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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 1-9722133-C-T (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=1&pos=9722133&ref=C&alt=T&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "1",
"pos": 9722133,
"ref": "C",
"alt": "T",
"effect": "synonymous_variant",
"transcript": "NM_005026.5",
"consequences": [
{
"aa_ref": "S",
"aa_alt": "S",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 17,
"exon_rank_end": null,
"exon_count": 24,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PIK3CD",
"gene_hgnc_id": 8977,
"hgvs_c": "c.2214C>T",
"hgvs_p": "p.Ser738Ser",
"transcript": "NM_005026.5",
"protein_id": "NP_005017.3",
"transcript_support_level": null,
"aa_start": 738,
"aa_end": null,
"aa_length": 1044,
"cds_start": 2214,
"cds_end": null,
"cds_length": 3135,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": "ENST00000377346.9",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_005026.5"
},
{
"aa_ref": "S",
"aa_alt": "S",
"canonical": true,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 17,
"exon_rank_end": null,
"exon_count": 24,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PIK3CD",
"gene_hgnc_id": 8977,
"hgvs_c": "c.2214C>T",
"hgvs_p": "p.Ser738Ser",
"transcript": "ENST00000377346.9",
"protein_id": "ENSP00000366563.4",
"transcript_support_level": 1,
"aa_start": 738,
"aa_end": null,
"aa_length": 1044,
"cds_start": 2214,
"cds_end": null,
"cds_length": 3135,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": "NM_005026.5",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000377346.9"
},
{
"aa_ref": "S",
"aa_alt": "S",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 16,
"exon_rank_end": null,
"exon_count": 23,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PIK3CD",
"gene_hgnc_id": 8977,
"hgvs_c": "c.2286C>T",
"hgvs_p": "p.Ser762Ser",
"transcript": "ENST00000361110.6",
"protein_id": "ENSP00000354410.2",
"transcript_support_level": 1,
"aa_start": 762,
"aa_end": null,
"aa_length": 1068,
"cds_start": 2286,
"cds_end": null,
"cds_length": 3207,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000361110.6"
},
{
"aa_ref": "S",
"aa_alt": "S",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 17,
"exon_rank_end": null,
"exon_count": 24,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PIK3CD",
"gene_hgnc_id": 8977,
"hgvs_c": "c.2391C>T",
"hgvs_p": "p.Ser797Ser",
"transcript": "ENST00000892288.1",
"protein_id": "ENSP00000562347.1",
"transcript_support_level": null,
"aa_start": 797,
"aa_end": null,
"aa_length": 1103,
"cds_start": 2391,
"cds_end": null,
"cds_length": 3312,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000892288.1"
},
{
"aa_ref": "S",
"aa_alt": "S",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 18,
"exon_rank_end": null,
"exon_count": 25,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PIK3CD",
"gene_hgnc_id": 8977,
"hgvs_c": "c.2391C>T",
"hgvs_p": "p.Ser797Ser",
"transcript": "ENST00000960482.1",
"protein_id": "ENSP00000630541.1",
"transcript_support_level": null,
"aa_start": 797,
"aa_end": null,
"aa_length": 1103,
"cds_start": 2391,
"cds_end": null,
"cds_length": 3312,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000960482.1"
},
{
"aa_ref": "S",
"aa_alt": "S",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 16,
"exon_rank_end": null,
"exon_count": 23,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PIK3CD",
"gene_hgnc_id": 8977,
"hgvs_c": "c.2214C>T",
"hgvs_p": "p.Ser738Ser",
"transcript": "NM_001437546.1",
"protein_id": "NP_001424475.1",
"transcript_support_level": null,
"aa_start": 738,
"aa_end": null,
"aa_length": 1044,
"cds_start": 2214,
"cds_end": null,
"cds_length": 3135,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001437546.1"
},
{
"aa_ref": "S",
"aa_alt": "S",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 16,
"exon_rank_end": null,
"exon_count": 23,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PIK3CD",
"gene_hgnc_id": 8977,
"hgvs_c": "c.2214C>T",
"hgvs_p": "p.Ser738Ser",
"transcript": "ENST00000698712.1",
"protein_id": "ENSP00000513889.1",
"transcript_support_level": null,
"aa_start": 738,
"aa_end": null,
"aa_length": 1044,
"cds_start": 2214,
"cds_end": null,
"cds_length": 3135,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000698712.1"
},
{
"aa_ref": "S",
"aa_alt": "S",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 17,
"exon_rank_end": null,
"exon_count": 24,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PIK3CD",
"gene_hgnc_id": 8977,
"hgvs_c": "c.2214C>T",
"hgvs_p": "p.Ser738Ser",
"transcript": "ENST00000698713.1",
"protein_id": "ENSP00000513890.1",
"transcript_support_level": null,
"aa_start": 738,
"aa_end": null,
"aa_length": 1044,
"cds_start": 2214,
"cds_end": null,
"cds_length": 3135,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000698713.1"
},
{
"aa_ref": "S",
"aa_alt": "S",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 18,
"exon_rank_end": null,
"exon_count": 25,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PIK3CD",
"gene_hgnc_id": 8977,
"hgvs_c": "c.2214C>T",
"hgvs_p": "p.Ser738Ser",
"transcript": "ENST00000892287.1",
"protein_id": "ENSP00000562346.1",
"transcript_support_level": null,
"aa_start": 738,
"aa_end": null,
"aa_length": 1044,
"cds_start": 2214,
"cds_end": null,
"cds_length": 3135,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000892287.1"
},
{
"aa_ref": "S",
"aa_alt": "S",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 18,
"exon_rank_end": null,
"exon_count": 25,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PIK3CD",
"gene_hgnc_id": 8977,
"hgvs_c": "c.2214C>T",
"hgvs_p": "p.Ser738Ser",
"transcript": "ENST00000892289.1",
"protein_id": "ENSP00000562348.1",
"transcript_support_level": null,
"aa_start": 738,
"aa_end": null,
"aa_length": 1044,
"cds_start": 2214,
"cds_end": null,
"cds_length": 3135,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000892289.1"
},
{
"aa_ref": "S",
"aa_alt": "S",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 19,
"exon_rank_end": null,
"exon_count": 26,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PIK3CD",
"gene_hgnc_id": 8977,
"hgvs_c": "c.2214C>T",
"hgvs_p": "p.Ser738Ser",
"transcript": "ENST00000932635.1",
"protein_id": "ENSP00000602694.1",
"transcript_support_level": null,
"aa_start": 738,
"aa_end": null,
"aa_length": 1044,
"cds_start": 2214,
"cds_end": null,
"cds_length": 3135,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000932635.1"
},
{
"aa_ref": "S",
"aa_alt": "S",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 18,
"exon_rank_end": null,
"exon_count": 25,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PIK3CD",
"gene_hgnc_id": 8977,
"hgvs_c": "c.2214C>T",
"hgvs_p": "p.Ser738Ser",
"transcript": "ENST00000932636.1",
"protein_id": "ENSP00000602695.1",
"transcript_support_level": null,
"aa_start": 738,
"aa_end": null,
"aa_length": 1044,
"cds_start": 2214,
"cds_end": null,
"cds_length": 3135,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000932636.1"
},
{
"aa_ref": "S",
"aa_alt": "S",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 18,
"exon_rank_end": null,
"exon_count": 25,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PIK3CD",
"gene_hgnc_id": 8977,
"hgvs_c": "c.2214C>T",
"hgvs_p": "p.Ser738Ser",
"transcript": "ENST00000932638.1",
"protein_id": "ENSP00000602697.1",
"transcript_support_level": null,
"aa_start": 738,
"aa_end": null,
"aa_length": 1044,
"cds_start": 2214,
"cds_end": null,
"cds_length": 3135,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000932638.1"
},
{
"aa_ref": "S",
"aa_alt": "S",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 18,
"exon_rank_end": null,
"exon_count": 25,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PIK3CD",
"gene_hgnc_id": 8977,
"hgvs_c": "c.2214C>T",
"hgvs_p": "p.Ser738Ser",
"transcript": "ENST00000960479.1",
"protein_id": "ENSP00000630538.1",
"transcript_support_level": null,
"aa_start": 738,
"aa_end": null,
"aa_length": 1044,
"cds_start": 2214,
"cds_end": null,
"cds_length": 3135,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000960479.1"
},
{
"aa_ref": "S",
"aa_alt": "S",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 18,
"exon_rank_end": null,
"exon_count": 25,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PIK3CD",
"gene_hgnc_id": 8977,
"hgvs_c": "c.2214C>T",
"hgvs_p": "p.Ser738Ser",
"transcript": "ENST00000960481.1",
"protein_id": "ENSP00000630540.1",
"transcript_support_level": null,
"aa_start": 738,
"aa_end": null,
"aa_length": 1044,
"cds_start": 2214,
"cds_end": null,
"cds_length": 3135,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000960481.1"
},
{
"aa_ref": "S",
"aa_alt": "S",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 17,
"exon_rank_end": null,
"exon_count": 24,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PIK3CD",
"gene_hgnc_id": 8977,
"hgvs_c": "c.2211C>T",
"hgvs_p": "p.Ser737Ser",
"transcript": "NM_001350234.2",
"protein_id": "NP_001337163.1",
"transcript_support_level": null,
"aa_start": 737,
"aa_end": null,
"aa_length": 1043,
"cds_start": 2211,
"cds_end": null,
"cds_length": 3132,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001350234.2"
},
{
"aa_ref": "S",
"aa_alt": "S",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 17,
"exon_rank_end": null,
"exon_count": 24,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PIK3CD",
"gene_hgnc_id": 8977,
"hgvs_c": "c.2211C>T",
"hgvs_p": "p.Ser737Ser",
"transcript": "NM_001439206.1",
"protein_id": "NP_001426135.1",
"transcript_support_level": null,
"aa_start": 737,
"aa_end": null,
"aa_length": 1043,
"cds_start": 2211,
"cds_end": null,
"cds_length": 3132,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001439206.1"
},
{
"aa_ref": "S",
"aa_alt": "S",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 17,
"exon_rank_end": null,
"exon_count": 24,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PIK3CD",
"gene_hgnc_id": 8977,
"hgvs_c": "c.2211C>T",
"hgvs_p": "p.Ser737Ser",
"transcript": "ENST00000698710.1",
"protein_id": "ENSP00000513888.1",
"transcript_support_level": null,
"aa_start": 737,
"aa_end": null,
"aa_length": 1043,
"cds_start": 2211,
"cds_end": null,
"cds_length": 3132,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000698710.1"
},
{
"aa_ref": "S",
"aa_alt": "S",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 17,
"exon_rank_end": null,
"exon_count": 24,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PIK3CD",
"gene_hgnc_id": 8977,
"hgvs_c": "c.2211C>T",
"hgvs_p": "p.Ser737Ser",
"transcript": "ENST00000698715.1",
"protein_id": "ENSP00000513892.1",
"transcript_support_level": null,
"aa_start": 737,
"aa_end": null,
"aa_length": 1043,
"cds_start": 2211,
"cds_end": null,
"cds_length": 3132,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000698715.1"
},
{
"aa_ref": "S",
"aa_alt": "S",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 17,
"exon_rank_end": null,
"exon_count": 24,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PIK3CD",
"gene_hgnc_id": 8977,
"hgvs_c": "c.2211C>T",
"hgvs_p": "p.Ser737Ser",
"transcript": "ENST00000932637.1",
"protein_id": "ENSP00000602696.1",
"transcript_support_level": null,
"aa_start": 737,
"aa_end": null,
"aa_length": 1043,
"cds_start": 2211,
"cds_end": null,
"cds_length": 3132,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000932637.1"
},
{
"aa_ref": "S",
"aa_alt": "S",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 15,
"exon_rank_end": null,
"exon_count": 22,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PIK3CD",
"gene_hgnc_id": 8977,
"hgvs_c": "c.2202C>T",
"hgvs_p": "p.Ser734Ser",
"transcript": "ENST00000698716.1",
"protein_id": "ENSP00000513893.1",
"transcript_support_level": null,
"aa_start": 734,
"aa_end": null,
"aa_length": 1040,
"cds_start": 2202,
"cds_end": null,
"cds_length": 3123,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000698716.1"
},
{
"aa_ref": "S",
"aa_alt": "S",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 16,
"exon_rank_end": null,
"exon_count": 23,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PIK3CD",
"gene_hgnc_id": 8977,
"hgvs_c": "c.2127C>T",
"hgvs_p": "p.Ser709Ser",
"transcript": "NM_001350235.1",
"protein_id": "NP_001337164.1",
"transcript_support_level": null,
"aa_start": 709,
"aa_end": null,
"aa_length": 1015,
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}