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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 10-109877877-A-C (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=10&pos=109877877&ref=A&alt=C&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "10",
"pos": 109877877,
"ref": "A",
"alt": "C",
"effect": "intron_variant",
"transcript": "ENST00000502935.6",
"consequences": [
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 21,
"intron_rank": 13,
"intron_rank_end": null,
"gene_symbol": "XPNPEP1",
"gene_hgnc_id": 12822,
"hgvs_c": "c.1242-10T>G",
"hgvs_p": null,
"transcript": "NM_020383.4",
"protein_id": "NP_065116.3",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 666,
"cds_start": -4,
"cds_end": null,
"cds_length": 2001,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 2497,
"mane_select": "ENST00000502935.6",
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": true,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 21,
"intron_rank": 13,
"intron_rank_end": null,
"gene_symbol": "XPNPEP1",
"gene_hgnc_id": 12822,
"hgvs_c": "c.1242-10T>G",
"hgvs_p": null,
"transcript": "ENST00000502935.6",
"protein_id": "ENSP00000421566.1",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": 666,
"cds_start": -4,
"cds_end": null,
"cds_length": 2001,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 2497,
"mane_select": "NM_020383.4",
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 20,
"intron_rank": 13,
"intron_rank_end": null,
"gene_symbol": "XPNPEP1",
"gene_hgnc_id": 12822,
"hgvs_c": "c.1242-10T>G",
"hgvs_p": null,
"transcript": "ENST00000322238.12",
"protein_id": "ENSP00000324011.8",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": 642,
"cds_start": -4,
"cds_end": null,
"cds_length": 1929,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 2467,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": false,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 17,
"intron_rank": 10,
"intron_rank_end": null,
"gene_symbol": "XPNPEP1",
"gene_hgnc_id": 12822,
"hgvs_c": "n.1017-10T>G",
"hgvs_p": null,
"transcript": "ENST00000488118.6",
"protein_id": null,
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": null,
"cds_start": -4,
"cds_end": null,
"cds_length": null,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 4384,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 22,
"intron_rank": 13,
"intron_rank_end": null,
"gene_symbol": "XPNPEP1",
"gene_hgnc_id": 12822,
"hgvs_c": "c.1242-10T>G",
"hgvs_p": null,
"transcript": "NM_001324133.2",
"protein_id": "NP_001311062.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 695,
"cds_start": -4,
"cds_end": null,
"cds_length": 2088,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 2555,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 21,
"intron_rank": 13,
"intron_rank_end": null,
"gene_symbol": "XPNPEP1",
"gene_hgnc_id": 12822,
"hgvs_c": "c.1227-10T>G",
"hgvs_p": null,
"transcript": "NM_001324136.1",
"protein_id": "NP_001311065.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 661,
"cds_start": -4,
"cds_end": null,
"cds_length": 1986,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 2754,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 20,
"intron_rank": 12,
"intron_rank_end": null,
"gene_symbol": "XPNPEP1",
"gene_hgnc_id": 12822,
"hgvs_c": "c.1191-10T>G",
"hgvs_p": null,
"transcript": "NM_001324135.2",
"protein_id": "NP_001311064.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 649,
"cds_start": -4,
"cds_end": null,
"cds_length": 1950,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 2446,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 20,
"intron_rank": 13,
"intron_rank_end": null,
"gene_symbol": "XPNPEP1",
"gene_hgnc_id": 12822,
"hgvs_c": "c.1242-10T>G",
"hgvs_p": null,
"transcript": "NM_001167604.2",
"protein_id": "NP_001161076.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 642,
"cds_start": -4,
"cds_end": null,
"cds_length": 1929,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 2425,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 20,
"intron_rank": 12,
"intron_rank_end": null,
"gene_symbol": "XPNPEP1",
"gene_hgnc_id": 12822,
"hgvs_c": "c.1113-10T>G",
"hgvs_p": null,
"transcript": "NM_001324132.2",
"protein_id": "NP_001311061.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 623,
"cds_start": -4,
"cds_end": null,
"cds_length": 1872,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 2408,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 19,
"intron_rank": 11,
"intron_rank_end": null,
"gene_symbol": "XPNPEP1",
"gene_hgnc_id": 12822,
"hgvs_c": "c.900-10T>G",
"hgvs_p": null,
"transcript": "NM_001324128.2",
"protein_id": "NP_001311057.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 552,
"cds_start": -4,
"cds_end": null,
"cds_length": 1659,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 2344,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 19,
"intron_rank": 11,
"intron_rank_end": null,
"gene_symbol": "XPNPEP1",
"gene_hgnc_id": 12822,
"hgvs_c": "c.900-10T>G",
"hgvs_p": null,
"transcript": "ENST00000369683.5",
"protein_id": "ENSP00000358697.1",
"transcript_support_level": 2,
"aa_start": null,
"aa_end": null,
"aa_length": 552,
"cds_start": -4,
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"cdna_start": null,
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"cdna_length": 2344,
"mane_select": null,
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"biotype": null,
"feature": null
},
{
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"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 21,
"intron_rank": 13,
"intron_rank_end": null,
"gene_symbol": "XPNPEP1",
"gene_hgnc_id": 12822,
"hgvs_c": "c.849-10T>G",
"hgvs_p": null,
"transcript": "NM_001324131.2",
"protein_id": "NP_001311060.1",
"transcript_support_level": null,
"aa_start": null,
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"aa_length": 535,
"cds_start": -4,
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"cds_length": 1608,
"cdna_start": null,
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"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
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"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 19,
"intron_rank": 11,
"intron_rank_end": null,
"gene_symbol": "XPNPEP1",
"gene_hgnc_id": 12822,
"hgvs_c": "c.720-10T>G",
"hgvs_p": null,
"transcript": "NM_001324134.2",
"protein_id": "NP_001311063.1",
"transcript_support_level": null,
"aa_start": null,
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"aa_length": 492,
"cds_start": -4,
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"cdna_start": null,
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"biotype": null,
"feature": null
},
{
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"canonical": false,
"protein_coding": false,
"strand": false,
"consequences": [
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],
"exon_rank": null,
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"exon_count": 5,
"intron_rank": 4,
"intron_rank_end": null,
"gene_symbol": "XPNPEP1",
"gene_hgnc_id": 12822,
"hgvs_c": "n.322-10T>G",
"hgvs_p": null,
"transcript": "ENST00000460055.5",
"protein_id": null,
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"aa_start": null,
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},
{
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"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
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"intron_rank": 5,
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"gene_symbol": "XPNPEP1",
"gene_hgnc_id": 12822,
"hgvs_c": "n.605-10T>G",
"hgvs_p": null,
"transcript": "ENST00000472336.5",
"protein_id": null,
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"aa_start": null,
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"cds_start": -4,
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"mane_select": null,
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"biotype": null,
"feature": null
},
{
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"canonical": false,
"protein_coding": false,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
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"exon_count": 7,
"intron_rank": 3,
"intron_rank_end": null,
"gene_symbol": "XPNPEP1",
"gene_hgnc_id": 12822,
"hgvs_c": "n.328-10T>G",
"hgvs_p": null,
"transcript": "ENST00000494564.5",
"protein_id": null,
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},
{
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],
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"intron_rank": 1,
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"gene_symbol": "XPNPEP1",
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"hgvs_c": "n.371-10T>G",
"hgvs_p": null,
"transcript": "ENST00000508525.1",
"protein_id": null,
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"mane_select": null,
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},
{
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"protein_coding": false,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 7,
"intron_rank": 3,
"intron_rank_end": null,
"gene_symbol": "XPNPEP1",
"gene_hgnc_id": 12822,
"hgvs_c": "n.163-10T>G",
"hgvs_p": null,
"transcript": "ENST00000510988.5",
"protein_id": null,
"transcript_support_level": 3,
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},
{
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"canonical": false,
"protein_coding": false,
"strand": false,
"consequences": [
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],
"exon_rank": null,
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"exon_count": 6,
"intron_rank": 5,
"intron_rank_end": null,
"gene_symbol": "XPNPEP1",
"gene_hgnc_id": 12822,
"hgvs_c": "n.618-10T>G",
"hgvs_p": null,
"transcript": "ENST00000513817.5",
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},
{
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"strand": false,
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],
"exon_rank": null,
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"gene_symbol": "XPNPEP1",
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"hgvs_c": "c.1098-10T>G",
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"transcript": "XM_017016613.3",
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},
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"strand": false,
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],
"exon_rank": null,
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"intron_rank": 13,
"intron_rank_end": null,
"gene_symbol": "XPNPEP1",
"gene_hgnc_id": 12822,
"hgvs_c": "c.1242-10T>G",
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"transcript": "XM_011540134.3",
"protein_id": "XP_011538436.1",
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},
{
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"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
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"exon_count": 19,
"intron_rank": 13,
"intron_rank_end": null,
"gene_symbol": "XPNPEP1",
"gene_hgnc_id": 12822,
"hgvs_c": "c.1242-10T>G",
"hgvs_p": null,
"transcript": "XM_047425713.1",
"protein_id": "XP_047281669.1",
"transcript_support_level": null,
"aa_start": null,
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"cds_start": -4,
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"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
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"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 20,
"intron_rank": 12,
"intron_rank_end": null,
"gene_symbol": "XPNPEP1",
"gene_hgnc_id": 12822,
"hgvs_c": "c.900-10T>G",
"hgvs_p": null,
"transcript": "XM_047425714.1",
"protein_id": "XP_047281670.1",
"transcript_support_level": null,
"aa_start": null,
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"cds_start": -4,
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"cdna_start": null,
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"cdna_length": 2326,
"mane_select": null,
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"biotype": null,
"feature": null
}
],
"gene_symbol": "XPNPEP1",
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"dbsnp": "rs2273740",
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"hom_count_reference_population": 31642,
"allele_count_reference_population": 292115,
"gnomad_exomes_af": 0.178679,
"gnomad_genomes_af": 0.203174,
"gnomad_exomes_ac": 261196,
"gnomad_genomes_ac": 30919,
"gnomad_exomes_homalt": 27998,
"gnomad_genomes_homalt": 3644,
"gnomad_mito_homoplasmic": null,
"gnomad_mito_heteroplasmic": null,
"computational_score_selected": -0.41999998688697815,
"computational_prediction_selected": "Benign",
"computational_source_selected": "BayesDel_noAF",
"splice_score_selected": 0.27799999713897705,
"splice_prediction_selected": "Benign",
"splice_source_selected": "dbscSNV1_RF",
"revel_score": null,
"revel_prediction": null,
"alphamissense_score": null,
"alphamissense_prediction": null,
"bayesdelnoaf_score": -0.42,
"bayesdelnoaf_prediction": "Benign",
"phylop100way_score": 3.472,
"phylop100way_prediction": "Benign",
"spliceai_max_score": 0.02,
"spliceai_max_prediction": "Benign",
"dbscsnv_ada_score": 0.0376821772537761,
"dbscsnv_ada_prediction": "Benign",
"apogee2_score": null,
"apogee2_prediction": null,
"mitotip_score": null,
"mitotip_prediction": null,
"acmg_score": -10,
"acmg_classification": "Benign",
"acmg_criteria": "BP4_Moderate,BA1",
"acmg_by_gene": [
{
"score": -10,
"benign_score": 10,
"pathogenic_score": 0,
"criteria": [
"BP4_Moderate",
"BA1"
],
"verdict": "Benign",
"transcript": "ENST00000502935.6",
"gene_symbol": "XPNPEP1",
"hgnc_id": 12822,
"effects": [
"intron_variant"
],
"inheritance_mode": "AR",
"hgvs_c": "c.1242-10T>G",
"hgvs_p": null
}
],
"clinvar_disease": "",
"clinvar_classification": "",
"clinvar_review_status": "",
"clinvar_submissions_summary": "",
"phenotype_combined": null,
"pathogenicity_classification_combined": null,
"custom_annotations": null
}
],
"message": null
}