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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 10-103449656-C-G (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=10&pos=103449656&ref=C&alt=G&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "10",
"pos": 103449656,
"ref": "C",
"alt": "G",
"effect": "missense_variant",
"transcript": "ENST00000260743.10",
"consequences": [
{
"aa_ref": "A",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 4,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CALHM2",
"gene_hgnc_id": 23493,
"hgvs_c": "c.286G>C",
"hgvs_p": "p.Ala96Pro",
"transcript": "NM_015916.5",
"protein_id": "NP_057000.2",
"transcript_support_level": null,
"aa_start": 96,
"aa_end": null,
"aa_length": 323,
"cds_start": 286,
"cds_end": null,
"cds_length": 972,
"cdna_start": 862,
"cdna_end": null,
"cdna_length": 1914,
"mane_select": "ENST00000260743.10",
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "A",
"aa_alt": "P",
"canonical": true,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 4,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CALHM2",
"gene_hgnc_id": 23493,
"hgvs_c": "c.286G>C",
"hgvs_p": "p.Ala96Pro",
"transcript": "ENST00000260743.10",
"protein_id": "ENSP00000260743.5",
"transcript_support_level": 1,
"aa_start": 96,
"aa_end": null,
"aa_length": 323,
"cds_start": 286,
"cds_end": null,
"cds_length": 972,
"cdna_start": 862,
"cdna_end": null,
"cdna_length": 1914,
"mane_select": "NM_015916.5",
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "A",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 4,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CALHM2",
"gene_hgnc_id": 23493,
"hgvs_c": "c.286G>C",
"hgvs_p": "p.Ala96Pro",
"transcript": "ENST00000369788.7",
"protein_id": "ENSP00000358803.3",
"transcript_support_level": 2,
"aa_start": 96,
"aa_end": null,
"aa_length": 323,
"cds_start": 286,
"cds_end": null,
"cds_length": 972,
"cdna_start": 791,
"cdna_end": null,
"cdna_length": 1843,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "A",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 4,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CALHM2",
"gene_hgnc_id": 23493,
"hgvs_c": "c.286G>C",
"hgvs_p": "p.Ala96Pro",
"transcript": "XM_006717880.3",
"protein_id": "XP_006717943.1",
"transcript_support_level": null,
"aa_start": 96,
"aa_end": null,
"aa_length": 323,
"cds_start": 286,
"cds_end": null,
"cds_length": 972,
"cdna_start": 778,
"cdna_end": null,
"cdna_length": 1830,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "A",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 2,
"exon_rank_end": null,
"exon_count": 3,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CALHM2",
"gene_hgnc_id": 23493,
"hgvs_c": "c.286G>C",
"hgvs_p": "p.Ala96Pro",
"transcript": "XM_006717883.3",
"protein_id": "XP_006717946.1",
"transcript_support_level": null,
"aa_start": 96,
"aa_end": null,
"aa_length": 323,
"cds_start": 286,
"cds_end": null,
"cds_length": 972,
"cdna_start": 659,
"cdna_end": null,
"cdna_length": 1711,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "A",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 4,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CALHM2",
"gene_hgnc_id": 23493,
"hgvs_c": "c.286G>C",
"hgvs_p": "p.Ala96Pro",
"transcript": "XM_011539848.3",
"protein_id": "XP_011538150.1",
"transcript_support_level": null,
"aa_start": 96,
"aa_end": null,
"aa_length": 323,
"cds_start": 286,
"cds_end": null,
"cds_length": 972,
"cdna_start": 1460,
"cdna_end": null,
"cdna_length": 2512,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "A",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 4,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CALHM2",
"gene_hgnc_id": 23493,
"hgvs_c": "c.286G>C",
"hgvs_p": "p.Ala96Pro",
"transcript": "XM_017016306.2",
"protein_id": "XP_016871795.1",
"transcript_support_level": null,
"aa_start": 96,
"aa_end": null,
"aa_length": 323,
"cds_start": 286,
"cds_end": null,
"cds_length": 972,
"cdna_start": 1336,
"cdna_end": null,
"cdna_length": 2388,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "A",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 4,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CALHM2",
"gene_hgnc_id": 23493,
"hgvs_c": "c.286G>C",
"hgvs_p": "p.Ala96Pro",
"transcript": "XM_017016307.2",
"protein_id": "XP_016871796.1",
"transcript_support_level": null,
"aa_start": 96,
"aa_end": null,
"aa_length": 323,
"cds_start": 286,
"cds_end": null,
"cds_length": 972,
"cdna_start": 1233,
"cdna_end": null,
"cdna_length": 2285,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "A",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 4,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CALHM2",
"gene_hgnc_id": 23493,
"hgvs_c": "c.286G>C",
"hgvs_p": "p.Ala96Pro",
"transcript": "XM_024448034.2",
"protein_id": "XP_024303802.1",
"transcript_support_level": null,
"aa_start": 96,
"aa_end": null,
"aa_length": 323,
"cds_start": 286,
"cds_end": null,
"cds_length": 972,
"cdna_start": 1563,
"cdna_end": null,
"cdna_length": 2615,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "A",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 4,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CALHM2",
"gene_hgnc_id": 23493,
"hgvs_c": "c.286G>C",
"hgvs_p": "p.Ala96Pro",
"transcript": "XM_047425265.1",
"protein_id": "XP_047281221.1",
"transcript_support_level": null,
"aa_start": 96,
"aa_end": null,
"aa_length": 323,
"cds_start": 286,
"cds_end": null,
"cds_length": 972,
"cdna_start": 1613,
"cdna_end": null,
"cdna_length": 2665,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "A",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 4,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CALHM2",
"gene_hgnc_id": 23493,
"hgvs_c": "c.286G>C",
"hgvs_p": "p.Ala96Pro",
"transcript": "XM_047425266.1",
"protein_id": "XP_047281222.1",
"transcript_support_level": null,
"aa_start": 96,
"aa_end": null,
"aa_length": 323,
"cds_start": 286,
"cds_end": null,
"cds_length": 972,
"cdna_start": 2314,
"cdna_end": null,
"cdna_length": 3366,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "A",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 5,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CALHM2",
"gene_hgnc_id": 23493,
"hgvs_c": "c.286G>C",
"hgvs_p": "p.Ala96Pro",
"transcript": "XM_047425267.1",
"protein_id": "XP_047281223.1",
"transcript_support_level": null,
"aa_start": 96,
"aa_end": null,
"aa_length": 323,
"cds_start": 286,
"cds_end": null,
"cds_length": 972,
"cdna_start": 1020,
"cdna_end": null,
"cdna_length": 2072,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "A",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 4,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CALHM2",
"gene_hgnc_id": 23493,
"hgvs_c": "c.286G>C",
"hgvs_p": "p.Ala96Pro",
"transcript": "XM_047425268.1",
"protein_id": "XP_047281224.1",
"transcript_support_level": null,
"aa_start": 96,
"aa_end": null,
"aa_length": 323,
"cds_start": 286,
"cds_end": null,
"cds_length": 972,
"cdna_start": 1479,
"cdna_end": null,
"cdna_length": 2531,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "A",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 4,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CALHM2",
"gene_hgnc_id": 23493,
"hgvs_c": "c.286G>C",
"hgvs_p": "p.Ala96Pro",
"transcript": "XM_047425269.1",
"protein_id": "XP_047281225.1",
"transcript_support_level": null,
"aa_start": 96,
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"feature": null
},
{
"aa_ref": "A",
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"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 5,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CALHM2",
"gene_hgnc_id": 23493,
"hgvs_c": "c.286G>C",
"hgvs_p": "p.Ala96Pro",
"transcript": "XM_047425270.1",
"protein_id": "XP_047281226.1",
"transcript_support_level": null,
"aa_start": 96,
"aa_end": null,
"aa_length": 323,
"cds_start": 286,
"cds_end": null,
"cds_length": 972,
"cdna_start": 1637,
"cdna_end": null,
"cdna_length": 2689,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "A",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 2,
"exon_rank_end": null,
"exon_count": 3,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CALHM2",
"gene_hgnc_id": 23493,
"hgvs_c": "c.286G>C",
"hgvs_p": "p.Ala96Pro",
"transcript": "XM_047425271.1",
"protein_id": "XP_047281227.1",
"transcript_support_level": null,
"aa_start": 96,
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"cds_start": 286,
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"cdna_start": 1360,
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"mane_select": null,
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"feature": null
},
{
"aa_ref": "A",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 4,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CALHM2",
"gene_hgnc_id": 23493,
"hgvs_c": "c.286G>C",
"hgvs_p": "p.Ala96Pro",
"transcript": "XM_047425272.1",
"protein_id": "XP_047281228.1",
"transcript_support_level": null,
"aa_start": 96,
"aa_end": null,
"aa_length": 323,
"cds_start": 286,
"cds_end": null,
"cds_length": 972,
"cdna_start": 1252,
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"cdna_length": 2304,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "A",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 4,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CALHM2",
"gene_hgnc_id": 23493,
"hgvs_c": "c.286G>C",
"hgvs_p": "p.Ala96Pro",
"transcript": "XM_006717884.5",
"protein_id": "XP_006717947.1",
"transcript_support_level": null,
"aa_start": 96,
"aa_end": null,
"aa_length": 196,
"cds_start": 286,
"cds_end": null,
"cds_length": 591,
"cdna_start": 1460,
"cdna_end": null,
"cdna_length": 2499,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "A",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 4,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CALHM2",
"gene_hgnc_id": 23493,
"hgvs_c": "c.286G>C",
"hgvs_p": "p.Ala96Pro",
"transcript": "XM_017016308.3",
"protein_id": "XP_016871797.1",
"transcript_support_level": null,
"aa_start": 96,
"aa_end": null,
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"cds_start": 286,
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"cdna_start": 862,
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"feature": null
},
{
"aa_ref": "A",
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"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 2,
"exon_rank_end": null,
"exon_count": 3,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CALHM2",
"gene_hgnc_id": 23493,
"hgvs_c": "c.286G>C",
"hgvs_p": "p.Ala96Pro",
"transcript": "XM_017016309.3",
"protein_id": "XP_016871798.1",
"transcript_support_level": null,
"aa_start": 96,
"aa_end": null,
"aa_length": 196,
"cds_start": 286,
"cds_end": null,
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"cdna_start": 659,
"cdna_end": null,
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"mane_select": null,
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"biotype": null,
"feature": null
},
{
"aa_ref": "A",
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"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 4,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CALHM2",
"gene_hgnc_id": 23493,
"hgvs_c": "c.286G>C",
"hgvs_p": "p.Ala96Pro",
"transcript": "XM_024448035.2",
"protein_id": "XP_024303803.1",
"transcript_support_level": null,
"aa_start": 96,
"aa_end": null,
"aa_length": 196,
"cds_start": 286,
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"cdna_start": 1563,
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"cdna_length": 2602,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "A",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 4,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CALHM2",
"gene_hgnc_id": 23493,
"hgvs_c": "c.286G>C",
"hgvs_p": "p.Ala96Pro",
"transcript": "XM_047425274.1",
"protein_id": "XP_047281230.1",
"transcript_support_level": null,
"aa_start": 96,
"aa_end": null,
"aa_length": 196,
"cds_start": 286,
"cds_end": null,
"cds_length": 591,
"cdna_start": 1613,
"cdna_end": null,
"cdna_length": 2652,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "A",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 5,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CALHM2",
"gene_hgnc_id": 23493,
"hgvs_c": "c.286G>C",
"hgvs_p": "p.Ala96Pro",
"transcript": "XM_047425275.1",
"protein_id": "XP_047281231.1",
"transcript_support_level": null,
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}
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}