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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 10-114314042-T-G (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=10&pos=114314042&ref=T&alt=G&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "10",
"pos": 114314042,
"ref": "T",
"alt": "G",
"effect": "missense_variant",
"transcript": "ENST00000304129.9",
"consequences": [
{
"aa_ref": "K",
"aa_alt": "N",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 19,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "AFAP1L2",
"gene_hgnc_id": 25901,
"hgvs_c": "c.621A>C",
"hgvs_p": "p.Lys207Asn",
"transcript": "NM_001001936.3",
"protein_id": "NP_001001936.1",
"transcript_support_level": null,
"aa_start": 207,
"aa_end": null,
"aa_length": 818,
"cds_start": 621,
"cds_end": null,
"cds_length": 2457,
"cdna_start": 668,
"cdna_end": null,
"cdna_length": 3722,
"mane_select": "ENST00000304129.9",
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "K",
"aa_alt": "N",
"canonical": true,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 19,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "AFAP1L2",
"gene_hgnc_id": 25901,
"hgvs_c": "c.621A>C",
"hgvs_p": "p.Lys207Asn",
"transcript": "ENST00000304129.9",
"protein_id": "ENSP00000303042.4",
"transcript_support_level": 1,
"aa_start": 207,
"aa_end": null,
"aa_length": 818,
"cds_start": 621,
"cds_end": null,
"cds_length": 2457,
"cdna_start": 668,
"cdna_end": null,
"cdna_length": 3722,
"mane_select": "NM_001001936.3",
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "K",
"aa_alt": "N",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 19,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "AFAP1L2",
"gene_hgnc_id": 25901,
"hgvs_c": "c.621A>C",
"hgvs_p": "p.Lys207Asn",
"transcript": "ENST00000369271.7",
"protein_id": "ENSP00000358276.3",
"transcript_support_level": 1,
"aa_start": 207,
"aa_end": null,
"aa_length": 814,
"cds_start": 621,
"cds_end": null,
"cds_length": 2445,
"cdna_start": 922,
"cdna_end": null,
"cdna_length": 3964,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "K",
"aa_alt": "N",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 20,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "AFAP1L2",
"gene_hgnc_id": 25901,
"hgvs_c": "c.780A>C",
"hgvs_p": "p.Lys260Asn",
"transcript": "NM_001287824.2",
"protein_id": "NP_001274753.1",
"transcript_support_level": null,
"aa_start": 260,
"aa_end": null,
"aa_length": 871,
"cds_start": 780,
"cds_end": null,
"cds_length": 2616,
"cdna_start": 827,
"cdna_end": null,
"cdna_length": 3881,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "K",
"aa_alt": "N",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 20,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "AFAP1L2",
"gene_hgnc_id": 25901,
"hgvs_c": "c.705A>C",
"hgvs_p": "p.Lys235Asn",
"transcript": "NM_001351065.2",
"protein_id": "NP_001337994.1",
"transcript_support_level": null,
"aa_start": 235,
"aa_end": null,
"aa_length": 846,
"cds_start": 705,
"cds_end": null,
"cds_length": 2541,
"cdna_start": 752,
"cdna_end": null,
"cdna_length": 3806,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "K",
"aa_alt": "N",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 20,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "AFAP1L2",
"gene_hgnc_id": 25901,
"hgvs_c": "c.705A>C",
"hgvs_p": "p.Lys235Asn",
"transcript": "NM_001351077.2",
"protein_id": "NP_001338006.1",
"transcript_support_level": null,
"aa_start": 235,
"aa_end": null,
"aa_length": 845,
"cds_start": 705,
"cds_end": null,
"cds_length": 2538,
"cdna_start": 752,
"cdna_end": null,
"cdna_length": 3803,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "K",
"aa_alt": "N",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 20,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "AFAP1L2",
"gene_hgnc_id": 25901,
"hgvs_c": "c.705A>C",
"hgvs_p": "p.Lys235Asn",
"transcript": "NM_001351078.2",
"protein_id": "NP_001338007.1",
"transcript_support_level": null,
"aa_start": 235,
"aa_end": null,
"aa_length": 842,
"cds_start": 705,
"cds_end": null,
"cds_length": 2529,
"cdna_start": 752,
"cdna_end": null,
"cdna_length": 3794,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "K",
"aa_alt": "N",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 20,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "AFAP1L2",
"gene_hgnc_id": 25901,
"hgvs_c": "c.705A>C",
"hgvs_p": "p.Lys235Asn",
"transcript": "ENST00000696688.1",
"protein_id": "ENSP00000512810.1",
"transcript_support_level": null,
"aa_start": 235,
"aa_end": null,
"aa_length": 842,
"cds_start": 705,
"cds_end": null,
"cds_length": 2529,
"cdna_start": 965,
"cdna_end": null,
"cdna_length": 3985,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "K",
"aa_alt": "N",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 20,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "AFAP1L2",
"gene_hgnc_id": 25901,
"hgvs_c": "c.705A>C",
"hgvs_p": "p.Lys235Asn",
"transcript": "NM_001351079.2",
"protein_id": "NP_001338008.1",
"transcript_support_level": null,
"aa_start": 235,
"aa_end": null,
"aa_length": 841,
"cds_start": 705,
"cds_end": null,
"cds_length": 2526,
"cdna_start": 752,
"cdna_end": null,
"cdna_length": 3791,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "K",
"aa_alt": "N",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 20,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "AFAP1L2",
"gene_hgnc_id": 25901,
"hgvs_c": "c.675A>C",
"hgvs_p": "p.Lys225Asn",
"transcript": "NM_001351067.2",
"protein_id": "NP_001337996.1",
"transcript_support_level": null,
"aa_start": 225,
"aa_end": null,
"aa_length": 835,
"cds_start": 675,
"cds_end": null,
"cds_length": 2508,
"cdna_start": 722,
"cdna_end": null,
"cdna_length": 3773,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "K",
"aa_alt": "N",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 20,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "AFAP1L2",
"gene_hgnc_id": 25901,
"hgvs_c": "c.675A>C",
"hgvs_p": "p.Lys225Asn",
"transcript": "NM_001351068.2",
"protein_id": "NP_001337997.1",
"transcript_support_level": null,
"aa_start": 225,
"aa_end": null,
"aa_length": 832,
"cds_start": 675,
"cds_end": null,
"cds_length": 2499,
"cdna_start": 722,
"cdna_end": null,
"cdna_length": 3764,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "K",
"aa_alt": "N",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 20,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "AFAP1L2",
"gene_hgnc_id": 25901,
"hgvs_c": "c.675A>C",
"hgvs_p": "p.Lys225Asn",
"transcript": "NM_001351064.2",
"protein_id": "NP_001337993.1",
"transcript_support_level": null,
"aa_start": 225,
"aa_end": null,
"aa_length": 831,
"cds_start": 675,
"cds_end": null,
"cds_length": 2496,
"cdna_start": 722,
"cdna_end": null,
"cdna_length": 3761,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "K",
"aa_alt": "N",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 19,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "AFAP1L2",
"gene_hgnc_id": 25901,
"hgvs_c": "c.621A>C",
"hgvs_p": "p.Lys207Asn",
"transcript": "NM_001351069.2",
"protein_id": "NP_001337998.1",
"transcript_support_level": null,
"aa_start": 207,
"aa_end": null,
"aa_length": 817,
"cds_start": 621,
"cds_end": null,
"cds_length": 2454,
"cdna_start": 668,
"cdna_end": null,
"cdna_length": 3719,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "K",
"aa_alt": "N",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 19,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "AFAP1L2",
"gene_hgnc_id": 25901,
"hgvs_c": "c.621A>C",
"hgvs_p": "p.Lys207Asn",
"transcript": "NM_032550.4",
"protein_id": "NP_115939.1",
"transcript_support_level": null,
"aa_start": 207,
"aa_end": null,
"aa_length": 814,
"cds_start": 621,
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"cdna_start": 668,
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"mane_select": null,
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"biotype": null,
"feature": null
},
{
"aa_ref": "K",
"aa_alt": "N",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 19,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "AFAP1L2",
"gene_hgnc_id": 25901,
"hgvs_c": "c.621A>C",
"hgvs_p": "p.Lys207Asn",
"transcript": "NM_001351074.2",
"protein_id": "NP_001338003.1",
"transcript_support_level": null,
"aa_start": 207,
"aa_end": null,
"aa_length": 813,
"cds_start": 621,
"cds_end": null,
"cds_length": 2442,
"cdna_start": 668,
"cdna_end": null,
"cdna_length": 3707,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "K",
"aa_alt": "N",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 9,
"exon_rank_end": null,
"exon_count": 21,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "AFAP1L2",
"gene_hgnc_id": 25901,
"hgvs_c": "c.537A>C",
"hgvs_p": "p.Lys179Asn",
"transcript": "NM_001351071.2",
"protein_id": "NP_001338000.1",
"transcript_support_level": null,
"aa_start": 179,
"aa_end": null,
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"cds_start": 537,
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"cdna_start": 977,
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"mane_select": null,
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"biotype": null,
"feature": null
},
{
"aa_ref": "K",
"aa_alt": "N",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 9,
"exon_rank_end": null,
"exon_count": 21,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "AFAP1L2",
"gene_hgnc_id": 25901,
"hgvs_c": "c.537A>C",
"hgvs_p": "p.Lys179Asn",
"transcript": "NM_001351072.2",
"protein_id": "NP_001338001.1",
"transcript_support_level": null,
"aa_start": 179,
"aa_end": null,
"aa_length": 785,
"cds_start": 537,
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"cds_length": 2358,
"cdna_start": 977,
"cdna_end": null,
"cdna_length": 4016,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "K",
"aa_alt": "N",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 19,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "AFAP1L2",
"gene_hgnc_id": 25901,
"hgvs_c": "c.705A>C",
"hgvs_p": "p.Lys235Asn",
"transcript": "NM_001351080.2",
"protein_id": "NP_001338009.1",
"transcript_support_level": null,
"aa_start": 235,
"aa_end": null,
"aa_length": 763,
"cds_start": 705,
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"cdna_start": 752,
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"mane_select": null,
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"biotype": null,
"feature": null
},
{
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"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 19,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "AFAP1L2",
"gene_hgnc_id": 25901,
"hgvs_c": "c.705A>C",
"hgvs_p": "p.Lys235Asn",
"transcript": "NM_001351066.2",
"protein_id": "NP_001337995.1",
"transcript_support_level": null,
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"mane_select": null,
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"feature": null
},
{
"aa_ref": "K",
"aa_alt": "N",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 20,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "AFAP1L2",
"gene_hgnc_id": 25901,
"hgvs_c": "c.453A>C",
"hgvs_p": "p.Lys151Asn",
"transcript": "NM_001351070.2",
"protein_id": "NP_001337999.1",
"transcript_support_level": null,
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},
{
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"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 8,
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"exon_count": 20,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "AFAP1L2",
"gene_hgnc_id": 25901,
"hgvs_c": "c.453A>C",
"hgvs_p": "p.Lys151Asn",
"transcript": "NM_001351073.2",
"protein_id": "NP_001338002.1",
"transcript_support_level": null,
"aa_start": 151,
"aa_end": null,
"aa_length": 757,
"cds_start": 453,
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"cds_length": 2274,
"cdna_start": 893,
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"mane_select": null,
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"biotype": null,
"feature": null
},
{
"aa_ref": "K",
"aa_alt": "N",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 18,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "AFAP1L2",
"gene_hgnc_id": 25901,
"hgvs_c": "c.621A>C",
"hgvs_p": "p.Lys207Asn",
"transcript": "NM_001351075.2",
"protein_id": "NP_001338004.1",
"transcript_support_level": null,
"aa_start": 207,
"aa_end": null,
"aa_length": 735,
"cds_start": 621,
"cds_end": null,
"cds_length": 2208,
"cdna_start": 668,
"cdna_end": null,
"cdna_length": 3473,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "K",
"aa_alt": "N",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 18,
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}