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GeneBe API Showcase

This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.

API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.

Documentation & Advanced Usage

Complete API documentation:docs.genebe.net/docs/api/overview/

Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/

Python client for pandas:pypi.org/project/genebe/

Java CLI for VCF files:github.com/pstawinski/genebe-cli

All tools documented at:docs.genebe.net

API Request Examples for Variant: 1-61455362-C-A (hg38)

Bash / cURL Example

bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=1&pos=61455362&ref=C&alt=A&genome=hg38&allGenes=true"

API Response

json
{
  "variants": [
    {
      "chr": "1",
      "pos": 61455362,
      "ref": "C",
      "alt": "A",
      "effect": "3_prime_UTR_variant",
      "transcript": "ENST00000403491.8",
      "consequences": [
        {
          "aa_ref": "P",
          "aa_alt": "T",
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 10,
          "exon_rank_end": null,
          "exon_count": 10,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "NFIA",
          "gene_hgnc_id": 7784,
          "hgvs_c": "c.1480C>A",
          "hgvs_p": "p.Pro494Thr",
          "transcript": "ENST00000371187.7",
          "protein_id": "ENSP00000360229.3",
          "transcript_support_level": 1,
          "aa_start": 494,
          "aa_end": null,
          "aa_length": 498,
          "cds_start": 1480,
          "cds_end": null,
          "cds_length": 1497,
          "cdna_start": 1651,
          "cdna_end": null,
          "cdna_length": 2683,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "3_prime_UTR_variant"
          ],
          "exon_rank": 11,
          "exon_rank_end": null,
          "exon_count": 11,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "NFIA",
          "gene_hgnc_id": 7784,
          "hgvs_c": "c.*42C>A",
          "hgvs_p": null,
          "transcript": "NM_001134673.4",
          "protein_id": "NP_001128145.1",
          "transcript_support_level": null,
          "aa_start": null,
          "aa_end": null,
          "aa_length": 509,
          "cds_start": -4,
          "cds_end": null,
          "cds_length": 1530,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": 9229,
          "mane_select": "ENST00000403491.8",
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": true,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "3_prime_UTR_variant"
          ],
          "exon_rank": 11,
          "exon_rank_end": null,
          "exon_count": 11,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "NFIA",
          "gene_hgnc_id": 7784,
          "hgvs_c": "c.*42C>A",
          "hgvs_p": null,
          "transcript": "ENST00000403491.8",
          "protein_id": "ENSP00000384523.3",
          "transcript_support_level": 1,
          "aa_start": null,
          "aa_end": null,
          "aa_length": 509,
          "cds_start": -4,
          "cds_end": null,
          "cds_length": 1530,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": 9229,
          "mane_select": "NM_001134673.4",
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "3_prime_UTR_variant"
          ],
          "exon_rank": 3,
          "exon_rank_end": null,
          "exon_count": 3,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "NFIA",
          "gene_hgnc_id": 7784,
          "hgvs_c": "c.*42C>A",
          "hgvs_p": null,
          "transcript": "ENST00000493627.1",
          "protein_id": "ENSP00000474817.1",
          "transcript_support_level": 1,
          "aa_start": null,
          "aa_end": null,
          "aa_length": 46,
          "cds_start": -4,
          "cds_end": null,
          "cds_length": 141,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": 696,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": "P",
          "aa_alt": "T",
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 11,
          "exon_rank_end": null,
          "exon_count": 11,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "NFIA",
          "gene_hgnc_id": 7784,
          "hgvs_c": "c.1519C>A",
          "hgvs_p": "p.Pro507Thr",
          "transcript": "ENST00000482020.2",
          "protein_id": "ENSP00000474806.2",
          "transcript_support_level": 3,
          "aa_start": 507,
          "aa_end": null,
          "aa_length": 511,
          "cds_start": 1519,
          "cds_end": null,
          "cds_length": 1536,
          "cdna_start": 1619,
          "cdna_end": null,
          "cdna_length": 2513,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": "P",
          "aa_alt": "T",
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 10,
          "exon_rank_end": null,
          "exon_count": 10,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "NFIA",
          "gene_hgnc_id": 7784,
          "hgvs_c": "c.1480C>A",
          "hgvs_p": "p.Pro494Thr",
          "transcript": "NM_005595.5",
          "protein_id": "NP_005586.1",
          "transcript_support_level": null,
          "aa_start": 494,
          "aa_end": null,
          "aa_length": 498,
          "cds_start": 1480,
          "cds_end": null,
          "cds_length": 1497,
          "cdna_start": 1711,
          "cdna_end": null,
          "cdna_length": 9137,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": "P",
          "aa_alt": "T",
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 10,
          "exon_rank_end": null,
          "exon_count": 10,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "NFIA",
          "gene_hgnc_id": 7784,
          "hgvs_c": "c.1456C>A",
          "hgvs_p": "p.Pro486Thr",
          "transcript": "ENST00000699964.1",
          "protein_id": "ENSP00000514720.1",
          "transcript_support_level": null,
          "aa_start": 486,
          "aa_end": null,
          "aa_length": 490,
          "cds_start": 1456,
          "cds_end": null,
          "cds_length": 1473,
          "cdna_start": 1696,
          "cdna_end": null,
          "cdna_length": 2617,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": "P",
          "aa_alt": "T",
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 8,
          "exon_rank_end": null,
          "exon_count": 8,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "NFIA",
          "gene_hgnc_id": 7784,
          "hgvs_c": "c.1234C>A",
          "hgvs_p": "p.Pro412Thr",
          "transcript": "ENST00000699967.1",
          "protein_id": "ENSP00000514723.1",
          "transcript_support_level": null,
          "aa_start": 412,
          "aa_end": null,
          "aa_length": 416,
          "cds_start": 1234,
          "cds_end": null,
          "cds_length": 1251,
          "cdna_start": 1565,
          "cdna_end": null,
          "cdna_length": 2198,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": "P",
          "aa_alt": "T",
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 10,
          "exon_rank_end": null,
          "exon_count": 10,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "NFIA",
          "gene_hgnc_id": 7784,
          "hgvs_c": "c.712C>A",
          "hgvs_p": "p.Pro238Thr",
          "transcript": "ENST00000663597.1",
          "protein_id": "ENSP00000499597.1",
          "transcript_support_level": null,
          "aa_start": 238,
          "aa_end": null,
          "aa_length": 242,
          "cds_start": 712,
          "cds_end": null,
          "cds_length": 729,
          "cdna_start": 1014,
          "cdna_end": null,
          "cdna_length": 2330,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": false,
          "strand": true,
          "consequences": [
            "non_coding_transcript_exon_variant"
          ],
          "exon_rank": 10,
          "exon_rank_end": null,
          "exon_count": 10,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "NFIA",
          "gene_hgnc_id": 7784,
          "hgvs_c": "n.*619C>A",
          "hgvs_p": null,
          "transcript": "ENST00000655770.1",
          "protein_id": "ENSP00000499326.1",
          "transcript_support_level": null,
          "aa_start": null,
          "aa_end": null,
          "aa_length": null,
          "cds_start": -4,
          "cds_end": null,
          "cds_length": null,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": 3886,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": false,
          "strand": true,
          "consequences": [
            "non_coding_transcript_exon_variant"
          ],
          "exon_rank": 14,
          "exon_rank_end": null,
          "exon_count": 14,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "NFIA",
          "gene_hgnc_id": 7784,
          "hgvs_c": "n.*1196C>A",
          "hgvs_p": null,
          "transcript": "ENST00000662015.1",
          "protein_id": "ENSP00000499312.1",
          "transcript_support_level": null,
          "aa_start": null,
          "aa_end": null,
          "aa_length": null,
          "cds_start": -4,
          "cds_end": null,
          "cds_length": null,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": 4676,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": false,
          "strand": true,
          "consequences": [
            "non_coding_transcript_exon_variant"
          ],
          "exon_rank": 12,
          "exon_rank_end": null,
          "exon_count": 12,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "NFIA",
          "gene_hgnc_id": 7784,
          "hgvs_c": "n.*1664C>A",
          "hgvs_p": null,
          "transcript": "ENST00000664495.1",
          "protein_id": "ENSP00000499306.1",
          "transcript_support_level": null,
          "aa_start": null,
          "aa_end": null,
          "aa_length": null,
          "cds_start": -4,
          "cds_end": null,
          "cds_length": null,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": 4535,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": false,
          "strand": true,
          "consequences": [
            "non_coding_transcript_exon_variant"
          ],
          "exon_rank": 12,
          "exon_rank_end": null,
          "exon_count": 12,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "NFIA",
          "gene_hgnc_id": 7784,
          "hgvs_c": "n.*639C>A",
          "hgvs_p": null,
          "transcript": "ENST00000670151.1",
          "protein_id": "ENSP00000499729.1",
          "transcript_support_level": null,
          "aa_start": null,
          "aa_end": null,
          "aa_length": null,
          "cds_start": -4,
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          "cds_length": null,
          "cdna_start": null,
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          "cdna_length": 4528,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": false,
          "strand": true,
          "consequences": [
            "non_coding_transcript_exon_variant"
          ],
          "exon_rank": 12,
          "exon_rank_end": null,
          "exon_count": 12,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "NFIA",
          "gene_hgnc_id": 7784,
          "hgvs_c": "n.*163C>A",
          "hgvs_p": null,
          "transcript": "ENST00000699966.1",
          "protein_id": "ENSP00000514722.1",
          "transcript_support_level": null,
          "aa_start": null,
          "aa_end": null,
          "aa_length": null,
          "cds_start": -4,
          "cds_end": null,
          "cds_length": null,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": 3098,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "3_prime_UTR_variant"
          ],
          "exon_rank": 12,
          "exon_rank_end": null,
          "exon_count": 12,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "NFIA",
          "gene_hgnc_id": 7784,
          "hgvs_c": "c.*42C>A",
          "hgvs_p": null,
          "transcript": "NM_001145512.2",
          "protein_id": "NP_001138984.1",
          "transcript_support_level": null,
          "aa_start": null,
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          "aa_length": 554,
          "cds_start": -4,
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          "cdna_start": null,
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          "cdna_length": 9338,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "3_prime_UTR_variant"
          ],
          "exon_rank": 12,
          "exon_rank_end": null,
          "exon_count": 12,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "NFIA",
          "gene_hgnc_id": 7784,
          "hgvs_c": "c.*42C>A",
          "hgvs_p": null,
          "transcript": "ENST00000371189.8",
          "protein_id": "ENSP00000360231.3",
          "transcript_support_level": 2,
          "aa_start": null,
          "aa_end": null,
          "aa_length": 554,
          "cds_start": -4,
          "cds_end": null,
          "cds_length": 1665,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": 1989,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "3_prime_UTR_variant"
          ],
          "exon_rank": 12,
          "exon_rank_end": null,
          "exon_count": 12,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "NFIA",
          "gene_hgnc_id": 7784,
          "hgvs_c": "c.*42C>A",
          "hgvs_p": null,
          "transcript": "ENST00000699987.1",
          "protein_id": "ENSP00000514740.1",
          "transcript_support_level": null,
          "aa_start": null,
          "aa_end": null,
          "aa_length": 550,
          "cds_start": -4,
          "cds_end": null,
          "cds_length": 1653,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": 3047,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "3_prime_UTR_variant"
          ],
          "exon_rank": 11,
          "exon_rank_end": null,
          "exon_count": 11,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "NFIA",
          "gene_hgnc_id": 7784,
          "hgvs_c": "c.*42C>A",
          "hgvs_p": null,
          "transcript": "ENST00000371191.5",
          "protein_id": "ENSP00000360233.1",
          "transcript_support_level": 5,
          "aa_start": null,
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          "aa_length": 532,
          "cds_start": -4,
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          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": 1916,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "3_prime_UTR_variant"
          ],
          "exon_rank": 11,
          "exon_rank_end": null,
          "exon_count": 11,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "NFIA",
          "gene_hgnc_id": 7784,
          "hgvs_c": "c.*2C>A",
          "hgvs_p": null,
          "transcript": "ENST00000699965.1",
          "protein_id": "ENSP00000514721.1",
          "transcript_support_level": null,
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          "aa_length": 510,
          "cds_start": -4,
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          "cdna_start": null,
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          "cdna_length": 4396,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "3_prime_UTR_variant"
          ],
          "exon_rank": 12,
          "exon_rank_end": null,
          "exon_count": 12,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "NFIA",
          "gene_hgnc_id": 7784,
          "hgvs_c": "c.*100C>A",
          "hgvs_p": null,
          "transcript": "ENST00000664149.1",
          "protein_id": "ENSP00000499651.1",
          "transcript_support_level": null,
          "aa_start": null,
          "aa_end": null,
          "aa_length": 508,
          "cds_start": -4,
          "cds_end": null,
          "cds_length": 1527,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": 3401,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "3_prime_UTR_variant"
          ],
          "exon_rank": 11,
          "exon_rank_end": null,
          "exon_count": 11,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "NFIA",
          "gene_hgnc_id": 7784,
          "hgvs_c": "c.*42C>A",
          "hgvs_p": null,
          "transcript": "NM_001145511.2",
          "protein_id": "NP_001138983.1",
          "transcript_support_level": null,
          "aa_start": null,
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