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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 10-114447925-T-A (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=10&pos=114447925&ref=T&alt=A&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "10",
"pos": 114447925,
"ref": "T",
"alt": "A",
"effect": "missense_variant",
"transcript": "NM_002313.7",
"consequences": [
{
"aa_ref": "I",
"aa_alt": "F",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 15,
"exon_rank_end": null,
"exon_count": 23,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ABLIM1",
"gene_hgnc_id": 78,
"hgvs_c": "c.1690A>T",
"hgvs_p": "p.Ile564Phe",
"transcript": "NM_002313.7",
"protein_id": "NP_002304.3",
"transcript_support_level": null,
"aa_start": 564,
"aa_end": null,
"aa_length": 778,
"cds_start": 1690,
"cds_end": null,
"cds_length": 2337,
"cdna_start": 1765,
"cdna_end": null,
"cdna_length": 7560,
"mane_select": "ENST00000533213.7",
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "I",
"aa_alt": "F",
"canonical": true,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 15,
"exon_rank_end": null,
"exon_count": 23,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ABLIM1",
"gene_hgnc_id": 78,
"hgvs_c": "c.1690A>T",
"hgvs_p": "p.Ile564Phe",
"transcript": "ENST00000533213.7",
"protein_id": "ENSP00000433629.3",
"transcript_support_level": 5,
"aa_start": 564,
"aa_end": null,
"aa_length": 778,
"cds_start": 1690,
"cds_end": null,
"cds_length": 2337,
"cdna_start": 1765,
"cdna_end": null,
"cdna_length": 7560,
"mane_select": "NM_002313.7",
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "I",
"aa_alt": "F",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 17,
"exon_rank_end": null,
"exon_count": 25,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ABLIM1",
"gene_hgnc_id": 78,
"hgvs_c": "c.1858A>T",
"hgvs_p": "p.Ile620Phe",
"transcript": "ENST00000649363.1",
"protein_id": "ENSP00000497150.1",
"transcript_support_level": null,
"aa_start": 620,
"aa_end": null,
"aa_length": 834,
"cds_start": 1858,
"cds_end": null,
"cds_length": 2505,
"cdna_start": 1941,
"cdna_end": null,
"cdna_length": 2670,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "I",
"aa_alt": "F",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 16,
"exon_rank_end": null,
"exon_count": 24,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ABLIM1",
"gene_hgnc_id": 78,
"hgvs_c": "c.1600A>T",
"hgvs_p": "p.Ile534Phe",
"transcript": "NM_001322882.2",
"protein_id": "NP_001309811.1",
"transcript_support_level": null,
"aa_start": 534,
"aa_end": null,
"aa_length": 748,
"cds_start": 1600,
"cds_end": null,
"cds_length": 2247,
"cdna_start": 2250,
"cdna_end": null,
"cdna_length": 8047,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "I",
"aa_alt": "F",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 16,
"exon_rank_end": null,
"exon_count": 24,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ABLIM1",
"gene_hgnc_id": 78,
"hgvs_c": "c.1600A>T",
"hgvs_p": "p.Ile534Phe",
"transcript": "ENST00000369256.6",
"protein_id": "ENSP00000358260.3",
"transcript_support_level": 5,
"aa_start": 534,
"aa_end": null,
"aa_length": 748,
"cds_start": 1600,
"cds_end": null,
"cds_length": 2247,
"cdna_start": 2250,
"cdna_end": null,
"cdna_length": 3203,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "I",
"aa_alt": "F",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 15,
"exon_rank_end": null,
"exon_count": 23,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ABLIM1",
"gene_hgnc_id": 78,
"hgvs_c": "c.1510A>T",
"hgvs_p": "p.Ile504Phe",
"transcript": "NM_001003407.2",
"protein_id": "NP_001003407.1",
"transcript_support_level": null,
"aa_start": 504,
"aa_end": null,
"aa_length": 718,
"cds_start": 1510,
"cds_end": null,
"cds_length": 2157,
"cdna_start": 1600,
"cdna_end": null,
"cdna_length": 7395,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "I",
"aa_alt": "F",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 15,
"exon_rank_end": null,
"exon_count": 23,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ABLIM1",
"gene_hgnc_id": 78,
"hgvs_c": "c.1510A>T",
"hgvs_p": "p.Ile504Phe",
"transcript": "ENST00000392955.8",
"protein_id": "ENSP00000376682.4",
"transcript_support_level": 5,
"aa_start": 504,
"aa_end": null,
"aa_length": 718,
"cds_start": 1510,
"cds_end": null,
"cds_length": 2157,
"cdna_start": 1614,
"cdna_end": null,
"cdna_length": 7411,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "I",
"aa_alt": "F",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 14,
"exon_rank_end": null,
"exon_count": 22,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ABLIM1",
"gene_hgnc_id": 78,
"hgvs_c": "c.1405A>T",
"hgvs_p": "p.Ile469Phe",
"transcript": "NM_001322883.2",
"protein_id": "NP_001309812.1",
"transcript_support_level": null,
"aa_start": 469,
"aa_end": null,
"aa_length": 683,
"cds_start": 1405,
"cds_end": null,
"cds_length": 2052,
"cdna_start": 1495,
"cdna_end": null,
"cdna_length": 7290,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "I",
"aa_alt": "F",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 14,
"exon_rank_end": null,
"exon_count": 22,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ABLIM1",
"gene_hgnc_id": 78,
"hgvs_c": "c.1360A>T",
"hgvs_p": "p.Ile454Phe",
"transcript": "NM_001322884.3",
"protein_id": "NP_001309813.1",
"transcript_support_level": null,
"aa_start": 454,
"aa_end": null,
"aa_length": 668,
"cds_start": 1360,
"cds_end": null,
"cds_length": 2007,
"cdna_start": 1591,
"cdna_end": null,
"cdna_length": 7386,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "I",
"aa_alt": "F",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 14,
"exon_rank_end": null,
"exon_count": 22,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ABLIM1",
"gene_hgnc_id": 78,
"hgvs_c": "c.1354A>T",
"hgvs_p": "p.Ile452Phe",
"transcript": "NM_001322885.3",
"protein_id": "NP_001309814.1",
"transcript_support_level": null,
"aa_start": 452,
"aa_end": null,
"aa_length": 666,
"cds_start": 1354,
"cds_end": null,
"cds_length": 2001,
"cdna_start": 1585,
"cdna_end": null,
"cdna_length": 7380,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "I",
"aa_alt": "F",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 14,
"exon_rank_end": null,
"exon_count": 22,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ABLIM1",
"gene_hgnc_id": 78,
"hgvs_c": "c.1129A>T",
"hgvs_p": "p.Ile377Phe",
"transcript": "NM_001352442.2",
"protein_id": "NP_001339371.1",
"transcript_support_level": null,
"aa_start": 377,
"aa_end": null,
"aa_length": 591,
"cds_start": 1129,
"cds_end": null,
"cds_length": 1776,
"cdna_start": 1421,
"cdna_end": null,
"cdna_length": 7216,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "I",
"aa_alt": "F",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 10,
"exon_rank_end": null,
"exon_count": 18,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ABLIM1",
"gene_hgnc_id": 78,
"hgvs_c": "c.748A>T",
"hgvs_p": "p.Ile250Phe",
"transcript": "NM_001352443.2",
"protein_id": "NP_001339372.1",
"transcript_support_level": null,
"aa_start": 250,
"aa_end": null,
"aa_length": 464,
"cds_start": 748,
"cds_end": null,
"cds_length": 1395,
"cdna_start": 1056,
"cdna_end": null,
"cdna_length": 6851,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "I",
"aa_alt": "F",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 10,
"exon_rank_end": null,
"exon_count": 18,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ABLIM1",
"gene_hgnc_id": 78,
"hgvs_c": "c.721A>T",
"hgvs_p": "p.Ile241Phe",
"transcript": "NM_006720.4",
"protein_id": "NP_006711.3",
"transcript_support_level": null,
"aa_start": 241,
"aa_end": null,
"aa_length": 455,
"cds_start": 721,
"cds_end": null,
"cds_length": 1368,
"cdna_start": 1029,
"cdna_end": null,
"cdna_length": 6824,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "I",
"aa_alt": "F",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 10,
"exon_rank_end": null,
"exon_count": 18,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ABLIM1",
"gene_hgnc_id": 78,
"hgvs_c": "c.721A>T",
"hgvs_p": "p.Ile241Phe",
"transcript": "ENST00000392952.7",
"protein_id": "ENSP00000376679.3",
"transcript_support_level": 5,
"aa_start": 241,
"aa_end": null,
"aa_length": 455,
"cds_start": 721,
"cds_end": null,
"cds_length": 1368,
"cdna_start": 1047,
"cdna_end": null,
"cdna_length": 6841,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "I",
"aa_alt": "F",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 9,
"exon_rank_end": null,
"exon_count": 17,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ABLIM1",
"gene_hgnc_id": 78,
"hgvs_c": "c.643A>T",
"hgvs_p": "p.Ile215Phe",
"transcript": "NM_001322890.2",
"protein_id": "NP_001309819.1",
"transcript_support_level": null,
"aa_start": 215,
"aa_end": null,
"aa_length": 429,
"cds_start": 643,
"cds_end": null,
"cds_length": 1290,
"cdna_start": 951,
"cdna_end": null,
"cdna_length": 6746,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "I",
"aa_alt": "F",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 9,
"exon_rank_end": null,
"exon_count": 17,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ABLIM1",
"gene_hgnc_id": 78,
"hgvs_c": "c.643A>T",
"hgvs_p": "p.Ile215Phe",
"transcript": "NM_001322891.2",
"protein_id": "NP_001309820.1",
"transcript_support_level": null,
"aa_start": 215,
"aa_end": null,
"aa_length": 429,
"cds_start": 643,
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"cds_length": 1290,
"cdna_start": 972,
"cdna_end": null,
"cdna_length": 6767,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "I",
"aa_alt": "F",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 9,
"exon_rank_end": null,
"exon_count": 17,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ABLIM1",
"gene_hgnc_id": 78,
"hgvs_c": "c.637A>T",
"hgvs_p": "p.Ile213Phe",
"transcript": "NM_001322892.2",
"protein_id": "NP_001309821.1",
"transcript_support_level": null,
"aa_start": 213,
"aa_end": null,
"aa_length": 427,
"cds_start": 637,
"cds_end": null,
"cds_length": 1284,
"cdna_start": 945,
"cdna_end": null,
"cdna_length": 6740,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "I",
"aa_alt": "F",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 9,
"exon_rank_end": null,
"exon_count": 17,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ABLIM1",
"gene_hgnc_id": 78,
"hgvs_c": "c.637A>T",
"hgvs_p": "p.Ile213Phe",
"transcript": "NM_001322893.2",
"protein_id": "NP_001309822.1",
"transcript_support_level": null,
"aa_start": 213,
"aa_end": null,
"aa_length": 427,
"cds_start": 637,
"cds_end": null,
"cds_length": 1284,
"cdna_start": 966,
"cdna_end": null,
"cdna_length": 6761,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "I",
"aa_alt": "F",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 16,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ABLIM1",
"gene_hgnc_id": 78,
"hgvs_c": "c.559A>T",
"hgvs_p": "p.Ile187Phe",
"transcript": "NM_001322896.2",
"protein_id": "NP_001309825.1",
"transcript_support_level": null,
"aa_start": 187,
"aa_end": null,
"aa_length": 401,
"cds_start": 559,
"cds_end": null,
"cds_length": 1206,
"cdna_start": 867,
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"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "I",
"aa_alt": "F",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 16,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ABLIM1",
"gene_hgnc_id": 78,
"hgvs_c": "c.559A>T",
"hgvs_p": "p.Ile187Phe",
"transcript": "ENST00000369253.6",
"protein_id": "ENSP00000358257.2",
"transcript_support_level": 5,
"aa_start": 187,
"aa_end": null,
"aa_length": 401,
"cds_start": 559,
"cds_end": null,
"cds_length": 1206,
"cdna_start": 789,
"cdna_end": null,
"cdna_length": 2255,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "I",
"aa_alt": "F",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 19,
"exon_rank_end": null,
"exon_count": 27,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ABLIM1",
"gene_hgnc_id": 78,
"hgvs_c": "c.1855A>T",
"hgvs_p": "p.Ile619Phe",
"transcript": "XM_024448010.2",
"protein_id": "XP_024303778.2",
"transcript_support_level": null,
"aa_start": 619,
"aa_end": null,
"aa_length": 833,
"cds_start": 1855,
"cds_end": null,
"cds_length": 2502,
"cdna_start": 1922,
"cdna_end": null,
"cdna_length": 7719,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "I",
"aa_alt": "F",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 18,
"exon_rank_end": null,
"exon_count": 26,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ABLIM1",
"gene_hgnc_id": 78,
"hgvs_c": "c.1741A>T",
"hgvs_p": "p.Ile581Phe",
"transcript": "XM_047425229.1",
"protein_id": "XP_047281185.1",
"transcript_support_level": null,
"aa_start": 581,
"aa_end": null,
"aa_length": 795,
"cds_start": 1741,
"cds_end": null,
"cds_length": 2388,
"cdna_start": 1808,
"cdna_end": null,
"cdna_length": 7605,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "I",
"aa_alt": "F",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 18,
"exon_rank_end": null,
"exon_count": 26,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ABLIM1",
"gene_hgnc_id": 78,
"hgvs_c": "c.1735A>T",
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"phenotype_combined": "not specified",
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}
],
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}