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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 1-70249410-G-C (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=1&pos=70249410&ref=G&alt=C&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "1",
"pos": 70249410,
"ref": "G",
"alt": "C",
"effect": "intron_variant",
"transcript": "ENST00000370949.2",
"consequences": [
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": false,
"strand": true,
"consequences": [
"non_coding_transcript_exon_variant"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 2,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SRSF11",
"gene_hgnc_id": 10782,
"hgvs_c": "n.1017G>C",
"hgvs_p": null,
"transcript": "ENST00000461935.1",
"protein_id": null,
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": null,
"cds_start": -4,
"cds_end": null,
"cds_length": null,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 3501,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 12,
"intron_rank": 9,
"intron_rank_end": null,
"gene_symbol": "SRSF11",
"gene_hgnc_id": 10782,
"hgvs_c": "c.1023-542G>C",
"hgvs_p": null,
"transcript": "NM_001350605.2",
"protein_id": "NP_001337534.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 484,
"cds_start": -4,
"cds_end": null,
"cds_length": 1455,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 3959,
"mane_select": "ENST00000370949.2",
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": true,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 12,
"intron_rank": 9,
"intron_rank_end": null,
"gene_symbol": "SRSF11",
"gene_hgnc_id": 10782,
"hgvs_c": "c.1023-542G>C",
"hgvs_p": null,
"transcript": "ENST00000370949.2",
"protein_id": "ENSP00000359987.2",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": 484,
"cds_start": -4,
"cds_end": null,
"cds_length": 1455,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 3959,
"mane_select": "NM_001350605.2",
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 12,
"intron_rank": 9,
"intron_rank_end": null,
"gene_symbol": "SRSF11",
"gene_hgnc_id": 10782,
"hgvs_c": "c.1023-521G>C",
"hgvs_p": null,
"transcript": "ENST00000395136.7",
"protein_id": "ENSP00000378568.3",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": 491,
"cds_start": -4,
"cds_end": null,
"cds_length": 1476,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 1717,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 13,
"intron_rank": 10,
"intron_rank_end": null,
"gene_symbol": "SRSF11",
"gene_hgnc_id": 10782,
"hgvs_c": "c.1023-542G>C",
"hgvs_p": null,
"transcript": "ENST00000370950.7",
"protein_id": "ENSP00000359988.3",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": 484,
"cds_start": -4,
"cds_end": null,
"cds_length": 1455,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 3784,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 13,
"intron_rank": 10,
"intron_rank_end": null,
"gene_symbol": "SRSF11",
"gene_hgnc_id": 10782,
"hgvs_c": "c.1023-542G>C",
"hgvs_p": null,
"transcript": "ENST00000370951.5",
"protein_id": "ENSP00000359989.1",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": 483,
"cds_start": -4,
"cds_end": null,
"cds_length": 1452,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 2385,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": false,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": 8,
"intron_rank_end": null,
"gene_symbol": "SRSF11",
"gene_hgnc_id": 10782,
"hgvs_c": "n.2384-542G>C",
"hgvs_p": null,
"transcript": "ENST00000484162.5",
"protein_id": null,
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": null,
"cds_start": -4,
"cds_end": null,
"cds_length": null,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 4008,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 14,
"intron_rank": 11,
"intron_rank_end": null,
"gene_symbol": "SRSF11",
"gene_hgnc_id": 10782,
"hgvs_c": "c.1056-542G>C",
"hgvs_p": null,
"transcript": "NM_001394402.1",
"protein_id": "NP_001381331.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 494,
"cds_start": -4,
"cds_end": null,
"cds_length": 1485,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 3839,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 13,
"intron_rank": 10,
"intron_rank_end": null,
"gene_symbol": "SRSF11",
"gene_hgnc_id": 10782,
"hgvs_c": "c.1056-542G>C",
"hgvs_p": null,
"transcript": "NM_001394403.1",
"protein_id": "NP_001381332.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 494,
"cds_start": -4,
"cds_end": null,
"cds_length": 1485,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 3989,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 13,
"intron_rank": 10,
"intron_rank_end": null,
"gene_symbol": "SRSF11",
"gene_hgnc_id": 10782,
"hgvs_c": "c.1023-521G>C",
"hgvs_p": null,
"transcript": "NM_001350608.2",
"protein_id": "NP_001337537.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 491,
"cds_start": -4,
"cds_end": null,
"cds_length": 1476,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 3833,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 13,
"intron_rank": 10,
"intron_rank_end": null,
"gene_symbol": "SRSF11",
"gene_hgnc_id": 10782,
"hgvs_c": "c.1023-521G>C",
"hgvs_p": null,
"transcript": "NM_001394404.1",
"protein_id": "NP_001381333.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 491,
"cds_start": -4,
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"cdna_start": null,
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"cdna_length": 3830,
"mane_select": null,
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"biotype": null,
"feature": null
},
{
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"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 13,
"intron_rank": 10,
"intron_rank_end": null,
"gene_symbol": "SRSF11",
"gene_hgnc_id": 10782,
"hgvs_c": "c.1023-521G>C",
"hgvs_p": null,
"transcript": "NM_001350609.2",
"protein_id": "NP_001337538.1",
"transcript_support_level": null,
"aa_start": null,
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"cds_start": -4,
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"cdna_start": null,
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"mane_select": null,
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"biotype": null,
"feature": null
},
{
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"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 12,
"intron_rank": 9,
"intron_rank_end": null,
"gene_symbol": "SRSF11",
"gene_hgnc_id": 10782,
"hgvs_c": "c.1023-521G>C",
"hgvs_p": null,
"transcript": "NM_001394405.1",
"protein_id": "NP_001381334.1",
"transcript_support_level": null,
"aa_start": null,
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"cds_start": -4,
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"cdna_start": null,
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},
{
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"protein_coding": true,
"strand": true,
"consequences": [
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],
"exon_rank": null,
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"exon_count": 13,
"intron_rank": 10,
"intron_rank_end": null,
"gene_symbol": "SRSF11",
"gene_hgnc_id": 10782,
"hgvs_c": "c.1023-542G>C",
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"transcript": "NM_001350606.2",
"protein_id": "NP_001337535.1",
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},
{
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"strand": true,
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],
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"intron_rank": 10,
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"gene_symbol": "SRSF11",
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"hgvs_c": "c.1023-542G>C",
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"transcript": "NM_001394406.1",
"protein_id": "NP_001381335.1",
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},
{
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"protein_coding": true,
"strand": true,
"consequences": [
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],
"exon_rank": null,
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"exon_count": 13,
"intron_rank": 10,
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"gene_symbol": "SRSF11",
"gene_hgnc_id": 10782,
"hgvs_c": "c.1023-542G>C",
"hgvs_p": null,
"transcript": "NM_004768.5",
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},
{
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],
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"intron_rank": 10,
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"gene_symbol": "SRSF11",
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"hgvs_c": "c.1023-542G>C",
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"transcript": "NM_001190987.3",
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},
{
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"strand": true,
"consequences": [
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],
"exon_rank": null,
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"exon_count": 13,
"intron_rank": 10,
"intron_rank_end": null,
"gene_symbol": "SRSF11",
"gene_hgnc_id": 10782,
"hgvs_c": "c.1023-542G>C",
"hgvs_p": null,
"transcript": "NM_001350607.2",
"protein_id": "NP_001337536.1",
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},
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],
"exon_rank": null,
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"exon_count": 13,
"intron_rank": 10,
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"gene_symbol": "SRSF11",
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"hgvs_c": "c.1023-542G>C",
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"transcript": "NM_001394407.1",
"protein_id": "NP_001381336.1",
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],
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"gene_symbol": "SRSF11",
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},
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],
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"intron_rank": 10,
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"gene_symbol": "SRSF11",
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"hgvs_c": "c.453-521G>C",
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},
{
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"strand": true,
"consequences": [
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],
"exon_rank": null,
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"intron_rank": 10,
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"gene_symbol": "SRSF11",
"gene_hgnc_id": 10782,
"hgvs_c": "c.453-521G>C",
"hgvs_p": null,
"transcript": "NM_001350611.2",
"protein_id": "NP_001337540.1",
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"cds_start": -4,
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"cdna_start": null,
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"biotype": null,
"feature": null
},
{
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"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 14,
"intron_rank": 11,
"intron_rank_end": null,
"gene_symbol": "SRSF11",
"gene_hgnc_id": 10782,
"hgvs_c": "c.453-542G>C",
"hgvs_p": null,
"transcript": "NM_001350612.2",
"protein_id": "NP_001337541.1",
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"mane_select": null,
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