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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 10-101002787-C-T (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=10&pos=101002787&ref=C&alt=T&genome=hg38&allGenes=true"API Response
json
{
"message": null,
"variants": [
{
"acmg_by_gene": [
{
"benign_score": 9,
"criteria": [
"BP4_Strong",
"BP7",
"BS2"
],
"effects": [
"synonymous_variant"
],
"gene_symbol": "LZTS2",
"hgnc_id": 29381,
"hgvs_c": "c.249C>T",
"hgvs_p": "p.Val83Val",
"inheritance_mode": "AD",
"pathogenic_score": 0,
"score": -9,
"transcript": "NM_032429.4",
"verdict": "Benign"
}
],
"acmg_classification": "Benign",
"acmg_criteria": "BP4_Strong,BP7,BS2",
"acmg_score": -9,
"allele_count_reference_population": 2696,
"alphamissense_prediction": null,
"alphamissense_score": null,
"alt": "T",
"apogee2_prediction": null,
"apogee2_score": null,
"bayesdelnoaf_prediction": "Benign",
"bayesdelnoaf_score": -0.67,
"chr": "10",
"clinvar_classification": "",
"clinvar_disease": "",
"clinvar_review_status": "",
"clinvar_submissions_summary": "",
"computational_prediction_selected": "Benign",
"computational_score_selected": -0.6700000166893005,
"computational_source_selected": "BayesDel_noAF",
"consequences": [
{
"aa_alt": "V",
"aa_end": null,
"aa_length": 669,
"aa_ref": "V",
"aa_start": 83,
"biotype": "protein_coding",
"canonical": false,
"cdna_end": null,
"cdna_length": 2862,
"cdna_start": 436,
"cds_end": null,
"cds_length": 2010,
"cds_start": 249,
"consequences": [
"synonymous_variant"
],
"exon_count": 5,
"exon_rank": 2,
"exon_rank_end": null,
"feature": "NM_001318100.2",
"gene_hgnc_id": 29381,
"gene_symbol": "LZTS2",
"hgvs_c": "c.249C>T",
"hgvs_p": "p.Val83Val",
"intron_rank": null,
"intron_rank_end": null,
"mane_plus": null,
"mane_select": "ENST00000454422.2",
"protein_coding": true,
"protein_id": "NP_001305029.1",
"strand": true,
"transcript": "NM_001318100.2",
"transcript_support_level": null
},
{
"aa_alt": "V",
"aa_end": null,
"aa_length": 669,
"aa_ref": "V",
"aa_start": 83,
"biotype": "protein_coding",
"canonical": true,
"cdna_end": null,
"cdna_length": 2862,
"cdna_start": 436,
"cds_end": null,
"cds_length": 2010,
"cds_start": 249,
"consequences": [
"synonymous_variant"
],
"exon_count": 5,
"exon_rank": 2,
"exon_rank_end": null,
"feature": "ENST00000454422.2",
"gene_hgnc_id": 29381,
"gene_symbol": "LZTS2",
"hgvs_c": "c.249C>T",
"hgvs_p": "p.Val83Val",
"intron_rank": null,
"intron_rank_end": null,
"mane_plus": null,
"mane_select": "NM_001318100.2",
"protein_coding": true,
"protein_id": "ENSP00000416972.2",
"strand": true,
"transcript": "ENST00000454422.2",
"transcript_support_level": 2
},
{
"aa_alt": "V",
"aa_end": null,
"aa_length": 669,
"aa_ref": "V",
"aa_start": 83,
"biotype": "protein_coding",
"canonical": false,
"cdna_end": null,
"cdna_length": 5741,
"cdna_start": 3312,
"cds_end": null,
"cds_length": 2010,
"cds_start": 249,
"consequences": [
"synonymous_variant"
],
"exon_count": 4,
"exon_rank": 1,
"exon_rank_end": null,
"feature": "ENST00000370220.1",
"gene_hgnc_id": 29381,
"gene_symbol": "LZTS2",
"hgvs_c": "c.249C>T",
"hgvs_p": "p.Val83Val",
"intron_rank": null,
"intron_rank_end": null,
"mane_plus": null,
"mane_select": null,
"protein_coding": true,
"protein_id": "ENSP00000359240.1",
"strand": true,
"transcript": "ENST00000370220.1",
"transcript_support_level": 1
},
{
"aa_alt": "V",
"aa_end": null,
"aa_length": 669,
"aa_ref": "V",
"aa_start": 83,
"biotype": "protein_coding",
"canonical": false,
"cdna_end": null,
"cdna_length": 2883,
"cdna_start": 454,
"cds_end": null,
"cds_length": 2010,
"cds_start": 249,
"consequences": [
"synonymous_variant"
],
"exon_count": 5,
"exon_rank": 2,
"exon_rank_end": null,
"feature": "ENST00000370223.7",
"gene_hgnc_id": 29381,
"gene_symbol": "LZTS2",
"hgvs_c": "c.249C>T",
"hgvs_p": "p.Val83Val",
"intron_rank": null,
"intron_rank_end": null,
"mane_plus": null,
"mane_select": null,
"protein_coding": true,
"protein_id": "ENSP00000359243.3",
"strand": true,
"transcript": "ENST00000370223.7",
"transcript_support_level": 1
},
{
"aa_alt": "V",
"aa_end": null,
"aa_length": 678,
"aa_ref": "V",
"aa_start": 83,
"biotype": "protein_coding",
"canonical": false,
"cdna_end": null,
"cdna_length": 2895,
"cdna_start": 442,
"cds_end": null,
"cds_length": 2037,
"cds_start": 249,
"consequences": [
"synonymous_variant"
],
"exon_count": 5,
"exon_rank": 2,
"exon_rank_end": null,
"feature": "ENST00000853699.1",
"gene_hgnc_id": 29381,
"gene_symbol": "LZTS2",
"hgvs_c": "c.249C>T",
"hgvs_p": "p.Val83Val",
"intron_rank": null,
"intron_rank_end": null,
"mane_plus": null,
"mane_select": null,
"protein_coding": true,
"protein_id": "ENSP00000523757.1",
"strand": true,
"transcript": "ENST00000853699.1",
"transcript_support_level": null
},
{
"aa_alt": "V",
"aa_end": null,
"aa_length": 678,
"aa_ref": "V",
"aa_start": 83,
"biotype": "protein_coding",
"canonical": false,
"cdna_end": null,
"cdna_length": 2858,
"cdna_start": 405,
"cds_end": null,
"cds_length": 2037,
"cds_start": 249,
"consequences": [
"synonymous_variant"
],
"exon_count": 5,
"exon_rank": 2,
"exon_rank_end": null,
"feature": "ENST00000962998.1",
"gene_hgnc_id": 29381,
"gene_symbol": "LZTS2",
"hgvs_c": "c.249C>T",
"hgvs_p": "p.Val83Val",
"intron_rank": null,
"intron_rank_end": null,
"mane_plus": null,
"mane_select": null,
"protein_coding": true,
"protein_id": "ENSP00000633057.1",
"strand": true,
"transcript": "ENST00000962998.1",
"transcript_support_level": null
},
{
"aa_alt": "V",
"aa_end": null,
"aa_length": 669,
"aa_ref": "V",
"aa_start": 83,
"biotype": "protein_coding",
"canonical": false,
"cdna_end": null,
"cdna_length": 2849,
"cdna_start": 423,
"cds_end": null,
"cds_length": 2010,
"cds_start": 249,
"consequences": [
"synonymous_variant"
],
"exon_count": 5,
"exon_rank": 2,
"exon_rank_end": null,
"feature": "NM_001318099.2",
"gene_hgnc_id": 29381,
"gene_symbol": "LZTS2",
"hgvs_c": "c.249C>T",
"hgvs_p": "p.Val83Val",
"intron_rank": null,
"intron_rank_end": null,
"mane_plus": null,
"mane_select": null,
"protein_coding": true,
"protein_id": "NP_001305028.1",
"strand": true,
"transcript": "NM_001318099.2",
"transcript_support_level": null
},
{
"aa_alt": "V",
"aa_end": null,
"aa_length": 669,
"aa_ref": "V",
"aa_start": 83,
"biotype": "protein_coding",
"canonical": false,
"cdna_end": null,
"cdna_length": 3016,
"cdna_start": 590,
"cds_end": null,
"cds_length": 2010,
"cds_start": 249,
"consequences": [
"synonymous_variant"
],
"exon_count": 5,
"exon_rank": 2,
"exon_rank_end": null,
"feature": "NM_001394950.1",
"gene_hgnc_id": 29381,
"gene_symbol": "LZTS2",
"hgvs_c": "c.249C>T",
"hgvs_p": "p.Val83Val",
"intron_rank": null,
"intron_rank_end": null,
"mane_plus": null,
"mane_select": null,
"protein_coding": true,
"protein_id": "NP_001381879.1",
"strand": true,
"transcript": "NM_001394950.1",
"transcript_support_level": null
},
{
"aa_alt": "V",
"aa_end": null,
"aa_length": 669,
"aa_ref": "V",
"aa_start": 83,
"biotype": "protein_coding",
"canonical": false,
"cdna_end": null,
"cdna_length": 2822,
"cdna_start": 396,
"cds_end": null,
"cds_length": 2010,
"cds_start": 249,
"consequences": [
"synonymous_variant"
],
"exon_count": 5,
"exon_rank": 2,
"exon_rank_end": null,
"feature": "NM_001394951.1",
"gene_hgnc_id": 29381,
"gene_symbol": "LZTS2",
"hgvs_c": "c.249C>T",
"hgvs_p": "p.Val83Val",
"intron_rank": null,
"intron_rank_end": null,
"mane_plus": null,
"mane_select": null,
"protein_coding": true,
"protein_id": "NP_001381880.1",
"strand": true,
"transcript": "NM_001394951.1",
"transcript_support_level": null
},
{
"aa_alt": "V",
"aa_end": null,
"aa_length": 669,
"aa_ref": "V",
"aa_start": 83,
"biotype": "protein_coding",
"canonical": false,
"cdna_end": null,
"cdna_length": 2801,
"cdna_start": 375,
"cds_end": null,
"cds_length": 2010,
"cds_start": 249,
"consequences": [
"synonymous_variant"
],
"exon_count": 5,
"exon_rank": 2,
"exon_rank_end": null,
"feature": "NM_001394952.1",
"gene_hgnc_id": 29381,
"gene_symbol": "LZTS2",
"hgvs_c": "c.249C>T",
"hgvs_p": "p.Val83Val",
"intron_rank": null,
"intron_rank_end": null,
"mane_plus": null,
"mane_select": null,
"protein_coding": true,
"protein_id": "NP_001381881.1",
"strand": true,
"transcript": "NM_001394952.1",
"transcript_support_level": null
},
{
"aa_alt": "V",
"aa_end": null,
"aa_length": 669,
"aa_ref": "V",
"aa_start": 83,
"biotype": "protein_coding",
"canonical": false,
"cdna_end": null,
"cdna_length": 2881,
"cdna_start": 455,
"cds_end": null,
"cds_length": 2010,
"cds_start": 249,
"consequences": [
"synonymous_variant"
],
"exon_count": 5,
"exon_rank": 2,
"exon_rank_end": null,
"feature": "NM_032429.4",
"gene_hgnc_id": 29381,
"gene_symbol": "LZTS2",
"hgvs_c": "c.249C>T",
"hgvs_p": "p.Val83Val",
"intron_rank": null,
"intron_rank_end": null,
"mane_plus": null,
"mane_select": null,
"protein_coding": true,
"protein_id": "NP_115805.1",
"strand": true,
"transcript": "NM_032429.4",
"transcript_support_level": null
},
{
"aa_alt": "V",
"aa_end": null,
"aa_length": 669,
"aa_ref": "V",
"aa_start": 83,
"biotype": "protein_coding",
"canonical": false,
"cdna_end": null,
"cdna_length": 2950,
"cdna_start": 524,
"cds_end": null,
"cds_length": 2010,
"cds_start": 249,
"consequences": [
"synonymous_variant"
],
"exon_count": 6,
"exon_rank": 3,
"exon_rank_end": null,
"feature": "ENST00000853681.1",
"gene_hgnc_id": 29381,
"gene_symbol": "LZTS2",
"hgvs_c": "c.249C>T",
"hgvs_p": "p.Val83Val",
"intron_rank": null,
"intron_rank_end": null,
"mane_plus": null,
"mane_select": null,
"protein_coding": true,
"protein_id": "ENSP00000523740.1",
"strand": true,
"transcript": "ENST00000853681.1",
"transcript_support_level": null
},
{
"aa_alt": "V",
"aa_end": null,
"aa_length": 669,
"aa_ref": "V",
"aa_start": 83,
"biotype": "protein_coding",
"canonical": false,
"cdna_end": null,
"cdna_length": 2826,
"cdna_start": 416,
"cds_end": null,
"cds_length": 2010,
"cds_start": 249,
"consequences": [
"synonymous_variant"
],
"exon_count": 5,
"exon_rank": 2,
"exon_rank_end": null,
"feature": "ENST00000853682.1",
"gene_hgnc_id": 29381,
"gene_symbol": "LZTS2",
"hgvs_c": "c.249C>T",
"hgvs_p": "p.Val83Val",
"intron_rank": null,
"intron_rank_end": null,
"mane_plus": null,
"mane_select": null,
"protein_coding": true,
"protein_id": "ENSP00000523741.1",
"strand": true,
"transcript": "ENST00000853682.1",
"transcript_support_level": null
},
{
"aa_alt": "V",
"aa_end": null,
"aa_length": 669,
"aa_ref": "V",
"aa_start": 83,
"biotype": "protein_coding",
"canonical": false,
"cdna_end": null,
"cdna_length": 2789,
"cdna_start": 369,
"cds_end": null,
"cds_length": 2010,
"cds_start": 249,
"consequences": [
"synonymous_variant"
],
"exon_count": 5,
"exon_rank": 2,
"exon_rank_end": null,
"feature": "ENST00000853703.1",
"gene_hgnc_id": 29381,
"gene_symbol": "LZTS2",
"hgvs_c": "c.249C>T",
"hgvs_p": "p.Val83Val",
"intron_rank": null,
"intron_rank_end": null,
"mane_plus": null,
"mane_select": null,
"protein_coding": true,
"protein_id": "ENSP00000523762.1",
"strand": true,
"transcript": "ENST00000853703.1",
"transcript_support_level": null
},
{
"aa_alt": "V",
"aa_end": null,
"aa_length": 669,
"aa_ref": "V",
"aa_start": 83,
"biotype": "protein_coding",
"canonical": false,
"cdna_end": null,
"cdna_length": 2896,
"cdna_start": 470,
"cds_end": null,
"cds_length": 2010,
"cds_start": 249,
"consequences": [
"synonymous_variant"
],
"exon_count": 5,
"exon_rank": 2,
"exon_rank_end": null,
"feature": "ENST00000853705.1",
"gene_hgnc_id": 29381,
"gene_symbol": "LZTS2",
"hgvs_c": "c.249C>T",
"hgvs_p": "p.Val83Val",
"intron_rank": null,
"intron_rank_end": null,
"mane_plus": null,
"mane_select": null,
"protein_coding": true,
"protein_id": "ENSP00000523764.1",
"strand": true,
"transcript": "ENST00000853705.1",
"transcript_support_level": null
},
{
"aa_alt": "V",
"aa_end": null,
"aa_length": 669,
"aa_ref": "V",
"aa_start": 83,
"biotype": "protein_coding",
"canonical": false,
"cdna_end": null,
"cdna_length": 4177,
"cdna_start": 1767,
"cds_end": null,
"cds_length": 2010,
"cds_start": 249,
"consequences": [
"synonymous_variant"
],
"exon_count": 5,
"exon_rank": 2,
"exon_rank_end": null,
"feature": "ENST00000853707.1",
"gene_hgnc_id": 29381,
"gene_symbol": "LZTS2",
"hgvs_c": "c.249C>T",
"hgvs_p": "p.Val83Val",
"intron_rank": null,
"intron_rank_end": null,
"mane_plus": null,
"mane_select": null,
"protein_coding": true,
"protein_id": "ENSP00000523766.1",
"strand": true,
"transcript": "ENST00000853707.1",
"transcript_support_level": null
},
{
"aa_alt": "V",
"aa_end": null,
"aa_length": 669,
"aa_ref": "V",
"aa_start": 83,
"biotype": "protein_coding",
"canonical": false,
"cdna_end": null,
"cdna_length": 2973,
"cdna_start": 544,
"cds_end": null,
"cds_length": 2010,
"cds_start": 249,
"consequences": [
"synonymous_variant"
],
"exon_count": 6,
"exon_rank": 3,
"exon_rank_end": null,
"feature": "ENST00000912443.1",
"gene_hgnc_id": 29381,
"gene_symbol": "LZTS2",
"hgvs_c": "c.249C>T",
"hgvs_p": "p.Val83Val",
"intron_rank": null,
"intron_rank_end": null,
"mane_plus": null,
"mane_select": null,
"protein_coding": true,
"protein_id": "ENSP00000582502.1",
"strand": true,
"transcript": "ENST00000912443.1",
"transcript_support_level": null
},
{
"aa_alt": "V",
"aa_end": null,
"aa_length": 669,
"aa_ref": "V",
"aa_start": 83,
"biotype": "protein_coding",
"canonical": false,
"cdna_end": null,
"cdna_length": 3065,
"cdna_start": 636,
"cds_end": null,
"cds_length": 2010,
"cds_start": 249,
"consequences": [
"synonymous_variant"
],
"exon_count": 6,
"exon_rank": 3,
"exon_rank_end": null,
"feature": "ENST00000912444.1",
"gene_hgnc_id": 29381,
"gene_symbol": "LZTS2",
"hgvs_c": "c.249C>T",
"hgvs_p": "p.Val83Val",
"intron_rank": null,
"intron_rank_end": null,
"mane_plus": null,
"mane_select": null,
"protein_coding": true,
"protein_id": "ENSP00000582503.1",
"strand": true,
"transcript": "ENST00000912444.1",
"transcript_support_level": null
},
{
"aa_alt": "V",
"aa_end": null,
"aa_length": 669,
"aa_ref": "V",
"aa_start": 83,
"biotype": "protein_coding",
"canonical": false,
"cdna_end": null,
"cdna_length": 2930,
"cdna_start": 503,
"cds_end": null,
"cds_length": 2010,
"cds_start": 249,
"consequences": [
"synonymous_variant"
],
"exon_count": 5,
"exon_rank": 2,
"exon_rank_end": null,
"feature": "ENST00000912445.1",
"gene_hgnc_id": 29381,
"gene_symbol": "LZTS2",
"hgvs_c": "c.249C>T",
"hgvs_p": "p.Val83Val",
"intron_rank": null,
"intron_rank_end": null,
"mane_plus": null,
"mane_select": null,
"protein_coding": true,
"protein_id": "ENSP00000582504.1",
"strand": true,
"transcript": "ENST00000912445.1",
"transcript_support_level": null
},
{
"aa_alt": "V",
"aa_end": null,
"aa_length": 669,
"aa_ref": "V",
"aa_start": 83,
"biotype": "protein_coding",
"canonical": false,
"cdna_end": null,
"cdna_length": 2969,
"cdna_start": 543,
"cds_end": null,
"cds_length": 2010,
"cds_start": 249,
"consequences": [
"synonymous_variant"
],
"exon_count": 5,
"exon_rank": 2,
"exon_rank_end": null,
"feature": "ENST00000912446.1",
"gene_hgnc_id": 29381,
"gene_symbol": "LZTS2",
"hgvs_c": "c.249C>T",
"hgvs_p": "p.Val83Val",
"intron_rank": null,
"intron_rank_end": null,
"mane_plus": null,
"mane_select": null,
"protein_coding": true,
"protein_id": "ENSP00000582505.1",
"strand": true,
"transcript": "ENST00000912446.1",
"transcript_support_level": null
},
{
"aa_alt": "V",
"aa_end": null,
"aa_length": 669,
"aa_ref": "V",
"aa_start": 83,
"biotype": "protein_coding",
"canonical": false,
"cdna_end": null,
"cdna_length": 2983,
"cdna_start": 557,
"cds_end": null,
"cds_length": 2010,
"cds_start": 249,
"consequences": [
"synonymous_variant"
],
"exon_count": 6,
"exon_rank": 3,
"exon_rank_end": null,
"feature": "ENST00000912447.1",
"gene_hgnc_id": 29381,
"gene_symbol": "LZTS2",
"hgvs_c": "c.249C>T",
"hgvs_p": "p.Val83Val",
"intron_rank": null,
"intron_rank_end": null,
"mane_plus": null,
"mane_select": null,
"protein_coding": true,
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