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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 10-132348013-C-T (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=10&pos=132348013&ref=C&alt=T&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "10",
"pos": 132348013,
"ref": "C",
"alt": "T",
"effect": "missense_variant",
"transcript": "ENST00000368614.8",
"consequences": [
{
"aa_ref": "R",
"aa_alt": "C",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "LRRC27",
"gene_hgnc_id": 29346,
"hgvs_c": "c.583C>T",
"hgvs_p": "p.Arg195Cys",
"transcript": "NM_030626.3",
"protein_id": "NP_085129.1",
"transcript_support_level": null,
"aa_start": 195,
"aa_end": null,
"aa_length": 530,
"cds_start": 583,
"cds_end": null,
"cds_length": 1593,
"cdna_start": 695,
"cdna_end": null,
"cdna_length": 7971,
"mane_select": "ENST00000368614.8",
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "R",
"aa_alt": "C",
"canonical": true,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "LRRC27",
"gene_hgnc_id": 29346,
"hgvs_c": "c.583C>T",
"hgvs_p": "p.Arg195Cys",
"transcript": "ENST00000368614.8",
"protein_id": "ENSP00000357603.3",
"transcript_support_level": 1,
"aa_start": 195,
"aa_end": null,
"aa_length": 530,
"cds_start": 583,
"cds_end": null,
"cds_length": 1593,
"cdna_start": 695,
"cdna_end": null,
"cdna_length": 7971,
"mane_select": "NM_030626.3",
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "R",
"aa_alt": "C",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "LRRC27",
"gene_hgnc_id": 29346,
"hgvs_c": "c.583C>T",
"hgvs_p": "p.Arg195Cys",
"transcript": "ENST00000368613.8",
"protein_id": "ENSP00000357602.4",
"transcript_support_level": 1,
"aa_start": 195,
"aa_end": null,
"aa_length": 530,
"cds_start": 583,
"cds_end": null,
"cds_length": 1593,
"cdna_start": 889,
"cdna_end": null,
"cdna_length": 2113,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "R",
"aa_alt": "C",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "LRRC27",
"gene_hgnc_id": 29346,
"hgvs_c": "c.583C>T",
"hgvs_p": "p.Arg195Cys",
"transcript": "ENST00000625755.2",
"protein_id": "ENSP00000486582.1",
"transcript_support_level": 1,
"aa_start": 195,
"aa_end": null,
"aa_length": 383,
"cds_start": 583,
"cds_end": null,
"cds_length": 1152,
"cdna_start": 733,
"cdna_end": null,
"cdna_length": 1738,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "R",
"aa_alt": "C",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "LRRC27",
"gene_hgnc_id": 29346,
"hgvs_c": "c.583C>T",
"hgvs_p": "p.Arg195Cys",
"transcript": "NM_001143757.2",
"protein_id": "NP_001137229.1",
"transcript_support_level": null,
"aa_start": 195,
"aa_end": null,
"aa_length": 530,
"cds_start": 583,
"cds_end": null,
"cds_length": 1593,
"cdna_start": 975,
"cdna_end": null,
"cdna_length": 8251,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "R",
"aa_alt": "C",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "LRRC27",
"gene_hgnc_id": 29346,
"hgvs_c": "c.397C>T",
"hgvs_p": "p.Arg133Cys",
"transcript": "ENST00000368612.3",
"protein_id": "ENSP00000357601.1",
"transcript_support_level": 2,
"aa_start": 133,
"aa_end": null,
"aa_length": 468,
"cds_start": 397,
"cds_end": null,
"cds_length": 1407,
"cdna_start": 542,
"cdna_end": null,
"cdna_length": 1765,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "R",
"aa_alt": "C",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "LRRC27",
"gene_hgnc_id": 29346,
"hgvs_c": "c.583C>T",
"hgvs_p": "p.Arg195Cys",
"transcript": "NM_001143758.2",
"protein_id": "NP_001137230.1",
"transcript_support_level": null,
"aa_start": 195,
"aa_end": null,
"aa_length": 383,
"cds_start": 583,
"cds_end": null,
"cds_length": 1152,
"cdna_start": 695,
"cdna_end": null,
"cdna_length": 1700,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "R",
"aa_alt": "C",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "LRRC27",
"gene_hgnc_id": 29346,
"hgvs_c": "c.583C>T",
"hgvs_p": "p.Arg195Cys",
"transcript": "NM_001143759.2",
"protein_id": "NP_001137231.1",
"transcript_support_level": null,
"aa_start": 195,
"aa_end": null,
"aa_length": 383,
"cds_start": 583,
"cds_end": null,
"cds_length": 1152,
"cdna_start": 695,
"cdna_end": null,
"cdna_length": 1771,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "R",
"aa_alt": "C",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "LRRC27",
"gene_hgnc_id": 29346,
"hgvs_c": "c.583C>T",
"hgvs_p": "p.Arg195Cys",
"transcript": "ENST00000344079.9",
"protein_id": "ENSP00000342641.5",
"transcript_support_level": 2,
"aa_start": 195,
"aa_end": null,
"aa_length": 383,
"cds_start": 583,
"cds_end": null,
"cds_length": 1152,
"cdna_start": 734,
"cdna_end": null,
"cdna_length": 1809,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "R",
"aa_alt": "C",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 5,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "LRRC27",
"gene_hgnc_id": 29346,
"hgvs_c": "c.202C>T",
"hgvs_p": "p.Arg68Cys",
"transcript": "NM_001309474.2",
"protein_id": "NP_001296403.1",
"transcript_support_level": null,
"aa_start": 68,
"aa_end": null,
"aa_length": 368,
"cds_start": 202,
"cds_end": null,
"cds_length": 1107,
"cdna_start": 455,
"cdna_end": null,
"cdna_length": 1444,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "R",
"aa_alt": "C",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "LRRC27",
"gene_hgnc_id": 29346,
"hgvs_c": "c.583C>T",
"hgvs_p": "p.Arg195Cys",
"transcript": "XM_011540208.2",
"protein_id": "XP_011538510.1",
"transcript_support_level": null,
"aa_start": 195,
"aa_end": null,
"aa_length": 530,
"cds_start": 583,
"cds_end": null,
"cds_length": 1593,
"cdna_start": 861,
"cdna_end": null,
"cdna_length": 8137,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "R",
"aa_alt": "C",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "LRRC27",
"gene_hgnc_id": 29346,
"hgvs_c": "c.583C>T",
"hgvs_p": "p.Arg195Cys",
"transcript": "XM_047425785.1",
"protein_id": "XP_047281741.1",
"transcript_support_level": null,
"aa_start": 195,
"aa_end": null,
"aa_length": 530,
"cds_start": 583,
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"cdna_start": 1545,
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"cdna_length": 8821,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "R",
"aa_alt": "C",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "LRRC27",
"gene_hgnc_id": 29346,
"hgvs_c": "c.583C>T",
"hgvs_p": "p.Arg195Cys",
"transcript": "XM_047425786.1",
"protein_id": "XP_047281742.1",
"transcript_support_level": null,
"aa_start": 195,
"aa_end": null,
"aa_length": 530,
"cds_start": 583,
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"cdna_start": 837,
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"mane_select": null,
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"biotype": null,
"feature": null
},
{
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"aa_alt": "C",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
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],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": null,
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"gene_symbol": "LRRC27",
"gene_hgnc_id": 29346,
"hgvs_c": "c.583C>T",
"hgvs_p": "p.Arg195Cys",
"transcript": "XM_011540209.3",
"protein_id": "XP_011538511.1",
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"mane_select": null,
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"feature": null
},
{
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"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "LRRC27",
"gene_hgnc_id": 29346,
"hgvs_c": "c.583C>T",
"hgvs_p": "p.Arg195Cys",
"transcript": "XM_047425787.1",
"protein_id": "XP_047281743.1",
"transcript_support_level": null,
"aa_start": 195,
"aa_end": null,
"aa_length": 520,
"cds_start": 583,
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"cdna_start": 1545,
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"mane_select": null,
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"biotype": null,
"feature": null
},
{
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"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "LRRC27",
"gene_hgnc_id": 29346,
"hgvs_c": "c.583C>T",
"hgvs_p": "p.Arg195Cys",
"transcript": "XM_017016690.3",
"protein_id": "XP_016872179.1",
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"feature": null
},
{
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"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
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],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "LRRC27",
"gene_hgnc_id": 29346,
"hgvs_c": "c.583C>T",
"hgvs_p": "p.Arg195Cys",
"transcript": "XM_006717984.4",
"protein_id": "XP_006718047.1",
"transcript_support_level": null,
"aa_start": 195,
"aa_end": null,
"aa_length": 495,
"cds_start": 583,
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"cdna_start": 695,
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"mane_select": null,
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"feature": null
},
{
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"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "LRRC27",
"gene_hgnc_id": 29346,
"hgvs_c": "c.583C>T",
"hgvs_p": "p.Arg195Cys",
"transcript": "XM_024448208.2",
"protein_id": "XP_024303976.1",
"transcript_support_level": null,
"aa_start": 195,
"aa_end": null,
"aa_length": 495,
"cds_start": 583,
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"cdna_start": 975,
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"mane_select": null,
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"feature": null
},
{
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"protein_coding": true,
"strand": true,
"consequences": [
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],
"exon_rank": 6,
"exon_rank_end": null,
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"intron_rank": null,
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"gene_symbol": "LRRC27",
"gene_hgnc_id": 29346,
"hgvs_c": "c.583C>T",
"hgvs_p": "p.Arg195Cys",
"transcript": "XM_047425788.1",
"protein_id": "XP_047281744.1",
"transcript_support_level": null,
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},
{
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"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "LRRC27",
"gene_hgnc_id": 29346,
"hgvs_c": "c.583C>T",
"hgvs_p": "p.Arg195Cys",
"transcript": "XM_047425789.1",
"protein_id": "XP_047281745.1",
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},
{
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"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
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"intron_rank": null,
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"gene_symbol": "LRRC27",
"gene_hgnc_id": 29346,
"hgvs_c": "c.583C>T",
"hgvs_p": "p.Arg195Cys",
"transcript": "XM_017016691.3",
"protein_id": "XP_016872180.1",
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"cds_start": 583,
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"cdna_start": 695,
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"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "R",
"aa_alt": "C",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "LRRC27",
"gene_hgnc_id": 29346,
"hgvs_c": "c.583C>T",
"hgvs_p": "p.Arg195Cys",
"transcript": "XM_047425790.1",
"protein_id": "XP_047281746.1",
"transcript_support_level": null,
"aa_start": 195,
"aa_end": null,
"aa_length": 418,
"cds_start": 583,
"cds_end": null,
"cds_length": 1257,
"cdna_start": 975,
"cdna_end": null,
"cdna_length": 1824,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "R",
"aa_alt": "C",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 5,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "LRRC27",
"gene_hgnc_id": 29346,
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}