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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 10-113589078-C-A (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=10&pos=113589078&ref=C&alt=A&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "10",
"pos": 113589078,
"ref": "C",
"alt": "A",
"effect": "missense_variant",
"transcript": "NM_001261463.2",
"consequences": [
{
"aa_ref": "R",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 42,
"exon_rank_end": null,
"exon_count": 42,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NRAP",
"gene_hgnc_id": 7988,
"hgvs_c": "c.5093G>T",
"hgvs_p": "p.Arg1698Leu",
"transcript": "ENST00000369358.8",
"protein_id": "ENSP00000358365.4",
"transcript_support_level": 1,
"aa_start": 1698,
"aa_end": null,
"aa_length": 1731,
"cds_start": 5093,
"cds_end": null,
"cds_length": 5196,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000369358.8"
},
{
"aa_ref": "R",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant",
"splice_region_variant"
],
"exon_rank": 42,
"exon_rank_end": null,
"exon_count": 42,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NRAP",
"gene_hgnc_id": 7988,
"hgvs_c": "c.5090G>T",
"hgvs_p": "p.Arg1697Leu",
"transcript": "NM_198060.4",
"protein_id": "NP_932326.2",
"transcript_support_level": null,
"aa_start": 1697,
"aa_end": null,
"aa_length": 1730,
"cds_start": 5090,
"cds_end": null,
"cds_length": 5193,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": "ENST00000359988.4",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_198060.4"
},
{
"aa_ref": "R",
"aa_alt": "L",
"canonical": true,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant",
"splice_region_variant"
],
"exon_rank": 42,
"exon_rank_end": null,
"exon_count": 42,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NRAP",
"gene_hgnc_id": 7988,
"hgvs_c": "c.5090G>T",
"hgvs_p": "p.Arg1697Leu",
"transcript": "ENST00000359988.4",
"protein_id": "ENSP00000353078.3",
"transcript_support_level": 1,
"aa_start": 1697,
"aa_end": null,
"aa_length": 1730,
"cds_start": 5090,
"cds_end": null,
"cds_length": 5193,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": "NM_198060.4",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000359988.4"
},
{
"aa_ref": "R",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant",
"splice_region_variant"
],
"exon_rank": 41,
"exon_rank_end": null,
"exon_count": 41,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NRAP",
"gene_hgnc_id": 7988,
"hgvs_c": "c.4985G>T",
"hgvs_p": "p.Arg1662Leu",
"transcript": "ENST00000360478.7",
"protein_id": "ENSP00000353666.3",
"transcript_support_level": 1,
"aa_start": 1662,
"aa_end": null,
"aa_length": 1695,
"cds_start": 4985,
"cds_end": null,
"cds_length": 5088,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000360478.7"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"3_prime_UTR_variant"
],
"exon_rank": 13,
"exon_rank_end": null,
"exon_count": 13,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "HABP2",
"gene_hgnc_id": 4798,
"hgvs_c": "c.*709C>A",
"hgvs_p": null,
"transcript": "NM_004132.5",
"protein_id": "NP_004123.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 560,
"cds_start": null,
"cds_end": null,
"cds_length": 1683,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": "ENST00000351270.4",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_004132.5"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": true,
"protein_coding": true,
"strand": true,
"consequences": [
"3_prime_UTR_variant"
],
"exon_rank": 13,
"exon_rank_end": null,
"exon_count": 13,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "HABP2",
"gene_hgnc_id": 4798,
"hgvs_c": "c.*709C>A",
"hgvs_p": null,
"transcript": "ENST00000351270.4",
"protein_id": "ENSP00000277903.4",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": 560,
"cds_start": null,
"cds_end": null,
"cds_length": 1683,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": "NM_004132.5",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000351270.4"
},
{
"aa_ref": "R",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 42,
"exon_rank_end": null,
"exon_count": 42,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NRAP",
"gene_hgnc_id": 7988,
"hgvs_c": "c.5093G>T",
"hgvs_p": "p.Arg1698Leu",
"transcript": "NM_001261463.2",
"protein_id": "NP_001248392.1",
"transcript_support_level": null,
"aa_start": 1698,
"aa_end": null,
"aa_length": 1731,
"cds_start": 5093,
"cds_end": null,
"cds_length": 5196,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001261463.2"
},
{
"aa_ref": "R",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 41,
"exon_rank_end": null,
"exon_count": 41,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NRAP",
"gene_hgnc_id": 7988,
"hgvs_c": "c.4988G>T",
"hgvs_p": "p.Arg1663Leu",
"transcript": "ENST00000883351.1",
"protein_id": "ENSP00000553410.1",
"transcript_support_level": null,
"aa_start": 1663,
"aa_end": null,
"aa_length": 1696,
"cds_start": 4988,
"cds_end": null,
"cds_length": 5091,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000883351.1"
},
{
"aa_ref": "R",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 41,
"exon_rank_end": null,
"exon_count": 41,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NRAP",
"gene_hgnc_id": 7988,
"hgvs_c": "c.4985G>T",
"hgvs_p": "p.Arg1662Leu",
"transcript": "ENST00000883369.1",
"protein_id": "ENSP00000553428.1",
"transcript_support_level": null,
"aa_start": 1662,
"aa_end": null,
"aa_length": 1695,
"cds_start": 4985,
"cds_end": null,
"cds_length": 5088,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000883369.1"
},
{
"aa_ref": "R",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 41,
"exon_rank_end": null,
"exon_count": 41,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NRAP",
"gene_hgnc_id": 7988,
"hgvs_c": "c.4979G>T",
"hgvs_p": "p.Arg1660Leu",
"transcript": "ENST00000945579.1",
"protein_id": "ENSP00000615638.1",
"transcript_support_level": null,
"aa_start": 1660,
"aa_end": null,
"aa_length": 1693,
"cds_start": 4979,
"cds_end": null,
"cds_length": 5082,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000945579.1"
},
{
"aa_ref": "R",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 40,
"exon_rank_end": null,
"exon_count": 40,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NRAP",
"gene_hgnc_id": 7988,
"hgvs_c": "c.4883G>T",
"hgvs_p": "p.Arg1628Leu",
"transcript": "ENST00000883355.1",
"protein_id": "ENSP00000553414.1",
"transcript_support_level": null,
"aa_start": 1628,
"aa_end": null,
"aa_length": 1661,
"cds_start": 4883,
"cds_end": null,
"cds_length": 4986,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000883355.1"
},
{
"aa_ref": "R",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 40,
"exon_rank_end": null,
"exon_count": 40,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NRAP",
"gene_hgnc_id": 7988,
"hgvs_c": "c.4883G>T",
"hgvs_p": "p.Arg1628Leu",
"transcript": "ENST00000883364.1",
"protein_id": "ENSP00000553423.1",
"transcript_support_level": null,
"aa_start": 1628,
"aa_end": null,
"aa_length": 1661,
"cds_start": 4883,
"cds_end": null,
"cds_length": 4986,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000883364.1"
},
{
"aa_ref": "R",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 40,
"exon_rank_end": null,
"exon_count": 40,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NRAP",
"gene_hgnc_id": 7988,
"hgvs_c": "c.4880G>T",
"hgvs_p": "p.Arg1627Leu",
"transcript": "ENST00000883365.1",
"protein_id": "ENSP00000553424.1",
"transcript_support_level": null,
"aa_start": 1627,
"aa_end": null,
"aa_length": 1660,
"cds_start": 4880,
"cds_end": null,
"cds_length": 4983,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000883365.1"
},
{
"aa_ref": "R",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 40,
"exon_rank_end": null,
"exon_count": 40,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NRAP",
"gene_hgnc_id": 7988,
"hgvs_c": "c.4880G>T",
"hgvs_p": "p.Arg1627Leu",
"transcript": "ENST00000945550.1",
"protein_id": "ENSP00000615609.1",
"transcript_support_level": null,
"aa_start": 1627,
"aa_end": null,
"aa_length": 1660,
"cds_start": 4880,
"cds_end": null,
"cds_length": 4983,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000945550.1"
},
{
"aa_ref": "R",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 40,
"exon_rank_end": null,
"exon_count": 40,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NRAP",
"gene_hgnc_id": 7988,
"hgvs_c": "c.4874G>T",
"hgvs_p": "p.Arg1625Leu",
"transcript": "ENST00000883372.1",
"protein_id": "ENSP00000553431.1",
"transcript_support_level": null,
"aa_start": 1625,
"aa_end": null,
"aa_length": 1658,
"cds_start": 4874,
"cds_end": null,
"cds_length": 4977,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000883372.1"
},
{
"aa_ref": "R",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 39,
"exon_rank_end": null,
"exon_count": 39,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NRAP",
"gene_hgnc_id": 7988,
"hgvs_c": "c.4778G>T",
"hgvs_p": "p.Arg1593Leu",
"transcript": "ENST00000945585.1",
"protein_id": "ENSP00000615644.1",
"transcript_support_level": null,
"aa_start": 1593,
"aa_end": null,
"aa_length": 1626,
"cds_start": 4778,
"cds_end": null,
"cds_length": 4881,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000945585.1"
},
{
"aa_ref": "R",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 39,
"exon_rank_end": null,
"exon_count": 39,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NRAP",
"gene_hgnc_id": 7988,
"hgvs_c": "c.4775G>T",
"hgvs_p": "p.Arg1592Leu",
"transcript": "ENST00000883353.1",
"protein_id": "ENSP00000553412.1",
"transcript_support_level": null,
"aa_start": 1592,
"aa_end": null,
"aa_length": 1625,
"cds_start": 4775,
"cds_end": null,
"cds_length": 4878,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000883353.1"
},
{
"aa_ref": "R",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 39,
"exon_rank_end": null,
"exon_count": 39,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NRAP",
"gene_hgnc_id": 7988,
"hgvs_c": "c.4775G>T",
"hgvs_p": "p.Arg1592Leu",
"transcript": "ENST00000883368.1",
"protein_id": "ENSP00000553427.1",
"transcript_support_level": null,
"aa_start": 1592,
"aa_end": null,
"aa_length": 1625,
"cds_start": 4775,
"cds_end": null,
"cds_length": 4878,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000883368.1"
},
{
"aa_ref": "R",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 39,
"exon_rank_end": null,
"exon_count": 39,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NRAP",
"gene_hgnc_id": 7988,
"hgvs_c": "c.4775G>T",
"hgvs_p": "p.Arg1592Leu",
"transcript": "ENST00000945591.1",
"protein_id": "ENSP00000615650.1",
"transcript_support_level": null,
"aa_start": 1592,
"aa_end": null,
"aa_length": 1625,
"cds_start": 4775,
"cds_end": null,
"cds_length": 4878,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000945591.1"
},
{
"aa_ref": "R",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 39,
"exon_rank_end": null,
"exon_count": 39,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NRAP",
"gene_hgnc_id": 7988,
"hgvs_c": "c.4766G>T",
"hgvs_p": "p.Arg1589Leu",
"transcript": "ENST00000883367.1",
"protein_id": "ENSP00000553426.1",
"transcript_support_level": null,
"aa_start": 1589,
"aa_end": null,
"aa_length": 1622,
"cds_start": 4766,
"cds_end": null,
"cds_length": 4869,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000883367.1"
},
{
"aa_ref": "R",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 40,
"exon_rank_end": null,
"exon_count": 40,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NRAP",
"gene_hgnc_id": 7988,
"hgvs_c": "c.4676G>T",
"hgvs_p": "p.Arg1559Leu",
"transcript": "ENST00000883354.1",
"protein_id": "ENSP00000553413.1",
"transcript_support_level": null,
"aa_start": 1559,
"aa_end": null,
"aa_length": 1592,
"cds_start": 4676,
"cds_end": null,
"cds_length": 4779,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000883354.1"
},
{
"aa_ref": "R",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 40,
"exon_rank_end": null,
"exon_count": 40,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NRAP",
"gene_hgnc_id": 7988,
"hgvs_c": "c.4676G>T",
"hgvs_p": "p.Arg1559Leu",
"transcript": "ENST00000945583.1",
"protein_id": "ENSP00000615642.1",
"transcript_support_level": null,
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}
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}