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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 10-114441043-T-C (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=10&pos=114441043&ref=T&alt=C&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "10",
"pos": 114441043,
"ref": "T",
"alt": "C",
"effect": "missense_variant",
"transcript": "ENST00000533213.7",
"consequences": [
{
"aa_ref": "Y",
"aa_alt": "C",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 19,
"exon_rank_end": null,
"exon_count": 23,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ABLIM1",
"gene_hgnc_id": 78,
"hgvs_c": "c.2033A>G",
"hgvs_p": "p.Tyr678Cys",
"transcript": "NM_002313.7",
"protein_id": "NP_002304.3",
"transcript_support_level": null,
"aa_start": 678,
"aa_end": null,
"aa_length": 778,
"cds_start": 2033,
"cds_end": null,
"cds_length": 2337,
"cdna_start": 2108,
"cdna_end": null,
"cdna_length": 7560,
"mane_select": "ENST00000533213.7",
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "Y",
"aa_alt": "C",
"canonical": true,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 19,
"exon_rank_end": null,
"exon_count": 23,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ABLIM1",
"gene_hgnc_id": 78,
"hgvs_c": "c.2033A>G",
"hgvs_p": "p.Tyr678Cys",
"transcript": "ENST00000533213.7",
"protein_id": "ENSP00000433629.3",
"transcript_support_level": 5,
"aa_start": 678,
"aa_end": null,
"aa_length": 778,
"cds_start": 2033,
"cds_end": null,
"cds_length": 2337,
"cdna_start": 2108,
"cdna_end": null,
"cdna_length": 7560,
"mane_select": "NM_002313.7",
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "Y",
"aa_alt": "C",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 21,
"exon_rank_end": null,
"exon_count": 25,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ABLIM1",
"gene_hgnc_id": 78,
"hgvs_c": "c.2201A>G",
"hgvs_p": "p.Tyr734Cys",
"transcript": "ENST00000649363.1",
"protein_id": "ENSP00000497150.1",
"transcript_support_level": null,
"aa_start": 734,
"aa_end": null,
"aa_length": 834,
"cds_start": 2201,
"cds_end": null,
"cds_length": 2505,
"cdna_start": 2284,
"cdna_end": null,
"cdna_length": 2670,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "Y",
"aa_alt": "C",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 20,
"exon_rank_end": null,
"exon_count": 24,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ABLIM1",
"gene_hgnc_id": 78,
"hgvs_c": "c.1943A>G",
"hgvs_p": "p.Tyr648Cys",
"transcript": "NM_001322882.2",
"protein_id": "NP_001309811.1",
"transcript_support_level": null,
"aa_start": 648,
"aa_end": null,
"aa_length": 748,
"cds_start": 1943,
"cds_end": null,
"cds_length": 2247,
"cdna_start": 2593,
"cdna_end": null,
"cdna_length": 8047,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "Y",
"aa_alt": "C",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 20,
"exon_rank_end": null,
"exon_count": 24,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ABLIM1",
"gene_hgnc_id": 78,
"hgvs_c": "c.1943A>G",
"hgvs_p": "p.Tyr648Cys",
"transcript": "ENST00000369256.6",
"protein_id": "ENSP00000358260.3",
"transcript_support_level": 5,
"aa_start": 648,
"aa_end": null,
"aa_length": 748,
"cds_start": 1943,
"cds_end": null,
"cds_length": 2247,
"cdna_start": 2593,
"cdna_end": null,
"cdna_length": 3203,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "Y",
"aa_alt": "C",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 19,
"exon_rank_end": null,
"exon_count": 23,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ABLIM1",
"gene_hgnc_id": 78,
"hgvs_c": "c.1853A>G",
"hgvs_p": "p.Tyr618Cys",
"transcript": "NM_001003407.2",
"protein_id": "NP_001003407.1",
"transcript_support_level": null,
"aa_start": 618,
"aa_end": null,
"aa_length": 718,
"cds_start": 1853,
"cds_end": null,
"cds_length": 2157,
"cdna_start": 1943,
"cdna_end": null,
"cdna_length": 7395,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "Y",
"aa_alt": "C",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 19,
"exon_rank_end": null,
"exon_count": 23,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ABLIM1",
"gene_hgnc_id": 78,
"hgvs_c": "c.1853A>G",
"hgvs_p": "p.Tyr618Cys",
"transcript": "ENST00000392955.8",
"protein_id": "ENSP00000376682.4",
"transcript_support_level": 5,
"aa_start": 618,
"aa_end": null,
"aa_length": 718,
"cds_start": 1853,
"cds_end": null,
"cds_length": 2157,
"cdna_start": 1957,
"cdna_end": null,
"cdna_length": 7411,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "Y",
"aa_alt": "C",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 18,
"exon_rank_end": null,
"exon_count": 22,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ABLIM1",
"gene_hgnc_id": 78,
"hgvs_c": "c.1748A>G",
"hgvs_p": "p.Tyr583Cys",
"transcript": "NM_001322883.2",
"protein_id": "NP_001309812.1",
"transcript_support_level": null,
"aa_start": 583,
"aa_end": null,
"aa_length": 683,
"cds_start": 1748,
"cds_end": null,
"cds_length": 2052,
"cdna_start": 1838,
"cdna_end": null,
"cdna_length": 7290,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "Y",
"aa_alt": "C",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 18,
"exon_rank_end": null,
"exon_count": 22,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ABLIM1",
"gene_hgnc_id": 78,
"hgvs_c": "c.1703A>G",
"hgvs_p": "p.Tyr568Cys",
"transcript": "NM_001322884.3",
"protein_id": "NP_001309813.1",
"transcript_support_level": null,
"aa_start": 568,
"aa_end": null,
"aa_length": 668,
"cds_start": 1703,
"cds_end": null,
"cds_length": 2007,
"cdna_start": 1934,
"cdna_end": null,
"cdna_length": 7386,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "Y",
"aa_alt": "C",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 18,
"exon_rank_end": null,
"exon_count": 22,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ABLIM1",
"gene_hgnc_id": 78,
"hgvs_c": "c.1697A>G",
"hgvs_p": "p.Tyr566Cys",
"transcript": "NM_001322885.3",
"protein_id": "NP_001309814.1",
"transcript_support_level": null,
"aa_start": 566,
"aa_end": null,
"aa_length": 666,
"cds_start": 1697,
"cds_end": null,
"cds_length": 2001,
"cdna_start": 1928,
"cdna_end": null,
"cdna_length": 7380,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "Y",
"aa_alt": "C",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 18,
"exon_rank_end": null,
"exon_count": 22,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ABLIM1",
"gene_hgnc_id": 78,
"hgvs_c": "c.1664A>G",
"hgvs_p": "p.Tyr555Cys",
"transcript": "NM_001352440.1",
"protein_id": "NP_001339369.1",
"transcript_support_level": null,
"aa_start": 555,
"aa_end": null,
"aa_length": 655,
"cds_start": 1664,
"cds_end": null,
"cds_length": 1968,
"cdna_start": 2144,
"cdna_end": null,
"cdna_length": 7598,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "Y",
"aa_alt": "C",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 18,
"exon_rank_end": null,
"exon_count": 22,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ABLIM1",
"gene_hgnc_id": 78,
"hgvs_c": "c.1664A>G",
"hgvs_p": "p.Tyr555Cys",
"transcript": "ENST00000651023.2",
"protein_id": "ENSP00000499023.2",
"transcript_support_level": null,
"aa_start": 555,
"aa_end": null,
"aa_length": 655,
"cds_start": 1664,
"cds_end": null,
"cds_length": 1968,
"cdna_start": 1839,
"cdna_end": null,
"cdna_length": 2944,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "Y",
"aa_alt": "C",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 18,
"exon_rank_end": null,
"exon_count": 22,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ABLIM1",
"gene_hgnc_id": 78,
"hgvs_c": "c.1661A>G",
"hgvs_p": "p.Tyr554Cys",
"transcript": "NM_001322886.3",
"protein_id": "NP_001309815.1",
"transcript_support_level": null,
"aa_start": 554,
"aa_end": null,
"aa_length": 654,
"cds_start": 1661,
"cds_end": null,
"cds_length": 1965,
"cdna_start": 1892,
"cdna_end": null,
"cdna_length": 7344,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "Y",
"aa_alt": "C",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 17,
"exon_rank_end": null,
"exon_count": 21,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ABLIM1",
"gene_hgnc_id": 78,
"hgvs_c": "c.1607A>G",
"hgvs_p": "p.Tyr536Cys",
"transcript": "NM_001322887.2",
"protein_id": "NP_001309816.1",
"transcript_support_level": null,
"aa_start": 536,
"aa_end": null,
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"cds_start": 1607,
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"cdna_start": 1697,
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"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "Y",
"aa_alt": "C",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 17,
"exon_rank_end": null,
"exon_count": 21,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ABLIM1",
"gene_hgnc_id": 78,
"hgvs_c": "c.1559A>G",
"hgvs_p": "p.Tyr520Cys",
"transcript": "NM_001352441.1",
"protein_id": "NP_001339370.1",
"transcript_support_level": null,
"aa_start": 520,
"aa_end": null,
"aa_length": 620,
"cds_start": 1559,
"cds_end": null,
"cds_length": 1863,
"cdna_start": 2039,
"cdna_end": null,
"cdna_length": 7493,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "Y",
"aa_alt": "C",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 17,
"exon_rank_end": null,
"exon_count": 21,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ABLIM1",
"gene_hgnc_id": 78,
"hgvs_c": "c.1559A>G",
"hgvs_p": "p.Tyr520Cys",
"transcript": "ENST00000707119.1",
"protein_id": "ENSP00000516747.1",
"transcript_support_level": null,
"aa_start": 520,
"aa_end": null,
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"cds_start": 1559,
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"cdna_start": 1686,
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"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "Y",
"aa_alt": "C",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 18,
"exon_rank_end": null,
"exon_count": 22,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ABLIM1",
"gene_hgnc_id": 78,
"hgvs_c": "c.1472A>G",
"hgvs_p": "p.Tyr491Cys",
"transcript": "NM_001352442.2",
"protein_id": "NP_001339371.1",
"transcript_support_level": null,
"aa_start": 491,
"aa_end": null,
"aa_length": 591,
"cds_start": 1472,
"cds_end": null,
"cds_length": 1776,
"cdna_start": 1764,
"cdna_end": null,
"cdna_length": 7216,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "Y",
"aa_alt": "C",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 14,
"exon_rank_end": null,
"exon_count": 18,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ABLIM1",
"gene_hgnc_id": 78,
"hgvs_c": "c.1091A>G",
"hgvs_p": "p.Tyr364Cys",
"transcript": "NM_001352443.2",
"protein_id": "NP_001339372.1",
"transcript_support_level": null,
"aa_start": 364,
"aa_end": null,
"aa_length": 464,
"cds_start": 1091,
"cds_end": null,
"cds_length": 1395,
"cdna_start": 1399,
"cdna_end": null,
"cdna_length": 6851,
"mane_select": null,
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"biotype": null,
"feature": null
},
{
"aa_ref": "Y",
"aa_alt": "C",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 14,
"exon_rank_end": null,
"exon_count": 18,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ABLIM1",
"gene_hgnc_id": 78,
"hgvs_c": "c.1064A>G",
"hgvs_p": "p.Tyr355Cys",
"transcript": "NM_001322888.2",
"protein_id": "NP_001309817.1",
"transcript_support_level": null,
"aa_start": 355,
"aa_end": null,
"aa_length": 455,
"cds_start": 1064,
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"feature": null
},
{
"aa_ref": "Y",
"aa_alt": "C",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 14,
"exon_rank_end": null,
"exon_count": 18,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ABLIM1",
"gene_hgnc_id": 78,
"hgvs_c": "c.1064A>G",
"hgvs_p": "p.Tyr355Cys",
"transcript": "NM_006720.4",
"protein_id": "NP_006711.3",
"transcript_support_level": null,
"aa_start": 355,
"aa_end": null,
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"cds_start": 1064,
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"cdna_start": 1372,
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"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "Y",
"aa_alt": "C",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 14,
"exon_rank_end": null,
"exon_count": 18,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ABLIM1",
"gene_hgnc_id": 78,
"hgvs_c": "c.1064A>G",
"hgvs_p": "p.Tyr355Cys",
"transcript": "ENST00000392952.7",
"protein_id": "ENSP00000376679.3",
"transcript_support_level": 5,
"aa_start": 355,
"aa_end": null,
"aa_length": 455,
"cds_start": 1064,
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"cds_length": 1368,
"cdna_start": 1390,
"cdna_end": null,
"cdna_length": 6841,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "Y",
"aa_alt": "C",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 14,
"exon_rank_end": null,
"exon_count": 18,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ABLIM1",
"gene_hgnc_id": 78,
"hgvs_c": "c.1028A>G",
"hgvs_p": "p.Tyr343Cys",
"transcript": "NM_001322889.2",
"protein_id": "NP_001309818.1",
"transcript_support_level": null,
"aa_start": 343,
"aa_end": null,
"aa_length": 443,
"cds_start": 1028,
"cds_end": null,
"cds_length": 1332,
"cdna_start": 1357,
"cdna_end": null,
"cdna_length": 6809,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "Y",
"aa_alt": "C",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 13,
"exon_rank_end": null,
"exon_count": 17,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ABLIM1",
"gene_hgnc_id": 78,
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}