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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 1-59378777-C-G (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=1&pos=59378777&ref=C&alt=G&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "1",
"pos": 59378777,
"ref": "C",
"alt": "G",
"effect": "missense_variant",
"transcript": "NM_001113411.2",
"consequences": [
{
"aa_ref": "A",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 5,
"exon_rank_end": null,
"exon_count": 16,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "FGGY",
"gene_hgnc_id": 25610,
"hgvs_c": "c.494C>G",
"hgvs_p": "p.Ala165Gly",
"transcript": "NM_018291.5",
"protein_id": "NP_060761.3",
"transcript_support_level": null,
"aa_start": 165,
"aa_end": null,
"aa_length": 551,
"cds_start": 494,
"cds_end": null,
"cds_length": 1656,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": "ENST00000303721.12",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_018291.5"
},
{
"aa_ref": "A",
"aa_alt": "G",
"canonical": true,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 5,
"exon_rank_end": null,
"exon_count": 16,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "FGGY",
"gene_hgnc_id": 25610,
"hgvs_c": "c.494C>G",
"hgvs_p": "p.Ala165Gly",
"transcript": "ENST00000303721.12",
"protein_id": "ENSP00000305922.8",
"transcript_support_level": 1,
"aa_start": 165,
"aa_end": null,
"aa_length": 551,
"cds_start": 494,
"cds_end": null,
"cds_length": 1656,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": "NM_018291.5",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000303721.12"
},
{
"aa_ref": "A",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 5,
"exon_rank_end": null,
"exon_count": 17,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "FGGY",
"gene_hgnc_id": 25610,
"hgvs_c": "c.494C>G",
"hgvs_p": "p.Ala165Gly",
"transcript": "ENST00000371218.8",
"protein_id": "ENSP00000360262.4",
"transcript_support_level": 1,
"aa_start": 165,
"aa_end": null,
"aa_length": 575,
"cds_start": 494,
"cds_end": null,
"cds_length": 1728,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000371218.8"
},
{
"aa_ref": "A",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 5,
"exon_rank_end": null,
"exon_count": 17,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "FGGY",
"gene_hgnc_id": 25610,
"hgvs_c": "c.494C>G",
"hgvs_p": "p.Ala165Gly",
"transcript": "NM_001113411.2",
"protein_id": "NP_001106882.1",
"transcript_support_level": null,
"aa_start": 165,
"aa_end": null,
"aa_length": 575,
"cds_start": 494,
"cds_end": null,
"cds_length": 1728,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001113411.2"
},
{
"aa_ref": "A",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 5,
"exon_rank_end": null,
"exon_count": 17,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "FGGY",
"gene_hgnc_id": 25610,
"hgvs_c": "c.494C>G",
"hgvs_p": "p.Ala165Gly",
"transcript": "NM_001350790.2",
"protein_id": "NP_001337719.1",
"transcript_support_level": null,
"aa_start": 165,
"aa_end": null,
"aa_length": 575,
"cds_start": 494,
"cds_end": null,
"cds_length": 1728,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001350790.2"
},
{
"aa_ref": "A",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 5,
"exon_rank_end": null,
"exon_count": 17,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "FGGY",
"gene_hgnc_id": 25610,
"hgvs_c": "c.494C>G",
"hgvs_p": "p.Ala165Gly",
"transcript": "ENST00000894285.1",
"protein_id": "ENSP00000564344.1",
"transcript_support_level": null,
"aa_start": 165,
"aa_end": null,
"aa_length": 575,
"cds_start": 494,
"cds_end": null,
"cds_length": 1728,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000894285.1"
},
{
"aa_ref": "A",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 5,
"exon_rank_end": null,
"exon_count": 17,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "FGGY",
"gene_hgnc_id": 25610,
"hgvs_c": "c.494C>G",
"hgvs_p": "p.Ala165Gly",
"transcript": "ENST00000894287.1",
"protein_id": "ENSP00000564346.1",
"transcript_support_level": null,
"aa_start": 165,
"aa_end": null,
"aa_length": 575,
"cds_start": 494,
"cds_end": null,
"cds_length": 1728,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000894287.1"
},
{
"aa_ref": "A",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 5,
"exon_rank_end": null,
"exon_count": 17,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "FGGY",
"gene_hgnc_id": 25610,
"hgvs_c": "c.494C>G",
"hgvs_p": "p.Ala165Gly",
"transcript": "ENST00000894293.1",
"protein_id": "ENSP00000564352.1",
"transcript_support_level": null,
"aa_start": 165,
"aa_end": null,
"aa_length": 575,
"cds_start": 494,
"cds_end": null,
"cds_length": 1728,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000894293.1"
},
{
"aa_ref": "A",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 5,
"exon_rank_end": null,
"exon_count": 16,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "FGGY",
"gene_hgnc_id": 25610,
"hgvs_c": "c.494C>G",
"hgvs_p": "p.Ala165Gly",
"transcript": "ENST00000941452.1",
"protein_id": "ENSP00000611511.1",
"transcript_support_level": null,
"aa_start": 165,
"aa_end": null,
"aa_length": 558,
"cds_start": 494,
"cds_end": null,
"cds_length": 1677,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000941452.1"
},
{
"aa_ref": "A",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 5,
"exon_rank_end": null,
"exon_count": 16,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "FGGY",
"gene_hgnc_id": 25610,
"hgvs_c": "c.494C>G",
"hgvs_p": "p.Ala165Gly",
"transcript": "NM_001350791.2",
"protein_id": "NP_001337720.1",
"transcript_support_level": null,
"aa_start": 165,
"aa_end": null,
"aa_length": 551,
"cds_start": 494,
"cds_end": null,
"cds_length": 1656,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001350791.2"
},
{
"aa_ref": "A",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 17,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "FGGY",
"gene_hgnc_id": 25610,
"hgvs_c": "c.494C>G",
"hgvs_p": "p.Ala165Gly",
"transcript": "ENST00000894270.1",
"protein_id": "ENSP00000564329.1",
"transcript_support_level": null,
"aa_start": 165,
"aa_end": null,
"aa_length": 551,
"cds_start": 494,
"cds_end": null,
"cds_length": 1656,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000894270.1"
},
{
"aa_ref": "A",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 17,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "FGGY",
"gene_hgnc_id": 25610,
"hgvs_c": "c.494C>G",
"hgvs_p": "p.Ala165Gly",
"transcript": "ENST00000894271.1",
"protein_id": "ENSP00000564330.1",
"transcript_support_level": null,
"aa_start": 165,
"aa_end": null,
"aa_length": 551,
"cds_start": 494,
"cds_end": null,
"cds_length": 1656,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000894271.1"
},
{
"aa_ref": "A",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 17,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "FGGY",
"gene_hgnc_id": 25610,
"hgvs_c": "c.494C>G",
"hgvs_p": "p.Ala165Gly",
"transcript": "ENST00000894272.1",
"protein_id": "ENSP00000564331.1",
"transcript_support_level": null,
"aa_start": 165,
"aa_end": null,
"aa_length": 551,
"cds_start": 494,
"cds_end": null,
"cds_length": 1656,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000894272.1"
},
{
"aa_ref": "A",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 5,
"exon_rank_end": null,
"exon_count": 16,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "FGGY",
"gene_hgnc_id": 25610,
"hgvs_c": "c.494C>G",
"hgvs_p": "p.Ala165Gly",
"transcript": "ENST00000894273.1",
"protein_id": "ENSP00000564332.1",
"transcript_support_level": null,
"aa_start": 165,
"aa_end": null,
"aa_length": 551,
"cds_start": 494,
"cds_end": null,
"cds_length": 1656,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000894273.1"
},
{
"aa_ref": "A",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 17,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "FGGY",
"gene_hgnc_id": 25610,
"hgvs_c": "c.494C>G",
"hgvs_p": "p.Ala165Gly",
"transcript": "ENST00000894276.1",
"protein_id": "ENSP00000564335.1",
"transcript_support_level": null,
"aa_start": 165,
"aa_end": null,
"aa_length": 551,
"cds_start": 494,
"cds_end": null,
"cds_length": 1656,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000894276.1"
},
{
"aa_ref": "A",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 18,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "FGGY",
"gene_hgnc_id": 25610,
"hgvs_c": "c.494C>G",
"hgvs_p": "p.Ala165Gly",
"transcript": "ENST00000894278.1",
"protein_id": "ENSP00000564337.1",
"transcript_support_level": null,
"aa_start": 165,
"aa_end": null,
"aa_length": 551,
"cds_start": 494,
"cds_end": null,
"cds_length": 1656,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000894278.1"
},
{
"aa_ref": "A",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 17,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "FGGY",
"gene_hgnc_id": 25610,
"hgvs_c": "c.494C>G",
"hgvs_p": "p.Ala165Gly",
"transcript": "ENST00000894279.1",
"protein_id": "ENSP00000564338.1",
"transcript_support_level": null,
"aa_start": 165,
"aa_end": null,
"aa_length": 551,
"cds_start": 494,
"cds_end": null,
"cds_length": 1656,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000894279.1"
},
{
"aa_ref": "A",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 17,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "FGGY",
"gene_hgnc_id": 25610,
"hgvs_c": "c.494C>G",
"hgvs_p": "p.Ala165Gly",
"transcript": "ENST00000894280.1",
"protein_id": "ENSP00000564339.1",
"transcript_support_level": null,
"aa_start": 165,
"aa_end": null,
"aa_length": 551,
"cds_start": 494,
"cds_end": null,
"cds_length": 1656,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000894280.1"
},
{
"aa_ref": "A",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 5,
"exon_rank_end": null,
"exon_count": 16,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "FGGY",
"gene_hgnc_id": 25610,
"hgvs_c": "c.494C>G",
"hgvs_p": "p.Ala165Gly",
"transcript": "ENST00000894281.1",
"protein_id": "ENSP00000564340.1",
"transcript_support_level": null,
"aa_start": 165,
"aa_end": null,
"aa_length": 551,
"cds_start": 494,
"cds_end": null,
"cds_length": 1656,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000894281.1"
},
{
"aa_ref": "A",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 5,
"exon_rank_end": null,
"exon_count": 16,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "FGGY",
"gene_hgnc_id": 25610,
"hgvs_c": "c.494C>G",
"hgvs_p": "p.Ala165Gly",
"transcript": "ENST00000894282.1",
"protein_id": "ENSP00000564341.1",
"transcript_support_level": null,
"aa_start": 165,
"aa_end": null,
"aa_length": 551,
"cds_start": 494,
"cds_end": null,
"cds_length": 1656,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000894282.1"
},
{
"aa_ref": "A",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 5,
"exon_rank_end": null,
"exon_count": 16,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "FGGY",
"gene_hgnc_id": 25610,
"hgvs_c": "c.494C>G",
"hgvs_p": "p.Ala165Gly",
"transcript": "ENST00000894283.1",
"protein_id": "ENSP00000564342.1",
"transcript_support_level": null,
"aa_start": 165,
"aa_end": null,
"aa_length": 551,
"cds_start": 494,
"cds_end": null,
"cds_length": 1656,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000894283.1"
},
{
"aa_ref": "A",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 5,
"exon_rank_end": null,
"exon_count": 16,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "FGGY",
"gene_hgnc_id": 25610,
"hgvs_c": "c.494C>G",
"hgvs_p": "p.Ala165Gly",
"transcript": "ENST00000894284.1",
"protein_id": "ENSP00000564343.1",
"transcript_support_level": null,
"aa_start": 165,
"aa_end": null,
"aa_length": 551,
"cds_start": 494,
"cds_end": null,
"cds_length": 1656,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000894284.1"
},
{
"aa_ref": "A",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
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}
],
"message": null
}