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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 1-944729-C-T (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=1&pos=944729&ref=C&alt=T&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "1",
"pos": 944729,
"ref": "C",
"alt": "T",
"effect": "missense_variant",
"transcript": "NM_015658.4",
"consequences": [
{
"aa_ref": "E",
"aa_alt": "K",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 19,
"exon_rank_end": null,
"exon_count": 19,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NOC2L",
"gene_hgnc_id": 24517,
"hgvs_c": "c.2215G>A",
"hgvs_p": "p.Glu739Lys",
"transcript": "NM_015658.4",
"protein_id": "NP_056473.3",
"transcript_support_level": null,
"aa_start": 739,
"aa_end": null,
"aa_length": 749,
"cds_start": 2215,
"cds_end": null,
"cds_length": 2250,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": "ENST00000327044.7",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_015658.4"
},
{
"aa_ref": "E",
"aa_alt": "K",
"canonical": true,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 19,
"exon_rank_end": null,
"exon_count": 19,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NOC2L",
"gene_hgnc_id": 24517,
"hgvs_c": "c.2215G>A",
"hgvs_p": "p.Glu739Lys",
"transcript": "ENST00000327044.7",
"protein_id": "ENSP00000317992.6",
"transcript_support_level": 1,
"aa_start": 739,
"aa_end": null,
"aa_length": 749,
"cds_start": 2215,
"cds_end": null,
"cds_length": 2250,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": "NM_015658.4",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000327044.7"
},
{
"aa_ref": "E",
"aa_alt": "K",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 20,
"exon_rank_end": null,
"exon_count": 20,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NOC2L",
"gene_hgnc_id": 24517,
"hgvs_c": "c.2446G>A",
"hgvs_p": "p.Glu816Lys",
"transcript": "ENST00000968819.1",
"protein_id": "ENSP00000638878.1",
"transcript_support_level": null,
"aa_start": 816,
"aa_end": null,
"aa_length": 826,
"cds_start": 2446,
"cds_end": null,
"cds_length": 2481,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000968819.1"
},
{
"aa_ref": "E",
"aa_alt": "K",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 19,
"exon_rank_end": null,
"exon_count": 19,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NOC2L",
"gene_hgnc_id": 24517,
"hgvs_c": "c.2332G>A",
"hgvs_p": "p.Glu778Lys",
"transcript": "ENST00000934955.1",
"protein_id": "ENSP00000605014.1",
"transcript_support_level": null,
"aa_start": 778,
"aa_end": null,
"aa_length": 788,
"cds_start": 2332,
"cds_end": null,
"cds_length": 2367,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000934955.1"
},
{
"aa_ref": "E",
"aa_alt": "K",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 19,
"exon_rank_end": null,
"exon_count": 19,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NOC2L",
"gene_hgnc_id": 24517,
"hgvs_c": "c.2302G>A",
"hgvs_p": "p.Glu768Lys",
"transcript": "ENST00000934954.1",
"protein_id": "ENSP00000605013.1",
"transcript_support_level": null,
"aa_start": 768,
"aa_end": null,
"aa_length": 778,
"cds_start": 2302,
"cds_end": null,
"cds_length": 2337,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000934954.1"
},
{
"aa_ref": "E",
"aa_alt": "K",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 20,
"exon_rank_end": null,
"exon_count": 20,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NOC2L",
"gene_hgnc_id": 24517,
"hgvs_c": "c.2299G>A",
"hgvs_p": "p.Glu767Lys",
"transcript": "ENST00000934957.1",
"protein_id": "ENSP00000605016.1",
"transcript_support_level": null,
"aa_start": 767,
"aa_end": null,
"aa_length": 777,
"cds_start": 2299,
"cds_end": null,
"cds_length": 2334,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000934957.1"
},
{
"aa_ref": "E",
"aa_alt": "K",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 20,
"exon_rank_end": null,
"exon_count": 20,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NOC2L",
"gene_hgnc_id": 24517,
"hgvs_c": "c.2299G>A",
"hgvs_p": "p.Glu767Lys",
"transcript": "ENST00000968816.1",
"protein_id": "ENSP00000638875.1",
"transcript_support_level": null,
"aa_start": 767,
"aa_end": null,
"aa_length": 777,
"cds_start": 2299,
"cds_end": null,
"cds_length": 2334,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000968816.1"
},
{
"aa_ref": "E",
"aa_alt": "K",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 20,
"exon_rank_end": null,
"exon_count": 20,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NOC2L",
"gene_hgnc_id": 24517,
"hgvs_c": "c.2296G>A",
"hgvs_p": "p.Glu766Lys",
"transcript": "ENST00000934949.1",
"protein_id": "ENSP00000605008.1",
"transcript_support_level": null,
"aa_start": 766,
"aa_end": null,
"aa_length": 776,
"cds_start": 2296,
"cds_end": null,
"cds_length": 2331,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000934949.1"
},
{
"aa_ref": "E",
"aa_alt": "K",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 20,
"exon_rank_end": null,
"exon_count": 20,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NOC2L",
"gene_hgnc_id": 24517,
"hgvs_c": "c.2290G>A",
"hgvs_p": "p.Glu764Lys",
"transcript": "ENST00000870729.1",
"protein_id": "ENSP00000540788.1",
"transcript_support_level": null,
"aa_start": 764,
"aa_end": null,
"aa_length": 774,
"cds_start": 2290,
"cds_end": null,
"cds_length": 2325,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000870729.1"
},
{
"aa_ref": "E",
"aa_alt": "K",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 19,
"exon_rank_end": null,
"exon_count": 19,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NOC2L",
"gene_hgnc_id": 24517,
"hgvs_c": "c.2287G>A",
"hgvs_p": "p.Glu763Lys",
"transcript": "ENST00000968806.1",
"protein_id": "ENSP00000638865.1",
"transcript_support_level": null,
"aa_start": 763,
"aa_end": null,
"aa_length": 773,
"cds_start": 2287,
"cds_end": null,
"cds_length": 2322,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000968806.1"
},
{
"aa_ref": "E",
"aa_alt": "K",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 20,
"exon_rank_end": null,
"exon_count": 20,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NOC2L",
"gene_hgnc_id": 24517,
"hgvs_c": "c.2284G>A",
"hgvs_p": "p.Glu762Lys",
"transcript": "ENST00000870734.1",
"protein_id": "ENSP00000540793.1",
"transcript_support_level": null,
"aa_start": 762,
"aa_end": null,
"aa_length": 772,
"cds_start": 2284,
"cds_end": null,
"cds_length": 2319,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000870734.1"
},
{
"aa_ref": "E",
"aa_alt": "K",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 20,
"exon_rank_end": null,
"exon_count": 20,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NOC2L",
"gene_hgnc_id": 24517,
"hgvs_c": "c.2284G>A",
"hgvs_p": "p.Glu762Lys",
"transcript": "ENST00000968822.1",
"protein_id": "ENSP00000638881.1",
"transcript_support_level": null,
"aa_start": 762,
"aa_end": null,
"aa_length": 772,
"cds_start": 2284,
"cds_end": null,
"cds_length": 2319,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000968822.1"
},
{
"aa_ref": "E",
"aa_alt": "K",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 20,
"exon_rank_end": null,
"exon_count": 20,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NOC2L",
"gene_hgnc_id": 24517,
"hgvs_c": "c.2281G>A",
"hgvs_p": "p.Glu761Lys",
"transcript": "ENST00000968812.1",
"protein_id": "ENSP00000638871.1",
"transcript_support_level": null,
"aa_start": 761,
"aa_end": null,
"aa_length": 771,
"cds_start": 2281,
"cds_end": null,
"cds_length": 2316,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000968812.1"
},
{
"aa_ref": "E",
"aa_alt": "K",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 20,
"exon_rank_end": null,
"exon_count": 20,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NOC2L",
"gene_hgnc_id": 24517,
"hgvs_c": "c.2281G>A",
"hgvs_p": "p.Glu761Lys",
"transcript": "ENST00000968821.1",
"protein_id": "ENSP00000638880.1",
"transcript_support_level": null,
"aa_start": 761,
"aa_end": null,
"aa_length": 771,
"cds_start": 2281,
"cds_end": null,
"cds_length": 2316,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000968821.1"
},
{
"aa_ref": "E",
"aa_alt": "K",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 20,
"exon_rank_end": null,
"exon_count": 20,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NOC2L",
"gene_hgnc_id": 24517,
"hgvs_c": "c.2275G>A",
"hgvs_p": "p.Glu759Lys",
"transcript": "ENST00000870726.1",
"protein_id": "ENSP00000540785.1",
"transcript_support_level": null,
"aa_start": 759,
"aa_end": null,
"aa_length": 769,
"cds_start": 2275,
"cds_end": null,
"cds_length": 2310,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000870726.1"
},
{
"aa_ref": "E",
"aa_alt": "K",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 19,
"exon_rank_end": null,
"exon_count": 19,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NOC2L",
"gene_hgnc_id": 24517,
"hgvs_c": "c.2272G>A",
"hgvs_p": "p.Glu758Lys",
"transcript": "ENST00000934958.1",
"protein_id": "ENSP00000605017.1",
"transcript_support_level": null,
"aa_start": 758,
"aa_end": null,
"aa_length": 768,
"cds_start": 2272,
"cds_end": null,
"cds_length": 2307,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000934958.1"
},
{
"aa_ref": "E",
"aa_alt": "K",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 19,
"exon_rank_end": null,
"exon_count": 19,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NOC2L",
"gene_hgnc_id": 24517,
"hgvs_c": "c.2269G>A",
"hgvs_p": "p.Glu757Lys",
"transcript": "ENST00000934941.1",
"protein_id": "ENSP00000605000.1",
"transcript_support_level": null,
"aa_start": 757,
"aa_end": null,
"aa_length": 767,
"cds_start": 2269,
"cds_end": null,
"cds_length": 2304,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000934941.1"
},
{
"aa_ref": "E",
"aa_alt": "K",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 20,
"exon_rank_end": null,
"exon_count": 20,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NOC2L",
"gene_hgnc_id": 24517,
"hgvs_c": "c.2263G>A",
"hgvs_p": "p.Glu755Lys",
"transcript": "ENST00000870733.1",
"protein_id": "ENSP00000540792.1",
"transcript_support_level": null,
"aa_start": 755,
"aa_end": null,
"aa_length": 765,
"cds_start": 2263,
"cds_end": null,
"cds_length": 2298,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000870733.1"
},
{
"aa_ref": "E",
"aa_alt": "K",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 19,
"exon_rank_end": null,
"exon_count": 19,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NOC2L",
"gene_hgnc_id": 24517,
"hgvs_c": "c.2248G>A",
"hgvs_p": "p.Glu750Lys",
"transcript": "ENST00000934959.1",
"protein_id": "ENSP00000605018.1",
"transcript_support_level": null,
"aa_start": 750,
"aa_end": null,
"aa_length": 760,
"cds_start": 2248,
"cds_end": null,
"cds_length": 2283,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000934959.1"
},
{
"aa_ref": "E",
"aa_alt": "K",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 20,
"exon_rank_end": null,
"exon_count": 20,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NOC2L",
"gene_hgnc_id": 24517,
"hgvs_c": "c.2242G>A",
"hgvs_p": "p.Glu748Lys",
"transcript": "ENST00000968820.1",
"protein_id": "ENSP00000638879.1",
"transcript_support_level": null,
"aa_start": 748,
"aa_end": null,
"aa_length": 758,
"cds_start": 2242,
"cds_end": null,
"cds_length": 2277,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000968820.1"
},
{
"aa_ref": "E",
"aa_alt": "K",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 19,
"exon_rank_end": null,
"exon_count": 19,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NOC2L",
"gene_hgnc_id": 24517,
"hgvs_c": "c.2236G>A",
"hgvs_p": "p.Glu746Lys",
"transcript": "ENST00000870738.1",
"protein_id": "ENSP00000540797.1",
"transcript_support_level": null,
"aa_start": 746,
"aa_end": null,
"aa_length": 756,
"cds_start": 2236,
"cds_end": null,
"cds_length": 2271,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000870738.1"
},
{
"aa_ref": "E",
"aa_alt": "K",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 19,
"exon_rank_end": null,
"exon_count": 19,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NOC2L",
"gene_hgnc_id": 24517,
"hgvs_c": "c.2236G>A",
"hgvs_p": "p.Glu746Lys",
"transcript": "ENST00000934950.1",
"protein_id": "ENSP00000605009.1",
"transcript_support_level": null,
"aa_start": 746,
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{
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}
],
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}