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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 1-59457015-C-T (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=1&pos=59457015&ref=C&alt=T&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "1",
"pos": 59457015,
"ref": "C",
"alt": "T",
"effect": "synonymous_variant",
"transcript": "NM_018291.5",
"consequences": [
{
"aa_ref": "D",
"aa_alt": "D",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 16,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "FGGY",
"gene_hgnc_id": 25610,
"hgvs_c": "c.609C>T",
"hgvs_p": "p.Asp203Asp",
"transcript": "NM_018291.5",
"protein_id": "NP_060761.3",
"transcript_support_level": null,
"aa_start": 203,
"aa_end": null,
"aa_length": 551,
"cds_start": 609,
"cds_end": null,
"cds_length": 1656,
"cdna_start": 680,
"cdna_end": null,
"cdna_length": 1873,
"mane_select": "ENST00000303721.12",
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "D",
"aa_alt": "D",
"canonical": true,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 16,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "FGGY",
"gene_hgnc_id": 25610,
"hgvs_c": "c.609C>T",
"hgvs_p": "p.Asp203Asp",
"transcript": "ENST00000303721.12",
"protein_id": "ENSP00000305922.8",
"transcript_support_level": 1,
"aa_start": 203,
"aa_end": null,
"aa_length": 551,
"cds_start": 609,
"cds_end": null,
"cds_length": 1656,
"cdna_start": 680,
"cdna_end": null,
"cdna_length": 1873,
"mane_select": "NM_018291.5",
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "D",
"aa_alt": "D",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 17,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "FGGY",
"gene_hgnc_id": 25610,
"hgvs_c": "c.609C>T",
"hgvs_p": "p.Asp203Asp",
"transcript": "ENST00000371218.8",
"protein_id": "ENSP00000360262.4",
"transcript_support_level": 1,
"aa_start": 203,
"aa_end": null,
"aa_length": 575,
"cds_start": 609,
"cds_end": null,
"cds_length": 1728,
"cdna_start": 793,
"cdna_end": null,
"cdna_length": 2052,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": false,
"strand": true,
"consequences": [
"5_prime_UTR_premature_start_codon_gain_variant"
],
"exon_rank": 2,
"exon_rank_end": null,
"exon_count": 14,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "FGGY",
"gene_hgnc_id": 25610,
"hgvs_c": "n.-16C>T",
"hgvs_p": null,
"transcript": "ENST00000635297.1",
"protein_id": "ENSP00000489549.1",
"transcript_support_level": 5,
"aa_start": null,
"aa_end": null,
"aa_length": null,
"cds_start": -4,
"cds_end": null,
"cds_length": null,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 1738,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"5_prime_UTR_premature_start_codon_gain_variant"
],
"exon_rank": 2,
"exon_rank_end": null,
"exon_count": 13,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "FGGY",
"gene_hgnc_id": 25610,
"hgvs_c": "c.-16C>T",
"hgvs_p": null,
"transcript": "XM_017001677.2",
"protein_id": "XP_016857166.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 367,
"cds_start": -4,
"cds_end": null,
"cds_length": 1104,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 35440,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"5_prime_UTR_premature_start_codon_gain_variant"
],
"exon_rank": 2,
"exon_rank_end": null,
"exon_count": 13,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "FGGY",
"gene_hgnc_id": 25610,
"hgvs_c": "c.-16C>T",
"hgvs_p": null,
"transcript": "XM_017001678.2",
"protein_id": "XP_016857167.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 367,
"cds_start": -4,
"cds_end": null,
"cds_length": 1104,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 2251,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"5_prime_UTR_premature_start_codon_gain_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 14,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "FGGY",
"gene_hgnc_id": 25610,
"hgvs_c": "c.-16C>T",
"hgvs_p": null,
"transcript": "XM_047424399.1",
"protein_id": "XP_047280355.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 367,
"cds_start": -4,
"cds_end": null,
"cds_length": 1104,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 1470,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"5_prime_UTR_premature_start_codon_gain_variant"
],
"exon_rank": 2,
"exon_rank_end": null,
"exon_count": 13,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "FGGY",
"gene_hgnc_id": 25610,
"hgvs_c": "c.-16C>T",
"hgvs_p": null,
"transcript": "XM_047424400.1",
"protein_id": "XP_047280356.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 367,
"cds_start": -4,
"cds_end": null,
"cds_length": 1104,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 15481,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"5_prime_UTR_premature_start_codon_gain_variant"
],
"exon_rank": 2,
"exon_rank_end": null,
"exon_count": 12,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "FGGY",
"gene_hgnc_id": 25610,
"hgvs_c": "c.-16C>T",
"hgvs_p": null,
"transcript": "XM_024448229.2",
"protein_id": "XP_024303997.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 343,
"cds_start": -4,
"cds_end": null,
"cds_length": 1032,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 2179,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "D",
"aa_alt": "D",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 17,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "FGGY",
"gene_hgnc_id": 25610,
"hgvs_c": "c.609C>T",
"hgvs_p": "p.Asp203Asp",
"transcript": "NM_001113411.2",
"protein_id": "NP_001106882.1",
"transcript_support_level": null,
"aa_start": 203,
"aa_end": null,
"aa_length": 575,
"cds_start": 609,
"cds_end": null,
"cds_length": 1728,
"cdna_start": 680,
"cdna_end": null,
"cdna_length": 1942,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "D",
"aa_alt": "D",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 17,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "FGGY",
"gene_hgnc_id": 25610,
"hgvs_c": "c.609C>T",
"hgvs_p": "p.Asp203Asp",
"transcript": "NM_001350790.2",
"protein_id": "NP_001337719.1",
"transcript_support_level": null,
"aa_start": 203,
"aa_end": null,
"aa_length": 575,
"cds_start": 609,
"cds_end": null,
"cds_length": 1728,
"cdna_start": 768,
"cdna_end": null,
"cdna_length": 2030,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "D",
"aa_alt": "D",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 16,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "FGGY",
"gene_hgnc_id": 25610,
"hgvs_c": "c.609C>T",
"hgvs_p": "p.Asp203Asp",
"transcript": "NM_001350791.2",
"protein_id": "NP_001337720.1",
"transcript_support_level": null,
"aa_start": 203,
"aa_end": null,
"aa_length": 551,
"cds_start": 609,
"cds_end": null,
"cds_length": 1656,
"cdna_start": 772,
"cdna_end": null,
"cdna_length": 1962,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "D",
"aa_alt": "D",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 18,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "FGGY",
"gene_hgnc_id": 25610,
"hgvs_c": "c.441C>T",
"hgvs_p": "p.Asp147Asp",
"transcript": "NM_001350792.2",
"protein_id": "NP_001337721.1",
"transcript_support_level": null,
"aa_start": 147,
"aa_end": null,
"aa_length": 495,
"cds_start": 441,
"cds_end": null,
"cds_length": 1488,
"cdna_start": 935,
"cdna_end": null,
"cdna_length": 2125,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "D",
"aa_alt": "D",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 18,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "FGGY",
"gene_hgnc_id": 25610,
"hgvs_c": "c.441C>T",
"hgvs_p": "p.Asp147Asp",
"transcript": "NM_001350793.2",
"protein_id": "NP_001337722.1",
"transcript_support_level": null,
"aa_start": 147,
"aa_end": null,
"aa_length": 495,
"cds_start": 441,
"cds_end": null,
"cds_length": 1488,
"cdna_start": 885,
"cdna_end": null,
"cdna_length": 2075,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "D",
"aa_alt": "D",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 15,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "FGGY",
"gene_hgnc_id": 25610,
"hgvs_c": "c.609C>T",
"hgvs_p": "p.Asp203Asp",
"transcript": "NM_001350794.2",
"protein_id": "NP_001337723.1",
"transcript_support_level": null,
"aa_start": 203,
"aa_end": null,
"aa_length": 491,
"cds_start": 609,
"cds_end": null,
"cds_length": 1476,
"cdna_start": 768,
"cdna_end": null,
"cdna_length": 1863,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "D",
"aa_alt": "D",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 15,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "FGGY",
"gene_hgnc_id": 25610,
"hgvs_c": "c.345C>T",
"hgvs_p": "p.Asp115Asp",
"transcript": "NM_001350795.2",
"protein_id": "NP_001337724.1",
"transcript_support_level": null,
"aa_start": 115,
"aa_end": null,
"aa_length": 487,
"cds_start": 345,
"cds_end": null,
"cds_length": 1464,
"cdna_start": 416,
"cdna_end": null,
"cdna_length": 1678,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "D",
"aa_alt": "D",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 14,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "FGGY",
"gene_hgnc_id": 25610,
"hgvs_c": "c.345C>T",
"hgvs_p": "p.Asp115Asp",
"transcript": "NM_001244714.2",
"protein_id": "NP_001231643.1",
"transcript_support_level": null,
"aa_start": 115,
"aa_end": null,
"aa_length": 463,
"cds_start": 345,
"cds_end": null,
"cds_length": 1392,
"cdna_start": 504,
"cdna_end": null,
"cdna_length": 1694,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "D",
"aa_alt": "D",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 14,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "FGGY",
"gene_hgnc_id": 25610,
"hgvs_c": "c.345C>T",
"hgvs_p": "p.Asp115Asp",
"transcript": "ENST00000371212.5",
"protein_id": "ENSP00000360256.1",
"transcript_support_level": 2,
"aa_start": 115,
"aa_end": null,
"aa_length": 463,
"cds_start": 345,
"cds_end": null,
"cds_length": 1392,
"cdna_start": 449,
"cdna_end": null,
"cdna_length": 1640,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "D",
"aa_alt": "D",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 5,
"exon_rank_end": null,
"exon_count": 15,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "FGGY",
"gene_hgnc_id": 25610,
"hgvs_c": "c.273C>T",
"hgvs_p": "p.Asp91Asp",
"transcript": "NM_001350796.2",
"protein_id": "NP_001337725.1",
"transcript_support_level": null,
"aa_start": 91,
"aa_end": null,
"aa_length": 439,
"cds_start": 273,
"cds_end": null,
"cds_length": 1320,
"cdna_start": 503,
"cdna_end": null,
"cdna_length": 1693,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "D",
"aa_alt": "D",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 5,
"exon_rank_end": null,
"exon_count": 15,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "FGGY",
"gene_hgnc_id": 25610,
"hgvs_c": "c.207C>T",
"hgvs_p": "p.Asp69Asp",
"transcript": "NM_001350797.2",
"protein_id": "NP_001337726.1",
"transcript_support_level": null,
"aa_start": 69,
"aa_end": null,
"aa_length": 417,
"cds_start": 207,
"cds_end": null,
"cds_length": 1254,
"cdna_start": 566,
"cdna_end": null,
"cdna_length": 1756,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "D",
"aa_alt": "D",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 5,
"exon_rank_end": null,
"exon_count": 15,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "FGGY",
"gene_hgnc_id": 25610,
"hgvs_c": "c.273C>T",
"hgvs_p": "p.Asp91Asp",
"transcript": "NM_001350798.2",
"protein_id": "NP_001337727.1",
"transcript_support_level": null,
"aa_start": 91,
"aa_end": null,
"aa_length": 403,
"cds_start": 273,
"cds_end": null,
"cds_length": 1212,
"cdna_start": 503,
"cdna_end": null,
"cdna_length": 1670,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "D",
"aa_alt": "D",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 5,
"exon_rank_end": null,
"exon_count": 14,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "FGGY",
"gene_hgnc_id": 25610,
"hgvs_c": "c.273C>T",
"hgvs_p": "p.Asp91Asp",
"transcript": "NM_001350799.2",
"protein_id": "NP_001337728.1",
"transcript_support_level": null,
"aa_start": 91,
"aa_end": null,
"aa_length": 379,
"cds_start": 273,
"cds_end": null,
"cds_length": 1140,
"cdna_start": 656,
"cdna_end": null,
"cdna_length": 1751,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "D",
"aa_alt": "D",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 17,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "FGGY",
"gene_hgnc_id": 25610,
"hgvs_c": "c.609C>T",
"hgvs_p": "p.Asp203Asp",
"transcript": "XM_011541730.2",
"protein_id": "XP_011540032.1",
"transcript_support_level": null,
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}