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GeneBe API Showcase

This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.

API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.

Documentation & Advanced Usage

Complete API documentation:docs.genebe.net/docs/api/overview/

Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/

Python client for pandas:pypi.org/project/genebe/

Java CLI for VCF files:github.com/pstawinski/genebe-cli

All tools documented at:docs.genebe.net

API Request Examples for Variant: 1-46635893-T-C (hg38)

Bash / cURL Example

bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=1&pos=46635893&ref=T&alt=C&genome=hg38&allGenes=true"

API Response

json
{
  "variants": [
    {
      "chr": "1",
      "pos": 46635893,
      "ref": "T",
      "alt": "C",
      "effect": "synonymous_variant",
      "transcript": "NM_022745.6",
      "consequences": [
        {
          "aa_ref": "L",
          "aa_alt": "L",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "synonymous_variant"
          ],
          "exon_rank": 9,
          "exon_rank_end": null,
          "exon_count": 9,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "ATPAF1",
          "gene_hgnc_id": 18803,
          "hgvs_c": "c.870A>G",
          "hgvs_p": "p.Leu290Leu",
          "transcript": "NM_001394565.1",
          "protein_id": "NP_001381494.1",
          "transcript_support_level": null,
          "aa_start": 290,
          "aa_end": null,
          "aa_length": 328,
          "cds_start": 870,
          "cds_end": null,
          "cds_length": 987,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": "ENST00000574428.6",
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "NM_001394565.1"
        },
        {
          "aa_ref": "L",
          "aa_alt": "L",
          "canonical": true,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "synonymous_variant"
          ],
          "exon_rank": 9,
          "exon_rank_end": null,
          "exon_count": 9,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "ATPAF1",
          "gene_hgnc_id": 18803,
          "hgvs_c": "c.870A>G",
          "hgvs_p": "p.Leu290Leu",
          "transcript": "ENST00000574428.6",
          "protein_id": "ENSP00000459167.2",
          "transcript_support_level": 1,
          "aa_start": 290,
          "aa_end": null,
          "aa_length": 328,
          "cds_start": 870,
          "cds_end": null,
          "cds_length": 987,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": "NM_001394565.1",
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000574428.6"
        },
        {
          "aa_ref": "L",
          "aa_alt": "L",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "synonymous_variant"
          ],
          "exon_rank": 9,
          "exon_rank_end": null,
          "exon_count": 9,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "ATPAF1",
          "gene_hgnc_id": 18803,
          "hgvs_c": "c.939A>G",
          "hgvs_p": "p.Leu313Leu",
          "transcript": "ENST00000576409.5",
          "protein_id": "ENSP00000460964.1",
          "transcript_support_level": 1,
          "aa_start": 313,
          "aa_end": null,
          "aa_length": 351,
          "cds_start": 939,
          "cds_end": null,
          "cds_length": 1056,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000576409.5"
        },
        {
          "aa_ref": "L",
          "aa_alt": "L",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "synonymous_variant"
          ],
          "exon_rank": 9,
          "exon_rank_end": null,
          "exon_count": 9,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "ATPAF1",
          "gene_hgnc_id": 18803,
          "hgvs_c": "c.939A>G",
          "hgvs_p": "p.Leu313Leu",
          "transcript": "NM_022745.6",
          "protein_id": "NP_073582.3",
          "transcript_support_level": null,
          "aa_start": 313,
          "aa_end": null,
          "aa_length": 351,
          "cds_start": 939,
          "cds_end": null,
          "cds_length": 1056,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "NM_022745.6"
        },
        {
          "aa_ref": "L",
          "aa_alt": "L",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "synonymous_variant"
          ],
          "exon_rank": 9,
          "exon_rank_end": null,
          "exon_count": 9,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "ATPAF1",
          "gene_hgnc_id": 18803,
          "hgvs_c": "c.897A>G",
          "hgvs_p": "p.Leu299Leu",
          "transcript": "ENST00000870207.1",
          "protein_id": "ENSP00000540266.1",
          "transcript_support_level": null,
          "aa_start": 299,
          "aa_end": null,
          "aa_length": 337,
          "cds_start": 897,
          "cds_end": null,
          "cds_length": 1014,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000870207.1"
        },
        {
          "aa_ref": "L",
          "aa_alt": "L",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "synonymous_variant"
          ],
          "exon_rank": 9,
          "exon_rank_end": null,
          "exon_count": 9,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "ATPAF1",
          "gene_hgnc_id": 18803,
          "hgvs_c": "c.885A>G",
          "hgvs_p": "p.Leu295Leu",
          "transcript": "ENST00000923241.1",
          "protein_id": "ENSP00000593300.1",
          "transcript_support_level": null,
          "aa_start": 295,
          "aa_end": null,
          "aa_length": 333,
          "cds_start": 885,
          "cds_end": null,
          "cds_length": 1002,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000923241.1"
        },
        {
          "aa_ref": "L",
          "aa_alt": "L",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "synonymous_variant"
          ],
          "exon_rank": 9,
          "exon_rank_end": null,
          "exon_count": 9,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "ATPAF1",
          "gene_hgnc_id": 18803,
          "hgvs_c": "c.870A>G",
          "hgvs_p": "p.Leu290Leu",
          "transcript": "ENST00000870209.1",
          "protein_id": "ENSP00000540268.1",
          "transcript_support_level": null,
          "aa_start": 290,
          "aa_end": null,
          "aa_length": 328,
          "cds_start": 870,
          "cds_end": null,
          "cds_length": 987,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000870209.1"
        },
        {
          "aa_ref": "L",
          "aa_alt": "L",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "synonymous_variant"
          ],
          "exon_rank": 8,
          "exon_rank_end": null,
          "exon_count": 8,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "ATPAF1",
          "gene_hgnc_id": 18803,
          "hgvs_c": "c.807A>G",
          "hgvs_p": "p.Leu269Leu",
          "transcript": "ENST00000870203.1",
          "protein_id": "ENSP00000540262.1",
          "transcript_support_level": null,
          "aa_start": 269,
          "aa_end": null,
          "aa_length": 307,
          "cds_start": 807,
          "cds_end": null,
          "cds_length": 924,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000870203.1"
        },
        {
          "aa_ref": "L",
          "aa_alt": "L",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "synonymous_variant"
          ],
          "exon_rank": 8,
          "exon_rank_end": null,
          "exon_count": 8,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "ATPAF1",
          "gene_hgnc_id": 18803,
          "hgvs_c": "c.774A>G",
          "hgvs_p": "p.Leu258Leu",
          "transcript": "ENST00000923240.1",
          "protein_id": "ENSP00000593299.1",
          "transcript_support_level": null,
          "aa_start": 258,
          "aa_end": null,
          "aa_length": 296,
          "cds_start": 774,
          "cds_end": null,
          "cds_length": 891,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000923240.1"
        },
        {
          "aa_ref": "L",
          "aa_alt": "L",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "synonymous_variant"
          ],
          "exon_rank": 7,
          "exon_rank_end": null,
          "exon_count": 7,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "ATPAF1",
          "gene_hgnc_id": 18803,
          "hgvs_c": "c.771A>G",
          "hgvs_p": "p.Leu257Leu",
          "transcript": "ENST00000870206.1",
          "protein_id": "ENSP00000540265.1",
          "transcript_support_level": null,
          "aa_start": 257,
          "aa_end": null,
          "aa_length": 295,
          "cds_start": 771,
          "cds_end": null,
          "cds_length": 888,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000870206.1"
        },
        {
          "aa_ref": "L",
          "aa_alt": "L",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "synonymous_variant"
          ],
          "exon_rank": 8,
          "exon_rank_end": null,
          "exon_count": 8,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "ATPAF1",
          "gene_hgnc_id": 18803,
          "hgvs_c": "c.762A>G",
          "hgvs_p": "p.Leu254Leu",
          "transcript": "ENST00000870205.1",
          "protein_id": "ENSP00000540264.1",
          "transcript_support_level": null,
          "aa_start": 254,
          "aa_end": null,
          "aa_length": 292,
          "cds_start": 762,
          "cds_end": null,
          "cds_length": 879,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000870205.1"
        },
        {
          "aa_ref": "L",
          "aa_alt": "L",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "synonymous_variant"
          ],
          "exon_rank": 7,
          "exon_rank_end": null,
          "exon_count": 7,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "ATPAF1",
          "gene_hgnc_id": 18803,
          "hgvs_c": "c.756A>G",
          "hgvs_p": "p.Leu252Leu",
          "transcript": "ENST00000870208.1",
          "protein_id": "ENSP00000540267.1",
          "transcript_support_level": null,
          "aa_start": 252,
          "aa_end": null,
          "aa_length": 290,
          "cds_start": 756,
          "cds_end": null,
          "cds_length": 873,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000870208.1"
        },
        {
          "aa_ref": "L",
          "aa_alt": "L",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "synonymous_variant"
          ],
          "exon_rank": 7,
          "exon_rank_end": null,
          "exon_count": 7,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "ATPAF1",
          "gene_hgnc_id": 18803,
          "hgvs_c": "c.735A>G",
          "hgvs_p": "p.Leu245Leu",
          "transcript": "NM_001042546.2",
          "protein_id": "NP_001036011.2",
          "transcript_support_level": null,
          "aa_start": 245,
          "aa_end": null,
          "aa_length": 283,
          "cds_start": 735,
          "cds_end": null,
          "cds_length": 852,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "NM_001042546.2"
        },
        {
          "aa_ref": "L",
          "aa_alt": "L",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "synonymous_variant"
          ],
          "exon_rank": 7,
          "exon_rank_end": null,
          "exon_count": 7,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "ATPAF1",
          "gene_hgnc_id": 18803,
          "hgvs_c": "c.735A>G",
          "hgvs_p": "p.Leu245Leu",
          "transcript": "ENST00000329231.8",
          "protein_id": "ENSP00000330685.4",
          "transcript_support_level": 2,
          "aa_start": 245,
          "aa_end": null,
          "aa_length": 283,
          "cds_start": 735,
          "cds_end": null,
          "cds_length": 852,
          "cdna_start": null,
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          "mane_select": null,
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          "biotype": "protein_coding",
          "feature": "ENST00000329231.8"
        },
        {
          "aa_ref": "L",
          "aa_alt": "L",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "synonymous_variant"
          ],
          "exon_rank": 5,
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          "exon_count": 5,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "ATPAF1",
          "gene_hgnc_id": 18803,
          "hgvs_c": "c.657A>G",
          "hgvs_p": "p.Leu219Leu",
          "transcript": "ENST00000870204.1",
          "protein_id": "ENSP00000540263.1",
          "transcript_support_level": null,
          "aa_start": 219,
          "aa_end": null,
          "aa_length": 257,
          "cds_start": 657,
          "cds_end": null,
          "cds_length": 774,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000870204.1"
        },
        {
          "aa_ref": "L",
          "aa_alt": "L",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "synonymous_variant"
          ],
          "exon_rank": 6,
          "exon_rank_end": null,
          "exon_count": 6,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "ATPAF1",
          "gene_hgnc_id": 18803,
          "hgvs_c": "c.615A>G",
          "hgvs_p": "p.Leu205Leu",
          "transcript": "ENST00000870202.1",
          "protein_id": "ENSP00000540261.1",
          "transcript_support_level": null,
          "aa_start": 205,
          "aa_end": null,
          "aa_length": 243,
          "cds_start": 615,
          "cds_end": null,
          "cds_length": 732,
          "cdna_start": null,
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          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000870202.1"
        },
        {
          "aa_ref": "L",
          "aa_alt": "L",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "synonymous_variant"
          ],
          "exon_rank": 9,
          "exon_rank_end": null,
          "exon_count": 9,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "ATPAF1",
          "gene_hgnc_id": 18803,
          "hgvs_c": "c.606A>G",
          "hgvs_p": "p.Leu202Leu",
          "transcript": "NM_001243728.1",
          "protein_id": "NP_001230657.1",
          "transcript_support_level": null,
          "aa_start": 202,
          "aa_end": null,
          "aa_length": 240,
          "cds_start": 606,
          "cds_end": null,
          "cds_length": 723,
          "cdna_start": null,
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          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "NM_001243728.1"
        },
        {
          "aa_ref": "L",
          "aa_alt": "L",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "synonymous_variant"
          ],
          "exon_rank": 9,
          "exon_rank_end": null,
          "exon_count": 9,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "ATPAF1",
          "gene_hgnc_id": 18803,
          "hgvs_c": "c.606A>G",
          "hgvs_p": "p.Leu202Leu",
          "transcript": "ENST00000532925.5",
          "protein_id": "ENSP00000435732.1",
          "transcript_support_level": 2,
          "aa_start": 202,
          "aa_end": null,
          "aa_length": 240,
          "cds_start": 606,
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          "cds_length": 723,
          "cdna_start": null,
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          "cdna_length": null,
          "mane_select": null,
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          "biotype": "protein_coding",
          "feature": "ENST00000532925.5"
        },
        {
          "aa_ref": "L",
          "aa_alt": "L",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "synonymous_variant"
          ],
          "exon_rank": 5,
          "exon_rank_end": null,
          "exon_count": 5,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "ATPAF1",
          "gene_hgnc_id": 18803,
          "hgvs_c": "c.552A>G",
          "hgvs_p": "p.Leu184Leu",
          "transcript": "ENST00000870210.1",
          "protein_id": "ENSP00000540269.1",
          "transcript_support_level": null,
          "aa_start": 184,
          "aa_end": null,
          "aa_length": 222,
          "cds_start": 552,
          "cds_end": null,
          "cds_length": 669,
          "cdna_start": null,
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          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000870210.1"
        },
        {
          "aa_ref": "L",
          "aa_alt": "L",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "synonymous_variant"
          ],
          "exon_rank": 6,
          "exon_rank_end": null,
          "exon_count": 6,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "ATPAF1",
          "gene_hgnc_id": 18803,
          "hgvs_c": "c.432A>G",
          "hgvs_p": "p.Leu144Leu",
          "transcript": "ENST00000534216.5",
          "protein_id": "ENSP00000432771.1",
          "transcript_support_level": 5,
          "aa_start": 144,
          "aa_end": null,
          "aa_length": 182,
          "cds_start": 432,
          "cds_end": null,
          "cds_length": 549,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000534216.5"
        },
        {
          "aa_ref": "L",
          "aa_alt": "L",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "synonymous_variant"
          ],
          "exon_rank": 10,
          "exon_rank_end": null,
          "exon_count": 10,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "ATPAF1",
          "gene_hgnc_id": 18803,
          "hgvs_c": "c.417A>G",
          "hgvs_p": "p.Leu139Leu",
          "transcript": "NM_001256418.1",
          "protein_id": "NP_001243347.1",
          "transcript_support_level": null,
          "aa_start": 139,
          "aa_end": null,
          "aa_length": 177,
          "cds_start": 417,
          "cds_end": null,
          "cds_length": 534,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "NM_001256418.1"
        },
        {
          "aa_ref": "L",
          "aa_alt": "L",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "synonymous_variant"
          ],
          "exon_rank": 6,
          "exon_rank_end": null,
          "exon_count": 6,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "ATPAF1",
          "gene_hgnc_id": 18803,
          "hgvs_c": "c.408A>G",
          "hgvs_p": "p.Leu136Leu",
          "transcript": "ENST00000526821.5",
          "protein_id": "ENSP00000436690.1",
          "transcript_support_level": 3,
          "aa_start": 136,
          "aa_end": null,
          "aa_length": 174,
          "cds_start": 408,
          "cds_end": null,
          "cds_length": 525,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000526821.5"
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "splice_region_variant",
            "intron_variant"
          ],
          "exon_rank": null,
          "exon_rank_end": null,
          "exon_count": 4,
          "intron_rank": 3,
          "intron_rank_end": null,
          "gene_symbol": "ATPAF1",
          "gene_hgnc_id": 18803,
          "hgvs_c": "c.278+4A>G",
          "hgvs_p": null,
          "transcript": "ENST00000492233.5",
          "protein_id": "ENSP00000431258.1",
          "transcript_support_level": 3,
          "aa_start": null,
          "aa_end": null,
          "aa_length": 113,
          "cds_start": null,
          "cds_end": null,
          "cds_length": 342,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000492233.5"
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": false,
          "strand": false,
          "consequences": [
            "non_coding_transcript_exon_variant"
          ],
          "exon_rank": 10,
          "exon_rank_end": null,
          "exon_count": 10,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "ATPAF1",
          "gene_hgnc_id": 18803,
          "hgvs_c": "n.*559A>G",
          "hgvs_p": null,
          "transcript": "ENST00000529214.5",
          "protein_id": "ENSP00000436267.1",
          "transcript_support_level": 2,
          "aa_start": null,
          "aa_end": null,
          "aa_length": null,
          "cds_start": null,
          "cds_end": null,
          "cds_length": null,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "nonsense_mediated_decay",
          "feature": "ENST00000529214.5"
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": false,
          "strand": false,
          "consequences": [
            "3_prime_UTR_variant"
          ],
          "exon_rank": 10,
          "exon_rank_end": null,
          "exon_count": 10,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "ATPAF1",
          "gene_hgnc_id": 18803,
          "hgvs_c": "n.*559A>G",
          "hgvs_p": null,
          "transcript": "ENST00000529214.5",
          "protein_id": "ENSP00000436267.1",
          "transcript_support_level": 2,
          "aa_start": null,
          "aa_end": null,
          "aa_length": null,
          "cds_start": null,
          "cds_end": null,
          "cds_length": null,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "nonsense_mediated_decay",
          "feature": "ENST00000529214.5"
        }
      ],
      "gene_symbol": "ATPAF1",
      "gene_hgnc_id": 18803,
      "dbsnp": "rs41298535",
      "frequency_reference_population": 0.000109027205,
      "hom_count_reference_population": 0,
      "allele_count_reference_population": 176,
      "gnomad_exomes_af": 0.000110132,
      "gnomad_genomes_af": 0.0000984317,
      "gnomad_exomes_ac": 161,
      "gnomad_genomes_ac": 15,
      "gnomad_exomes_homalt": 0,
      "gnomad_genomes_homalt": 0,
      "gnomad_mito_homoplasmic": null,
      "gnomad_mito_heteroplasmic": null,
      "computational_score_selected": -0.46000000834465027,
      "computational_prediction_selected": "Benign",
      "computational_source_selected": "BayesDel_noAF",
      "splice_score_selected": 0,
      "splice_prediction_selected": "Benign",
      "splice_source_selected": "max_spliceai",
      "revel_score": null,
      "revel_prediction": null,
      "alphamissense_score": null,
      "alphamissense_prediction": null,
      "bayesdelnoaf_score": -0.46,
      "bayesdelnoaf_prediction": "Benign",
      "phylop100way_score": 1.439,
      "phylop100way_prediction": "Benign",
      "spliceai_max_score": 0,
      "spliceai_max_prediction": "Benign",
      "dbscsnv_ada_score": null,
      "dbscsnv_ada_prediction": null,
      "apogee2_score": null,
      "apogee2_prediction": null,
      "mitotip_score": null,
      "mitotip_prediction": null,
      "acmg_score": -5,
      "acmg_classification": "Likely_benign",
      "acmg_criteria": "BP4_Moderate,BP6_Moderate,BP7",
      "acmg_by_gene": [
        {
          "score": -5,
          "benign_score": 5,
          "pathogenic_score": 0,
          "criteria": [
            "BP4_Moderate",
            "BP6_Moderate",
            "BP7"
          ],
          "verdict": "Likely_benign",
          "transcript": "NM_022745.6",
          "gene_symbol": "ATPAF1",
          "hgnc_id": 18803,
          "effects": [
            "synonymous_variant"
          ],
          "inheritance_mode": "AR",
          "hgvs_c": "c.939A>G",
          "hgvs_p": "p.Leu313Leu"
        }
      ],
      "clinvar_disease": "not provided",
      "clinvar_classification": "Likely benign",
      "clinvar_review_status": "criteria provided, single submitter",
      "clinvar_submissions_summary": "LB:1",
      "phenotype_combined": "not provided",
      "pathogenicity_classification_combined": "Likely benign",
      "custom_annotations": null
    }
  ],
  "message": null
}