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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 1-51769069-T-A (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=1&pos=51769069&ref=T&alt=A&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "1",
"pos": 51769069,
"ref": "T",
"alt": "A",
"effect": "intron_variant",
"transcript": "ENST00000428468.6",
"consequences": [
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 24,
"intron_rank": 12,
"intron_rank_end": null,
"gene_symbol": "OSBPL9",
"gene_hgnc_id": 16386,
"hgvs_c": "c.939-3001T>A",
"hgvs_p": null,
"transcript": "NM_024586.6",
"protein_id": "NP_078862.4",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 736,
"cds_start": -4,
"cds_end": null,
"cds_length": 2211,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 3660,
"mane_select": "ENST00000428468.6",
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": true,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 24,
"intron_rank": 12,
"intron_rank_end": null,
"gene_symbol": "OSBPL9",
"gene_hgnc_id": 16386,
"hgvs_c": "c.939-3001T>A",
"hgvs_p": null,
"transcript": "ENST00000428468.6",
"protein_id": "ENSP00000407168.1",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": 736,
"cds_start": -4,
"cds_end": null,
"cds_length": 2211,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 3660,
"mane_select": "NM_024586.6",
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 23,
"intron_rank": 11,
"intron_rank_end": null,
"gene_symbol": "OSBPL9",
"gene_hgnc_id": 16386,
"hgvs_c": "c.888-3001T>A",
"hgvs_p": null,
"transcript": "ENST00000453295.5",
"protein_id": "ENSP00000413263.1",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": 719,
"cds_start": -4,
"cds_end": null,
"cds_length": 2160,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 2842,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 20,
"intron_rank": 8,
"intron_rank_end": null,
"gene_symbol": "OSBPL9",
"gene_hgnc_id": 16386,
"hgvs_c": "c.609-3001T>A",
"hgvs_p": null,
"transcript": "ENST00000361556.9",
"protein_id": "ENSP00000354970.5",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": 626,
"cds_start": -4,
"cds_end": null,
"cds_length": 1881,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 2721,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 20,
"intron_rank": 8,
"intron_rank_end": null,
"gene_symbol": "OSBPL9",
"gene_hgnc_id": 16386,
"hgvs_c": "c.405-3001T>A",
"hgvs_p": null,
"transcript": "ENST00000462759.5",
"protein_id": "ENSP00000433279.1",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": 558,
"cds_start": -4,
"cds_end": null,
"cds_length": 1677,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 2755,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 26,
"intron_rank": 14,
"intron_rank_end": null,
"gene_symbol": "OSBPL9",
"gene_hgnc_id": 16386,
"hgvs_c": "c.993-3001T>A",
"hgvs_p": null,
"transcript": "NM_001416292.1",
"protein_id": "NP_001403221.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 754,
"cds_start": -4,
"cds_end": null,
"cds_length": 2265,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 3372,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 27,
"intron_rank": 15,
"intron_rank_end": null,
"gene_symbol": "OSBPL9",
"gene_hgnc_id": 16386,
"hgvs_c": "c.993-3001T>A",
"hgvs_p": null,
"transcript": "NM_001416293.1",
"protein_id": "NP_001403222.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 754,
"cds_start": -4,
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"cds_length": 2265,
"cdna_start": null,
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"cdna_length": 3514,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 28,
"intron_rank": 16,
"intron_rank_end": null,
"gene_symbol": "OSBPL9",
"gene_hgnc_id": 16386,
"hgvs_c": "c.993-3001T>A",
"hgvs_p": null,
"transcript": "NM_001416294.1",
"protein_id": "NP_001403223.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 754,
"cds_start": -4,
"cds_end": null,
"cds_length": 2265,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 3629,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 24,
"intron_rank": 12,
"intron_rank_end": null,
"gene_symbol": "OSBPL9",
"gene_hgnc_id": 16386,
"hgvs_c": "c.969-3001T>A",
"hgvs_p": null,
"transcript": "NM_148909.4",
"protein_id": "NP_683707.3",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 746,
"cds_start": -4,
"cds_end": null,
"cds_length": 2241,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 3690,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
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"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
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"exon_count": 24,
"intron_rank": 12,
"intron_rank_end": null,
"gene_symbol": "OSBPL9",
"gene_hgnc_id": 16386,
"hgvs_c": "c.969-3001T>A",
"hgvs_p": null,
"transcript": "ENST00000447887.5",
"protein_id": "ENSP00000412733.1",
"transcript_support_level": 2,
"aa_start": null,
"aa_end": null,
"aa_length": 746,
"cds_start": -4,
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"cdna_start": null,
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"mane_select": null,
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"biotype": null,
"feature": null
},
{
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"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
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"exon_count": 25,
"intron_rank": 13,
"intron_rank_end": null,
"gene_symbol": "OSBPL9",
"gene_hgnc_id": 16386,
"hgvs_c": "c.954-3001T>A",
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"transcript": "NM_001416295.1",
"protein_id": "NP_001403224.1",
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},
{
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"consequences": [
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],
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"gene_symbol": "OSBPL9",
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"hgvs_c": "c.900-3001T>A",
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"transcript": "NM_148908.4",
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},
{
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],
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"gene_symbol": "OSBPL9",
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"hgvs_c": "c.900-3001T>A",
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"transcript": "ENST00000371714.5",
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},
{
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],
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"gene_symbol": "OSBPL9",
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"hgvs_c": "c.888-3001T>A",
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},
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],
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"transcript": "NM_148907.3",
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},
{
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"consequences": [
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],
"exon_rank": null,
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"gene_symbol": "OSBPL9",
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"hgvs_c": "c.444-3001T>A",
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},
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],
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"gene_symbol": "OSBPL9",
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"hgvs_c": "c.444-3001T>A",
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"transcript": "ENST00000531828.5",
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},
{
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],
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"gene_symbol": "OSBPL9",
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"hgvs_c": "c.405-3001T>A",
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"transcript": "NM_148904.4",
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},
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],
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"gene_symbol": "OSBPL9",
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"hgvs_c": "c.405-3001T>A",
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],
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"gene_symbol": "OSBPL9",
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],
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},
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"consequences": [
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],
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"intron_rank": 12,
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"gene_symbol": "OSBPL9",
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"hgvs_c": "c.381-3001T>A",
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"transcript": "NM_001350209.2",
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},
{
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"strand": true,
"consequences": [
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],
"exon_rank": null,
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"intron_rank": 10,
"intron_rank_end": null,
"gene_symbol": "OSBPL9",
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"hgvs_c": "c.294-3001T>A",
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}