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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 1-46933071-G-T (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=1&pos=46933071&ref=G&alt=T&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "1",
"pos": 46933071,
"ref": "G",
"alt": "T",
"effect": "intron_variant",
"transcript": "NM_000778.4",
"consequences": [
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 12,
"intron_rank": 9,
"intron_rank_end": null,
"gene_symbol": "CYP4A11",
"gene_hgnc_id": 2642,
"hgvs_c": "c.1223-24C>A",
"hgvs_p": null,
"transcript": "NM_000778.4",
"protein_id": "NP_000769.2",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 519,
"cds_start": null,
"cds_end": null,
"cds_length": 1560,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": "ENST00000310638.9",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_000778.4"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": true,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 12,
"intron_rank": 9,
"intron_rank_end": null,
"gene_symbol": "CYP4A11",
"gene_hgnc_id": 2642,
"hgvs_c": "c.1223-24C>A",
"hgvs_p": null,
"transcript": "ENST00000310638.9",
"protein_id": "ENSP00000311095.4",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": 519,
"cds_start": null,
"cds_end": null,
"cds_length": 1560,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": "NM_000778.4",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000310638.9"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": 9,
"intron_rank_end": null,
"gene_symbol": "CYP4A11",
"gene_hgnc_id": 2642,
"hgvs_c": "c.1223-24C>A",
"hgvs_p": null,
"transcript": "ENST00000371905.1",
"protein_id": "ENSP00000360972.1",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": 455,
"cds_start": null,
"cds_end": null,
"cds_length": 1368,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000371905.1"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": true,
"protein_coding": false,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": 6,
"intron_rank_end": null,
"gene_symbol": "CYP4A11",
"gene_hgnc_id": 2642,
"hgvs_c": "n.*21-24C>A",
"hgvs_p": null,
"transcript": "ENST00000465874.5",
"protein_id": "ENSP00000476368.1",
"transcript_support_level": 2,
"aa_start": null,
"aa_end": null,
"aa_length": null,
"cds_start": null,
"cds_end": null,
"cds_length": null,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "nonsense_mediated_decay",
"feature": "ENST00000465874.5"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 12,
"intron_rank": 9,
"intron_rank_end": null,
"gene_symbol": "CYP4A11",
"gene_hgnc_id": 2642,
"hgvs_c": "c.1334-24C>A",
"hgvs_p": null,
"transcript": "ENST00000909039.1",
"protein_id": "ENSP00000579098.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 556,
"cds_start": null,
"cds_end": null,
"cds_length": 1671,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000909039.1"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 12,
"intron_rank": 9,
"intron_rank_end": null,
"gene_symbol": "CYP4A11",
"gene_hgnc_id": 2642,
"hgvs_c": "c.1247-24C>A",
"hgvs_p": null,
"transcript": "ENST00000909036.1",
"protein_id": "ENSP00000579095.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 527,
"cds_start": null,
"cds_end": null,
"cds_length": 1584,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000909036.1"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 12,
"intron_rank": 9,
"intron_rank_end": null,
"gene_symbol": "CYP4A11",
"gene_hgnc_id": 2642,
"hgvs_c": "c.1241-24C>A",
"hgvs_p": null,
"transcript": "ENST00000909031.1",
"protein_id": "ENSP00000579090.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 525,
"cds_start": null,
"cds_end": null,
"cds_length": 1578,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000909031.1"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 12,
"intron_rank": 9,
"intron_rank_end": null,
"gene_symbol": "CYP4A11",
"gene_hgnc_id": 2642,
"hgvs_c": "c.1214-24C>A",
"hgvs_p": null,
"transcript": "ENST00000909028.1",
"protein_id": "ENSP00000579087.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 516,
"cds_start": null,
"cds_end": null,
"cds_length": 1551,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000909028.1"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 12,
"intron_rank": 9,
"intron_rank_end": null,
"gene_symbol": "CYP4A11",
"gene_hgnc_id": 2642,
"hgvs_c": "c.1205-24C>A",
"hgvs_p": null,
"transcript": "ENST00000909041.1",
"protein_id": "ENSP00000579100.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 513,
"cds_start": null,
"cds_end": null,
"cds_length": 1542,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000909041.1"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 12,
"intron_rank": 9,
"intron_rank_end": null,
"gene_symbol": "CYP4A11",
"gene_hgnc_id": 2642,
"hgvs_c": "c.1193-24C>A",
"hgvs_p": null,
"transcript": "ENST00000909056.1",
"protein_id": "ENSP00000579115.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 509,
"cds_start": null,
"cds_end": null,
"cds_length": 1530,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000909056.1"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": 8,
"intron_rank_end": null,
"gene_symbol": "CYP4A11",
"gene_hgnc_id": 2642,
"hgvs_c": "c.1178-24C>A",
"hgvs_p": null,
"transcript": "ENST00000909035.1",
"protein_id": "ENSP00000579094.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 504,
"cds_start": null,
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"cds_length": 1515,
"cdna_start": null,
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"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000909035.1"
},
{
"aa_ref": null,
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"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 12,
"intron_rank": 9,
"intron_rank_end": null,
"gene_symbol": "CYP4A11",
"gene_hgnc_id": 2642,
"hgvs_c": "c.1172-24C>A",
"hgvs_p": null,
"transcript": "ENST00000909045.1",
"protein_id": "ENSP00000579104.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 502,
"cds_start": null,
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"cds_length": 1509,
"cdna_start": null,
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"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000909045.1"
},
{
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"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 12,
"intron_rank": 9,
"intron_rank_end": null,
"gene_symbol": "CYP4A11",
"gene_hgnc_id": 2642,
"hgvs_c": "c.1160-24C>A",
"hgvs_p": null,
"transcript": "ENST00000909022.1",
"protein_id": "ENSP00000579081.1",
"transcript_support_level": null,
"aa_start": null,
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"aa_length": 498,
"cds_start": null,
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"cds_length": 1497,
"cdna_start": null,
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"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000909022.1"
},
{
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"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
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"exon_count": 12,
"intron_rank": 9,
"intron_rank_end": null,
"gene_symbol": "CYP4A11",
"gene_hgnc_id": 2642,
"hgvs_c": "c.1157-24C>A",
"hgvs_p": null,
"transcript": "ENST00000909027.1",
"protein_id": "ENSP00000579086.1",
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"cds_start": null,
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"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000909027.1"
},
{
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"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 12,
"intron_rank": 9,
"intron_rank_end": null,
"gene_symbol": "CYP4A11",
"gene_hgnc_id": 2642,
"hgvs_c": "c.1145-24C>A",
"hgvs_p": null,
"transcript": "ENST00000909058.1",
"protein_id": "ENSP00000579117.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 493,
"cds_start": null,
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"cds_length": 1482,
"cdna_start": null,
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"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000909058.1"
},
{
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"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
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"exon_count": 12,
"intron_rank": 9,
"intron_rank_end": null,
"gene_symbol": "CYP4A11",
"gene_hgnc_id": 2642,
"hgvs_c": "c.1127-24C>A",
"hgvs_p": null,
"transcript": "NM_001319155.2",
"protein_id": "NP_001306084.1",
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"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001319155.2"
},
{
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"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
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"exon_count": 12,
"intron_rank": 9,
"intron_rank_end": null,
"gene_symbol": "CYP4A11",
"gene_hgnc_id": 2642,
"hgvs_c": "c.1127-24C>A",
"hgvs_p": null,
"transcript": "ENST00000909023.1",
"protein_id": "ENSP00000579082.1",
"transcript_support_level": null,
"aa_start": null,
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"aa_length": 487,
"cds_start": null,
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"cdna_start": null,
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"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000909023.1"
},
{
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"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 12,
"intron_rank": 9,
"intron_rank_end": null,
"gene_symbol": "CYP4A11",
"gene_hgnc_id": 2642,
"hgvs_c": "c.1118-24C>A",
"hgvs_p": null,
"transcript": "ENST00000909057.1",
"protein_id": "ENSP00000579116.1",
"transcript_support_level": null,
"aa_start": null,
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"biotype": "protein_coding",
"feature": "ENST00000909057.1"
},
{
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"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
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"exon_count": 12,
"intron_rank": 9,
"intron_rank_end": null,
"gene_symbol": "CYP4A11",
"gene_hgnc_id": 2642,
"hgvs_c": "c.1094-24C>A",
"hgvs_p": null,
"transcript": "ENST00000909050.1",
"protein_id": "ENSP00000579109.1",
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},
{
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"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
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"intron_rank": 8,
"intron_rank_end": null,
"gene_symbol": "CYP4A11",
"gene_hgnc_id": 2642,
"hgvs_c": "c.1088-24C>A",
"hgvs_p": null,
"transcript": "ENST00000909046.1",
"protein_id": "ENSP00000579105.1",
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"biotype": "protein_coding",
"feature": "ENST00000909046.1"
},
{
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"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
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"intron_rank": 8,
"intron_rank_end": null,
"gene_symbol": "CYP4A11",
"gene_hgnc_id": 2642,
"hgvs_c": "c.1076-24C>A",
"hgvs_p": null,
"transcript": "ENST00000909037.1",
"protein_id": "ENSP00000579096.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
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"cds_start": null,
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"cdna_start": null,
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"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000909037.1"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": 8,
"intron_rank_end": null,
"gene_symbol": "CYP4A11",
"gene_hgnc_id": 2642,
"hgvs_c": "c.1043-24C>A",
"hgvs_p": null,
"transcript": "ENST00000909049.1",
"protein_id": "ENSP00000579108.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 459,
"cds_start": null,
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"cds_length": 1380,
"cdna_start": null,
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"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000909049.1"
},
{
"aa_ref": null,
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"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
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}