← Back to variant description

GeneBe API Showcase

This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.

API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.

Documentation & Advanced Usage

Complete API documentation:docs.genebe.net/docs/api/overview/

Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/

Python client for pandas:pypi.org/project/genebe/

Java CLI for VCF files:github.com/pstawinski/genebe-cli

All tools documented at:docs.genebe.net

API Request Examples for Variant: 1-9731778-T-A (hg38)

Bash / cURL Example

bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=1&pos=9731778&ref=T&alt=A&genome=hg38&allGenes=true"

API Response

json
{
  "variants": [
    {
      "chr": "1",
      "pos": 9731778,
      "ref": "T",
      "alt": "A",
      "effect": "missense_variant",
      "transcript": "NM_001009566.3",
      "consequences": [
        {
          "aa_ref": "N",
          "aa_alt": "I",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 17,
          "exon_rank_end": null,
          "exon_count": 19,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "CLSTN1",
          "gene_hgnc_id": 17447,
          "hgvs_c": "c.2546A>T",
          "hgvs_p": "p.Asn849Ile",
          "transcript": "NM_001009566.3",
          "protein_id": "NP_001009566.1",
          "transcript_support_level": null,
          "aa_start": 849,
          "aa_end": null,
          "aa_length": 981,
          "cds_start": 2546,
          "cds_end": null,
          "cds_length": 2946,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": "ENST00000377298.9",
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "NM_001009566.3"
        },
        {
          "aa_ref": "N",
          "aa_alt": "I",
          "canonical": true,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 17,
          "exon_rank_end": null,
          "exon_count": 19,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "CLSTN1",
          "gene_hgnc_id": 17447,
          "hgvs_c": "c.2546A>T",
          "hgvs_p": "p.Asn849Ile",
          "transcript": "ENST00000377298.9",
          "protein_id": "ENSP00000366513.4",
          "transcript_support_level": 1,
          "aa_start": 849,
          "aa_end": null,
          "aa_length": 981,
          "cds_start": 2546,
          "cds_end": null,
          "cds_length": 2946,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": "NM_001009566.3",
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000377298.9"
        },
        {
          "aa_ref": "N",
          "aa_alt": "I",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 16,
          "exon_rank_end": null,
          "exon_count": 18,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "CLSTN1",
          "gene_hgnc_id": 17447,
          "hgvs_c": "c.2516A>T",
          "hgvs_p": "p.Asn839Ile",
          "transcript": "ENST00000361311.4",
          "protein_id": "ENSP00000354997.4",
          "transcript_support_level": 1,
          "aa_start": 839,
          "aa_end": null,
          "aa_length": 971,
          "cds_start": 2516,
          "cds_end": null,
          "cds_length": 2916,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000361311.4"
        },
        {
          "aa_ref": "N",
          "aa_alt": "I",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 15,
          "exon_rank_end": null,
          "exon_count": 17,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "CLSTN1",
          "gene_hgnc_id": 17447,
          "hgvs_c": "c.2552A>T",
          "hgvs_p": "p.Asn851Ile",
          "transcript": "ENST00000872287.1",
          "protein_id": "ENSP00000542346.1",
          "transcript_support_level": null,
          "aa_start": 851,
          "aa_end": null,
          "aa_length": 983,
          "cds_start": 2552,
          "cds_end": null,
          "cds_length": 2952,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000872287.1"
        },
        {
          "aa_ref": "N",
          "aa_alt": "I",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 16,
          "exon_rank_end": null,
          "exon_count": 18,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "CLSTN1",
          "gene_hgnc_id": 17447,
          "hgvs_c": "c.2546A>T",
          "hgvs_p": "p.Asn849Ile",
          "transcript": "ENST00000872285.1",
          "protein_id": "ENSP00000542344.1",
          "transcript_support_level": null,
          "aa_start": 849,
          "aa_end": null,
          "aa_length": 981,
          "cds_start": 2546,
          "cds_end": null,
          "cds_length": 2946,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000872285.1"
        },
        {
          "aa_ref": "N",
          "aa_alt": "I",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 16,
          "exon_rank_end": null,
          "exon_count": 18,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "CLSTN1",
          "gene_hgnc_id": 17447,
          "hgvs_c": "c.2516A>T",
          "hgvs_p": "p.Asn839Ile",
          "transcript": "NM_014944.4",
          "protein_id": "NP_055759.3",
          "transcript_support_level": null,
          "aa_start": 839,
          "aa_end": null,
          "aa_length": 971,
          "cds_start": 2516,
          "cds_end": null,
          "cds_length": 2916,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "NM_014944.4"
        },
        {
          "aa_ref": "N",
          "aa_alt": "I",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 15,
          "exon_rank_end": null,
          "exon_count": 17,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "CLSTN1",
          "gene_hgnc_id": 17447,
          "hgvs_c": "c.2516A>T",
          "hgvs_p": "p.Asn839Ile",
          "transcript": "ENST00000932459.1",
          "protein_id": "ENSP00000602518.1",
          "transcript_support_level": null,
          "aa_start": 839,
          "aa_end": null,
          "aa_length": 971,
          "cds_start": 2516,
          "cds_end": null,
          "cds_length": 2916,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000932459.1"
        },
        {
          "aa_ref": "N",
          "aa_alt": "I",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 16,
          "exon_rank_end": null,
          "exon_count": 18,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "CLSTN1",
          "gene_hgnc_id": 17447,
          "hgvs_c": "c.2513A>T",
          "hgvs_p": "p.Asn838Ile",
          "transcript": "ENST00000960690.1",
          "protein_id": "ENSP00000630749.1",
          "transcript_support_level": null,
          "aa_start": 838,
          "aa_end": null,
          "aa_length": 970,
          "cds_start": 2513,
          "cds_end": null,
          "cds_length": 2913,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000960690.1"
        },
        {
          "aa_ref": "N",
          "aa_alt": "I",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 16,
          "exon_rank_end": null,
          "exon_count": 18,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "CLSTN1",
          "gene_hgnc_id": 17447,
          "hgvs_c": "c.2510A>T",
          "hgvs_p": "p.Asn837Ile",
          "transcript": "ENST00000872284.1",
          "protein_id": "ENSP00000542343.1",
          "transcript_support_level": null,
          "aa_start": 837,
          "aa_end": null,
          "aa_length": 969,
          "cds_start": 2510,
          "cds_end": null,
          "cds_length": 2910,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000872284.1"
        },
        {
          "aa_ref": "N",
          "aa_alt": "I",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 16,
          "exon_rank_end": null,
          "exon_count": 18,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "CLSTN1",
          "gene_hgnc_id": 17447,
          "hgvs_c": "c.2510A>T",
          "hgvs_p": "p.Asn837Ile",
          "transcript": "ENST00000960689.1",
          "protein_id": "ENSP00000630748.1",
          "transcript_support_level": null,
          "aa_start": 837,
          "aa_end": null,
          "aa_length": 969,
          "cds_start": 2510,
          "cds_end": null,
          "cds_length": 2910,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000960689.1"
        },
        {
          "aa_ref": "N",
          "aa_alt": "I",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 15,
          "exon_rank_end": null,
          "exon_count": 17,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "CLSTN1",
          "gene_hgnc_id": 17447,
          "hgvs_c": "c.2492A>T",
          "hgvs_p": "p.Asn831Ile",
          "transcript": "ENST00000872288.1",
          "protein_id": "ENSP00000542347.1",
          "transcript_support_level": null,
          "aa_start": 831,
          "aa_end": null,
          "aa_length": 963,
          "cds_start": 2492,
          "cds_end": null,
          "cds_length": 2892,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000872288.1"
        },
        {
          "aa_ref": "N",
          "aa_alt": "I",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 16,
          "exon_rank_end": null,
          "exon_count": 18,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "CLSTN1",
          "gene_hgnc_id": 17447,
          "hgvs_c": "c.2489A>T",
          "hgvs_p": "p.Asn830Ile",
          "transcript": "NM_001302883.1",
          "protein_id": "NP_001289812.1",
          "transcript_support_level": null,
          "aa_start": 830,
          "aa_end": null,
          "aa_length": 962,
          "cds_start": 2489,
          "cds_end": null,
          "cds_length": 2889,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "NM_001302883.1"
        },
        {
          "aa_ref": "N",
          "aa_alt": "I",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 15,
          "exon_rank_end": null,
          "exon_count": 17,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "CLSTN1",
          "gene_hgnc_id": 17447,
          "hgvs_c": "c.2474A>T",
          "hgvs_p": "p.Asn825Ile",
          "transcript": "ENST00000932463.1",
          "protein_id": "ENSP00000602522.1",
          "transcript_support_level": null,
          "aa_start": 825,
          "aa_end": null,
          "aa_length": 957,
          "cds_start": 2474,
          "cds_end": null,
          "cds_length": 2874,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000932463.1"
        },
        {
          "aa_ref": "N",
          "aa_alt": "I",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 15,
          "exon_rank_end": null,
          "exon_count": 17,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "CLSTN1",
          "gene_hgnc_id": 17447,
          "hgvs_c": "c.2393A>T",
          "hgvs_p": "p.Asn798Ile",
          "transcript": "ENST00000932460.1",
          "protein_id": "ENSP00000602519.1",
          "transcript_support_level": null,
          "aa_start": 798,
          "aa_end": null,
          "aa_length": 930,
          "cds_start": 2393,
          "cds_end": null,
          "cds_length": 2793,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000932460.1"
        },
        {
          "aa_ref": "N",
          "aa_alt": "I",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 15,
          "exon_rank_end": null,
          "exon_count": 17,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "CLSTN1",
          "gene_hgnc_id": 17447,
          "hgvs_c": "c.2384A>T",
          "hgvs_p": "p.Asn795Ile",
          "transcript": "ENST00000932462.1",
          "protein_id": "ENSP00000602521.1",
          "transcript_support_level": null,
          "aa_start": 795,
          "aa_end": null,
          "aa_length": 927,
          "cds_start": 2384,
          "cds_end": null,
          "cds_length": 2784,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000932462.1"
        },
        {
          "aa_ref": "N",
          "aa_alt": "I",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 16,
          "exon_rank_end": null,
          "exon_count": 18,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "CLSTN1",
          "gene_hgnc_id": 17447,
          "hgvs_c": "c.2297A>T",
          "hgvs_p": "p.Asn766Ile",
          "transcript": "ENST00000960691.1",
          "protein_id": "ENSP00000630750.1",
          "transcript_support_level": null,
          "aa_start": 766,
          "aa_end": null,
          "aa_length": 898,
          "cds_start": 2297,
          "cds_end": null,
          "cds_length": 2697,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000960691.1"
        },
        {
          "aa_ref": "N",
          "aa_alt": "I",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 15,
          "exon_rank_end": null,
          "exon_count": 17,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "CLSTN1",
          "gene_hgnc_id": 17447,
          "hgvs_c": "c.2267A>T",
          "hgvs_p": "p.Asn756Ile",
          "transcript": "ENST00000932458.1",
          "protein_id": "ENSP00000602517.1",
          "transcript_support_level": null,
          "aa_start": 756,
          "aa_end": null,
          "aa_length": 888,
          "cds_start": 2267,
          "cds_end": null,
          "cds_length": 2667,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000932458.1"
        },
        {
          "aa_ref": "N",
          "aa_alt": "I",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 14,
          "exon_rank_end": null,
          "exon_count": 16,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "CLSTN1",
          "gene_hgnc_id": 17447,
          "hgvs_c": "c.2180A>T",
          "hgvs_p": "p.Asn727Ile",
          "transcript": "ENST00000872286.1",
          "protein_id": "ENSP00000542345.1",
          "transcript_support_level": null,
          "aa_start": 727,
          "aa_end": null,
          "aa_length": 859,
          "cds_start": 2180,
          "cds_end": null,
          "cds_length": 2580,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000872286.1"
        },
        {
          "aa_ref": "N",
          "aa_alt": "I",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 13,
          "exon_rank_end": null,
          "exon_count": 15,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "CLSTN1",
          "gene_hgnc_id": 17447,
          "hgvs_c": "c.2054A>T",
          "hgvs_p": "p.Asn685Ile",
          "transcript": "ENST00000932461.1",
          "protein_id": "ENSP00000602520.1",
          "transcript_support_level": null,
          "aa_start": 685,
          "aa_end": null,
          "aa_length": 817,
          "cds_start": 2054,
          "cds_end": null,
          "cds_length": 2454,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000932461.1"
        },
        {
          "aa_ref": "N",
          "aa_alt": "I",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 12,
          "exon_rank_end": null,
          "exon_count": 14,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "CLSTN1",
          "gene_hgnc_id": 17447,
          "hgvs_c": "c.1949A>T",
          "hgvs_p": "p.Asn650Ile",
          "transcript": "ENST00000435891.5",
          "protein_id": "ENSP00000401934.1",
          "transcript_support_level": 2,
          "aa_start": 650,
          "aa_end": null,
          "aa_length": 782,
          "cds_start": 1949,
          "cds_end": null,
          "cds_length": 2349,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000435891.5"
        },
        {
          "aa_ref": "N",
          "aa_alt": "I",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 12,
          "exon_rank_end": null,
          "exon_count": 14,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "CLSTN1",
          "gene_hgnc_id": 17447,
          "hgvs_c": "c.1775A>T",
          "hgvs_p": "p.Asn592Ile",
          "transcript": "ENST00000872289.1",
          "protein_id": "ENSP00000542348.1",
          "transcript_support_level": null,
          "aa_start": 592,
          "aa_end": null,
          "aa_length": 724,
          "cds_start": 1775,
          "cds_end": null,
          "cds_length": 2175,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000872289.1"
        },
        {
          "aa_ref": "N",
          "aa_alt": "I",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 15,
          "exon_rank_end": null,
          "exon_count": 17,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "CLSTN1",
          "gene_hgnc_id": 17447,
          "hgvs_c": "c.2459A>T",
          "hgvs_p": "p.Asn820Ile",
          "transcript": "XM_047449470.1",
          "protein_id": "XP_047305426.1",
          "transcript_support_level": null,
          "aa_start": 820,
          "aa_end": null,
          "aa_length": 952,
          "cds_start": 2459,
          "cds_end": null,
          "cds_length": 2859,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "XM_047449470.1"
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": false,
          "strand": false,
          "consequences": [
            "non_coding_transcript_exon_variant"
          ],
          "exon_rank": 2,
          "exon_rank_end": null,
          "exon_count": 4,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "CLSTN1",
          "gene_hgnc_id": 17447,
          "hgvs_c": "n.205A>T",
          "hgvs_p": null,
          "transcript": "ENST00000477264.1",
          "protein_id": null,
          "transcript_support_level": 2,
          "aa_start": null,
          "aa_end": null,
          "aa_length": null,
          "cds_start": null,
          "cds_end": null,
          "cds_length": null,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "pseudogene",
          "feature": "ENST00000477264.1"
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": false,
          "strand": false,
          "consequences": [
            "non_coding_transcript_exon_variant"
          ],
          "exon_rank": 17,
          "exon_rank_end": null,
          "exon_count": 19,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "CLSTN1",
          "gene_hgnc_id": 17447,
          "hgvs_c": "n.*1455A>T",
          "hgvs_p": null,
          "transcript": "ENST00000650348.1",
          "protein_id": "ENSP00000497950.1",
          "transcript_support_level": null,
          "aa_start": null,
          "aa_end": null,
          "aa_length": null,
          "cds_start": null,
          "cds_end": null,
          "cds_length": null,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "nonsense_mediated_decay",
          "feature": "ENST00000650348.1"
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": false,
          "strand": false,
          "consequences": [
            "3_prime_UTR_variant"
          ],
          "exon_rank": 17,
          "exon_rank_end": null,
          "exon_count": 19,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "CLSTN1",
          "gene_hgnc_id": 17447,
          "hgvs_c": "n.*1455A>T",
          "hgvs_p": null,
          "transcript": "ENST00000650348.1",
          "protein_id": "ENSP00000497950.1",
          "transcript_support_level": null,
          "aa_start": null,
          "aa_end": null,
          "aa_length": null,
          "cds_start": null,
          "cds_end": null,
          "cds_length": null,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "nonsense_mediated_decay",
          "feature": "ENST00000650348.1"
        }
      ],
      "gene_symbol": "CLSTN1",
      "gene_hgnc_id": 17447,
      "dbsnp": "rs146135346",
      "frequency_reference_population": 6.84046e-7,
      "hom_count_reference_population": 0,
      "allele_count_reference_population": 1,
      "gnomad_exomes_af": 6.84046e-7,
      "gnomad_genomes_af": null,
      "gnomad_exomes_ac": 1,
      "gnomad_genomes_ac": null,
      "gnomad_exomes_homalt": 0,
      "gnomad_genomes_homalt": null,
      "gnomad_mito_homoplasmic": null,
      "gnomad_mito_heteroplasmic": null,
      "computational_score_selected": 0.17610406875610352,
      "computational_prediction_selected": "Benign",
      "computational_source_selected": "MetaRNN",
      "splice_score_selected": 0,
      "splice_prediction_selected": "Benign",
      "splice_source_selected": "max_spliceai",
      "revel_score": 0.15,
      "revel_prediction": "Benign",
      "alphamissense_score": 0.135,
      "alphamissense_prediction": null,
      "bayesdelnoaf_score": -0.42,
      "bayesdelnoaf_prediction": "Benign",
      "phylop100way_score": 0.527,
      "phylop100way_prediction": "Benign",
      "spliceai_max_score": 0,
      "spliceai_max_prediction": "Benign",
      "dbscsnv_ada_score": null,
      "dbscsnv_ada_prediction": null,
      "apogee2_score": null,
      "apogee2_prediction": null,
      "mitotip_score": null,
      "mitotip_prediction": null,
      "acmg_score": 0,
      "acmg_classification": "Uncertain_significance",
      "acmg_criteria": "PM2,BP4_Moderate",
      "acmg_by_gene": [
        {
          "score": 0,
          "benign_score": 2,
          "pathogenic_score": 2,
          "criteria": [
            "PM2",
            "BP4_Moderate"
          ],
          "verdict": "Uncertain_significance",
          "transcript": "NM_001009566.3",
          "gene_symbol": "CLSTN1",
          "hgnc_id": 17447,
          "effects": [
            "missense_variant"
          ],
          "inheritance_mode": "AD",
          "hgvs_c": "c.2546A>T",
          "hgvs_p": "p.Asn849Ile"
        }
      ],
      "clinvar_disease": "",
      "clinvar_classification": "",
      "clinvar_review_status": "",
      "clinvar_submissions_summary": "",
      "phenotype_combined": null,
      "pathogenicity_classification_combined": null,
      "custom_annotations": null
    }
  ],
  "message": null
}