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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 10-27186515-T-G (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=10&pos=27186515&ref=T&alt=G&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "10",
"pos": 27186515,
"ref": "T",
"alt": "G",
"effect": "synonymous_variant",
"transcript": "NM_001320757.2",
"consequences": [
{
"aa_ref": "T",
"aa_alt": "T",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 12,
"exon_rank_end": null,
"exon_count": 12,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "MASTL",
"gene_hgnc_id": 19042,
"hgvs_c": "c.2619T>G",
"hgvs_p": "p.Thr873Thr",
"transcript": "NM_001172303.3",
"protein_id": "NP_001165774.1",
"transcript_support_level": null,
"aa_start": 873,
"aa_end": null,
"aa_length": 879,
"cds_start": 2619,
"cds_end": null,
"cds_length": 2640,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": "ENST00000375940.9",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001172303.3"
},
{
"aa_ref": "T",
"aa_alt": "T",
"canonical": true,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 12,
"exon_rank_end": null,
"exon_count": 12,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "MASTL",
"gene_hgnc_id": 19042,
"hgvs_c": "c.2619T>G",
"hgvs_p": "p.Thr873Thr",
"transcript": "ENST00000375940.9",
"protein_id": "ENSP00000365107.5",
"transcript_support_level": 1,
"aa_start": 873,
"aa_end": null,
"aa_length": 879,
"cds_start": 2619,
"cds_end": null,
"cds_length": 2640,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": "NM_001172303.3",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000375940.9"
},
{
"aa_ref": "T",
"aa_alt": "T",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 12,
"exon_rank_end": null,
"exon_count": 12,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "MASTL",
"gene_hgnc_id": 19042,
"hgvs_c": "c.2616T>G",
"hgvs_p": "p.Thr872Thr",
"transcript": "ENST00000375946.8",
"protein_id": "ENSP00000365113.4",
"transcript_support_level": 1,
"aa_start": 872,
"aa_end": null,
"aa_length": 878,
"cds_start": 2616,
"cds_end": null,
"cds_length": 2637,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000375946.8"
},
{
"aa_ref": "T",
"aa_alt": "T",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 13,
"exon_rank_end": null,
"exon_count": 13,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "MASTL",
"gene_hgnc_id": 19042,
"hgvs_c": "c.2634T>G",
"hgvs_p": "p.Thr878Thr",
"transcript": "NM_001320757.2",
"protein_id": "NP_001307686.1",
"transcript_support_level": null,
"aa_start": 878,
"aa_end": null,
"aa_length": 884,
"cds_start": 2634,
"cds_end": null,
"cds_length": 2655,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001320757.2"
},
{
"aa_ref": "T",
"aa_alt": "T",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 13,
"exon_rank_end": null,
"exon_count": 13,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "MASTL",
"gene_hgnc_id": 19042,
"hgvs_c": "c.2634T>G",
"hgvs_p": "p.Thr878Thr",
"transcript": "ENST00000969651.1",
"protein_id": "ENSP00000639710.1",
"transcript_support_level": null,
"aa_start": 878,
"aa_end": null,
"aa_length": 884,
"cds_start": 2634,
"cds_end": null,
"cds_length": 2655,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000969651.1"
},
{
"aa_ref": "T",
"aa_alt": "T",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 13,
"exon_rank_end": null,
"exon_count": 13,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "MASTL",
"gene_hgnc_id": 19042,
"hgvs_c": "c.2631T>G",
"hgvs_p": "p.Thr877Thr",
"transcript": "NM_001320756.2",
"protein_id": "NP_001307685.1",
"transcript_support_level": null,
"aa_start": 877,
"aa_end": null,
"aa_length": 883,
"cds_start": 2631,
"cds_end": null,
"cds_length": 2652,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001320756.2"
},
{
"aa_ref": "T",
"aa_alt": "T",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 13,
"exon_rank_end": null,
"exon_count": 13,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "MASTL",
"gene_hgnc_id": 19042,
"hgvs_c": "c.2631T>G",
"hgvs_p": "p.Thr877Thr",
"transcript": "ENST00000969653.1",
"protein_id": "ENSP00000639712.1",
"transcript_support_level": null,
"aa_start": 877,
"aa_end": null,
"aa_length": 883,
"cds_start": 2631,
"cds_end": null,
"cds_length": 2652,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000969653.1"
},
{
"aa_ref": "T",
"aa_alt": "T",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 12,
"exon_rank_end": null,
"exon_count": 12,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "MASTL",
"gene_hgnc_id": 19042,
"hgvs_c": "c.2616T>G",
"hgvs_p": "p.Thr872Thr",
"transcript": "NM_032844.5",
"protein_id": "NP_116233.2",
"transcript_support_level": null,
"aa_start": 872,
"aa_end": null,
"aa_length": 878,
"cds_start": 2616,
"cds_end": null,
"cds_length": 2637,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_032844.5"
},
{
"aa_ref": "T",
"aa_alt": "T",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 11,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "MASTL",
"gene_hgnc_id": 19042,
"hgvs_c": "c.2517T>G",
"hgvs_p": "p.Thr839Thr",
"transcript": "ENST00000933942.1",
"protein_id": "ENSP00000604001.1",
"transcript_support_level": null,
"aa_start": 839,
"aa_end": null,
"aa_length": 845,
"cds_start": 2517,
"cds_end": null,
"cds_length": 2538,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000933942.1"
},
{
"aa_ref": "T",
"aa_alt": "T",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 11,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "MASTL",
"gene_hgnc_id": 19042,
"hgvs_c": "c.2514T>G",
"hgvs_p": "p.Thr838Thr",
"transcript": "ENST00000896815.1",
"protein_id": "ENSP00000566874.1",
"transcript_support_level": null,
"aa_start": 838,
"aa_end": null,
"aa_length": 844,
"cds_start": 2514,
"cds_end": null,
"cds_length": 2535,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000896815.1"
},
{
"aa_ref": "T",
"aa_alt": "T",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 11,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "MASTL",
"gene_hgnc_id": 19042,
"hgvs_c": "c.2505T>G",
"hgvs_p": "p.Thr835Thr",
"transcript": "ENST00000896814.1",
"protein_id": "ENSP00000566873.1",
"transcript_support_level": null,
"aa_start": 835,
"aa_end": null,
"aa_length": 841,
"cds_start": 2505,
"cds_end": null,
"cds_length": 2526,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000896814.1"
},
{
"aa_ref": "T",
"aa_alt": "T",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 11,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "MASTL",
"gene_hgnc_id": 19042,
"hgvs_c": "c.2502T>G",
"hgvs_p": "p.Thr834Thr",
"transcript": "NM_001172304.3",
"protein_id": "NP_001165775.1",
"transcript_support_level": null,
"aa_start": 834,
"aa_end": null,
"aa_length": 840,
"cds_start": 2502,
"cds_end": null,
"cds_length": 2523,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001172304.3"
},
{
"aa_ref": "T",
"aa_alt": "T",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 11,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "MASTL",
"gene_hgnc_id": 19042,
"hgvs_c": "c.2502T>G",
"hgvs_p": "p.Thr834Thr",
"transcript": "ENST00000342386.10",
"protein_id": "ENSP00000343446.5",
"transcript_support_level": 2,
"aa_start": 834,
"aa_end": null,
"aa_length": 840,
"cds_start": 2502,
"cds_end": null,
"cds_length": 2523,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000342386.10"
},
{
"aa_ref": "T",
"aa_alt": "T",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 11,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "MASTL",
"gene_hgnc_id": 19042,
"hgvs_c": "c.2481T>G",
"hgvs_p": "p.Thr827Thr",
"transcript": "ENST00000933947.1",
"protein_id": "ENSP00000604006.1",
"transcript_support_level": null,
"aa_start": 827,
"aa_end": null,
"aa_length": 833,
"cds_start": 2481,
"cds_end": null,
"cds_length": 2502,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000933947.1"
},
{
"aa_ref": "T",
"aa_alt": "T",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 11,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "MASTL",
"gene_hgnc_id": 19042,
"hgvs_c": "c.2478T>G",
"hgvs_p": "p.Thr826Thr",
"transcript": "ENST00000933948.1",
"protein_id": "ENSP00000604007.1",
"transcript_support_level": null,
"aa_start": 826,
"aa_end": null,
"aa_length": 832,
"cds_start": 2478,
"cds_end": null,
"cds_length": 2499,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000933948.1"
},
{
"aa_ref": "T",
"aa_alt": "T",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 10,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "MASTL",
"gene_hgnc_id": 19042,
"hgvs_c": "c.2400T>G",
"hgvs_p": "p.Thr800Thr",
"transcript": "ENST00000933941.1",
"protein_id": "ENSP00000604000.1",
"transcript_support_level": null,
"aa_start": 800,
"aa_end": null,
"aa_length": 806,
"cds_start": 2400,
"cds_end": null,
"cds_length": 2421,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000933941.1"
},
{
"aa_ref": "T",
"aa_alt": "T",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 14,
"exon_rank_end": null,
"exon_count": 14,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "MASTL",
"gene_hgnc_id": 19042,
"hgvs_c": "c.2151T>G",
"hgvs_p": "p.Thr717Thr",
"transcript": "NM_001372029.1",
"protein_id": "NP_001358958.1",
"transcript_support_level": null,
"aa_start": 717,
"aa_end": null,
"aa_length": 723,
"cds_start": 2151,
"cds_end": null,
"cds_length": 2172,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001372029.1"
},
{
"aa_ref": "T",
"aa_alt": "T",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 13,
"exon_rank_end": null,
"exon_count": 13,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "MASTL",
"gene_hgnc_id": 19042,
"hgvs_c": "c.2136T>G",
"hgvs_p": "p.Thr712Thr",
"transcript": "NM_001372030.1",
"protein_id": "NP_001358959.1",
"transcript_support_level": null,
"aa_start": 712,
"aa_end": null,
"aa_length": 718,
"cds_start": 2136,
"cds_end": null,
"cds_length": 2157,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001372030.1"
},
{
"aa_ref": "T",
"aa_alt": "T",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 11,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "MASTL",
"gene_hgnc_id": 19042,
"hgvs_c": "c.1479T>G",
"hgvs_p": "p.Thr493Thr",
"transcript": "ENST00000933944.1",
"protein_id": "ENSP00000604003.1",
"transcript_support_level": null,
"aa_start": 493,
"aa_end": null,
"aa_length": 499,
"cds_start": 1479,
"cds_end": null,
"cds_length": 1500,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000933944.1"
},
{
"aa_ref": "T",
"aa_alt": "T",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 11,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "MASTL",
"gene_hgnc_id": 19042,
"hgvs_c": "c.1476T>G",
"hgvs_p": "p.Thr492Thr",
"transcript": "ENST00000933946.1",
"protein_id": "ENSP00000604005.1",
"transcript_support_level": null,
"aa_start": 492,
"aa_end": null,
"aa_length": 498,
"cds_start": 1476,
"cds_end": null,
"cds_length": 1497,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000933946.1"
},
{
"aa_ref": "T",
"aa_alt": "T",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 3,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "MASTL",
"gene_hgnc_id": 19042,
"hgvs_c": "c.1419T>G",
"hgvs_p": "p.Thr473Thr",
"transcript": "ENST00000477034.2",
"protein_id": "ENSP00000478938.1",
"transcript_support_level": 2,
"aa_start": 473,
"aa_end": null,
"aa_length": 479,
"cds_start": 1419,
"cds_end": null,
"cds_length": 1440,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000477034.2"
},
{
"aa_ref": "T",
"aa_alt": "T",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 10,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "MASTL",
"gene_hgnc_id": 19042,
"hgvs_c": "c.1374T>G",
"hgvs_p": "p.Thr458Thr",
"transcript": "ENST00000969652.1",
"protein_id": "ENSP00000639711.1",
"transcript_support_level": null,
"aa_start": 458,
"aa_end": null,
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}
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}