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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 10-17157650-A-T (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=10&pos=17157650&ref=A&alt=T&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "10",
"pos": 17157650,
"ref": "A",
"alt": "T",
"effect": "missense_variant",
"transcript": "NM_004412.7",
"consequences": [
{
"aa_ref": "D",
"aa_alt": "E",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TRDMT1",
"gene_hgnc_id": 2977,
"hgvs_c": "c.678T>A",
"hgvs_p": "p.Asp226Glu",
"transcript": "NM_004412.7",
"protein_id": "NP_004403.1",
"transcript_support_level": null,
"aa_start": 226,
"aa_end": null,
"aa_length": 391,
"cds_start": 678,
"cds_end": null,
"cds_length": 1176,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": "ENST00000377799.8",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_004412.7"
},
{
"aa_ref": "D",
"aa_alt": "E",
"canonical": true,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TRDMT1",
"gene_hgnc_id": 2977,
"hgvs_c": "c.678T>A",
"hgvs_p": "p.Asp226Glu",
"transcript": "ENST00000377799.8",
"protein_id": "ENSP00000367030.3",
"transcript_support_level": 1,
"aa_start": 226,
"aa_end": null,
"aa_length": 391,
"cds_start": 678,
"cds_end": null,
"cds_length": 1176,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": "NM_004412.7",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000377799.8"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": false,
"strand": false,
"consequences": [
"non_coding_transcript_exon_variant"
],
"exon_rank": 9,
"exon_rank_end": null,
"exon_count": 12,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TRDMT1",
"gene_hgnc_id": 2977,
"hgvs_c": "n.*698T>A",
"hgvs_p": null,
"transcript": "ENST00000354631.7",
"protein_id": "ENSP00000346652.3",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": null,
"cds_start": null,
"cds_end": null,
"cds_length": null,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "nonsense_mediated_decay",
"feature": "ENST00000354631.7"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": false,
"strand": false,
"consequences": [
"3_prime_UTR_variant"
],
"exon_rank": 9,
"exon_rank_end": null,
"exon_count": 12,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TRDMT1",
"gene_hgnc_id": 2977,
"hgvs_c": "n.*698T>A",
"hgvs_p": null,
"transcript": "ENST00000354631.7",
"protein_id": "ENSP00000346652.3",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": null,
"cds_start": null,
"cds_end": null,
"cds_length": null,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "nonsense_mediated_decay",
"feature": "ENST00000354631.7"
},
{
"aa_ref": "D",
"aa_alt": "E",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TRDMT1",
"gene_hgnc_id": 2977,
"hgvs_c": "c.699T>A",
"hgvs_p": "p.Asp233Glu",
"transcript": "ENST00000929578.1",
"protein_id": "ENSP00000599637.1",
"transcript_support_level": null,
"aa_start": 233,
"aa_end": null,
"aa_length": 398,
"cds_start": 699,
"cds_end": null,
"cds_length": 1197,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000929578.1"
},
{
"aa_ref": "D",
"aa_alt": "E",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TRDMT1",
"gene_hgnc_id": 2977,
"hgvs_c": "c.678T>A",
"hgvs_p": "p.Asp226Glu",
"transcript": "NM_001351219.2",
"protein_id": "NP_001338148.1",
"transcript_support_level": null,
"aa_start": 226,
"aa_end": null,
"aa_length": 384,
"cds_start": 678,
"cds_end": null,
"cds_length": 1155,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001351219.2"
},
{
"aa_ref": "D",
"aa_alt": "E",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TRDMT1",
"gene_hgnc_id": 2977,
"hgvs_c": "c.678T>A",
"hgvs_p": "p.Asp226Glu",
"transcript": "ENST00000852532.1",
"protein_id": "ENSP00000522591.1",
"transcript_support_level": null,
"aa_start": 226,
"aa_end": null,
"aa_length": 384,
"cds_start": 678,
"cds_end": null,
"cds_length": 1155,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000852532.1"
},
{
"aa_ref": "D",
"aa_alt": "E",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TRDMT1",
"gene_hgnc_id": 2977,
"hgvs_c": "c.678T>A",
"hgvs_p": "p.Asp226Glu",
"transcript": "NM_001351220.2",
"protein_id": "NP_001338149.1",
"transcript_support_level": null,
"aa_start": 226,
"aa_end": null,
"aa_length": 377,
"cds_start": 678,
"cds_end": null,
"cds_length": 1134,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001351220.2"
},
{
"aa_ref": "D",
"aa_alt": "E",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TRDMT1",
"gene_hgnc_id": 2977,
"hgvs_c": "c.612T>A",
"hgvs_p": "p.Asp204Glu",
"transcript": "ENST00000852531.1",
"protein_id": "ENSP00000522590.1",
"transcript_support_level": null,
"aa_start": 204,
"aa_end": null,
"aa_length": 369,
"cds_start": 612,
"cds_end": null,
"cds_length": 1110,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000852531.1"
},
{
"aa_ref": "D",
"aa_alt": "E",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TRDMT1",
"gene_hgnc_id": 2977,
"hgvs_c": "c.597T>A",
"hgvs_p": "p.Asp199Glu",
"transcript": "ENST00000929579.1",
"protein_id": "ENSP00000599638.1",
"transcript_support_level": null,
"aa_start": 199,
"aa_end": null,
"aa_length": 364,
"cds_start": 597,
"cds_end": null,
"cds_length": 1095,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000929579.1"
},
{
"aa_ref": "D",
"aa_alt": "E",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TRDMT1",
"gene_hgnc_id": 2977,
"hgvs_c": "c.594T>A",
"hgvs_p": "p.Asp198Glu",
"transcript": "ENST00000949131.1",
"protein_id": "ENSP00000619190.1",
"transcript_support_level": null,
"aa_start": 198,
"aa_end": null,
"aa_length": 363,
"cds_start": 594,
"cds_end": null,
"cds_length": 1092,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000949131.1"
},
{
"aa_ref": "D",
"aa_alt": "E",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TRDMT1",
"gene_hgnc_id": 2977,
"hgvs_c": "c.612T>A",
"hgvs_p": "p.Asp204Glu",
"transcript": "ENST00000852533.1",
"protein_id": "ENSP00000522592.1",
"transcript_support_level": null,
"aa_start": 204,
"aa_end": null,
"aa_length": 362,
"cds_start": 612,
"cds_end": null,
"cds_length": 1089,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000852533.1"
},
{
"aa_ref": "D",
"aa_alt": "E",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TRDMT1",
"gene_hgnc_id": 2977,
"hgvs_c": "c.540T>A",
"hgvs_p": "p.Asp180Glu",
"transcript": "NM_001351221.2",
"protein_id": "NP_001338150.1",
"transcript_support_level": null,
"aa_start": 180,
"aa_end": null,
"aa_length": 338,
"cds_start": 540,
"cds_end": null,
"cds_length": 1017,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001351221.2"
},
{
"aa_ref": "D",
"aa_alt": "E",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TRDMT1",
"gene_hgnc_id": 2977,
"hgvs_c": "c.540T>A",
"hgvs_p": "p.Asp180Glu",
"transcript": "ENST00000929575.1",
"protein_id": "ENSP00000599634.1",
"transcript_support_level": null,
"aa_start": 180,
"aa_end": null,
"aa_length": 338,
"cds_start": 540,
"cds_end": null,
"cds_length": 1017,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000929575.1"
},
{
"aa_ref": "D",
"aa_alt": "E",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 5,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TRDMT1",
"gene_hgnc_id": 2977,
"hgvs_c": "c.483T>A",
"hgvs_p": "p.Asp161Glu",
"transcript": "ENST00000929577.1",
"protein_id": "ENSP00000599636.1",
"transcript_support_level": null,
"aa_start": 161,
"aa_end": null,
"aa_length": 326,
"cds_start": 483,
"cds_end": null,
"cds_length": 981,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000929577.1"
},
{
"aa_ref": "D",
"aa_alt": "E",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 9,
"exon_rank_end": null,
"exon_count": 12,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TRDMT1",
"gene_hgnc_id": 2977,
"hgvs_c": "c.465T>A",
"hgvs_p": "p.Asp155Glu",
"transcript": "NM_001321007.2",
"protein_id": "NP_001307936.1",
"transcript_support_level": null,
"aa_start": 155,
"aa_end": null,
"aa_length": 320,
"cds_start": 465,
"cds_end": null,
"cds_length": 963,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001321007.2"
},
{
"aa_ref": "D",
"aa_alt": "E",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 5,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TRDMT1",
"gene_hgnc_id": 2977,
"hgvs_c": "c.456T>A",
"hgvs_p": "p.Asp152Glu",
"transcript": "ENST00000949130.1",
"protein_id": "ENSP00000619189.1",
"transcript_support_level": null,
"aa_start": 152,
"aa_end": null,
"aa_length": 317,
"cds_start": 456,
"cds_end": null,
"cds_length": 954,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000949130.1"
},
{
"aa_ref": "D",
"aa_alt": "E",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TRDMT1",
"gene_hgnc_id": 2977,
"hgvs_c": "c.435T>A",
"hgvs_p": "p.Asp145Glu",
"transcript": "NM_001321006.2",
"protein_id": "NP_001307935.1",
"transcript_support_level": null,
"aa_start": 145,
"aa_end": null,
"aa_length": 310,
"cds_start": 435,
"cds_end": null,
"cds_length": 933,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001321006.2"
},
{
"aa_ref": "D",
"aa_alt": "E",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 9,
"exon_rank_end": null,
"exon_count": 12,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TRDMT1",
"gene_hgnc_id": 2977,
"hgvs_c": "c.465T>A",
"hgvs_p": "p.Asp155Glu",
"transcript": "NM_001351222.2",
"protein_id": "NP_001338151.1",
"transcript_support_level": null,
"aa_start": 155,
"aa_end": null,
"aa_length": 299,
"cds_start": 465,
"cds_end": null,
"cds_length": 900,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001351222.2"
},
{
"aa_ref": "D",
"aa_alt": "E",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 9,
"exon_rank_end": null,
"exon_count": 12,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TRDMT1",
"gene_hgnc_id": 2977,
"hgvs_c": "c.465T>A",
"hgvs_p": "p.Asp155Glu",
"transcript": "NM_001351223.2",
"protein_id": "NP_001338152.1",
"transcript_support_level": null,
"aa_start": 155,
"aa_end": null,
"aa_length": 299,
"cds_start": 465,
"cds_end": null,
"cds_length": 900,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001351223.2"
},
{
"aa_ref": "D",
"aa_alt": "E",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 6,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TRDMT1",
"gene_hgnc_id": 2977,
"hgvs_c": "c.309T>A",
"hgvs_p": "p.Asp103Glu",
"transcript": "ENST00000929576.1",
"protein_id": "ENSP00000599635.1",
"transcript_support_level": null,
"aa_start": 103,
"aa_end": null,
"aa_length": 268,
"cds_start": 309,
"cds_end": null,
"cds_length": 807,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000929576.1"
},
{
"aa_ref": "D",
"aa_alt": "E",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 5,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TRDMT1",
"gene_hgnc_id": 2977,
"hgvs_c": "c.309T>A",
"hgvs_p": "p.Asp103Glu",
"transcript": "ENST00000488990.5",
"protein_id": "ENSP00000419625.1",
"transcript_support_level": 2,
"aa_start": 103,
"aa_end": null,
"aa_length": 254,
"cds_start": 309,
"cds_end": null,
"cds_length": 765,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
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}