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GeneBe API Showcase

This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.

API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.

Documentation & Advanced Usage

Complete API documentation:docs.genebe.net/docs/api/overview/

Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/

Python client for pandas:pypi.org/project/genebe/

Java CLI for VCF files:github.com/pstawinski/genebe-cli

All tools documented at:docs.genebe.net

API Request Examples for Variant: 1-945572-G-C (hg38)

Bash / cURL Example

bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=1&pos=945572&ref=G&alt=C&genome=hg38&allGenes=true"

API Response

json
{
  "variants": [
    {
      "chr": "1",
      "pos": 945572,
      "ref": "G",
      "alt": "C",
      "effect": "missense_variant",
      "transcript": "NM_015658.4",
      "consequences": [
        {
          "aa_ref": "L",
          "aa_alt": "V",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 17,
          "exon_rank_end": null,
          "exon_count": 19,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "NOC2L",
          "gene_hgnc_id": 24517,
          "hgvs_c": "c.1999C>G",
          "hgvs_p": "p.Leu667Val",
          "transcript": "NM_015658.4",
          "protein_id": "NP_056473.3",
          "transcript_support_level": null,
          "aa_start": 667,
          "aa_end": null,
          "aa_length": 749,
          "cds_start": 1999,
          "cds_end": null,
          "cds_length": 2250,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": "ENST00000327044.7",
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "NM_015658.4"
        },
        {
          "aa_ref": "L",
          "aa_alt": "V",
          "canonical": true,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 17,
          "exon_rank_end": null,
          "exon_count": 19,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "NOC2L",
          "gene_hgnc_id": 24517,
          "hgvs_c": "c.1999C>G",
          "hgvs_p": "p.Leu667Val",
          "transcript": "ENST00000327044.7",
          "protein_id": "ENSP00000317992.6",
          "transcript_support_level": 1,
          "aa_start": 667,
          "aa_end": null,
          "aa_length": 749,
          "cds_start": 1999,
          "cds_end": null,
          "cds_length": 2250,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": "NM_015658.4",
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000327044.7"
        },
        {
          "aa_ref": "L",
          "aa_alt": "V",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 18,
          "exon_rank_end": null,
          "exon_count": 20,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "NOC2L",
          "gene_hgnc_id": 24517,
          "hgvs_c": "c.2215C>G",
          "hgvs_p": "p.Leu739Val",
          "transcript": "ENST00000968819.1",
          "protein_id": "ENSP00000638878.1",
          "transcript_support_level": null,
          "aa_start": 739,
          "aa_end": null,
          "aa_length": 826,
          "cds_start": 2215,
          "cds_end": null,
          "cds_length": 2481,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000968819.1"
        },
        {
          "aa_ref": "L",
          "aa_alt": "V",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 17,
          "exon_rank_end": null,
          "exon_count": 19,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "NOC2L",
          "gene_hgnc_id": 24517,
          "hgvs_c": "c.2101C>G",
          "hgvs_p": "p.Leu701Val",
          "transcript": "ENST00000934955.1",
          "protein_id": "ENSP00000605014.1",
          "transcript_support_level": null,
          "aa_start": 701,
          "aa_end": null,
          "aa_length": 788,
          "cds_start": 2101,
          "cds_end": null,
          "cds_length": 2367,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000934955.1"
        },
        {
          "aa_ref": "L",
          "aa_alt": "V",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 17,
          "exon_rank_end": null,
          "exon_count": 19,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "NOC2L",
          "gene_hgnc_id": 24517,
          "hgvs_c": "c.2071C>G",
          "hgvs_p": "p.Leu691Val",
          "transcript": "ENST00000934954.1",
          "protein_id": "ENSP00000605013.1",
          "transcript_support_level": null,
          "aa_start": 691,
          "aa_end": null,
          "aa_length": 778,
          "cds_start": 2071,
          "cds_end": null,
          "cds_length": 2337,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000934954.1"
        },
        {
          "aa_ref": "L",
          "aa_alt": "V",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 18,
          "exon_rank_end": null,
          "exon_count": 20,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "NOC2L",
          "gene_hgnc_id": 24517,
          "hgvs_c": "c.2068C>G",
          "hgvs_p": "p.Leu690Val",
          "transcript": "ENST00000934957.1",
          "protein_id": "ENSP00000605016.1",
          "transcript_support_level": null,
          "aa_start": 690,
          "aa_end": null,
          "aa_length": 777,
          "cds_start": 2068,
          "cds_end": null,
          "cds_length": 2334,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000934957.1"
        },
        {
          "aa_ref": "L",
          "aa_alt": "V",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 18,
          "exon_rank_end": null,
          "exon_count": 20,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "NOC2L",
          "gene_hgnc_id": 24517,
          "hgvs_c": "c.2068C>G",
          "hgvs_p": "p.Leu690Val",
          "transcript": "ENST00000968816.1",
          "protein_id": "ENSP00000638875.1",
          "transcript_support_level": null,
          "aa_start": 690,
          "aa_end": null,
          "aa_length": 777,
          "cds_start": 2068,
          "cds_end": null,
          "cds_length": 2334,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000968816.1"
        },
        {
          "aa_ref": "L",
          "aa_alt": "V",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 18,
          "exon_rank_end": null,
          "exon_count": 20,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "NOC2L",
          "gene_hgnc_id": 24517,
          "hgvs_c": "c.2065C>G",
          "hgvs_p": "p.Leu689Val",
          "transcript": "ENST00000934949.1",
          "protein_id": "ENSP00000605008.1",
          "transcript_support_level": null,
          "aa_start": 689,
          "aa_end": null,
          "aa_length": 776,
          "cds_start": 2065,
          "cds_end": null,
          "cds_length": 2331,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000934949.1"
        },
        {
          "aa_ref": "L",
          "aa_alt": "V",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 18,
          "exon_rank_end": null,
          "exon_count": 20,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "NOC2L",
          "gene_hgnc_id": 24517,
          "hgvs_c": "c.2059C>G",
          "hgvs_p": "p.Leu687Val",
          "transcript": "ENST00000870729.1",
          "protein_id": "ENSP00000540788.1",
          "transcript_support_level": null,
          "aa_start": 687,
          "aa_end": null,
          "aa_length": 774,
          "cds_start": 2059,
          "cds_end": null,
          "cds_length": 2325,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000870729.1"
        },
        {
          "aa_ref": "L",
          "aa_alt": "V",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 17,
          "exon_rank_end": null,
          "exon_count": 19,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "NOC2L",
          "gene_hgnc_id": 24517,
          "hgvs_c": "c.2071C>G",
          "hgvs_p": "p.Leu691Val",
          "transcript": "ENST00000968806.1",
          "protein_id": "ENSP00000638865.1",
          "transcript_support_level": null,
          "aa_start": 691,
          "aa_end": null,
          "aa_length": 773,
          "cds_start": 2071,
          "cds_end": null,
          "cds_length": 2322,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000968806.1"
        },
        {
          "aa_ref": "L",
          "aa_alt": "V",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 18,
          "exon_rank_end": null,
          "exon_count": 20,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "NOC2L",
          "gene_hgnc_id": 24517,
          "hgvs_c": "c.2053C>G",
          "hgvs_p": "p.Leu685Val",
          "transcript": "ENST00000870734.1",
          "protein_id": "ENSP00000540793.1",
          "transcript_support_level": null,
          "aa_start": 685,
          "aa_end": null,
          "aa_length": 772,
          "cds_start": 2053,
          "cds_end": null,
          "cds_length": 2319,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000870734.1"
        },
        {
          "aa_ref": "L",
          "aa_alt": "V",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 18,
          "exon_rank_end": null,
          "exon_count": 20,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "NOC2L",
          "gene_hgnc_id": 24517,
          "hgvs_c": "c.2068C>G",
          "hgvs_p": "p.Leu690Val",
          "transcript": "ENST00000968822.1",
          "protein_id": "ENSP00000638881.1",
          "transcript_support_level": null,
          "aa_start": 690,
          "aa_end": null,
          "aa_length": 772,
          "cds_start": 2068,
          "cds_end": null,
          "cds_length": 2319,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000968822.1"
        },
        {
          "aa_ref": "L",
          "aa_alt": "V",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 18,
          "exon_rank_end": null,
          "exon_count": 20,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "NOC2L",
          "gene_hgnc_id": 24517,
          "hgvs_c": "c.2050C>G",
          "hgvs_p": "p.Leu684Val",
          "transcript": "ENST00000968812.1",
          "protein_id": "ENSP00000638871.1",
          "transcript_support_level": null,
          "aa_start": 684,
          "aa_end": null,
          "aa_length": 771,
          "cds_start": 2050,
          "cds_end": null,
          "cds_length": 2316,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000968812.1"
        },
        {
          "aa_ref": "L",
          "aa_alt": "V",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 18,
          "exon_rank_end": null,
          "exon_count": 20,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "NOC2L",
          "gene_hgnc_id": 24517,
          "hgvs_c": "c.2065C>G",
          "hgvs_p": "p.Leu689Val",
          "transcript": "ENST00000968821.1",
          "protein_id": "ENSP00000638880.1",
          "transcript_support_level": null,
          "aa_start": 689,
          "aa_end": null,
          "aa_length": 771,
          "cds_start": 2065,
          "cds_end": null,
          "cds_length": 2316,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000968821.1"
        },
        {
          "aa_ref": "L",
          "aa_alt": "V",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 18,
          "exon_rank_end": null,
          "exon_count": 20,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "NOC2L",
          "gene_hgnc_id": 24517,
          "hgvs_c": "c.2059C>G",
          "hgvs_p": "p.Leu687Val",
          "transcript": "ENST00000870726.1",
          "protein_id": "ENSP00000540785.1",
          "transcript_support_level": null,
          "aa_start": 687,
          "aa_end": null,
          "aa_length": 769,
          "cds_start": 2059,
          "cds_end": null,
          "cds_length": 2310,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000870726.1"
        },
        {
          "aa_ref": "L",
          "aa_alt": "V",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 17,
          "exon_rank_end": null,
          "exon_count": 19,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "NOC2L",
          "gene_hgnc_id": 24517,
          "hgvs_c": "c.2041C>G",
          "hgvs_p": "p.Leu681Val",
          "transcript": "ENST00000934958.1",
          "protein_id": "ENSP00000605017.1",
          "transcript_support_level": null,
          "aa_start": 681,
          "aa_end": null,
          "aa_length": 768,
          "cds_start": 2041,
          "cds_end": null,
          "cds_length": 2307,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000934958.1"
        },
        {
          "aa_ref": "L",
          "aa_alt": "V",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 17,
          "exon_rank_end": null,
          "exon_count": 19,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "NOC2L",
          "gene_hgnc_id": 24517,
          "hgvs_c": "c.2053C>G",
          "hgvs_p": "p.Leu685Val",
          "transcript": "ENST00000934941.1",
          "protein_id": "ENSP00000605000.1",
          "transcript_support_level": null,
          "aa_start": 685,
          "aa_end": null,
          "aa_length": 767,
          "cds_start": 2053,
          "cds_end": null,
          "cds_length": 2304,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000934941.1"
        },
        {
          "aa_ref": "L",
          "aa_alt": "V",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 18,
          "exon_rank_end": null,
          "exon_count": 20,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "NOC2L",
          "gene_hgnc_id": 24517,
          "hgvs_c": "c.2047C>G",
          "hgvs_p": "p.Leu683Val",
          "transcript": "ENST00000870733.1",
          "protein_id": "ENSP00000540792.1",
          "transcript_support_level": null,
          "aa_start": 683,
          "aa_end": null,
          "aa_length": 765,
          "cds_start": 2047,
          "cds_end": null,
          "cds_length": 2298,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000870733.1"
        },
        {
          "aa_ref": "L",
          "aa_alt": "V",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 17,
          "exon_rank_end": null,
          "exon_count": 19,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "NOC2L",
          "gene_hgnc_id": 24517,
          "hgvs_c": "c.2017C>G",
          "hgvs_p": "p.Leu673Val",
          "transcript": "ENST00000934959.1",
          "protein_id": "ENSP00000605018.1",
          "transcript_support_level": null,
          "aa_start": 673,
          "aa_end": null,
          "aa_length": 760,
          "cds_start": 2017,
          "cds_end": null,
          "cds_length": 2283,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000934959.1"
        },
        {
          "aa_ref": "L",
          "aa_alt": "V",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 18,
          "exon_rank_end": null,
          "exon_count": 20,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "NOC2L",
          "gene_hgnc_id": 24517,
          "hgvs_c": "c.2011C>G",
          "hgvs_p": "p.Leu671Val",
          "transcript": "ENST00000968820.1",
          "protein_id": "ENSP00000638879.1",
          "transcript_support_level": null,
          "aa_start": 671,
          "aa_end": null,
          "aa_length": 758,
          "cds_start": 2011,
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      "computational_source_selected": "MetaRNN",
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          "transcript": "NM_015658.4",
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      "clinvar_disease": "",
      "clinvar_classification": "",
      "clinvar_review_status": "",
      "clinvar_submissions_summary": "",
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      "pathogenicity_classification_combined": null,
      "custom_annotations": null
    }
  ],
  "message": null
}
For research and educational, non-commercial use only. Not for clinical or diagnostic use. GeneBe does not provide medical advice. Data use for AI modeling is prohibited: if used, the cost is $0.001 per byte of downloaded uncompressed data.