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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 10-114297357-G-T (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=10&pos=114297357&ref=G&alt=T&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "10",
"pos": 114297357,
"ref": "G",
"alt": "T",
"effect": "synonymous_variant",
"transcript": "NM_001287824.2",
"consequences": [
{
"aa_ref": "R",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 17,
"exon_rank_end": null,
"exon_count": 19,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "AFAP1L2",
"gene_hgnc_id": 25901,
"hgvs_c": "c.2170C>A",
"hgvs_p": "p.Arg724Arg",
"transcript": "NM_001001936.3",
"protein_id": "NP_001001936.1",
"transcript_support_level": null,
"aa_start": 724,
"aa_end": null,
"aa_length": 818,
"cds_start": 2170,
"cds_end": null,
"cds_length": 2457,
"cdna_start": 2217,
"cdna_end": null,
"cdna_length": 3722,
"mane_select": "ENST00000304129.9",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001001936.3"
},
{
"aa_ref": "R",
"aa_alt": "R",
"canonical": true,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 17,
"exon_rank_end": null,
"exon_count": 19,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "AFAP1L2",
"gene_hgnc_id": 25901,
"hgvs_c": "c.2170C>A",
"hgvs_p": "p.Arg724Arg",
"transcript": "ENST00000304129.9",
"protein_id": "ENSP00000303042.4",
"transcript_support_level": 1,
"aa_start": 724,
"aa_end": null,
"aa_length": 818,
"cds_start": 2170,
"cds_end": null,
"cds_length": 2457,
"cdna_start": 2217,
"cdna_end": null,
"cdna_length": 3722,
"mane_select": "NM_001001936.3",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000304129.9"
},
{
"aa_ref": "R",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 17,
"exon_rank_end": null,
"exon_count": 19,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "AFAP1L2",
"gene_hgnc_id": 25901,
"hgvs_c": "c.2170C>A",
"hgvs_p": "p.Arg724Arg",
"transcript": "ENST00000369271.7",
"protein_id": "ENSP00000358276.3",
"transcript_support_level": 1,
"aa_start": 724,
"aa_end": null,
"aa_length": 814,
"cds_start": 2170,
"cds_end": null,
"cds_length": 2445,
"cdna_start": 2471,
"cdna_end": null,
"cdna_length": 3964,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000369271.7"
},
{
"aa_ref": "R",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 19,
"exon_rank_end": null,
"exon_count": 21,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "AFAP1L2",
"gene_hgnc_id": 25901,
"hgvs_c": "c.2413C>A",
"hgvs_p": "p.Arg805Arg",
"transcript": "ENST00000941481.1",
"protein_id": "ENSP00000611540.1",
"transcript_support_level": null,
"aa_start": 805,
"aa_end": null,
"aa_length": 895,
"cds_start": 2413,
"cds_end": null,
"cds_length": 2688,
"cdna_start": 2487,
"cdna_end": null,
"cdna_length": 3554,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000941481.1"
},
{
"aa_ref": "R",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 18,
"exon_rank_end": null,
"exon_count": 20,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "AFAP1L2",
"gene_hgnc_id": 25901,
"hgvs_c": "c.2329C>A",
"hgvs_p": "p.Arg777Arg",
"transcript": "NM_001287824.2",
"protein_id": "NP_001274753.1",
"transcript_support_level": null,
"aa_start": 777,
"aa_end": null,
"aa_length": 871,
"cds_start": 2329,
"cds_end": null,
"cds_length": 2616,
"cdna_start": 2376,
"cdna_end": null,
"cdna_length": 3881,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001287824.2"
},
{
"aa_ref": "R",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 18,
"exon_rank_end": null,
"exon_count": 20,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "AFAP1L2",
"gene_hgnc_id": 25901,
"hgvs_c": "c.2326C>A",
"hgvs_p": "p.Arg776Arg",
"transcript": "ENST00000853964.1",
"protein_id": "ENSP00000524023.1",
"transcript_support_level": null,
"aa_start": 776,
"aa_end": null,
"aa_length": 870,
"cds_start": 2326,
"cds_end": null,
"cds_length": 2613,
"cdna_start": 2376,
"cdna_end": null,
"cdna_length": 3881,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000853964.1"
},
{
"aa_ref": "R",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 18,
"exon_rank_end": null,
"exon_count": 20,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "AFAP1L2",
"gene_hgnc_id": 25901,
"hgvs_c": "c.2329C>A",
"hgvs_p": "p.Arg777Arg",
"transcript": "ENST00000853966.1",
"protein_id": "ENSP00000524025.1",
"transcript_support_level": null,
"aa_start": 777,
"aa_end": null,
"aa_length": 867,
"cds_start": 2329,
"cds_end": null,
"cds_length": 2604,
"cdna_start": 2379,
"cdna_end": null,
"cdna_length": 3869,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000853966.1"
},
{
"aa_ref": "R",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 19,
"exon_rank_end": null,
"exon_count": 21,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "AFAP1L2",
"gene_hgnc_id": 25901,
"hgvs_c": "c.2308C>A",
"hgvs_p": "p.Arg770Arg",
"transcript": "ENST00000853965.1",
"protein_id": "ENSP00000524024.1",
"transcript_support_level": null,
"aa_start": 770,
"aa_end": null,
"aa_length": 864,
"cds_start": 2308,
"cds_end": null,
"cds_length": 2595,
"cdna_start": 2358,
"cdna_end": null,
"cdna_length": 3863,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000853965.1"
},
{
"aa_ref": "R",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 18,
"exon_rank_end": null,
"exon_count": 20,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "AFAP1L2",
"gene_hgnc_id": 25901,
"hgvs_c": "c.2254C>A",
"hgvs_p": "p.Arg752Arg",
"transcript": "NM_001351065.2",
"protein_id": "NP_001337994.1",
"transcript_support_level": null,
"aa_start": 752,
"aa_end": null,
"aa_length": 846,
"cds_start": 2254,
"cds_end": null,
"cds_length": 2541,
"cdna_start": 2301,
"cdna_end": null,
"cdna_length": 3806,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001351065.2"
},
{
"aa_ref": "R",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 18,
"exon_rank_end": null,
"exon_count": 20,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "AFAP1L2",
"gene_hgnc_id": 25901,
"hgvs_c": "c.2254C>A",
"hgvs_p": "p.Arg752Arg",
"transcript": "ENST00000941480.1",
"protein_id": "ENSP00000611539.1",
"transcript_support_level": null,
"aa_start": 752,
"aa_end": null,
"aa_length": 846,
"cds_start": 2254,
"cds_end": null,
"cds_length": 2541,
"cdna_start": 2528,
"cdna_end": null,
"cdna_length": 4029,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000941480.1"
},
{
"aa_ref": "R",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 18,
"exon_rank_end": null,
"exon_count": 20,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "AFAP1L2",
"gene_hgnc_id": 25901,
"hgvs_c": "c.2251C>A",
"hgvs_p": "p.Arg751Arg",
"transcript": "NM_001351077.2",
"protein_id": "NP_001338006.1",
"transcript_support_level": null,
"aa_start": 751,
"aa_end": null,
"aa_length": 845,
"cds_start": 2251,
"cds_end": null,
"cds_length": 2538,
"cdna_start": 2298,
"cdna_end": null,
"cdna_length": 3803,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001351077.2"
},
{
"aa_ref": "R",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 18,
"exon_rank_end": null,
"exon_count": 20,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "AFAP1L2",
"gene_hgnc_id": 25901,
"hgvs_c": "c.2251C>A",
"hgvs_p": "p.Arg751Arg",
"transcript": "ENST00000853967.1",
"protein_id": "ENSP00000524026.1",
"transcript_support_level": null,
"aa_start": 751,
"aa_end": null,
"aa_length": 845,
"cds_start": 2251,
"cds_end": null,
"cds_length": 2538,
"cdna_start": 2293,
"cdna_end": null,
"cdna_length": 3379,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000853967.1"
},
{
"aa_ref": "R",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 18,
"exon_rank_end": null,
"exon_count": 20,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "AFAP1L2",
"gene_hgnc_id": 25901,
"hgvs_c": "c.2254C>A",
"hgvs_p": "p.Arg752Arg",
"transcript": "NM_001351078.2",
"protein_id": "NP_001338007.1",
"transcript_support_level": null,
"aa_start": 752,
"aa_end": null,
"aa_length": 842,
"cds_start": 2254,
"cds_end": null,
"cds_length": 2529,
"cdna_start": 2301,
"cdna_end": null,
"cdna_length": 3794,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001351078.2"
},
{
"aa_ref": "R",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 18,
"exon_rank_end": null,
"exon_count": 20,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "AFAP1L2",
"gene_hgnc_id": 25901,
"hgvs_c": "c.2254C>A",
"hgvs_p": "p.Arg752Arg",
"transcript": "ENST00000696688.1",
"protein_id": "ENSP00000512810.1",
"transcript_support_level": null,
"aa_start": 752,
"aa_end": null,
"aa_length": 842,
"cds_start": 2254,
"cds_end": null,
"cds_length": 2529,
"cdna_start": 2514,
"cdna_end": null,
"cdna_length": 3985,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000696688.1"
},
{
"aa_ref": "R",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 18,
"exon_rank_end": null,
"exon_count": 20,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "AFAP1L2",
"gene_hgnc_id": 25901,
"hgvs_c": "c.2251C>A",
"hgvs_p": "p.Arg751Arg",
"transcript": "NM_001351079.2",
"protein_id": "NP_001338008.1",
"transcript_support_level": null,
"aa_start": 751,
"aa_end": null,
"aa_length": 841,
"cds_start": 2251,
"cds_end": null,
"cds_length": 2526,
"cdna_start": 2298,
"cdna_end": null,
"cdna_length": 3791,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001351079.2"
},
{
"aa_ref": "R",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 18,
"exon_rank_end": null,
"exon_count": 20,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "AFAP1L2",
"gene_hgnc_id": 25901,
"hgvs_c": "c.2221C>A",
"hgvs_p": "p.Arg741Arg",
"transcript": "NM_001351067.2",
"protein_id": "NP_001337996.1",
"transcript_support_level": null,
"aa_start": 741,
"aa_end": null,
"aa_length": 835,
"cds_start": 2221,
"cds_end": null,
"cds_length": 2508,
"cdna_start": 2268,
"cdna_end": null,
"cdna_length": 3773,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001351067.2"
},
{
"aa_ref": "R",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 18,
"exon_rank_end": null,
"exon_count": 20,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "AFAP1L2",
"gene_hgnc_id": 25901,
"hgvs_c": "c.2224C>A",
"hgvs_p": "p.Arg742Arg",
"transcript": "NM_001351068.2",
"protein_id": "NP_001337997.1",
"transcript_support_level": null,
"aa_start": 742,
"aa_end": null,
"aa_length": 832,
"cds_start": 2224,
"cds_end": null,
"cds_length": 2499,
"cdna_start": 2271,
"cdna_end": null,
"cdna_length": 3764,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001351068.2"
},
{
"aa_ref": "R",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 18,
"exon_rank_end": null,
"exon_count": 20,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "AFAP1L2",
"gene_hgnc_id": 25901,
"hgvs_c": "c.2221C>A",
"hgvs_p": "p.Arg741Arg",
"transcript": "NM_001351064.2",
"protein_id": "NP_001337993.1",
"transcript_support_level": null,
"aa_start": 741,
"aa_end": null,
"aa_length": 831,
"cds_start": 2221,
"cds_end": null,
"cds_length": 2496,
"cdna_start": 2268,
"cdna_end": null,
"cdna_length": 3761,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001351064.2"
},
{
"aa_ref": "R",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 17,
"exon_rank_end": null,
"exon_count": 19,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "AFAP1L2",
"gene_hgnc_id": 25901,
"hgvs_c": "c.2167C>A",
"hgvs_p": "p.Arg723Arg",
"transcript": "NM_001351069.2",
"protein_id": "NP_001337998.1",
"transcript_support_level": null,
"aa_start": 723,
"aa_end": null,
"aa_length": 817,
"cds_start": 2167,
"cds_end": null,
"cds_length": 2454,
"cdna_start": 2214,
"cdna_end": null,
"cdna_length": 3719,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001351069.2"
},
{
"aa_ref": "R",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 17,
"exon_rank_end": null,
"exon_count": 19,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "AFAP1L2",
"gene_hgnc_id": 25901,
"hgvs_c": "c.2167C>A",
"hgvs_p": "p.Arg723Arg",
"transcript": "ENST00000853960.1",
"protein_id": "ENSP00000524019.1",
"transcript_support_level": null,
"aa_start": 723,
"aa_end": null,
"aa_length": 817,
"cds_start": 2167,
"cds_end": null,
"cds_length": 2454,
"cdna_start": 2416,
"cdna_end": null,
"cdna_length": 5141,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000853960.1"
},
{
"aa_ref": "R",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 17,
"exon_rank_end": null,
"exon_count": 19,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "AFAP1L2",
"gene_hgnc_id": 25901,
"hgvs_c": "c.2170C>A",
"hgvs_p": "p.Arg724Arg",
"transcript": "NM_032550.4",
"protein_id": "NP_115939.1",
"transcript_support_level": null,
"aa_start": 724,
"aa_end": null,
"aa_length": 814,
"cds_start": 2170,
"cds_end": null,
"cds_length": 2445,
"cdna_start": 2217,
"cdna_end": null,
"cdna_length": 3710,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_032550.4"
},
{
"aa_ref": "R",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 17,
"exon_rank_end": null,
"exon_count": 19,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "AFAP1L2",
"gene_hgnc_id": 25901,
"hgvs_c": "c.2167C>A",
"hgvs_p": "p.Arg723Arg",
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{
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"BP7"
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"verdict": "Likely_benign",
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"clinvar_review_status": "",
"clinvar_submissions_summary": "",
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"custom_annotations": null
}
],
"message": null
}