_ref": "A",
          "aa_start": 112,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 2033,
          "cdna_start": 662,
          "cds_end": null,
          "cds_length": 1368,
          "cds_start": 334,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 11,
          "exon_rank": 5,
          "exon_rank_end": null,
          "feature": "ENST00000951910.1",
          "gene_hgnc_id": 29957,
          "gene_symbol": "AZIN2",
          "hgvs_c": "c.334G>A",
          "hgvs_p": "p.Ala112Thr",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000621969.1",
          "strand": true,
          "transcript": "ENST00000951910.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "T",
          "aa_end": null,
          "aa_length": 402,
          "aa_ref": "A",
          "aa_start": 54,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 4851,
          "cdna_start": 492,
          "cds_end": null,
          "cds_length": 1209,
          "cds_start": 160,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 10,
          "exon_rank": 4,
          "exon_rank_end": null,
          "feature": "NM_001376730.1",
          "gene_hgnc_id": 29957,
          "gene_symbol": "AZIN2",
          "hgvs_c": "c.160G>A",
          "hgvs_p": "p.Ala54Thr",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
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      "mitotip_prediction": null,
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      "pathogenicity_classification_combined": "Uncertain significance",
      "phenotype_combined": "not specified",
      "phylop100way_prediction": "Benign",
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    }
  ]
}
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