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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 10-109865261-C-T (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=10&pos=109865261&ref=C&alt=T&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "10",
"pos": 109865261,
"ref": "C",
"alt": "T",
"effect": "missense_variant",
"transcript": "NM_001324133.2",
"consequences": [
{
"aa_ref": "E",
"aa_alt": "K",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 21,
"exon_rank_end": null,
"exon_count": 21,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "XPNPEP1",
"gene_hgnc_id": 12822,
"hgvs_c": "c.1924G>A",
"hgvs_p": "p.Glu642Lys",
"transcript": "NM_020383.4",
"protein_id": "NP_065116.3",
"transcript_support_level": null,
"aa_start": 642,
"aa_end": null,
"aa_length": 666,
"cds_start": 1924,
"cds_end": null,
"cds_length": 2001,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": "ENST00000502935.6",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_020383.4"
},
{
"aa_ref": "E",
"aa_alt": "K",
"canonical": true,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 21,
"exon_rank_end": null,
"exon_count": 21,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "XPNPEP1",
"gene_hgnc_id": 12822,
"hgvs_c": "c.1924G>A",
"hgvs_p": "p.Glu642Lys",
"transcript": "ENST00000502935.6",
"protein_id": "ENSP00000421566.1",
"transcript_support_level": 1,
"aa_start": 642,
"aa_end": null,
"aa_length": 666,
"cds_start": 1924,
"cds_end": null,
"cds_length": 2001,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": "NM_020383.4",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000502935.6"
},
{
"aa_ref": "E",
"aa_alt": "K",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 20,
"exon_rank_end": null,
"exon_count": 20,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "XPNPEP1",
"gene_hgnc_id": 12822,
"hgvs_c": "c.1852G>A",
"hgvs_p": "p.Glu618Lys",
"transcript": "ENST00000322238.12",
"protein_id": "ENSP00000324011.8",
"transcript_support_level": 1,
"aa_start": 618,
"aa_end": null,
"aa_length": 642,
"cds_start": 1852,
"cds_end": null,
"cds_length": 1929,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000322238.12"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": false,
"strand": false,
"consequences": [
"non_coding_transcript_exon_variant"
],
"exon_rank": 17,
"exon_rank_end": null,
"exon_count": 17,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "XPNPEP1",
"gene_hgnc_id": 12822,
"hgvs_c": "n.3889G>A",
"hgvs_p": null,
"transcript": "ENST00000488118.6",
"protein_id": null,
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": null,
"cds_start": null,
"cds_end": null,
"cds_length": null,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "retained_intron",
"feature": "ENST00000488118.6"
},
{
"aa_ref": "E",
"aa_alt": "K",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 22,
"exon_rank_end": null,
"exon_count": 22,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "XPNPEP1",
"gene_hgnc_id": 12822,
"hgvs_c": "c.2047G>A",
"hgvs_p": "p.Glu683Lys",
"transcript": "ENST00000927705.1",
"protein_id": "ENSP00000597764.1",
"transcript_support_level": null,
"aa_start": 683,
"aa_end": null,
"aa_length": 707,
"cds_start": 2047,
"cds_end": null,
"cds_length": 2124,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000927705.1"
},
{
"aa_ref": "E",
"aa_alt": "K",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 22,
"exon_rank_end": null,
"exon_count": 22,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "XPNPEP1",
"gene_hgnc_id": 12822,
"hgvs_c": "c.2044G>A",
"hgvs_p": "p.Glu682Lys",
"transcript": "ENST00000891178.1",
"protein_id": "ENSP00000561237.1",
"transcript_support_level": null,
"aa_start": 682,
"aa_end": null,
"aa_length": 706,
"cds_start": 2044,
"cds_end": null,
"cds_length": 2121,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000891178.1"
},
{
"aa_ref": "G",
"aa_alt": "E",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 22,
"exon_rank_end": null,
"exon_count": 22,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "XPNPEP1",
"gene_hgnc_id": 12822,
"hgvs_c": "c.1982G>A",
"hgvs_p": "p.Gly661Glu",
"transcript": "NM_001324133.2",
"protein_id": "NP_001311062.1",
"transcript_support_level": null,
"aa_start": 661,
"aa_end": null,
"aa_length": 695,
"cds_start": 1982,
"cds_end": null,
"cds_length": 2088,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001324133.2"
},
{
"aa_ref": "E",
"aa_alt": "K",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 22,
"exon_rank_end": null,
"exon_count": 22,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "XPNPEP1",
"gene_hgnc_id": 12822,
"hgvs_c": "c.1984G>A",
"hgvs_p": "p.Glu662Lys",
"transcript": "ENST00000942378.1",
"protein_id": "ENSP00000612437.1",
"transcript_support_level": null,
"aa_start": 662,
"aa_end": null,
"aa_length": 686,
"cds_start": 1984,
"cds_end": null,
"cds_length": 2061,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000942378.1"
},
{
"aa_ref": "E",
"aa_alt": "K",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 21,
"exon_rank_end": null,
"exon_count": 21,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "XPNPEP1",
"gene_hgnc_id": 12822,
"hgvs_c": "c.1948G>A",
"hgvs_p": "p.Glu650Lys",
"transcript": "ENST00000942379.1",
"protein_id": "ENSP00000612438.1",
"transcript_support_level": null,
"aa_start": 650,
"aa_end": null,
"aa_length": 674,
"cds_start": 1948,
"cds_end": null,
"cds_length": 2025,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000942379.1"
},
{
"aa_ref": "E",
"aa_alt": "K",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 21,
"exon_rank_end": null,
"exon_count": 21,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "XPNPEP1",
"gene_hgnc_id": 12822,
"hgvs_c": "c.1909G>A",
"hgvs_p": "p.Glu637Lys",
"transcript": "NM_001324136.1",
"protein_id": "NP_001311065.1",
"transcript_support_level": null,
"aa_start": 637,
"aa_end": null,
"aa_length": 661,
"cds_start": 1909,
"cds_end": null,
"cds_length": 1986,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001324136.1"
},
{
"aa_ref": "E",
"aa_alt": "K",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 20,
"exon_rank_end": null,
"exon_count": 20,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "XPNPEP1",
"gene_hgnc_id": 12822,
"hgvs_c": "c.1873G>A",
"hgvs_p": "p.Glu625Lys",
"transcript": "NM_001324135.2",
"protein_id": "NP_001311064.1",
"transcript_support_level": null,
"aa_start": 625,
"aa_end": null,
"aa_length": 649,
"cds_start": 1873,
"cds_end": null,
"cds_length": 1950,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001324135.2"
},
{
"aa_ref": "E",
"aa_alt": "K",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 20,
"exon_rank_end": null,
"exon_count": 20,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "XPNPEP1",
"gene_hgnc_id": 12822,
"hgvs_c": "c.1873G>A",
"hgvs_p": "p.Glu625Lys",
"transcript": "ENST00000891174.1",
"protein_id": "ENSP00000561233.1",
"transcript_support_level": null,
"aa_start": 625,
"aa_end": null,
"aa_length": 649,
"cds_start": 1873,
"cds_end": null,
"cds_length": 1950,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000891174.1"
},
{
"aa_ref": "E",
"aa_alt": "K",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 20,
"exon_rank_end": null,
"exon_count": 20,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "XPNPEP1",
"gene_hgnc_id": 12822,
"hgvs_c": "c.1852G>A",
"hgvs_p": "p.Glu618Lys",
"transcript": "NM_001167604.2",
"protein_id": "NP_001161076.1",
"transcript_support_level": null,
"aa_start": 618,
"aa_end": null,
"aa_length": 642,
"cds_start": 1852,
"cds_end": null,
"cds_length": 1929,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001167604.2"
},
{
"aa_ref": "E",
"aa_alt": "K",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 20,
"exon_rank_end": null,
"exon_count": 20,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "XPNPEP1",
"gene_hgnc_id": 12822,
"hgvs_c": "c.1828G>A",
"hgvs_p": "p.Glu610Lys",
"transcript": "ENST00000891176.1",
"protein_id": "ENSP00000561235.1",
"transcript_support_level": null,
"aa_start": 610,
"aa_end": null,
"aa_length": 634,
"cds_start": 1828,
"cds_end": null,
"cds_length": 1905,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000891176.1"
},
{
"aa_ref": "E",
"aa_alt": "K",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 20,
"exon_rank_end": null,
"exon_count": 20,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "XPNPEP1",
"gene_hgnc_id": 12822,
"hgvs_c": "c.1825G>A",
"hgvs_p": "p.Glu609Lys",
"transcript": "ENST00000942377.1",
"protein_id": "ENSP00000612436.1",
"transcript_support_level": null,
"aa_start": 609,
"aa_end": null,
"aa_length": 633,
"cds_start": 1825,
"cds_end": null,
"cds_length": 1902,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000942377.1"
},
{
"aa_ref": "E",
"aa_alt": "K",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 20,
"exon_rank_end": null,
"exon_count": 20,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "XPNPEP1",
"gene_hgnc_id": 12822,
"hgvs_c": "c.1819G>A",
"hgvs_p": "p.Glu607Lys",
"transcript": "ENST00000942380.1",
"protein_id": "ENSP00000612439.1",
"transcript_support_level": null,
"aa_start": 607,
"aa_end": null,
"aa_length": 631,
"cds_start": 1819,
"cds_end": null,
"cds_length": 1896,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000942380.1"
},
{
"aa_ref": "E",
"aa_alt": "K",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 19,
"exon_rank_end": null,
"exon_count": 19,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "XPNPEP1",
"gene_hgnc_id": 12822,
"hgvs_c": "c.1801G>A",
"hgvs_p": "p.Glu601Lys",
"transcript": "ENST00000891177.1",
"protein_id": "ENSP00000561236.1",
"transcript_support_level": null,
"aa_start": 601,
"aa_end": null,
"aa_length": 625,
"cds_start": 1801,
"cds_end": null,
"cds_length": 1878,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000891177.1"
},
{
"aa_ref": "E",
"aa_alt": "K",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 20,
"exon_rank_end": null,
"exon_count": 20,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "XPNPEP1",
"gene_hgnc_id": 12822,
"hgvs_c": "c.1795G>A",
"hgvs_p": "p.Glu599Lys",
"transcript": "NM_001324132.2",
"protein_id": "NP_001311061.1",
"transcript_support_level": null,
"aa_start": 599,
"aa_end": null,
"aa_length": 623,
"cds_start": 1795,
"cds_end": null,
"cds_length": 1872,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001324132.2"
},
{
"aa_ref": "E",
"aa_alt": "K",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 20,
"exon_rank_end": null,
"exon_count": 20,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "XPNPEP1",
"gene_hgnc_id": 12822,
"hgvs_c": "c.1750G>A",
"hgvs_p": "p.Glu584Lys",
"transcript": "ENST00000891175.1",
"protein_id": "ENSP00000561234.1",
"transcript_support_level": null,
"aa_start": 584,
"aa_end": null,
"aa_length": 608,
"cds_start": 1750,
"cds_end": null,
"cds_length": 1827,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000891175.1"
},
{
"aa_ref": "E",
"aa_alt": "K",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 19,
"exon_rank_end": null,
"exon_count": 19,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "XPNPEP1",
"gene_hgnc_id": 12822,
"hgvs_c": "c.1684G>A",
"hgvs_p": "p.Glu562Lys",
"transcript": "ENST00000942376.1",
"protein_id": "ENSP00000612435.1",
"transcript_support_level": null,
"aa_start": 562,
"aa_end": null,
"aa_length": 586,
"cds_start": 1684,
"cds_end": null,
"cds_length": 1761,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000942376.1"
},
{
"aa_ref": "E",
"aa_alt": "K",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 19,
"exon_rank_end": null,
"exon_count": 19,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "XPNPEP1",
"gene_hgnc_id": 12822,
"hgvs_c": "c.1678G>A",
"hgvs_p": "p.Glu560Lys",
"transcript": "ENST00000927704.1",
"protein_id": "ENSP00000597763.1",
"transcript_support_level": null,
"aa_start": 560,
"aa_end": null,
"aa_length": 584,
"cds_start": 1678,
"cds_end": null,
"cds_length": 1755,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000927704.1"
},
{
"aa_ref": "E",
"aa_alt": "K",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 19,
"exon_rank_end": null,
"exon_count": 19,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "XPNPEP1",
"gene_hgnc_id": 12822,
"hgvs_c": "c.1675G>A",
"hgvs_p": "p.Glu559Lys",
"transcript": "ENST00000942382.1",
"protein_id": "ENSP00000612441.1",
"transcript_support_level": null,
"aa_start": 559,
"aa_end": null,
"aa_length": 583,
"cds_start": 1675,
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],
"clinvar_disease": "not specified",
"clinvar_classification": "Uncertain significance",
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"clinvar_submissions_summary": "US:1",
"phenotype_combined": "not specified",
"pathogenicity_classification_combined": "Uncertain significance",
"custom_annotations": null
}
],
"message": null
}