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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 10-110118752-T-C (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=10&pos=110118752&ref=T&alt=C&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "10",
"pos": 110118752,
"ref": "T",
"alt": "C",
"effect": "intron_variant",
"transcript": "ENST00000356080.9",
"consequences": [
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 15,
"intron_rank": 6,
"intron_rank_end": null,
"gene_symbol": "ADD3",
"gene_hgnc_id": 245,
"hgvs_c": "c.717+16T>C",
"hgvs_p": null,
"transcript": "NM_016824.5",
"protein_id": "NP_058432.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 706,
"cds_start": -4,
"cds_end": null,
"cds_length": 2121,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 4413,
"mane_select": "ENST00000356080.9",
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": true,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 15,
"intron_rank": 6,
"intron_rank_end": null,
"gene_symbol": "ADD3",
"gene_hgnc_id": 245,
"hgvs_c": "c.717+16T>C",
"hgvs_p": null,
"transcript": "ENST00000356080.9",
"protein_id": "ENSP00000348381.4",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": 706,
"cds_start": -4,
"cds_end": null,
"cds_length": 2121,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 4413,
"mane_select": "NM_016824.5",
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 14,
"intron_rank": 6,
"intron_rank_end": null,
"gene_symbol": "ADD3",
"gene_hgnc_id": 245,
"hgvs_c": "c.717+16T>C",
"hgvs_p": null,
"transcript": "ENST00000277900.12",
"protein_id": "ENSP00000277900.8",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": 674,
"cds_start": -4,
"cds_end": null,
"cds_length": 2025,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 4337,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 14,
"intron_rank": 6,
"intron_rank_end": null,
"gene_symbol": "ADD3",
"gene_hgnc_id": 245,
"hgvs_c": "c.717+16T>C",
"hgvs_p": null,
"transcript": "ENST00000360162.7",
"protein_id": "ENSP00000353286.3",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": 674,
"cds_start": -4,
"cds_end": null,
"cds_length": 2025,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 3114,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 16,
"intron_rank": 7,
"intron_rank_end": null,
"gene_symbol": "ADD3",
"gene_hgnc_id": 245,
"hgvs_c": "c.717+16T>C",
"hgvs_p": null,
"transcript": "NM_001320591.2",
"protein_id": "NP_001307520.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 706,
"cds_start": -4,
"cds_end": null,
"cds_length": 2121,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 4359,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 15,
"intron_rank": 6,
"intron_rank_end": null,
"gene_symbol": "ADD3",
"gene_hgnc_id": 245,
"hgvs_c": "c.717+16T>C",
"hgvs_p": null,
"transcript": "NM_001320592.2",
"protein_id": "NP_001307521.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 706,
"cds_start": -4,
"cds_end": null,
"cds_length": 2121,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 4302,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 15,
"intron_rank": 6,
"intron_rank_end": null,
"gene_symbol": "ADD3",
"gene_hgnc_id": 245,
"hgvs_c": "c.717+16T>C",
"hgvs_p": null,
"transcript": "NM_001320593.2",
"protein_id": "NP_001307522.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 706,
"cds_start": -4,
"cds_end": null,
"cds_length": 2121,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 4298,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 14,
"intron_rank": 6,
"intron_rank_end": null,
"gene_symbol": "ADD3",
"gene_hgnc_id": 245,
"hgvs_c": "c.717+16T>C",
"hgvs_p": null,
"transcript": "NM_001121.4",
"protein_id": "NP_001112.2",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 674,
"cds_start": -4,
"cds_end": null,
"cds_length": 2025,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 4317,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 14,
"intron_rank": 6,
"intron_rank_end": null,
"gene_symbol": "ADD3",
"gene_hgnc_id": 245,
"hgvs_c": "c.717+16T>C",
"hgvs_p": null,
"transcript": "NM_019903.5",
"protein_id": "NP_063968.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 674,
"cds_start": -4,
"cds_end": null,
"cds_length": 2025,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 4206,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 16,
"intron_rank": 7,
"intron_rank_end": null,
"gene_symbol": "ADD3",
"gene_hgnc_id": 245,
"hgvs_c": "c.483+16T>C",
"hgvs_p": null,
"transcript": "NM_001320594.2",
"protein_id": "NP_001307523.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 628,
"cds_start": -4,
"cds_end": null,
"cds_length": 1887,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 4467,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": false,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 4,
"intron_rank": 2,
"intron_rank_end": null,
"gene_symbol": "ADD3",
"gene_hgnc_id": 245,
"hgvs_c": "n.111-3461T>C",
"hgvs_p": null,
"transcript": "ENST00000486014.1",
"protein_id": null,
"transcript_support_level": 3,
"aa_start": null,
"aa_end": null,
"aa_length": null,
"cds_start": -4,
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"cdna_start": null,
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"mane_select": null,
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"biotype": null,
"feature": null
},
{
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"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 16,
"intron_rank": 7,
"intron_rank_end": null,
"gene_symbol": "ADD3",
"gene_hgnc_id": 245,
"hgvs_c": "c.717+16T>C",
"hgvs_p": null,
"transcript": "XM_024447794.2",
"protein_id": "XP_024303562.1",
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"aa_start": null,
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"cds_start": -4,
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"feature": null
},
{
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"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
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"exon_count": 16,
"intron_rank": 7,
"intron_rank_end": null,
"gene_symbol": "ADD3",
"gene_hgnc_id": 245,
"hgvs_c": "c.717+16T>C",
"hgvs_p": null,
"transcript": "XM_024447795.1",
"protein_id": "XP_024303563.1",
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"aa_start": null,
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"cds_start": -4,
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},
{
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"protein_coding": true,
"strand": true,
"consequences": [
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],
"exon_rank": null,
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"exon_count": 17,
"intron_rank": 8,
"intron_rank_end": null,
"gene_symbol": "ADD3",
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"hgvs_c": "c.717+16T>C",
"hgvs_p": null,
"transcript": "XM_024447796.2",
"protein_id": "XP_024303564.1",
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},
{
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],
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"intron_rank": 7,
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"gene_symbol": "ADD3",
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"hgvs_c": "c.717+16T>C",
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"transcript": "XM_024447797.2",
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"feature": null
},
{
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"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
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],
"exon_rank": null,
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"exon_count": 15,
"intron_rank": 6,
"intron_rank_end": null,
"gene_symbol": "ADD3",
"gene_hgnc_id": 245,
"hgvs_c": "c.717+16T>C",
"hgvs_p": null,
"transcript": "XM_024447798.1",
"protein_id": "XP_024303566.1",
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},
{
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],
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"gene_symbol": "ADD3",
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"hgvs_c": "c.717+16T>C",
"hgvs_p": null,
"transcript": "XM_024447799.2",
"protein_id": "XP_024303567.1",
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},
{
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"strand": true,
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"intron_variant"
],
"exon_rank": null,
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"exon_count": 15,
"intron_rank": 6,
"intron_rank_end": null,
"gene_symbol": "ADD3",
"gene_hgnc_id": 245,
"hgvs_c": "c.717+16T>C",
"hgvs_p": null,
"transcript": "XM_024447800.2",
"protein_id": "XP_024303568.1",
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"feature": null
},
{
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"protein_coding": true,
"strand": true,
"consequences": [
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],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 16,
"intron_rank": 7,
"intron_rank_end": null,
"gene_symbol": "ADD3",
"gene_hgnc_id": 245,
"hgvs_c": "c.717+16T>C",
"hgvs_p": null,
"transcript": "XM_024447801.1",
"protein_id": "XP_024303569.1",
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},
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"strand": true,
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],
"exon_rank": null,
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"intron_rank": 6,
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"gene_symbol": "ADD3",
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},
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"strand": true,
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],
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"intron_rank": 7,
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"gene_symbol": "ADD3",
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"hgvs_c": "c.717+16T>C",
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"transcript": "XM_047424587.1",
"protein_id": "XP_047280543.1",
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},
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"consequences": [
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],
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"intron_rank": 8,
"intron_rank_end": null,
"gene_symbol": "ADD3",
"gene_hgnc_id": 245,
"hgvs_c": "c.717+16T>C",
"hgvs_p": null,
"transcript": "XM_047424588.1",
"protein_id": "XP_047280544.1",
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"aa_start": null,
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"biotype": null,
"feature": null
},
{
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"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 16,
"intron_rank": 7,
"intron_rank_end": null,
"gene_symbol": "ADD3",
"gene_hgnc_id": 245,
"hgvs_c": "c.717+16T>C",
"hgvs_p": null,
"transcript": "XM_047424589.1",
"protein_id": "XP_047280545.1",
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"aa_start": null,
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"mane_select": null,
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"feature": null
},
{
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"protein_coding": true,
"strand": true,
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