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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 10-24650736-T-A (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=10&pos=24650736&ref=T&alt=A&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "10",
"pos": 24650736,
"ref": "T",
"alt": "A",
"effect": "intron_variant",
"transcript": "ENST00000396432.7",
"consequences": [
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 26,
"intron_rank": 4,
"intron_rank_end": null,
"gene_symbol": "ARHGAP21",
"gene_hgnc_id": 23725,
"hgvs_c": "c.269-15633A>T",
"hgvs_p": null,
"transcript": "NM_020824.4",
"protein_id": "NP_065875.3",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 1958,
"cds_start": -4,
"cds_end": null,
"cds_length": 5877,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 7381,
"mane_select": "ENST00000396432.7",
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": true,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 26,
"intron_rank": 4,
"intron_rank_end": null,
"gene_symbol": "ARHGAP21",
"gene_hgnc_id": 23725,
"hgvs_c": "c.269-15633A>T",
"hgvs_p": null,
"transcript": "ENST00000396432.7",
"protein_id": "ENSP00000379709.2",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": 1958,
"cds_start": -4,
"cds_end": null,
"cds_length": 5877,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 7381,
"mane_select": "NM_020824.4",
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 17,
"intron_rank": 4,
"intron_rank_end": null,
"gene_symbol": "ARHGAP21",
"gene_hgnc_id": 23725,
"hgvs_c": "c.269-15633A>T",
"hgvs_p": null,
"transcript": "ENST00000446003.5",
"protein_id": "ENSP00000405018.1",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": 1130,
"cds_start": -4,
"cds_end": null,
"cds_length": 3395,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 3859,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"5_prime_UTR_variant"
],
"exon_rank": 5,
"exon_rank_end": null,
"exon_count": 28,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ARHGAP21",
"gene_hgnc_id": 23725,
"hgvs_c": "c.-178A>T",
"hgvs_p": null,
"transcript": "NM_001367450.1",
"protein_id": "NP_001354379.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 1860,
"cds_start": -4,
"cds_end": null,
"cds_length": 5583,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 7491,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 25,
"intron_rank": 3,
"intron_rank_end": null,
"gene_symbol": "ARHGAP21",
"gene_hgnc_id": 23725,
"hgvs_c": "c.290-15633A>T",
"hgvs_p": null,
"transcript": "ENST00000680286.1",
"protein_id": "ENSP00000506388.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 1965,
"cds_start": -4,
"cds_end": null,
"cds_length": 5898,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 6731,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 26,
"intron_rank": 4,
"intron_rank_end": null,
"gene_symbol": "ARHGAP21",
"gene_hgnc_id": 23725,
"hgvs_c": "c.269-15633A>T",
"hgvs_p": null,
"transcript": "NM_001367448.1",
"protein_id": "NP_001354377.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 1958,
"cds_start": -4,
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"cdna_start": null,
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"cdna_length": 7120,
"mane_select": null,
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"biotype": null,
"feature": null
},
{
"aa_ref": null,
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"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 26,
"intron_rank": 4,
"intron_rank_end": null,
"gene_symbol": "ARHGAP21",
"gene_hgnc_id": 23725,
"hgvs_c": "c.269-15633A>T",
"hgvs_p": null,
"transcript": "NM_001367454.1",
"protein_id": "NP_001354383.1",
"transcript_support_level": null,
"aa_start": null,
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"cds_start": -4,
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"cdna_start": null,
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"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
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"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 25,
"intron_rank": 4,
"intron_rank_end": null,
"gene_symbol": "ARHGAP21",
"gene_hgnc_id": 23725,
"hgvs_c": "c.269-15633A>T",
"hgvs_p": null,
"transcript": "NM_001367447.1",
"protein_id": "NP_001354376.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 1948,
"cds_start": -4,
"cds_end": null,
"cds_length": 5847,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 7351,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 25,
"intron_rank": 4,
"intron_rank_end": null,
"gene_symbol": "ARHGAP21",
"gene_hgnc_id": 23725,
"hgvs_c": "c.269-15633A>T",
"hgvs_p": null,
"transcript": "NM_001367451.1",
"protein_id": "NP_001354380.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 1948,
"cds_start": -4,
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"cdna_start": null,
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"mane_select": null,
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"feature": null
},
{
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"consequences": [
"intron_variant"
],
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"gene_symbol": "ARHGAP21",
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"hgvs_c": "c.269-15633A>T",
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"transcript": "NM_001367453.1",
"protein_id": "NP_001354382.1",
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},
{
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"consequences": [
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],
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"gene_symbol": "ARHGAP21",
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"hgvs_c": "c.269-15633A>T",
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"transcript": "ENST00000376410.7",
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},
{
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],
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},
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],
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],
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"gene_symbol": "ARHGAP21",
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],
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],
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],
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},
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],
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"intron_rank": 4,
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"gene_symbol": "ARHGAP21",
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}