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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 1-45004118-G-A (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=1&pos=45004118&ref=G&alt=A&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "1",
"pos": 45004118,
"ref": "G",
"alt": "A",
"effect": "synonymous_variant",
"transcript": "NM_024602.6",
"consequences": [
{
"aa_ref": "F",
"aa_alt": "F",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 18,
"exon_rank_end": null,
"exon_count": 21,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "HECTD3",
"gene_hgnc_id": 26117,
"hgvs_c": "c.2289C>T",
"hgvs_p": "p.Phe763Phe",
"transcript": "NM_024602.6",
"protein_id": "NP_078878.3",
"transcript_support_level": null,
"aa_start": 763,
"aa_end": null,
"aa_length": 861,
"cds_start": 2289,
"cds_end": null,
"cds_length": 2586,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": "ENST00000372172.5",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_024602.6"
},
{
"aa_ref": "F",
"aa_alt": "F",
"canonical": true,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 18,
"exon_rank_end": null,
"exon_count": 21,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "HECTD3",
"gene_hgnc_id": 26117,
"hgvs_c": "c.2289C>T",
"hgvs_p": "p.Phe763Phe",
"transcript": "ENST00000372172.5",
"protein_id": "ENSP00000361245.4",
"transcript_support_level": 5,
"aa_start": 763,
"aa_end": null,
"aa_length": 861,
"cds_start": 2289,
"cds_end": null,
"cds_length": 2586,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": "NM_024602.6",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000372172.5"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": false,
"strand": false,
"consequences": [
"non_coding_transcript_exon_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 6,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "HECTD3",
"gene_hgnc_id": 26117,
"hgvs_c": "n.1136C>T",
"hgvs_p": null,
"transcript": "ENST00000486132.5",
"protein_id": null,
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": null,
"cds_start": null,
"cds_end": null,
"cds_length": null,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "pseudogene",
"feature": "ENST00000486132.5"
},
{
"aa_ref": "F",
"aa_alt": "F",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 18,
"exon_rank_end": null,
"exon_count": 21,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "HECTD3",
"gene_hgnc_id": 26117,
"hgvs_c": "c.2430C>T",
"hgvs_p": "p.Phe810Phe",
"transcript": "ENST00000875142.1",
"protein_id": "ENSP00000545201.1",
"transcript_support_level": null,
"aa_start": 810,
"aa_end": null,
"aa_length": 908,
"cds_start": 2430,
"cds_end": null,
"cds_length": 2727,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000875142.1"
},
{
"aa_ref": "F",
"aa_alt": "F",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 18,
"exon_rank_end": null,
"exon_count": 21,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "HECTD3",
"gene_hgnc_id": 26117,
"hgvs_c": "c.2370C>T",
"hgvs_p": "p.Phe790Phe",
"transcript": "ENST00000875144.1",
"protein_id": "ENSP00000545203.1",
"transcript_support_level": null,
"aa_start": 790,
"aa_end": null,
"aa_length": 888,
"cds_start": 2370,
"cds_end": null,
"cds_length": 2667,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000875144.1"
},
{
"aa_ref": "F",
"aa_alt": "F",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 18,
"exon_rank_end": null,
"exon_count": 21,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "HECTD3",
"gene_hgnc_id": 26117,
"hgvs_c": "c.2316C>T",
"hgvs_p": "p.Phe772Phe",
"transcript": "ENST00000875143.1",
"protein_id": "ENSP00000545202.1",
"transcript_support_level": null,
"aa_start": 772,
"aa_end": null,
"aa_length": 870,
"cds_start": 2316,
"cds_end": null,
"cds_length": 2613,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000875143.1"
},
{
"aa_ref": "F",
"aa_alt": "F",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 18,
"exon_rank_end": null,
"exon_count": 21,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "HECTD3",
"gene_hgnc_id": 26117,
"hgvs_c": "c.2289C>T",
"hgvs_p": "p.Phe763Phe",
"transcript": "ENST00000875134.1",
"protein_id": "ENSP00000545193.1",
"transcript_support_level": null,
"aa_start": 763,
"aa_end": null,
"aa_length": 869,
"cds_start": 2289,
"cds_end": null,
"cds_length": 2610,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000875134.1"
},
{
"aa_ref": "F",
"aa_alt": "F",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 18,
"exon_rank_end": null,
"exon_count": 21,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "HECTD3",
"gene_hgnc_id": 26117,
"hgvs_c": "c.2313C>T",
"hgvs_p": "p.Phe771Phe",
"transcript": "ENST00000875141.1",
"protein_id": "ENSP00000545200.1",
"transcript_support_level": null,
"aa_start": 771,
"aa_end": null,
"aa_length": 869,
"cds_start": 2313,
"cds_end": null,
"cds_length": 2610,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000875141.1"
},
{
"aa_ref": "F",
"aa_alt": "F",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 18,
"exon_rank_end": null,
"exon_count": 21,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "HECTD3",
"gene_hgnc_id": 26117,
"hgvs_c": "c.2307C>T",
"hgvs_p": "p.Phe769Phe",
"transcript": "ENST00000875139.1",
"protein_id": "ENSP00000545198.1",
"transcript_support_level": null,
"aa_start": 769,
"aa_end": null,
"aa_length": 867,
"cds_start": 2307,
"cds_end": null,
"cds_length": 2604,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000875139.1"
},
{
"aa_ref": "F",
"aa_alt": "F",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 18,
"exon_rank_end": null,
"exon_count": 21,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "HECTD3",
"gene_hgnc_id": 26117,
"hgvs_c": "c.2286C>T",
"hgvs_p": "p.Phe762Phe",
"transcript": "ENST00000875136.1",
"protein_id": "ENSP00000545195.1",
"transcript_support_level": null,
"aa_start": 762,
"aa_end": null,
"aa_length": 860,
"cds_start": 2286,
"cds_end": null,
"cds_length": 2583,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000875136.1"
},
{
"aa_ref": "F",
"aa_alt": "F",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 18,
"exon_rank_end": null,
"exon_count": 21,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "HECTD3",
"gene_hgnc_id": 26117,
"hgvs_c": "c.2283C>T",
"hgvs_p": "p.Phe761Phe",
"transcript": "ENST00000875137.1",
"protein_id": "ENSP00000545196.1",
"transcript_support_level": null,
"aa_start": 761,
"aa_end": null,
"aa_length": 859,
"cds_start": 2283,
"cds_end": null,
"cds_length": 2580,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000875137.1"
},
{
"aa_ref": "F",
"aa_alt": "F",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 18,
"exon_rank_end": null,
"exon_count": 21,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "HECTD3",
"gene_hgnc_id": 26117,
"hgvs_c": "c.2262C>T",
"hgvs_p": "p.Phe754Phe",
"transcript": "ENST00000875140.1",
"protein_id": "ENSP00000545199.1",
"transcript_support_level": null,
"aa_start": 754,
"aa_end": null,
"aa_length": 852,
"cds_start": 2262,
"cds_end": null,
"cds_length": 2559,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000875140.1"
},
{
"aa_ref": "F",
"aa_alt": "F",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 18,
"exon_rank_end": null,
"exon_count": 21,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "HECTD3",
"gene_hgnc_id": 26117,
"hgvs_c": "c.2262C>T",
"hgvs_p": "p.Phe754Phe",
"transcript": "ENST00000927793.1",
"protein_id": "ENSP00000597852.1",
"transcript_support_level": null,
"aa_start": 754,
"aa_end": null,
"aa_length": 852,
"cds_start": 2262,
"cds_end": null,
"cds_length": 2559,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000927793.1"
},
{
"aa_ref": "F",
"aa_alt": "F",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 18,
"exon_rank_end": null,
"exon_count": 21,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "HECTD3",
"gene_hgnc_id": 26117,
"hgvs_c": "c.2256C>T",
"hgvs_p": "p.Phe752Phe",
"transcript": "ENST00000875135.1",
"protein_id": "ENSP00000545194.1",
"transcript_support_level": null,
"aa_start": 752,
"aa_end": null,
"aa_length": 850,
"cds_start": 2256,
"cds_end": null,
"cds_length": 2553,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000875135.1"
},
{
"aa_ref": "F",
"aa_alt": "F",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 18,
"exon_rank_end": null,
"exon_count": 21,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "HECTD3",
"gene_hgnc_id": 26117,
"hgvs_c": "c.2256C>T",
"hgvs_p": "p.Phe752Phe",
"transcript": "ENST00000875145.1",
"protein_id": "ENSP00000545204.1",
"transcript_support_level": null,
"aa_start": 752,
"aa_end": null,
"aa_length": 850,
"cds_start": 2256,
"cds_end": null,
"cds_length": 2553,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000875145.1"
},
{
"aa_ref": "F",
"aa_alt": "F",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 17,
"exon_rank_end": null,
"exon_count": 20,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "HECTD3",
"gene_hgnc_id": 26117,
"hgvs_c": "c.2199C>T",
"hgvs_p": "p.Phe733Phe",
"transcript": "ENST00000875138.1",
"protein_id": "ENSP00000545197.1",
"transcript_support_level": null,
"aa_start": 733,
"aa_end": null,
"aa_length": 831,
"cds_start": 2199,
"cds_end": null,
"cds_length": 2496,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000875138.1"
},
{
"aa_ref": "F",
"aa_alt": "F",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 18,
"exon_rank_end": null,
"exon_count": 21,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "HECTD3",
"gene_hgnc_id": 26117,
"hgvs_c": "c.2190C>T",
"hgvs_p": "p.Phe730Phe",
"transcript": "ENST00000949667.1",
"protein_id": "ENSP00000619726.1",
"transcript_support_level": null,
"aa_start": 730,
"aa_end": null,
"aa_length": 828,
"cds_start": 2190,
"cds_end": null,
"cds_length": 2487,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000949667.1"
},
{
"aa_ref": "F",
"aa_alt": "F",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 17,
"exon_rank_end": null,
"exon_count": 20,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "HECTD3",
"gene_hgnc_id": 26117,
"hgvs_c": "c.2109C>T",
"hgvs_p": "p.Phe703Phe",
"transcript": "ENST00000949668.1",
"protein_id": "ENSP00000619727.1",
"transcript_support_level": null,
"aa_start": 703,
"aa_end": null,
"aa_length": 801,
"cds_start": 2109,
"cds_end": null,
"cds_length": 2406,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000949668.1"
},
{
"aa_ref": "F",
"aa_alt": "F",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 10,
"exon_rank_end": null,
"exon_count": 13,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "HECTD3",
"gene_hgnc_id": 26117,
"hgvs_c": "c.1119C>T",
"hgvs_p": "p.Phe373Phe",
"transcript": "ENST00000372168.7",
"protein_id": "ENSP00000361241.3",
"transcript_support_level": 2,
"aa_start": 373,
"aa_end": null,
"aa_length": 471,
"cds_start": 1119,
"cds_end": null,
"cds_length": 1416,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000372168.7"
},
{
"aa_ref": "F",
"aa_alt": "F",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 16,
"exon_rank_end": null,
"exon_count": 19,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "HECTD3",
"gene_hgnc_id": 26117,
"hgvs_c": "c.1437C>T",
"hgvs_p": "p.Phe479Phe",
"transcript": "XM_047430487.1",
"protein_id": "XP_047286443.1",
"transcript_support_level": null,
"aa_start": 479,
"aa_end": null,
"aa_length": 577,
"cds_start": 1437,
"cds_end": null,
"cds_length": 1734,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "XM_047430487.1"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": false,
"strand": false,
"consequences": [
"non_coding_transcript_exon_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 7,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "HECTD3",
"gene_hgnc_id": 26117,
"hgvs_c": "n.856C>T",
"hgvs_p": null,
"transcript": "ENST00000466423.5",
"protein_id": null,
"transcript_support_level": 3,
"aa_start": null,
"aa_end": null,
"aa_length": null,
"cds_start": null,
"cds_end": null,
"cds_length": null,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "pseudogene",
"feature": "ENST00000466423.5"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": false,
"strand": false,
"consequences": [
"non_coding_transcript_exon_variant"
],
"exon_rank": 5,
"exon_rank_end": null,
"exon_count": 6,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "HECTD3",
"gene_hgnc_id": 26117,
"hgvs_c": "n.672C>T",
"hgvs_p": null,
"transcript": "ENST00000486296.5",
"protein_id": null,
"transcript_support_level": 5,
"aa_start": null,
"aa_end": null,
"aa_length": null,
"cds_start": null,
"cds_end": null,
"cds_length": null,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
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"mane_plus": null,
"biotype": "pseudogene",
"feature": "ENST00000486296.5"
},
{
"aa_ref": null,
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"canonical": false,
"protein_coding": false,
"strand": true,
"consequences": [
"intron_variant"
],
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"exon_count": 7,
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"gene_symbol": "ENSG00000300507",
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"hgvs_c": "n.543+147G>A",
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"transcript": "ENST00000772448.1",
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"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": null,
"cds_start": null,
"cds_end": null,
"cds_length": null,
"cdna_start": null,
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"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "pseudogene",
"feature": "ENST00000772448.1"
}
],
"gene_symbol": "HECTD3",
"gene_hgnc_id": 26117,
"dbsnp": "rs758431351",
"frequency_reference_population": 0.000009913407,
"hom_count_reference_population": 0,
"allele_count_reference_population": 16,
"gnomad_exomes_af": 0.00000889306,
"gnomad_genomes_af": 0.0000197158,
"gnomad_exomes_ac": 13,
"gnomad_genomes_ac": 3,
"gnomad_exomes_homalt": 0,
"gnomad_genomes_homalt": 0,
"gnomad_mito_homoplasmic": null,
"gnomad_mito_heteroplasmic": null,
"computational_score_selected": -0.3700000047683716,
"computational_prediction_selected": "Benign",
"computational_source_selected": "BayesDel_noAF",
"splice_score_selected": 0,
"splice_prediction_selected": "Benign",
"splice_source_selected": "max_spliceai",
"revel_score": null,
"revel_prediction": null,
"alphamissense_score": null,
"alphamissense_prediction": null,
"bayesdelnoaf_score": -0.37,
"bayesdelnoaf_prediction": "Benign",
"phylop100way_score": -0.585,
"phylop100way_prediction": "Benign",
"spliceai_max_score": 0,
"spliceai_max_prediction": "Benign",
"dbscsnv_ada_score": null,
"dbscsnv_ada_prediction": null,
"apogee2_score": null,
"apogee2_prediction": null,
"mitotip_score": null,
"mitotip_prediction": null,
"acmg_score": -1,
"acmg_classification": "Likely_benign",
"acmg_criteria": "PM2,BP4_Moderate,BP7",
"acmg_by_gene": [
{
"score": -1,
"benign_score": 3,
"pathogenic_score": 2,
"criteria": [
"PM2",
"BP4_Moderate",
"BP7"
],
"verdict": "Likely_benign",
"transcript": "NM_024602.6",
"gene_symbol": "HECTD3",
"hgnc_id": 26117,
"effects": [
"synonymous_variant"
],
"inheritance_mode": "AR",
"hgvs_c": "c.2289C>T",
"hgvs_p": "p.Phe763Phe"
},
{
"score": 0,
"benign_score": 2,
"pathogenic_score": 2,
"criteria": [
"PM2",
"BP4_Moderate"
],
"verdict": "Uncertain_significance",
"transcript": "ENST00000772448.1",
"gene_symbol": "ENSG00000300507",
"hgnc_id": null,
"effects": [
"intron_variant"
],
"inheritance_mode": "",
"hgvs_c": "n.543+147G>A",
"hgvs_p": null
}
],
"clinvar_disease": "",
"clinvar_classification": "",
"clinvar_review_status": "",
"clinvar_submissions_summary": "",
"phenotype_combined": null,
"pathogenicity_classification_combined": null,
"custom_annotations": null
}
],
"message": null
}