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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 10-103089684-C-G (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=10&pos=103089684&ref=C&alt=G&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "10",
"pos": 103089684,
"ref": "C",
"alt": "G",
"effect": "missense_variant",
"transcript": "ENST00000404739.8",
"consequences": [
{
"aa_ref": "E",
"aa_alt": "D",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 19,
"exon_rank_end": null,
"exon_count": 19,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NT5C2",
"gene_hgnc_id": 8022,
"hgvs_c": "c.1674G>C",
"hgvs_p": "p.Glu558Asp",
"transcript": "NM_001351169.2",
"protein_id": "NP_001338098.1",
"transcript_support_level": null,
"aa_start": 558,
"aa_end": null,
"aa_length": 561,
"cds_start": 1674,
"cds_end": null,
"cds_length": 1686,
"cdna_start": 1879,
"cdna_end": null,
"cdna_length": 3525,
"mane_select": "ENST00000404739.8",
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "E",
"aa_alt": "D",
"canonical": true,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 19,
"exon_rank_end": null,
"exon_count": 19,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NT5C2",
"gene_hgnc_id": 8022,
"hgvs_c": "c.1674G>C",
"hgvs_p": "p.Glu558Asp",
"transcript": "ENST00000404739.8",
"protein_id": "ENSP00000383960.3",
"transcript_support_level": 1,
"aa_start": 558,
"aa_end": null,
"aa_length": 561,
"cds_start": 1674,
"cds_end": null,
"cds_length": 1686,
"cdna_start": 1879,
"cdna_end": null,
"cdna_length": 3525,
"mane_select": "NM_001351169.2",
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "E",
"aa_alt": "D",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 18,
"exon_rank_end": null,
"exon_count": 18,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NT5C2",
"gene_hgnc_id": 8022,
"hgvs_c": "c.1674G>C",
"hgvs_p": "p.Glu558Asp",
"transcript": "ENST00000343289.9",
"protein_id": "ENSP00000339479.5",
"transcript_support_level": 1,
"aa_start": 558,
"aa_end": null,
"aa_length": 561,
"cds_start": 1674,
"cds_end": null,
"cds_length": 1686,
"cdna_start": 1769,
"cdna_end": null,
"cdna_length": 3435,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"3_prime_UTR_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CNNM2",
"gene_hgnc_id": 103,
"hgvs_c": "c.*12504C>G",
"hgvs_p": null,
"transcript": "NM_017649.5",
"protein_id": "NP_060119.3",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 875,
"cds_start": -4,
"cds_end": null,
"cds_length": 2628,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 15857,
"mane_select": "ENST00000369878.9",
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": true,
"protein_coding": true,
"strand": true,
"consequences": [
"3_prime_UTR_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CNNM2",
"gene_hgnc_id": 103,
"hgvs_c": "c.*12504C>G",
"hgvs_p": null,
"transcript": "ENST00000369878.9",
"protein_id": "ENSP00000358894.3",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": 875,
"cds_start": -4,
"cds_end": null,
"cds_length": 2628,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 15857,
"mane_select": "NM_017649.5",
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "E",
"aa_alt": "D",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 19,
"exon_rank_end": null,
"exon_count": 19,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NT5C2",
"gene_hgnc_id": 8022,
"hgvs_c": "c.1698G>C",
"hgvs_p": "p.Glu566Asp",
"transcript": "NM_001351170.2",
"protein_id": "NP_001338099.1",
"transcript_support_level": null,
"aa_start": 566,
"aa_end": null,
"aa_length": 569,
"cds_start": 1698,
"cds_end": null,
"cds_length": 1710,
"cdna_start": 1759,
"cdna_end": null,
"cdna_length": 3405,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "E",
"aa_alt": "D",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 20,
"exon_rank_end": null,
"exon_count": 20,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NT5C2",
"gene_hgnc_id": 8022,
"hgvs_c": "c.1698G>C",
"hgvs_p": "p.Glu566Asp",
"transcript": "NM_001351171.2",
"protein_id": "NP_001338100.1",
"transcript_support_level": null,
"aa_start": 566,
"aa_end": null,
"aa_length": 569,
"cds_start": 1698,
"cds_end": null,
"cds_length": 1710,
"cdna_start": 1857,
"cdna_end": null,
"cdna_length": 3503,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "E",
"aa_alt": "D",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 20,
"exon_rank_end": null,
"exon_count": 20,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NT5C2",
"gene_hgnc_id": 8022,
"hgvs_c": "c.1698G>C",
"hgvs_p": "p.Glu566Asp",
"transcript": "NM_001351172.2",
"protein_id": "NP_001338101.1",
"transcript_support_level": null,
"aa_start": 566,
"aa_end": null,
"aa_length": 569,
"cds_start": 1698,
"cds_end": null,
"cds_length": 1710,
"cdna_start": 1903,
"cdna_end": null,
"cdna_length": 3549,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "E",
"aa_alt": "D",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 19,
"exon_rank_end": null,
"exon_count": 19,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NT5C2",
"gene_hgnc_id": 8022,
"hgvs_c": "c.1698G>C",
"hgvs_p": "p.Glu566Asp",
"transcript": "NM_001351173.2",
"protein_id": "NP_001338102.1",
"transcript_support_level": null,
"aa_start": 566,
"aa_end": null,
"aa_length": 569,
"cds_start": 1698,
"cds_end": null,
"cds_length": 1710,
"cdna_start": 2294,
"cdna_end": null,
"cdna_length": 3940,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "E",
"aa_alt": "D",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 21,
"exon_rank_end": null,
"exon_count": 21,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NT5C2",
"gene_hgnc_id": 8022,
"hgvs_c": "c.1698G>C",
"hgvs_p": "p.Glu566Asp",
"transcript": "ENST00000674860.1",
"protein_id": "ENSP00000502816.1",
"transcript_support_level": null,
"aa_start": 566,
"aa_end": null,
"aa_length": 569,
"cds_start": 1698,
"cds_end": null,
"cds_length": 1710,
"cdna_start": 2050,
"cdna_end": null,
"cdna_length": 3614,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "E",
"aa_alt": "D",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 18,
"exon_rank_end": null,
"exon_count": 18,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NT5C2",
"gene_hgnc_id": 8022,
"hgvs_c": "c.1674G>C",
"hgvs_p": "p.Glu558Asp",
"transcript": "NM_001134373.3",
"protein_id": "NP_001127845.1",
"transcript_support_level": null,
"aa_start": 558,
"aa_end": null,
"aa_length": 561,
"cds_start": 1674,
"cds_end": null,
"cds_length": 1686,
"cdna_start": 1735,
"cdna_end": null,
"cdna_length": 3381,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "E",
"aa_alt": "D",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 19,
"exon_rank_end": null,
"exon_count": 19,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NT5C2",
"gene_hgnc_id": 8022,
"hgvs_c": "c.1674G>C",
"hgvs_p": "p.Glu558Asp",
"transcript": "NM_012229.5",
"protein_id": "NP_036361.1",
"transcript_support_level": null,
"aa_start": 558,
"aa_end": null,
"aa_length": 561,
"cds_start": 1674,
"cds_end": null,
"cds_length": 1686,
"cdna_start": 1833,
"cdna_end": null,
"cdna_length": 3479,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "E",
"aa_alt": "D",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 18,
"exon_rank_end": null,
"exon_count": 18,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NT5C2",
"gene_hgnc_id": 8022,
"hgvs_c": "c.1674G>C",
"hgvs_p": "p.Glu558Asp",
"transcript": "ENST00000674696.1",
"protein_id": "ENSP00000502679.1",
"transcript_support_level": null,
"aa_start": 558,
"aa_end": null,
"aa_length": 561,
"cds_start": 1674,
"cds_end": null,
"cds_length": 1686,
"cdna_start": 2315,
"cdna_end": null,
"cdna_length": 3497,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "E",
"aa_alt": "D",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 19,
"exon_rank_end": null,
"exon_count": 19,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NT5C2",
"gene_hgnc_id": 8022,
"hgvs_c": "c.1674G>C",
"hgvs_p": "p.Glu558Asp",
"transcript": "ENST00000675326.1",
"protein_id": "ENSP00000502205.1",
"transcript_support_level": null,
"aa_start": 558,
"aa_end": null,
"aa_length": 561,
"cds_start": 1674,
"cds_end": null,
"cds_length": 1686,
"cdna_start": 1951,
"cdna_end": null,
"cdna_length": 3118,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "E",
"aa_alt": "D",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 19,
"exon_rank_end": null,
"exon_count": 19,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NT5C2",
"gene_hgnc_id": 8022,
"hgvs_c": "c.1674G>C",
"hgvs_p": "p.Glu558Asp",
"transcript": "ENST00000676428.1",
"protein_id": "ENSP00000501689.1",
"transcript_support_level": null,
"aa_start": 558,
"aa_end": null,
"aa_length": 561,
"cds_start": 1674,
"cds_end": null,
"cds_length": 1686,
"cdna_start": 1912,
"cdna_end": null,
"cdna_length": 3425,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "E",
"aa_alt": "D",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 18,
"exon_rank_end": null,
"exon_count": 18,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NT5C2",
"gene_hgnc_id": 8022,
"hgvs_c": "c.1674G>C",
"hgvs_p": "p.Glu558Asp",
"transcript": "ENST00000676449.1",
"protein_id": "ENSP00000502801.1",
"transcript_support_level": null,
"aa_start": 558,
"aa_end": null,
"aa_length": 561,
"cds_start": 1674,
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"cds_length": 1686,
"cdna_start": 2150,
"cdna_end": null,
"cdna_length": 3670,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "E",
"aa_alt": "D",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 17,
"exon_rank_end": null,
"exon_count": 17,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NT5C2",
"gene_hgnc_id": 8022,
"hgvs_c": "c.1587G>C",
"hgvs_p": "p.Glu529Asp",
"transcript": "NM_001351174.1",
"protein_id": "NP_001338103.1",
"transcript_support_level": null,
"aa_start": 529,
"aa_end": null,
"aa_length": 532,
"cds_start": 1587,
"cds_end": null,
"cds_length": 1599,
"cdna_start": 2104,
"cdna_end": null,
"cdna_length": 3771,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "E",
"aa_alt": "D",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 17,
"exon_rank_end": null,
"exon_count": 17,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NT5C2",
"gene_hgnc_id": 8022,
"hgvs_c": "c.1587G>C",
"hgvs_p": "p.Glu529Asp",
"transcript": "ENST00000675985.1",
"protein_id": "ENSP00000502215.1",
"transcript_support_level": null,
"aa_start": 529,
"aa_end": null,
"aa_length": 532,
"cds_start": 1587,
"cds_end": null,
"cds_length": 1599,
"cdna_start": 1910,
"cdna_end": null,
"cdna_length": 3413,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "E",
"aa_alt": "D",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 20,
"exon_rank_end": null,
"exon_count": 20,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NT5C2",
"gene_hgnc_id": 8022,
"hgvs_c": "c.1581G>C",
"hgvs_p": "p.Glu527Asp",
"transcript": "NM_001351175.2",
"protein_id": "NP_001338104.1",
"transcript_support_level": null,
"aa_start": 527,
"aa_end": null,
"aa_length": 530,
"cds_start": 1581,
"cds_end": null,
"cds_length": 1593,
"cdna_start": 2003,
"cdna_end": null,
"cdna_length": 3649,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "E",
"aa_alt": "D",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 18,
"exon_rank_end": null,
"exon_count": 18,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NT5C2",
"gene_hgnc_id": 8022,
"hgvs_c": "c.1101G>C",
"hgvs_p": "p.Glu367Asp",
"transcript": "NM_001351176.2",
"protein_id": "NP_001338105.1",
"transcript_support_level": null,
"aa_start": 367,
"aa_end": null,
"aa_length": 370,
"cds_start": 1101,
"cds_end": null,
"cds_length": 1113,
"cdna_start": 1722,
"cdna_end": null,
"cdna_length": 3368,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "E",
"aa_alt": "D",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 19,
"exon_rank_end": null,
"exon_count": 19,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NT5C2",
"gene_hgnc_id": 8022,
"hgvs_c": "c.1101G>C",
"hgvs_p": "p.Glu367Asp",
"transcript": "NM_001351177.2",
"protein_id": "NP_001338106.1",
"transcript_support_level": null,
"aa_start": 367,
"aa_end": null,
"aa_length": 370,
"cds_start": 1101,
"cds_end": null,
"cds_length": 1113,
"cdna_start": 1796,
"cdna_end": null,
"cdna_length": 3442,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "E",
"aa_alt": "D",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 21,
"exon_rank_end": null,
"exon_count": 21,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NT5C2",
"gene_hgnc_id": 8022,
"hgvs_c": "c.1101G>C",
"hgvs_p": "p.Glu367Asp",
"transcript": "NM_001351178.2",
"protein_id": "NP_001338107.1",
"transcript_support_level": null,
"aa_start": 367,
"aa_end": null,
"aa_length": 370,
"cds_start": 1101,
"cds_end": null,
"cds_length": 1113,
"cdna_start": 1918,
"cdna_end": null,
"cdna_length": 3564,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "E",
"aa_alt": "D",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 20,
"exon_rank_end": null,
"exon_count": 20,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NT5C2",
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