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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 10-124398070-G-A (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=10&pos=124398070&ref=G&alt=A&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "10",
"pos": 124398070,
"ref": "G",
"alt": "A",
"effect": "stop_gained",
"transcript": "NM_000274.4",
"consequences": [
{
"aa_ref": "R",
"aa_alt": "*",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"stop_gained"
],
"exon_rank": 10,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "OAT",
"gene_hgnc_id": 8091,
"hgvs_c": "c.1192C>T",
"hgvs_p": "p.Arg398*",
"transcript": "NM_000274.4",
"protein_id": "NP_000265.1",
"transcript_support_level": null,
"aa_start": 398,
"aa_end": null,
"aa_length": 439,
"cds_start": 1192,
"cds_end": null,
"cds_length": 1320,
"cdna_start": 1272,
"cdna_end": null,
"cdna_length": 2039,
"mane_select": "ENST00000368845.6",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_000274.4"
},
{
"aa_ref": "R",
"aa_alt": "*",
"canonical": true,
"protein_coding": true,
"strand": false,
"consequences": [
"stop_gained"
],
"exon_rank": 10,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "OAT",
"gene_hgnc_id": 8091,
"hgvs_c": "c.1192C>T",
"hgvs_p": "p.Arg398*",
"transcript": "ENST00000368845.6",
"protein_id": "ENSP00000357838.5",
"transcript_support_level": 1,
"aa_start": 398,
"aa_end": null,
"aa_length": 439,
"cds_start": 1192,
"cds_end": null,
"cds_length": 1320,
"cdna_start": 1272,
"cdna_end": null,
"cdna_length": 2039,
"mane_select": "NM_000274.4",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000368845.6"
},
{
"aa_ref": "R",
"aa_alt": "*",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"stop_gained"
],
"exon_rank": 9,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "OAT",
"gene_hgnc_id": 8091,
"hgvs_c": "c.778C>T",
"hgvs_p": "p.Arg260*",
"transcript": "ENST00000539214.5",
"protein_id": "ENSP00000439042.1",
"transcript_support_level": 1,
"aa_start": 260,
"aa_end": null,
"aa_length": 301,
"cds_start": 778,
"cds_end": null,
"cds_length": 906,
"cdna_start": 1097,
"cdna_end": null,
"cdna_length": 1864,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000539214.5"
},
{
"aa_ref": "R",
"aa_alt": "*",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"stop_gained"
],
"exon_rank": 10,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "OAT",
"gene_hgnc_id": 8091,
"hgvs_c": "c.1195C>T",
"hgvs_p": "p.Arg399*",
"transcript": "ENST00000921313.1",
"protein_id": "ENSP00000591372.1",
"transcript_support_level": null,
"aa_start": 399,
"aa_end": null,
"aa_length": 440,
"cds_start": 1195,
"cds_end": null,
"cds_length": 1323,
"cdna_start": 1284,
"cdna_end": null,
"cdna_length": 2056,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000921313.1"
},
{
"aa_ref": "R",
"aa_alt": "*",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"stop_gained"
],
"exon_rank": 10,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "OAT",
"gene_hgnc_id": 8091,
"hgvs_c": "c.1192C>T",
"hgvs_p": "p.Arg398*",
"transcript": "NM_001322965.2",
"protein_id": "NP_001309894.1",
"transcript_support_level": null,
"aa_start": 398,
"aa_end": null,
"aa_length": 439,
"cds_start": 1192,
"cds_end": null,
"cds_length": 1320,
"cdna_start": 1267,
"cdna_end": null,
"cdna_length": 2034,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001322965.2"
},
{
"aa_ref": "R",
"aa_alt": "*",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"stop_gained"
],
"exon_rank": 11,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "OAT",
"gene_hgnc_id": 8091,
"hgvs_c": "c.1192C>T",
"hgvs_p": "p.Arg398*",
"transcript": "NM_001322966.2",
"protein_id": "NP_001309895.1",
"transcript_support_level": null,
"aa_start": 398,
"aa_end": null,
"aa_length": 439,
"cds_start": 1192,
"cds_end": null,
"cds_length": 1320,
"cdna_start": 1587,
"cdna_end": null,
"cdna_length": 2354,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001322966.2"
},
{
"aa_ref": "R",
"aa_alt": "*",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"stop_gained"
],
"exon_rank": 11,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "OAT",
"gene_hgnc_id": 8091,
"hgvs_c": "c.1192C>T",
"hgvs_p": "p.Arg398*",
"transcript": "NM_001322967.2",
"protein_id": "NP_001309896.1",
"transcript_support_level": null,
"aa_start": 398,
"aa_end": null,
"aa_length": 439,
"cds_start": 1192,
"cds_end": null,
"cds_length": 1320,
"cdna_start": 1392,
"cdna_end": null,
"cdna_length": 2159,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001322967.2"
},
{
"aa_ref": "R",
"aa_alt": "*",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"stop_gained"
],
"exon_rank": 12,
"exon_rank_end": null,
"exon_count": 12,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "OAT",
"gene_hgnc_id": 8091,
"hgvs_c": "c.1192C>T",
"hgvs_p": "p.Arg398*",
"transcript": "NM_001322968.2",
"protein_id": "NP_001309897.1",
"transcript_support_level": null,
"aa_start": 398,
"aa_end": null,
"aa_length": 439,
"cds_start": 1192,
"cds_end": null,
"cds_length": 1320,
"cdna_start": 1479,
"cdna_end": null,
"cdna_length": 2246,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001322968.2"
},
{
"aa_ref": "R",
"aa_alt": "*",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"stop_gained"
],
"exon_rank": 11,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "OAT",
"gene_hgnc_id": 8091,
"hgvs_c": "c.1192C>T",
"hgvs_p": "p.Arg398*",
"transcript": "NM_001322969.2",
"protein_id": "NP_001309898.1",
"transcript_support_level": null,
"aa_start": 398,
"aa_end": null,
"aa_length": 439,
"cds_start": 1192,
"cds_end": null,
"cds_length": 1320,
"cdna_start": 1359,
"cdna_end": null,
"cdna_length": 2126,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001322969.2"
},
{
"aa_ref": "R",
"aa_alt": "*",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"stop_gained"
],
"exon_rank": 12,
"exon_rank_end": null,
"exon_count": 12,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "OAT",
"gene_hgnc_id": 8091,
"hgvs_c": "c.1192C>T",
"hgvs_p": "p.Arg398*",
"transcript": "NM_001322970.2",
"protein_id": "NP_001309899.1",
"transcript_support_level": null,
"aa_start": 398,
"aa_end": null,
"aa_length": 439,
"cds_start": 1192,
"cds_end": null,
"cds_length": 1320,
"cdna_start": 1575,
"cdna_end": null,
"cdna_length": 2342,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001322970.2"
},
{
"aa_ref": "R",
"aa_alt": "*",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"stop_gained"
],
"exon_rank": 11,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "OAT",
"gene_hgnc_id": 8091,
"hgvs_c": "c.1192C>T",
"hgvs_p": "p.Arg398*",
"transcript": "ENST00000858831.1",
"protein_id": "ENSP00000528890.1",
"transcript_support_level": null,
"aa_start": 398,
"aa_end": null,
"aa_length": 439,
"cds_start": 1192,
"cds_end": null,
"cds_length": 1320,
"cdna_start": 1362,
"cdna_end": null,
"cdna_length": 2129,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000858831.1"
},
{
"aa_ref": "R",
"aa_alt": "*",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"stop_gained"
],
"exon_rank": 11,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "OAT",
"gene_hgnc_id": 8091,
"hgvs_c": "c.1192C>T",
"hgvs_p": "p.Arg398*",
"transcript": "ENST00000858833.1",
"protein_id": "ENSP00000528892.1",
"transcript_support_level": null,
"aa_start": 398,
"aa_end": null,
"aa_length": 439,
"cds_start": 1192,
"cds_end": null,
"cds_length": 1320,
"cdna_start": 1392,
"cdna_end": null,
"cdna_length": 2159,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000858833.1"
},
{
"aa_ref": "R",
"aa_alt": "*",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"stop_gained"
],
"exon_rank": 11,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "OAT",
"gene_hgnc_id": 8091,
"hgvs_c": "c.1192C>T",
"hgvs_p": "p.Arg398*",
"transcript": "ENST00000858834.1",
"protein_id": "ENSP00000528893.1",
"transcript_support_level": null,
"aa_start": 398,
"aa_end": null,
"aa_length": 439,
"cds_start": 1192,
"cds_end": null,
"cds_length": 1320,
"cdna_start": 1355,
"cdna_end": null,
"cdna_length": 2122,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000858834.1"
},
{
"aa_ref": "R",
"aa_alt": "*",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"stop_gained"
],
"exon_rank": 11,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "OAT",
"gene_hgnc_id": 8091,
"hgvs_c": "c.1192C>T",
"hgvs_p": "p.Arg398*",
"transcript": "ENST00000858835.1",
"protein_id": "ENSP00000528894.1",
"transcript_support_level": null,
"aa_start": 398,
"aa_end": null,
"aa_length": 439,
"cds_start": 1192,
"cds_end": null,
"cds_length": 1320,
"cdna_start": 1455,
"cdna_end": null,
"cdna_length": 2222,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000858835.1"
},
{
"aa_ref": "R",
"aa_alt": "*",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"stop_gained"
],
"exon_rank": 11,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "OAT",
"gene_hgnc_id": 8091,
"hgvs_c": "c.1192C>T",
"hgvs_p": "p.Arg398*",
"transcript": "ENST00000858836.1",
"protein_id": "ENSP00000528895.1",
"transcript_support_level": null,
"aa_start": 398,
"aa_end": null,
"aa_length": 439,
"cds_start": 1192,
"cds_end": null,
"cds_length": 1320,
"cdna_start": 1587,
"cdna_end": null,
"cdna_length": 2354,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000858836.1"
},
{
"aa_ref": "R",
"aa_alt": "*",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"stop_gained"
],
"exon_rank": 11,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "OAT",
"gene_hgnc_id": 8091,
"hgvs_c": "c.1192C>T",
"hgvs_p": "p.Arg398*",
"transcript": "ENST00000858838.1",
"protein_id": "ENSP00000528897.1",
"transcript_support_level": null,
"aa_start": 398,
"aa_end": null,
"aa_length": 439,
"cds_start": 1192,
"cds_end": null,
"cds_length": 1320,
"cdna_start": 1306,
"cdna_end": null,
"cdna_length": 2066,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000858838.1"
},
{
"aa_ref": "R",
"aa_alt": "*",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"stop_gained"
],
"exon_rank": 10,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "OAT",
"gene_hgnc_id": 8091,
"hgvs_c": "c.1192C>T",
"hgvs_p": "p.Arg398*",
"transcript": "ENST00000858839.1",
"protein_id": "ENSP00000528898.1",
"transcript_support_level": null,
"aa_start": 398,
"aa_end": null,
"aa_length": 439,
"cds_start": 1192,
"cds_end": null,
"cds_length": 1320,
"cdna_start": 1668,
"cdna_end": null,
"cdna_length": 2436,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000858839.1"
},
{
"aa_ref": "R",
"aa_alt": "*",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"stop_gained"
],
"exon_rank": 10,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "OAT",
"gene_hgnc_id": 8091,
"hgvs_c": "c.1192C>T",
"hgvs_p": "p.Arg398*",
"transcript": "ENST00000858840.1",
"protein_id": "ENSP00000528899.1",
"transcript_support_level": null,
"aa_start": 398,
"aa_end": null,
"aa_length": 439,
"cds_start": 1192,
"cds_end": null,
"cds_length": 1320,
"cdna_start": 1361,
"cdna_end": null,
"cdna_length": 2125,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000858840.1"
},
{
"aa_ref": "R",
"aa_alt": "*",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"stop_gained"
],
"exon_rank": 10,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "OAT",
"gene_hgnc_id": 8091,
"hgvs_c": "c.1192C>T",
"hgvs_p": "p.Arg398*",
"transcript": "ENST00000921311.1",
"protein_id": "ENSP00000591370.1",
"transcript_support_level": null,
"aa_start": 398,
"aa_end": null,
"aa_length": 439,
"cds_start": 1192,
"cds_end": null,
"cds_length": 1320,
"cdna_start": 1314,
"cdna_end": null,
"cdna_length": 2079,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000921311.1"
},
{
"aa_ref": "R",
"aa_alt": "*",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"stop_gained"
],
"exon_rank": 10,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "OAT",
"gene_hgnc_id": 8091,
"hgvs_c": "c.1192C>T",
"hgvs_p": "p.Arg398*",
"transcript": "ENST00000921312.1",
"protein_id": "ENSP00000591371.1",
"transcript_support_level": null,
"aa_start": 398,
"aa_end": null,
"aa_length": 439,
"cds_start": 1192,
"cds_end": null,
"cds_length": 1320,
"cdna_start": 1439,
"cdna_end": null,
"cdna_length": 2206,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000921312.1"
},
{
"aa_ref": "R",
"aa_alt": "*",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"stop_gained"
],
"exon_rank": 10,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "OAT",
"gene_hgnc_id": 8091,
"hgvs_c": "c.1192C>T",
"hgvs_p": "p.Arg398*",
"transcript": "ENST00000921315.1",
"protein_id": "ENSP00000591374.1",
"transcript_support_level": null,
"aa_start": 398,
"aa_end": null,
"aa_length": 439,
"cds_start": 1192,
"cds_end": null,
"cds_length": 1320,
"cdna_start": 1267,
"cdna_end": null,
"cdna_length": 2034,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000921315.1"
},
{
"aa_ref": "R",
"aa_alt": "*",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"stop_gained"
],
"exon_rank": 10,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "OAT",
"gene_hgnc_id": 8091,
"hgvs_c": "c.1192C>T",
"hgvs_p": "p.Arg398*",
"transcript": "ENST00000921319.1",
"protein_id": "ENSP00000591378.1",
"transcript_support_level": null,
"aa_start": 398,
"aa_end": null,
"aa_length": 439,
"cds_start": 1192,
"cds_end": null,
"cds_length": 1320,
"cdna_start": 3503,
"cdna_end": null,
"cdna_length": 4266,
"mane_select": null,
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}